Amino acid dipepetide frequency for Streptococcus phage Javan110

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.915AlaAla: 3.915 ± 0.972
0.635AlaCys: 0.635 ± 0.217
4.55AlaAsp: 4.55 ± 0.582
6.138AlaGlu: 6.138 ± 0.477
2.116AlaPhe: 2.116 ± 0.529
3.386AlaGly: 3.386 ± 0.615
0.529AlaHis: 0.529 ± 0.278
4.339AlaIle: 4.339 ± 0.76
5.397AlaLys: 5.397 ± 0.742
6.667AlaLeu: 6.667 ± 1.143
2.011AlaMet: 2.011 ± 0.39
3.386AlaAsn: 3.386 ± 0.906
1.376AlaPro: 1.376 ± 0.469
2.222AlaGln: 2.222 ± 0.413
2.434AlaArg: 2.434 ± 0.597
3.81AlaSer: 3.81 ± 0.775
3.915AlaThr: 3.915 ± 1.064
3.81AlaVal: 3.81 ± 0.643
0.212AlaTrp: 0.212 ± 0.131
2.751AlaTyr: 2.751 ± 0.659
0.0AlaXaa: 0.0 ± 0.0
Cys
0.106CysAla: 0.106 ± 0.102
0.0CysCys: 0.0 ± 0.0
0.529CysAsp: 0.529 ± 0.219
0.741CysGlu: 0.741 ± 0.229
0.317CysPhe: 0.317 ± 0.187
0.212CysGly: 0.212 ± 0.155
0.0CysHis: 0.0 ± 0.0
0.635CysIle: 0.635 ± 0.345
0.423CysLys: 0.423 ± 0.207
0.423CysLeu: 0.423 ± 0.237
0.0CysMet: 0.0 ± 0.0
0.529CysAsn: 0.529 ± 0.26
0.106CysPro: 0.106 ± 0.097
0.212CysGln: 0.212 ± 0.16
0.106CysArg: 0.106 ± 0.104
0.423CysSer: 0.423 ± 0.206
0.212CysThr: 0.212 ± 0.144
0.635CysVal: 0.635 ± 0.264
0.0CysTrp: 0.0 ± 0.0
0.423CysTyr: 0.423 ± 0.26
0.0CysXaa: 0.0 ± 0.0
Asp
3.28AspAla: 3.28 ± 0.481
0.212AspCys: 0.212 ± 0.145
3.598AspAsp: 3.598 ± 0.813
5.608AspGlu: 5.608 ± 0.876
4.021AspPhe: 4.021 ± 0.616
5.185AspGly: 5.185 ± 0.799
0.423AspHis: 0.423 ± 0.203
6.032AspIle: 6.032 ± 0.744
5.82AspLys: 5.82 ± 0.683
3.598AspLeu: 3.598 ± 0.64
1.905AspMet: 1.905 ± 0.453
3.28AspAsn: 3.28 ± 0.639
1.376AspPro: 1.376 ± 0.274
1.27AspGln: 1.27 ± 0.338
2.434AspArg: 2.434 ± 0.403
2.751AspSer: 2.751 ± 0.465
2.54AspThr: 2.54 ± 0.62
3.915AspVal: 3.915 ± 0.643
0.847AspTrp: 0.847 ± 0.252
3.492AspTyr: 3.492 ± 0.605
0.0AspXaa: 0.0 ± 0.0
Glu
4.55GluAla: 4.55 ± 0.74
0.212GluCys: 0.212 ± 0.157
3.598GluAsp: 3.598 ± 0.772
5.926GluGlu: 5.926 ± 1.072
3.598GluPhe: 3.598 ± 0.915
3.704GluGly: 3.704 ± 0.651
1.27GluHis: 1.27 ± 0.363
6.772GluIle: 6.772 ± 0.84
5.608GluLys: 5.608 ± 0.936
8.254GluLeu: 8.254 ± 1.055
2.857GluMet: 2.857 ± 0.605
4.868GluAsn: 4.868 ± 0.766
1.481GluPro: 1.481 ± 0.381
3.598GluGln: 3.598 ± 0.548
3.492GluArg: 3.492 ± 0.668
4.127GluSer: 4.127 ± 0.584
4.656GluThr: 4.656 ± 0.809
4.762GluVal: 4.762 ± 0.802
0.847GluTrp: 0.847 ± 0.3
2.751GluTyr: 2.751 ± 0.458
0.0GluXaa: 0.0 ± 0.0
Phe
2.751PheAla: 2.751 ± 0.575
0.212PheCys: 0.212 ± 0.132
3.175PheAsp: 3.175 ± 0.389
4.021PheGlu: 4.021 ± 0.769
1.587PhePhe: 1.587 ± 0.485
3.175PheGly: 3.175 ± 0.535
0.847PheHis: 0.847 ± 0.287
3.492PheIle: 3.492 ± 0.729
4.444PheLys: 4.444 ± 0.481
3.492PheLeu: 3.492 ± 0.628
1.058PheMet: 1.058 ± 0.306
2.963PheAsn: 2.963 ± 0.509
1.164PhePro: 1.164 ± 0.473
2.116PheGln: 2.116 ± 0.521
1.481PheArg: 1.481 ± 0.354
1.693PheSer: 1.693 ± 0.299
1.587PheThr: 1.587 ± 0.421
2.751PheVal: 2.751 ± 0.615
0.423PheTrp: 0.423 ± 0.223
1.905PheTyr: 1.905 ± 0.581
0.0PheXaa: 0.0 ± 0.0
Gly
2.857GlyAla: 2.857 ± 0.812
0.212GlyCys: 0.212 ± 0.152
4.127GlyAsp: 4.127 ± 0.684
3.81GlyGlu: 3.81 ± 0.573
1.587GlyPhe: 1.587 ± 0.477
3.915GlyGly: 3.915 ± 0.774
0.952GlyHis: 0.952 ± 0.287
5.079GlyIle: 5.079 ± 0.65
5.291GlyLys: 5.291 ± 0.698
4.233GlyLeu: 4.233 ± 0.567
1.481GlyMet: 1.481 ± 0.319
3.28GlyAsn: 3.28 ± 0.522
0.635GlyPro: 0.635 ± 0.217
1.799GlyGln: 1.799 ± 0.331
3.069GlyArg: 3.069 ± 0.6
2.751GlySer: 2.751 ± 0.539
3.598GlyThr: 3.598 ± 0.604
4.55GlyVal: 4.55 ± 0.721
0.635GlyTrp: 0.635 ± 0.256
3.704GlyTyr: 3.704 ± 0.723
0.0GlyXaa: 0.0 ± 0.0
His
0.847HisAla: 0.847 ± 0.369
0.317HisCys: 0.317 ± 0.159
0.952HisAsp: 0.952 ± 0.294
1.27HisGlu: 1.27 ± 0.308
0.741HisPhe: 0.741 ± 0.27
0.212HisGly: 0.212 ± 0.134
0.423HisHis: 0.423 ± 0.167
1.27HisIle: 1.27 ± 0.293
0.741HisLys: 0.741 ± 0.276
1.799HisLeu: 1.799 ± 0.434
0.317HisMet: 0.317 ± 0.164
1.376HisAsn: 1.376 ± 0.321
0.423HisPro: 0.423 ± 0.215
0.635HisGln: 0.635 ± 0.247
0.423HisArg: 0.423 ± 0.215
1.27HisSer: 1.27 ± 0.44
0.635HisThr: 0.635 ± 0.224
1.164HisVal: 1.164 ± 0.386
0.106HisTrp: 0.106 ± 0.093
0.741HisTyr: 0.741 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
5.82IleAla: 5.82 ± 0.814
0.635IleCys: 0.635 ± 0.282
5.82IleAsp: 5.82 ± 0.837
5.503IleGlu: 5.503 ± 0.585
3.28IlePhe: 3.28 ± 0.542
3.598IleGly: 3.598 ± 0.571
2.011IleHis: 2.011 ± 0.367
4.868IleIle: 4.868 ± 0.665
8.571IleLys: 8.571 ± 1.207
4.868IleLeu: 4.868 ± 0.976
2.646IleMet: 2.646 ± 0.487
3.704IleAsn: 3.704 ± 0.625
2.646IlePro: 2.646 ± 0.45
3.175IleGln: 3.175 ± 0.5
1.905IleArg: 1.905 ± 0.47
4.974IleSer: 4.974 ± 0.731
4.55IleThr: 4.55 ± 0.739
4.339IleVal: 4.339 ± 0.791
1.587IleTrp: 1.587 ± 0.709
2.222IleTyr: 2.222 ± 0.537
0.0IleXaa: 0.0 ± 0.0
Lys
6.667LysAla: 6.667 ± 0.776
0.741LysCys: 0.741 ± 0.279
5.503LysAsp: 5.503 ± 0.785
5.82LysGlu: 5.82 ± 0.837
3.28LysPhe: 3.28 ± 0.505
4.444LysGly: 4.444 ± 0.635
1.376LysHis: 1.376 ± 0.421
5.397LysIle: 5.397 ± 0.624
7.513LysLys: 7.513 ± 1.109
7.407LysLeu: 7.407 ± 0.896
2.857LysMet: 2.857 ± 0.61
6.138LysAsn: 6.138 ± 0.962
2.328LysPro: 2.328 ± 0.574
4.339LysGln: 4.339 ± 0.575
4.233LysArg: 4.233 ± 0.841
5.503LysSer: 5.503 ± 0.811
5.926LysThr: 5.926 ± 0.91
5.503LysVal: 5.503 ± 0.654
1.376LysTrp: 1.376 ± 0.382
2.328LysTyr: 2.328 ± 0.543
0.0LysXaa: 0.0 ± 0.0
Leu
5.926LeuAla: 5.926 ± 0.649
0.423LeuCys: 0.423 ± 0.189
4.868LeuAsp: 4.868 ± 0.787
7.513LeuGlu: 7.513 ± 0.917
3.069LeuPhe: 3.069 ± 0.652
5.397LeuGly: 5.397 ± 0.719
1.27LeuHis: 1.27 ± 0.474
6.349LeuIle: 6.349 ± 0.89
7.196LeuLys: 7.196 ± 0.77
6.349LeuLeu: 6.349 ± 0.778
2.54LeuMet: 2.54 ± 0.56
4.444LeuAsn: 4.444 ± 0.514
2.328LeuPro: 2.328 ± 0.47
3.069LeuGln: 3.069 ± 0.633
4.127LeuArg: 4.127 ± 0.765
4.233LeuSer: 4.233 ± 0.808
5.714LeuThr: 5.714 ± 0.767
3.492LeuVal: 3.492 ± 0.594
0.635LeuTrp: 0.635 ± 0.286
2.963LeuTyr: 2.963 ± 0.599
0.0LeuXaa: 0.0 ± 0.0
Met
2.011MetAla: 2.011 ± 0.447
0.106MetCys: 0.106 ± 0.117
1.058MetAsp: 1.058 ± 0.381
1.905MetGlu: 1.905 ± 0.555
1.058MetPhe: 1.058 ± 0.321
1.27MetGly: 1.27 ± 0.329
0.423MetHis: 0.423 ± 0.215
2.328MetIle: 2.328 ± 0.468
3.069MetLys: 3.069 ± 0.453
2.222MetLeu: 2.222 ± 0.473
0.529MetMet: 0.529 ± 0.272
1.905MetAsn: 1.905 ± 0.531
0.423MetPro: 0.423 ± 0.19
0.741MetGln: 0.741 ± 0.263
1.587MetArg: 1.587 ± 0.402
2.646MetSer: 2.646 ± 0.565
2.328MetThr: 2.328 ± 0.558
1.587MetVal: 1.587 ± 0.415
0.106MetTrp: 0.106 ± 0.11
0.635MetTyr: 0.635 ± 0.246
0.0MetXaa: 0.0 ± 0.0
Asn
3.28AsnAla: 3.28 ± 0.537
0.317AsnCys: 0.317 ± 0.194
3.598AsnAsp: 3.598 ± 0.668
3.598AsnGlu: 3.598 ± 0.478
2.963AsnPhe: 2.963 ± 0.442
4.656AsnGly: 4.656 ± 0.695
0.741AsnHis: 0.741 ± 0.273
4.021AsnIle: 4.021 ± 0.998
5.503AsnLys: 5.503 ± 0.601
5.291AsnLeu: 5.291 ± 0.592
1.376AsnMet: 1.376 ± 0.431
2.963AsnAsn: 2.963 ± 0.504
3.704AsnPro: 3.704 ± 0.796
2.751AsnGln: 2.751 ± 0.571
1.905AsnArg: 1.905 ± 0.536
4.233AsnSer: 4.233 ± 0.763
3.915AsnThr: 3.915 ± 0.977
3.492AsnVal: 3.492 ± 0.77
1.27AsnTrp: 1.27 ± 0.413
1.481AsnTyr: 1.481 ± 0.29
0.0AsnXaa: 0.0 ± 0.0
Pro
1.799ProAla: 1.799 ± 0.432
0.317ProCys: 0.317 ± 0.162
2.328ProAsp: 2.328 ± 0.734
2.328ProGlu: 2.328 ± 0.499
1.481ProPhe: 1.481 ± 0.508
1.058ProGly: 1.058 ± 0.419
0.212ProHis: 0.212 ± 0.129
2.646ProIle: 2.646 ± 0.485
2.328ProLys: 2.328 ± 0.595
2.222ProLeu: 2.222 ± 0.404
0.847ProMet: 0.847 ± 0.293
1.481ProAsn: 1.481 ± 0.604
0.635ProPro: 0.635 ± 0.244
1.376ProGln: 1.376 ± 0.408
1.164ProArg: 1.164 ± 0.365
1.27ProSer: 1.27 ± 0.284
1.799ProThr: 1.799 ± 0.354
2.011ProVal: 2.011 ± 0.41
0.423ProTrp: 0.423 ± 0.192
0.741ProTyr: 0.741 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
4.339GlnAla: 4.339 ± 0.908
0.317GlnCys: 0.317 ± 0.152
2.116GlnAsp: 2.116 ± 0.366
2.54GlnGlu: 2.54 ± 0.515
1.799GlnPhe: 1.799 ± 0.496
1.27GlnGly: 1.27 ± 0.357
0.741GlnHis: 0.741 ± 0.245
2.646GlnIle: 2.646 ± 0.416
4.021GlnLys: 4.021 ± 0.618
2.54GlnLeu: 2.54 ± 0.561
1.376GlnMet: 1.376 ± 0.408
2.751GlnAsn: 2.751 ± 0.461
1.164GlnPro: 1.164 ± 0.352
1.376GlnGln: 1.376 ± 0.365
1.905GlnArg: 1.905 ± 0.518
1.693GlnSer: 1.693 ± 0.524
2.222GlnThr: 2.222 ± 0.408
2.328GlnVal: 2.328 ± 0.435
0.212GlnTrp: 0.212 ± 0.153
1.164GlnTyr: 1.164 ± 0.248
0.0GlnXaa: 0.0 ± 0.0
Arg
2.434ArgAla: 2.434 ± 0.489
0.106ArgCys: 0.106 ± 0.097
2.857ArgAsp: 2.857 ± 0.578
3.915ArgGlu: 3.915 ± 0.691
1.905ArgPhe: 1.905 ± 0.547
1.693ArgGly: 1.693 ± 0.403
1.058ArgHis: 1.058 ± 0.311
3.492ArgIle: 3.492 ± 0.522
4.868ArgLys: 4.868 ± 1.019
3.598ArgLeu: 3.598 ± 0.779
0.741ArgMet: 0.741 ± 0.26
3.069ArgAsn: 3.069 ± 0.61
1.27ArgPro: 1.27 ± 0.423
1.376ArgGln: 1.376 ± 0.391
2.328ArgArg: 2.328 ± 0.513
1.693ArgSer: 1.693 ± 0.509
1.481ArgThr: 1.481 ± 0.391
2.646ArgVal: 2.646 ± 0.61
0.635ArgTrp: 0.635 ± 0.262
1.799ArgTyr: 1.799 ± 0.428
0.0ArgXaa: 0.0 ± 0.0
Ser
3.386SerAla: 3.386 ± 0.476
0.212SerCys: 0.212 ± 0.153
3.28SerAsp: 3.28 ± 0.53
3.386SerGlu: 3.386 ± 0.504
3.069SerPhe: 3.069 ± 0.476
3.386SerGly: 3.386 ± 0.655
0.741SerHis: 0.741 ± 0.395
4.127SerIle: 4.127 ± 0.705
4.233SerLys: 4.233 ± 0.735
4.656SerLeu: 4.656 ± 0.493
2.222SerMet: 2.222 ± 0.563
4.021SerAsn: 4.021 ± 0.572
2.54SerPro: 2.54 ± 0.7
2.751SerGln: 2.751 ± 0.442
2.54SerArg: 2.54 ± 0.323
4.762SerSer: 4.762 ± 0.762
2.963SerThr: 2.963 ± 0.774
3.175SerVal: 3.175 ± 0.463
0.635SerTrp: 0.635 ± 0.228
2.116SerTyr: 2.116 ± 0.36
0.0SerXaa: 0.0 ± 0.0
Thr
4.021ThrAla: 4.021 ± 0.807
0.317ThrCys: 0.317 ± 0.174
3.704ThrAsp: 3.704 ± 0.675
4.762ThrGlu: 4.762 ± 0.886
3.069ThrPhe: 3.069 ± 0.561
3.386ThrGly: 3.386 ± 0.609
0.741ThrHis: 0.741 ± 0.278
4.868ThrIle: 4.868 ± 0.996
4.762ThrLys: 4.762 ± 0.675
5.503ThrLeu: 5.503 ± 0.942
1.164ThrMet: 1.164 ± 0.381
2.646ThrAsn: 2.646 ± 0.797
1.376ThrPro: 1.376 ± 0.379
1.587ThrGln: 1.587 ± 0.459
2.857ThrArg: 2.857 ± 0.553
2.857ThrSer: 2.857 ± 1.006
3.175ThrThr: 3.175 ± 0.715
4.127ThrVal: 4.127 ± 0.744
0.847ThrTrp: 0.847 ± 0.351
2.222ThrTyr: 2.222 ± 0.596
0.0ThrXaa: 0.0 ± 0.0
Val
3.386ValAla: 3.386 ± 0.541
0.106ValCys: 0.106 ± 0.102
3.704ValAsp: 3.704 ± 0.745
5.079ValGlu: 5.079 ± 0.678
2.222ValPhe: 2.222 ± 0.413
3.915ValGly: 3.915 ± 0.789
1.164ValHis: 1.164 ± 0.361
4.762ValIle: 4.762 ± 0.821
5.397ValLys: 5.397 ± 0.733
4.55ValLeu: 4.55 ± 0.737
1.27ValMet: 1.27 ± 0.37
3.704ValAsn: 3.704 ± 0.578
1.905ValPro: 1.905 ± 0.466
1.693ValGln: 1.693 ± 0.326
2.222ValArg: 2.222 ± 0.532
4.762ValSer: 4.762 ± 0.412
4.021ValThr: 4.021 ± 0.508
4.021ValVal: 4.021 ± 0.514
0.847ValTrp: 0.847 ± 0.258
2.222ValTyr: 2.222 ± 0.584
0.0ValXaa: 0.0 ± 0.0
Trp
0.212TrpAla: 0.212 ± 0.142
0.317TrpCys: 0.317 ± 0.199
0.741TrpAsp: 0.741 ± 0.255
0.952TrpGlu: 0.952 ± 0.296
0.529TrpPhe: 0.529 ± 0.217
0.635TrpGly: 0.635 ± 0.247
0.106TrpHis: 0.106 ± 0.101
1.058TrpIle: 1.058 ± 0.352
0.635TrpLys: 0.635 ± 0.23
0.635TrpLeu: 0.635 ± 0.249
0.106TrpMet: 0.106 ± 0.117
2.328TrpAsn: 2.328 ± 0.971
0.106TrpPro: 0.106 ± 0.106
0.847TrpGln: 0.847 ± 0.291
0.529TrpArg: 0.529 ± 0.231
1.058TrpSer: 1.058 ± 0.252
0.317TrpThr: 0.317 ± 0.149
0.847TrpVal: 0.847 ± 0.314
0.106TrpTrp: 0.106 ± 0.084
0.529TrpTyr: 0.529 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.011TyrAla: 2.011 ± 0.442
0.317TyrCys: 0.317 ± 0.223
1.481TyrAsp: 1.481 ± 0.544
2.116TyrGlu: 2.116 ± 0.555
2.646TyrPhe: 2.646 ± 0.459
3.069TyrGly: 3.069 ± 0.66
0.635TyrHis: 0.635 ± 0.229
2.54TyrIle: 2.54 ± 0.547
2.857TyrLys: 2.857 ± 0.691
3.704TyrLeu: 3.704 ± 0.453
0.529TyrMet: 0.529 ± 0.216
2.222TyrAsn: 2.222 ± 0.39
1.481TyrPro: 1.481 ± 0.442
1.587TyrGln: 1.587 ± 0.457
2.222TyrArg: 2.222 ± 0.496
1.693TyrSer: 1.693 ± 0.429
2.434TyrThr: 2.434 ± 0.615
1.799TyrVal: 1.799 ± 0.465
0.847TyrTrp: 0.847 ± 0.243
2.116TyrTyr: 2.116 ± 0.581
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (9451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski