Human papillomavirus 197

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 24

Average proteome isoelectric point is 5.98

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A088FQG2|A0A088FQG2_9PAPI Replication protein E1 OS=Human papillomavirus 197 OX=1542134 GN=E1 PE=3 SV=1
MM1 pKa = 7.62EE2 pKa = 5.1PRR4 pKa = 11.84AKK6 pKa = 9.86RR7 pKa = 11.84RR8 pKa = 11.84KK9 pKa = 9.58RR10 pKa = 11.84DD11 pKa = 3.56TVDD14 pKa = 2.81NLYY17 pKa = 10.16RR18 pKa = 11.84QCKK21 pKa = 8.4LTGQCPDD28 pKa = 3.27DD29 pKa = 4.54VINKK33 pKa = 9.39VEE35 pKa = 4.16GTTLADD41 pKa = 3.77RR42 pKa = 11.84LLKK45 pKa = 10.5ILGSVIYY52 pKa = 10.6LGGLGIGTGRR62 pKa = 11.84GTGGATGYY70 pKa = 10.51RR71 pKa = 11.84PIGAQTPRR79 pKa = 11.84VTDD82 pKa = 3.45STPIRR87 pKa = 11.84PTIPVDD93 pKa = 3.35PLIPTDD99 pKa = 4.8IIPVDD104 pKa = 3.61PAGSSIVPLTDD115 pKa = 2.96AGIPEE120 pKa = 4.33DD121 pKa = 4.36VIIEE125 pKa = 4.3TGGSVVTAGPSDD137 pKa = 3.68PSVITTVDD145 pKa = 3.33PVSDD149 pKa = 3.69VTGVDD154 pKa = 3.68PQPTIITGEE163 pKa = 4.27DD164 pKa = 3.24DD165 pKa = 3.34TVAILDD171 pKa = 4.06VQPSTPAPKK180 pKa = 10.28KK181 pKa = 8.41VTTAVTQSASEE192 pKa = 4.02TLEE195 pKa = 3.73PSILLPIPEE204 pKa = 4.04SAANDD209 pKa = 2.96FHH211 pKa = 9.2IFVDD215 pKa = 4.2AQAIGEE221 pKa = 4.44TIGAEE226 pKa = 4.28TIPLEE231 pKa = 4.39DD232 pKa = 3.92FNEE235 pKa = 4.11IEE237 pKa = 4.2SFEE240 pKa = 4.43IEE242 pKa = 4.96DD243 pKa = 3.86IAPQTSTPEE252 pKa = 3.69QRR254 pKa = 11.84INRR257 pKa = 11.84AFQRR261 pKa = 11.84ARR263 pKa = 11.84SLYY266 pKa = 9.39NRR268 pKa = 11.84HH269 pKa = 6.11ISQIRR274 pKa = 11.84TRR276 pKa = 11.84NLDD279 pKa = 3.26FLGSVSRR286 pKa = 11.84AVQFEE291 pKa = 4.17FEE293 pKa = 4.25NPAFQGDD300 pKa = 3.53VTLQFEE306 pKa = 4.16QDD308 pKa = 3.48VRR310 pKa = 11.84EE311 pKa = 4.25VAAAPDD317 pKa = 3.4SDD319 pKa = 3.59FRR321 pKa = 11.84DD322 pKa = 3.05IRR324 pKa = 11.84TLSRR328 pKa = 11.84PQYY331 pKa = 9.19STTEE335 pKa = 3.9SGRR338 pKa = 11.84VRR340 pKa = 11.84VSRR343 pKa = 11.84LGRR346 pKa = 11.84RR347 pKa = 11.84GTILTRR353 pKa = 11.84SGTQIGEE360 pKa = 4.26NVHH363 pKa = 6.87FYY365 pKa = 11.42YY366 pKa = 10.74DD367 pKa = 3.97LSTIGSDD374 pKa = 2.9TADD377 pKa = 4.2AIEE380 pKa = 5.1LSTLGQQSGDD390 pKa = 3.44TTIVDD395 pKa = 4.26GLAEE399 pKa = 4.2SSFVDD404 pKa = 3.81VPNNTDD410 pKa = 2.74VAYY413 pKa = 10.43GEE415 pKa = 4.32EE416 pKa = 4.32TLFDD420 pKa = 4.08PQNEE424 pKa = 4.28EE425 pKa = 3.63FDD427 pKa = 3.96NLHH430 pKa = 6.65LVLTSTGRR438 pKa = 11.84RR439 pKa = 11.84GEE441 pKa = 3.91VDD443 pKa = 4.32NIPTLPPGTPLRR455 pKa = 11.84IFIDD459 pKa = 4.35DD460 pKa = 3.73YY461 pKa = 11.94GKK463 pKa = 10.52DD464 pKa = 3.7LIVNYY469 pKa = 9.63PMSYY473 pKa = 8.88DD474 pKa = 3.31TSTVIVPDD482 pKa = 3.98SAAHH486 pKa = 6.11PLEE489 pKa = 4.35PPILLDD495 pKa = 3.71YY496 pKa = 10.78LGSGYY501 pKa = 10.22YY502 pKa = 9.41LHH504 pKa = 7.36PSLWKK509 pKa = 8.62RR510 pKa = 11.84RR511 pKa = 11.84KK512 pKa = 9.38RR513 pKa = 11.84KK514 pKa = 10.03RR515 pKa = 11.84SDD517 pKa = 3.13TYY519 pKa = 11.64NSFTDD524 pKa = 5.12GIVDD528 pKa = 3.44ATEE531 pKa = 3.59WW532 pKa = 3.29

Molecular weight: 57.93 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A088FLI4|A0A088FLI4_9PAPI Protein E7 OS=Human papillomavirus 197 OX=1542134 GN=E7 PE=3 SV=1
MM1 pKa = 7.35EE2 pKa = 4.46WLAEE6 pKa = 4.05RR7 pKa = 11.84FNAVQEE13 pKa = 4.29TLLNLIEE20 pKa = 4.74QGAEE24 pKa = 3.98DD25 pKa = 5.21LDD27 pKa = 4.15SQITYY32 pKa = 9.18WNTVRR37 pKa = 11.84KK38 pKa = 9.28EE39 pKa = 4.05NVYY42 pKa = 9.6MYY44 pKa = 10.0YY45 pKa = 10.76AKK47 pKa = 10.38KK48 pKa = 10.51EE49 pKa = 4.11KK50 pKa = 9.33LTHH53 pKa = 6.89LGLQPLPVTAVSEE66 pKa = 4.49YY67 pKa = 10.03KK68 pKa = 10.48AKK70 pKa = 10.17QAIHH74 pKa = 6.46IVLLLEE80 pKa = 4.3SLKK83 pKa = 10.74KK84 pKa = 10.87SPFANEE90 pKa = 3.13AWTLQNTSAEE100 pKa = 4.34LLNTLPKK107 pKa = 10.77DD108 pKa = 3.88CFKK111 pKa = 10.93KK112 pKa = 10.62DD113 pKa = 3.42PYY115 pKa = 9.43TVHH118 pKa = 6.05VWFDD122 pKa = 3.5DD123 pKa = 3.44DD124 pKa = 4.76RR125 pKa = 11.84NNSFPYY131 pKa = 10.32VNWDD135 pKa = 3.58AIYY138 pKa = 10.77YY139 pKa = 10.08QDD141 pKa = 5.55AQGKK145 pKa = 4.24WHH147 pKa = 6.82KK148 pKa = 11.01VPGLVDD154 pKa = 3.71YY155 pKa = 11.46NGLYY159 pKa = 9.67YY160 pKa = 10.94NEE162 pKa = 4.3VGGDD166 pKa = 2.98RR167 pKa = 11.84VYY169 pKa = 10.74FALFDD174 pKa = 4.72ADD176 pKa = 3.5AQNYY180 pKa = 7.67GHH182 pKa = 6.65TGMWSVHH189 pKa = 5.54FKK191 pKa = 11.1HH192 pKa = 5.86EE193 pKa = 4.29TLSPISSSKK202 pKa = 10.62QSTSYY207 pKa = 10.5SGKK210 pKa = 8.0TSGVSTTTKK219 pKa = 10.32VPVPTAEE226 pKa = 4.07SPRR229 pKa = 11.84RR230 pKa = 11.84LQKK233 pKa = 10.74PEE235 pKa = 3.96VGSSTGEE242 pKa = 3.5KK243 pKa = 8.16TAIRR247 pKa = 11.84RR248 pKa = 11.84RR249 pKa = 11.84RR250 pKa = 11.84RR251 pKa = 11.84QQRR254 pKa = 11.84EE255 pKa = 4.02STPEE259 pKa = 4.0GEE261 pKa = 4.48PTTSSKK267 pKa = 10.27RR268 pKa = 11.84RR269 pKa = 11.84RR270 pKa = 11.84GGGGGADD277 pKa = 3.24RR278 pKa = 11.84LGVSPEE284 pKa = 4.05AVGSRR289 pKa = 11.84HH290 pKa = 5.89RR291 pKa = 11.84SVTASHH297 pKa = 7.33LSRR300 pKa = 11.84LEE302 pKa = 3.74LLKK305 pKa = 11.06EE306 pKa = 4.12EE307 pKa = 5.08ARR309 pKa = 11.84DD310 pKa = 3.56PPIIIITGPANTLKK324 pKa = 10.22CWRR327 pKa = 11.84YY328 pKa = 9.66RR329 pKa = 11.84KK330 pKa = 9.84RR331 pKa = 11.84NSNASWFLGISTIFTWVGGCSTNEE355 pKa = 3.75QARR358 pKa = 11.84MLVAFKK364 pKa = 10.77NDD366 pKa = 3.27QQRR369 pKa = 11.84EE370 pKa = 4.09QFVKK374 pKa = 10.67YY375 pKa = 10.07IQLPKK380 pKa = 10.26QATFAYY386 pKa = 9.37GQLDD390 pKa = 3.49RR391 pKa = 11.84LL392 pKa = 4.02

Molecular weight: 44.57 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2445

94

607

349.3

39.5

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.849 ± 0.407

2.331 ± 0.766

6.83 ± 0.627

5.93 ± 0.369

4.294 ± 0.458

5.726 ± 0.736

1.84 ± 0.26

5.685 ± 0.627

5.235 ± 0.896

8.957 ± 0.581

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.513 ± 0.378

5.276 ± 0.703

5.726 ± 1.001

4.99 ± 0.36

5.726 ± 0.649

6.585 ± 0.395

6.462 ± 0.997

6.135 ± 0.395

1.309 ± 0.288

3.599 ± 0.369
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski