Amino acid dipepetide frequency for Lachnospiraceae bacterium XBB1006

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.897AlaAla: 5.897 ± 0.113	1.21AlaCys: 1.21 ± 0.038	4.086AlaAsp: 4.086 ± 0.087	5.269AlaGlu: 5.269 ± 0.097	3.1AlaPhe: 3.1 ± 0.063	5.553AlaGly: 5.553 ± 0.103	1.182AlaHis: 1.182 ± 0.04	5.345AlaIle: 5.345 ± 0.094	6.08AlaLys: 6.08 ± 0.089	6.928AlaLeu: 6.928 ± 0.103	2.696AlaMet: 2.696 ± 0.064	3.036AlaAsn: 3.036 ± 0.061	1.914AlaPro: 1.914 ± 0.048	2.213AlaGln: 2.213 ± 0.056	2.953AlaArg: 2.953 ± 0.071	3.891AlaSer: 3.891 ± 0.075	4.105AlaThr: 4.105 ± 0.097	5.499AlaVal: 5.499 ± 0.097	0.547AlaTrp: 0.547 ± 0.025	3.009AlaTyr: 3.009 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.986CysAla: 0.986 ± 0.04	0.254CysCys: 0.254 ± 0.017	0.872CysAsp: 0.872 ± 0.032	1.075CysGlu: 1.075 ± 0.039	0.705CysPhe: 0.705 ± 0.033	1.406CysGly: 1.406 ± 0.046	0.303CysHis: 0.303 ± 0.02	1.093CysIle: 1.093 ± 0.034	1.078CysLys: 1.078 ± 0.039	1.137CysLeu: 1.137 ± 0.038	0.471CysMet: 0.471 ± 0.024	0.573CysAsn: 0.573 ± 0.026	0.643CysPro: 0.643 ± 0.033	0.406CysGln: 0.406 ± 0.022	0.63CysArg: 0.63 ± 0.03	0.802CysSer: 0.802 ± 0.029	0.733CysThr: 0.733 ± 0.033	1.131CysVal: 1.131 ± 0.04	0.117CysTrp: 0.117 ± 0.011	0.626CysTyr: 0.626 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.365AspAla: 4.365 ± 0.078	0.885AspCys: 0.885 ± 0.034	2.893AspAsp: 2.893 ± 0.069	4.979AspGlu: 4.979 ± 0.094	2.449AspPhe: 2.449 ± 0.059	4.284AspGly: 4.284 ± 0.078	0.873AspHis: 0.873 ± 0.033	4.115AspIle: 4.115 ± 0.073	3.603AspLys: 3.603 ± 0.076	4.203AspLeu: 4.203 ± 0.07	1.835AspMet: 1.835 ± 0.044	2.138AspAsn: 2.138 ± 0.058	1.523AspPro: 1.523 ± 0.052	1.112AspGln: 1.112 ± 0.037	2.148AspArg: 2.148 ± 0.053	2.811AspSer: 2.811 ± 0.065	2.939AspThr: 2.939 ± 0.063	4.302AspVal: 4.302 ± 0.077	0.493AspTrp: 0.493 ± 0.029	2.907AspTyr: 2.907 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.208GluAla: 6.208 ± 0.1	0.856GluCys: 0.856 ± 0.033	4.353GluAsp: 4.353 ± 0.083	8.396GluGlu: 8.396 ± 0.146	2.734GluPhe: 2.734 ± 0.056	4.792GluGly: 4.792 ± 0.072	1.593GluHis: 1.593 ± 0.052	5.469GluIle: 5.469 ± 0.089	7.404GluLys: 7.404 ± 0.119	6.936GluLeu: 6.936 ± 0.103	2.632GluMet: 2.632 ± 0.068	3.978GluAsn: 3.978 ± 0.069	2.05GluPro: 2.05 ± 0.07	3.206GluGln: 3.206 ± 0.065	3.895GluArg: 3.895 ± 0.084	3.598GluSer: 3.598 ± 0.079	3.825GluThr: 3.825 ± 0.074	5.294GluVal: 5.294 ± 0.093	0.61GluTrp: 0.61 ± 0.026	3.088GluTyr: 3.088 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.022PheAla: 3.022 ± 0.058	0.759PheCys: 0.759 ± 0.029	2.454PheAsp: 2.454 ± 0.057	2.94PheGlu: 2.94 ± 0.059	1.854PhePhe: 1.854 ± 0.054	2.812PheGly: 2.812 ± 0.077	0.802PheHis: 0.802 ± 0.031	2.349PheIle: 2.349 ± 0.06	2.052PheLys: 2.052 ± 0.047	3.865PheLeu: 3.865 ± 0.074	1.107PheMet: 1.107 ± 0.038	1.391PheAsn: 1.391 ± 0.042	1.236PhePro: 1.236 ± 0.038	1.216PheGln: 1.216 ± 0.045	1.606PheArg: 1.606 ± 0.043	2.836PheSer: 2.836 ± 0.067	2.295PheThr: 2.295 ± 0.057	3.061PheVal: 3.061 ± 0.068	0.414PheTrp: 0.414 ± 0.023	1.712PheTyr: 1.712 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.795GlyAla: 4.795 ± 0.091	1.251GlyCys: 1.251 ± 0.048	3.456GlyAsp: 3.456 ± 0.061	4.97GlyGlu: 4.97 ± 0.073	3.012GlyPhe: 3.012 ± 0.064	4.673GlyGly: 4.673 ± 0.096	1.23GlyHis: 1.23 ± 0.042	5.795GlyIle: 5.795 ± 0.108	6.014GlyLys: 6.014 ± 0.108	5.44GlyLeu: 5.44 ± 0.086	2.562GlyMet: 2.562 ± 0.065	3.061GlyAsn: 3.061 ± 0.07	1.155GlyPro: 1.155 ± 0.042	2.021GlyGln: 2.021 ± 0.055	2.917GlyArg: 2.917 ± 0.07	3.69GlySer: 3.69 ± 0.07	4.096GlyThr: 4.096 ± 0.09	5.204GlyVal: 5.204 ± 0.1	0.587GlyTrp: 0.587 ± 0.026	3.251GlyTyr: 3.251 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.221HisAla: 1.221 ± 0.05	0.307HisCys: 0.307 ± 0.021	0.881HisAsp: 0.881 ± 0.034	1.156HisGlu: 1.156 ± 0.04	0.802HisPhe: 0.802 ± 0.037	1.34HisGly: 1.34 ± 0.038	0.381HisHis: 0.381 ± 0.024	1.289HisIle: 1.289 ± 0.041	1.034HisLys: 1.034 ± 0.039	1.575HisLeu: 1.575 ± 0.035	0.578HisMet: 0.578 ± 0.029	0.719HisAsn: 0.719 ± 0.03	0.846HisPro: 0.846 ± 0.036	0.557HisGln: 0.557 ± 0.026	0.83HisArg: 0.83 ± 0.033	1.005HisSer: 1.005 ± 0.038	1.009HisThr: 1.009 ± 0.036	1.296HisVal: 1.296 ± 0.042	0.149HisTrp: 0.149 ± 0.015	0.878HisTyr: 0.878 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.788IleAla: 5.788 ± 0.088	1.207IleCys: 1.207 ± 0.042	3.854IleAsp: 3.854 ± 0.069	4.791IleGlu: 4.791 ± 0.078	2.575IlePhe: 2.575 ± 0.073	4.868IleGly: 4.868 ± 0.101	1.415IleHis: 1.415 ± 0.047	4.472IleIle: 4.472 ± 0.087	4.118IleLys: 4.118 ± 0.093	6.227IleLeu: 6.227 ± 0.098	2.05IleMet: 2.05 ± 0.055	2.609IleAsn: 2.609 ± 0.061	2.843IlePro: 2.843 ± 0.062	2.021IleGln: 2.021 ± 0.049	3.605IleArg: 3.605 ± 0.074	4.537IleSer: 4.537 ± 0.088	4.208IleThr: 4.208 ± 0.078	4.968IleVal: 4.968 ± 0.082	0.546IleTrp: 0.546 ± 0.03	2.453IleTyr: 2.453 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.518LysAla: 5.518 ± 0.094	0.712LysCys: 0.712 ± 0.032	4.26LysAsp: 4.26 ± 0.074	7.959LysGlu: 7.959 ± 0.118	1.971LysPhe: 1.971 ± 0.053	4.535LysGly: 4.535 ± 0.073	1.16LysHis: 1.16 ± 0.039	4.743LysIle: 4.743 ± 0.084	7.155LysLys: 7.155 ± 0.109	5.586LysLeu: 5.586 ± 0.093	2.423LysMet: 2.423 ± 0.057	3.971LysAsn: 3.971 ± 0.078	2.152LysPro: 2.152 ± 0.05	2.972LysGln: 2.972 ± 0.072	3.597LysArg: 3.597 ± 0.067	3.535LysSer: 3.535 ± 0.061	4.125LysThr: 4.125 ± 0.082	5.104LysVal: 5.104 ± 0.094	0.565LysTrp: 0.565 ± 0.031	2.789LysTyr: 2.789 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	6.705LeuAla: 6.705 ± 0.103	1.539LeuCys: 1.539 ± 0.041	4.798LeuAsp: 4.798 ± 0.08	6.305LeuGlu: 6.305 ± 0.103	3.524LeuPhe: 3.524 ± 0.08	5.695LeuGly: 5.695 ± 0.092	1.585LeuHis: 1.585 ± 0.046	5.091LeuIle: 5.091 ± 0.088	6.097LeuLys: 6.097 ± 0.091	8.404LeuLeu: 8.404 ± 0.135	2.524LeuMet: 2.524 ± 0.054	3.535LeuAsn: 3.535 ± 0.071	3.166LeuPro: 3.166 ± 0.074	2.86LeuGln: 2.86 ± 0.067	4.118LeuArg: 4.118 ± 0.083	6.127LeuSer: 6.127 ± 0.089	5.142LeuThr: 5.142 ± 0.082	5.922LeuVal: 5.922 ± 0.086	0.684LeuTrp: 0.684 ± 0.034	3.176LeuTyr: 3.176 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.567MetAla: 2.567 ± 0.063	0.379MetCys: 0.379 ± 0.024	2.13MetAsp: 2.13 ± 0.049	2.939MetGlu: 2.939 ± 0.064	1.036MetPhe: 1.036 ± 0.037	2.054MetGly: 2.054 ± 0.052	0.535MetHis: 0.535 ± 0.023	2.007MetIle: 2.007 ± 0.057	2.788MetLys: 2.788 ± 0.052	2.73MetLeu: 2.73 ± 0.057	1.075MetMet: 1.075 ± 0.046	1.587MetAsn: 1.587 ± 0.044	1.165MetPro: 1.165 ± 0.049	1.18MetGln: 1.18 ± 0.044	1.501MetArg: 1.501 ± 0.042	1.816MetSer: 1.816 ± 0.047	1.593MetThr: 1.593 ± 0.047	2.224MetVal: 2.224 ± 0.052	0.207MetTrp: 0.207 ± 0.016	0.942MetTyr: 0.942 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.219AsnAla: 3.219 ± 0.069	0.637AsnCys: 0.637 ± 0.032	1.967AsnAsp: 1.967 ± 0.058	3.069AsnGlu: 3.069 ± 0.06	1.533AsnPhe: 1.533 ± 0.047	3.465AsnGly: 3.465 ± 0.074	0.919AsnHis: 0.919 ± 0.039	2.918AsnIle: 2.918 ± 0.063	2.882AsnLys: 2.882 ± 0.066	3.673AsnLeu: 3.673 ± 0.071	1.376AsnMet: 1.376 ± 0.042	1.955AsnAsn: 1.955 ± 0.059	1.917AsnPro: 1.917 ± 0.054	1.515AsnGln: 1.515 ± 0.043	2.241AsnArg: 2.241 ± 0.055	2.06AsnSer: 2.06 ± 0.063	2.31AsnThr: 2.31 ± 0.055	3.211AsnVal: 3.211 ± 0.057	0.367AsnTrp: 0.367 ± 0.021	1.904AsnTyr: 1.904 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.075ProAla: 2.075 ± 0.067	0.435ProCys: 0.435 ± 0.024	1.979ProAsp: 1.979 ± 0.054	3.12ProGlu: 3.12 ± 0.065	1.463ProPhe: 1.463 ± 0.046	2.121ProGly: 2.121 ± 0.052	0.518ProHis: 0.518 ± 0.025	2.219ProIle: 2.219 ± 0.056	2.088ProLys: 2.088 ± 0.056	2.472ProLeu: 2.472 ± 0.059	0.932ProMet: 0.932 ± 0.038	1.23ProAsn: 1.23 ± 0.04	0.589ProPro: 0.589 ± 0.032	1.005ProGln: 1.005 ± 0.032	1.0ProArg: 1.0 ± 0.033	1.673ProSer: 1.673 ± 0.037	1.692ProThr: 1.692 ± 0.056	2.697ProVal: 2.697 ± 0.061	0.271ProTrp: 0.271 ± 0.019	1.385ProTyr: 1.385 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.421GlnAla: 2.421 ± 0.058	0.428GlnCys: 0.428 ± 0.024	1.494GlnAsp: 1.494 ± 0.046	2.691GlnGlu: 2.691 ± 0.066	1.224GlnPhe: 1.224 ± 0.043	1.91GlnGly: 1.91 ± 0.048	0.501GlnHis: 0.501 ± 0.023	2.435GlnIle: 2.435 ± 0.055	2.557GlnLys: 2.557 ± 0.055	2.852GlnLeu: 2.852 ± 0.062	1.291GlnMet: 1.291 ± 0.045	1.458GlnAsn: 1.458 ± 0.045	0.872GlnPro: 0.872 ± 0.035	1.275GlnGln: 1.275 ± 0.042	1.445GlnArg: 1.445 ± 0.047	1.603GlnSer: 1.603 ± 0.047	1.764GlnThr: 1.764 ± 0.049	2.233GlnVal: 2.233 ± 0.047	0.295GlnTrp: 0.295 ± 0.02	1.345GlnTyr: 1.345 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.837ArgAla: 2.837 ± 0.054	0.589ArgCys: 0.589 ± 0.027	2.143ArgAsp: 2.143 ± 0.049	3.864ArgGlu: 3.864 ± 0.079	1.877ArgPhe: 1.877 ± 0.052	2.594ArgGly: 2.594 ± 0.052	0.794ArgHis: 0.794 ± 0.031	3.521ArgIle: 3.521 ± 0.067	3.749ArgLys: 3.749 ± 0.073	4.002ArgLeu: 4.002 ± 0.077	1.671ArgMet: 1.671 ± 0.047	2.129ArgAsn: 2.129 ± 0.048	1.291ArgPro: 1.291 ± 0.043	1.602ArgGln: 1.602 ± 0.039	2.321ArgArg: 2.321 ± 0.06	2.007ArgSer: 2.007 ± 0.052	2.233ArgThr: 2.233 ± 0.048	3.085ArgVal: 3.085 ± 0.061	0.376ArgTrp: 0.376 ± 0.021	2.029ArgTyr: 2.029 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.875SerAla: 3.875 ± 0.075	0.786SerCys: 0.786 ± 0.035	2.966SerAsp: 2.966 ± 0.066	4.001SerGlu: 4.001 ± 0.071	2.586SerPhe: 2.586 ± 0.06	4.498SerGly: 4.498 ± 0.088	0.977SerHis: 0.977 ± 0.035	4.034SerIle: 4.034 ± 0.068	3.749SerLys: 3.749 ± 0.076	4.879SerLeu: 4.879 ± 0.079	1.92SerMet: 1.92 ± 0.052	2.251SerAsn: 2.251 ± 0.051	1.479SerPro: 1.479 ± 0.047	1.641SerGln: 1.641 ± 0.049	2.307SerArg: 2.307 ± 0.054	2.907SerSer: 2.907 ± 0.072	2.773SerThr: 2.773 ± 0.068	4.327SerVal: 4.327 ± 0.08	0.49SerTrp: 0.49 ± 0.03	2.53SerTyr: 2.53 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	4.046ThrAla: 4.046 ± 0.082	0.707ThrCys: 0.707 ± 0.025	2.912ThrAsp: 2.912 ± 0.067	3.732ThrGlu: 3.732 ± 0.069	2.243ThrPhe: 2.243 ± 0.045	4.301ThrGly: 4.301 ± 0.082	0.886ThrHis: 0.886 ± 0.032	4.337ThrIle: 4.337 ± 0.069	3.85ThrLys: 3.85 ± 0.082	4.935ThrLeu: 4.935 ± 0.087	1.673ThrMet: 1.673 ± 0.049	2.254ThrAsn: 2.254 ± 0.068	2.156ThrPro: 2.156 ± 0.054	1.572ThrGln: 1.572 ± 0.045	2.057ThrArg: 2.057 ± 0.053	2.887ThrSer: 2.887 ± 0.069	3.329ThrThr: 3.329 ± 0.088	4.603ThrVal: 4.603 ± 0.103	0.468ThrTrp: 0.468 ± 0.028	2.406ThrTyr: 2.406 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	5.573ValAla: 5.573 ± 0.088	1.307ValCys: 1.307 ± 0.048	4.245ValAsp: 4.245 ± 0.066	5.501ValGlu: 5.501 ± 0.092	2.917ValPhe: 2.917 ± 0.066	4.808ValGly: 4.808 ± 0.083	1.135ValHis: 1.135 ± 0.038	4.935ValIle: 4.935 ± 0.075	5.395ValLys: 5.395 ± 0.09	6.744ValLeu: 6.744 ± 0.102	2.194ValMet: 2.194 ± 0.054	3.048ValAsn: 3.048 ± 0.073	2.41ValPro: 2.41 ± 0.059	1.846ValGln: 1.846 ± 0.044	3.017ValArg: 3.017 ± 0.061	4.591ValSer: 4.591 ± 0.088	4.597ValThr: 4.597 ± 0.095	5.749ValVal: 5.749 ± 0.095	0.566ValTrp: 0.566 ± 0.027	2.793ValTyr: 2.793 ± 0.066	0.0ValXaa: 0.0 ± 0.0
Trp	0.48TrpAla: 0.48 ± 0.027	0.149TrpCys: 0.149 ± 0.012	0.481TrpAsp: 0.481 ± 0.025	0.737TrpGlu: 0.737 ± 0.033	0.382TrpPhe: 0.382 ± 0.022	0.6TrpGly: 0.6 ± 0.029	0.16TrpHis: 0.16 ± 0.015	0.544TrpIle: 0.544 ± 0.028	0.648TrpLys: 0.648 ± 0.033	0.757TrpLeu: 0.757 ± 0.034	0.298TrpMet: 0.298 ± 0.021	0.436TrpAsn: 0.436 ± 0.022	0.169TrpPro: 0.169 ± 0.015	0.336TrpGln: 0.336 ± 0.022	0.274TrpArg: 0.274 ± 0.018	0.404TrpSer: 0.404 ± 0.026	0.345TrpThr: 0.345 ± 0.021	0.52TrpVal: 0.52 ± 0.024	0.118TrpTrp: 0.118 ± 0.014	0.385TrpTyr: 0.385 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.918TyrAla: 2.918 ± 0.064	0.642TyrCys: 0.642 ± 0.033	2.636TyrAsp: 2.636 ± 0.056	3.425TyrGlu: 3.425 ± 0.066	1.798TyrPhe: 1.798 ± 0.047	2.869TyrGly: 2.869 ± 0.069	0.903TyrHis: 0.903 ± 0.032	2.446TyrIle: 2.446 ± 0.061	2.491TyrLys: 2.491 ± 0.06	3.651TyrLeu: 3.651 ± 0.068	1.145TyrMet: 1.145 ± 0.042	1.779TyrAsn: 1.779 ± 0.052	1.388TyrPro: 1.388 ± 0.043	1.536TyrGln: 1.536 ± 0.048	2.25TyrArg: 2.25 ± 0.059	2.196TyrSer: 2.196 ± 0.062	2.24TyrThr: 2.24 ± 0.054	2.939TyrVal: 2.939 ± 0.061	0.355TyrTrp: 0.355 ± 0.022	1.981TyrTyr: 1.981 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2560 proteins (814644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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