Amino acid dipepetide frequency for Aeromonas virus Aeh1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.184AlaAla: 5.184 ± 0.294
0.676AlaCys: 0.676 ± 0.09
4.108AlaAsp: 4.108 ± 0.254
4.605AlaGlu: 4.605 ± 0.266
2.799AlaPhe: 2.799 ± 0.179
4.963AlaGly: 4.963 ± 0.324
1.144AlaHis: 1.144 ± 0.105
4.894AlaIle: 4.894 ± 0.26
5.28AlaLys: 5.28 ± 0.31
4.605AlaLeu: 4.605 ± 0.273
2.385AlaMet: 2.385 ± 0.194
3.984AlaAsn: 3.984 ± 0.326
2.013AlaPro: 2.013 ± 0.193
2.468AlaGln: 2.468 ± 0.175
3.474AlaArg: 3.474 ± 0.239
3.819AlaSer: 3.819 ± 0.226
4.15AlaThr: 4.15 ± 0.376
4.605AlaVal: 4.605 ± 0.24
0.855AlaTrp: 0.855 ± 0.115
2.674AlaTyr: 2.674 ± 0.171
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.087
0.179CysCys: 0.179 ± 0.05
0.924CysAsp: 0.924 ± 0.106
0.772CysGlu: 0.772 ± 0.101
0.441CysPhe: 0.441 ± 0.072
0.786CysGly: 0.786 ± 0.12
0.303CysHis: 0.303 ± 0.064
0.758CysIle: 0.758 ± 0.102
0.951CysLys: 0.951 ± 0.13
0.8CysLeu: 0.8 ± 0.111
0.303CysMet: 0.303 ± 0.062
0.662CysAsn: 0.662 ± 0.107
0.483CysPro: 0.483 ± 0.089
0.262CysGln: 0.262 ± 0.058
0.827CysArg: 0.827 ± 0.125
0.855CysSer: 0.855 ± 0.122
0.565CysThr: 0.565 ± 0.087
0.882CysVal: 0.882 ± 0.103
0.179CysTrp: 0.179 ± 0.049
0.607CysTyr: 0.607 ± 0.092
0.0CysXaa: 0.0 ± 0.0
Asp
4.246AspAla: 4.246 ± 0.289
0.813AspCys: 0.813 ± 0.115
3.722AspAsp: 3.722 ± 0.264
4.081AspGlu: 4.081 ± 0.287
3.281AspPhe: 3.281 ± 0.23
5.17AspGly: 5.17 ± 0.298
1.117AspHis: 1.117 ± 0.15
4.922AspIle: 4.922 ± 0.261
4.053AspLys: 4.053 ± 0.231
4.798AspLeu: 4.798 ± 0.25
1.985AspMet: 1.985 ± 0.162
3.185AspAsn: 3.185 ± 0.231
1.971AspPro: 1.971 ± 0.193
1.958AspGln: 1.958 ± 0.181
2.868AspArg: 2.868 ± 0.159
3.557AspSer: 3.557 ± 0.258
3.281AspThr: 3.281 ± 0.245
4.894AspVal: 4.894 ± 0.291
1.006AspTrp: 1.006 ± 0.138
3.405AspTyr: 3.405 ± 0.227
0.0AspXaa: 0.0 ± 0.0
Glu
4.081GluAla: 4.081 ± 0.282
1.006GluCys: 1.006 ± 0.131
3.474GluAsp: 3.474 ± 0.277
4.191GluGlu: 4.191 ± 0.287
3.185GluPhe: 3.185 ± 0.267
2.812GluGly: 2.812 ± 0.187
1.42GluHis: 1.42 ± 0.152
4.977GluIle: 4.977 ± 0.321
4.108GluLys: 4.108 ± 0.285
6.562GluLeu: 6.562 ± 0.336
2.509GluMet: 2.509 ± 0.211
3.378GluAsn: 3.378 ± 0.204
1.323GluPro: 1.323 ± 0.143
3.033GluGln: 3.033 ± 0.217
3.86GluArg: 3.86 ± 0.23
3.819GluSer: 3.819 ± 0.244
4.067GluThr: 4.067 ± 0.221
4.673GluVal: 4.673 ± 0.276
0.869GluTrp: 0.869 ± 0.113
3.005GluTyr: 3.005 ± 0.204
0.0GluXaa: 0.0 ± 0.0
Phe
3.061PheAla: 3.061 ± 0.197
0.496PheCys: 0.496 ± 0.092
3.64PheAsp: 3.64 ± 0.216
3.295PheGlu: 3.295 ± 0.23
1.448PhePhe: 1.448 ± 0.148
3.019PheGly: 3.019 ± 0.184
0.731PheHis: 0.731 ± 0.102
2.316PheIle: 2.316 ± 0.165
3.254PheLys: 3.254 ± 0.217
2.288PheLeu: 2.288 ± 0.179
1.448PheMet: 1.448 ± 0.148
2.564PheAsn: 2.564 ± 0.2
1.089PhePro: 1.089 ± 0.122
1.199PheGln: 1.199 ± 0.118
1.985PheArg: 1.985 ± 0.143
2.316PheSer: 2.316 ± 0.175
2.399PheThr: 2.399 ± 0.183
3.667PheVal: 3.667 ± 0.261
0.579PheTrp: 0.579 ± 0.096
1.889PheTyr: 1.889 ± 0.161
0.0PheXaa: 0.0 ± 0.0
Gly
4.343GlyAla: 4.343 ± 0.318
0.717GlyCys: 0.717 ± 0.112
4.136GlyAsp: 4.136 ± 0.322
4.467GlyGlu: 4.467 ± 0.225
2.757GlyPhe: 2.757 ± 0.198
3.929GlyGly: 3.929 ± 0.366
1.075GlyHis: 1.075 ± 0.131
4.742GlyIle: 4.742 ± 0.257
5.625GlyLys: 5.625 ± 0.316
3.805GlyLeu: 3.805 ± 0.217
2.027GlyMet: 2.027 ± 0.187
3.929GlyAsn: 3.929 ± 0.288
1.213GlyPro: 1.213 ± 0.172
2.123GlyGln: 2.123 ± 0.189
2.73GlyArg: 2.73 ± 0.181
3.888GlySer: 3.888 ± 0.332
4.756GlyThr: 4.756 ± 0.341
4.701GlyVal: 4.701 ± 0.279
0.924GlyTrp: 0.924 ± 0.115
2.923GlyTyr: 2.923 ± 0.204
0.0GlyXaa: 0.0 ± 0.0
His
1.172HisAla: 1.172 ± 0.125
0.29HisCys: 0.29 ± 0.064
1.158HisAsp: 1.158 ± 0.143
1.365HisGlu: 1.365 ± 0.148
0.965HisPhe: 0.965 ± 0.117
1.434HisGly: 1.434 ± 0.16
0.455HisHis: 0.455 ± 0.093
1.268HisIle: 1.268 ± 0.141
1.42HisLys: 1.42 ± 0.139
1.42HisLeu: 1.42 ± 0.146
0.634HisMet: 0.634 ± 0.098
0.869HisAsn: 0.869 ± 0.107
0.703HisPro: 0.703 ± 0.115
0.524HisGln: 0.524 ± 0.085
0.841HisArg: 0.841 ± 0.114
1.172HisSer: 1.172 ± 0.116
0.924HisThr: 0.924 ± 0.106
1.392HisVal: 1.392 ± 0.167
0.427HisTrp: 0.427 ± 0.08
0.772HisTyr: 0.772 ± 0.115
0.0HisXaa: 0.0 ± 0.0
Ile
5.197IleAla: 5.197 ± 0.291
0.8IleCys: 0.8 ± 0.122
5.073IleAsp: 5.073 ± 0.291
5.694IleGlu: 5.694 ± 0.315
1.778IlePhe: 1.778 ± 0.156
4.66IleGly: 4.66 ± 0.295
0.993IleHis: 0.993 ± 0.11
3.695IleIle: 3.695 ± 0.25
5.487IleLys: 5.487 ± 0.298
3.998IleLeu: 3.998 ± 0.234
2.068IleMet: 2.068 ± 0.183
3.667IleAsn: 3.667 ± 0.24
2.454IlePro: 2.454 ± 0.199
2.495IleGln: 2.495 ± 0.2
3.584IleArg: 3.584 ± 0.227
3.901IleSer: 3.901 ± 0.236
4.246IleThr: 4.246 ± 0.272
4.894IleVal: 4.894 ± 0.263
0.538IleTrp: 0.538 ± 0.088
2.261IleTyr: 2.261 ± 0.182
0.0IleXaa: 0.0 ± 0.0
Lys
5.101LysAla: 5.101 ± 0.3
0.841LysCys: 0.841 ± 0.108
4.894LysAsp: 4.894 ± 0.248
4.963LysGlu: 4.963 ± 0.288
3.584LysPhe: 3.584 ± 0.219
3.226LysGly: 3.226 ± 0.249
1.572LysHis: 1.572 ± 0.15
5.087LysIle: 5.087 ± 0.243
5.377LysLys: 5.377 ± 0.344
5.942LysLeu: 5.942 ± 0.283
2.454LysMet: 2.454 ± 0.212
4.012LysAsn: 4.012 ± 0.244
2.288LysPro: 2.288 ± 0.185
3.102LysGln: 3.102 ± 0.276
3.846LysArg: 3.846 ± 0.236
4.605LysSer: 4.605 ± 0.255
4.191LysThr: 4.191 ± 0.25
4.977LysVal: 4.977 ± 0.279
1.006LysTrp: 1.006 ± 0.125
2.757LysTyr: 2.757 ± 0.222
0.0LysXaa: 0.0 ± 0.0
Leu
4.922LeuAla: 4.922 ± 0.279
1.034LeuCys: 1.034 ± 0.128
4.412LeuAsp: 4.412 ± 0.246
4.701LeuGlu: 4.701 ± 0.247
2.578LeuPhe: 2.578 ± 0.186
4.508LeuGly: 4.508 ± 0.239
1.544LeuHis: 1.544 ± 0.144
4.315LeuIle: 4.315 ± 0.25
6.052LeuLys: 6.052 ± 0.371
4.356LeuLeu: 4.356 ± 0.259
1.82LeuMet: 1.82 ± 0.189
4.136LeuAsn: 4.136 ± 0.264
2.757LeuPro: 2.757 ± 0.221
2.095LeuGln: 2.095 ± 0.171
3.212LeuArg: 3.212 ± 0.24
4.798LeuSer: 4.798 ± 0.233
4.398LeuThr: 4.398 ± 0.228
4.949LeuVal: 4.949 ± 0.238
0.744LeuTrp: 0.744 ± 0.107
2.785LeuTyr: 2.785 ± 0.199
0.0LeuXaa: 0.0 ± 0.0
Met
1.93MetAla: 1.93 ± 0.152
0.29MetCys: 0.29 ± 0.059
1.323MetAsp: 1.323 ± 0.132
1.723MetGlu: 1.723 ± 0.167
1.765MetPhe: 1.765 ± 0.161
1.627MetGly: 1.627 ± 0.164
0.689MetHis: 0.689 ± 0.113
2.523MetIle: 2.523 ± 0.209
3.116MetLys: 3.116 ± 0.232
2.454MetLeu: 2.454 ± 0.207
0.882MetMet: 0.882 ± 0.128
1.944MetAsn: 1.944 ± 0.171
1.034MetPro: 1.034 ± 0.119
1.117MetGln: 1.117 ± 0.134
1.296MetArg: 1.296 ± 0.13
2.55MetSer: 2.55 ± 0.191
2.247MetThr: 2.247 ± 0.169
1.668MetVal: 1.668 ± 0.138
0.248MetTrp: 0.248 ± 0.056
1.034MetTyr: 1.034 ± 0.132
0.0MetXaa: 0.0 ± 0.0
Asn
3.888AsnAla: 3.888 ± 0.245
0.717AsnCys: 0.717 ± 0.095
3.171AsnAsp: 3.171 ± 0.234
3.322AsnGlu: 3.322 ± 0.216
2.04AsnPhe: 2.04 ± 0.188
4.646AsnGly: 4.646 ± 0.252
1.006AsnHis: 1.006 ± 0.124
3.309AsnIle: 3.309 ± 0.216
4.163AsnLys: 4.163 ± 0.263
4.053AsnLeu: 4.053 ± 0.236
1.751AsnMet: 1.751 ± 0.174
2.592AsnAsn: 2.592 ± 0.21
2.206AsnPro: 2.206 ± 0.183
1.834AsnGln: 1.834 ± 0.149
2.799AsnArg: 2.799 ± 0.172
3.102AsnSer: 3.102 ± 0.213
2.95AsnThr: 2.95 ± 0.262
4.136AsnVal: 4.136 ± 0.266
0.662AsnTrp: 0.662 ± 0.078
1.765AsnTyr: 1.765 ± 0.165
0.0AsnXaa: 0.0 ± 0.0
Pro
2.137ProAla: 2.137 ± 0.197
0.331ProCys: 0.331 ± 0.068
2.233ProAsp: 2.233 ± 0.194
2.04ProGlu: 2.04 ± 0.177
1.392ProPhe: 1.392 ± 0.161
1.847ProGly: 1.847 ± 0.187
0.496ProHis: 0.496 ± 0.074
1.958ProIle: 1.958 ± 0.15
2.275ProLys: 2.275 ± 0.185
1.93ProLeu: 1.93 ± 0.173
0.937ProMet: 0.937 ± 0.113
1.696ProAsn: 1.696 ± 0.147
0.813ProPro: 0.813 ± 0.123
0.937ProGln: 0.937 ± 0.118
1.323ProArg: 1.323 ± 0.144
1.889ProSer: 1.889 ± 0.164
2.537ProThr: 2.537 ± 0.214
2.923ProVal: 2.923 ± 0.193
0.538ProTrp: 0.538 ± 0.097
1.034ProTyr: 1.034 ± 0.113
0.0ProXaa: 0.0 ± 0.0
Gln
2.619GlnAla: 2.619 ± 0.223
0.358GlnCys: 0.358 ± 0.066
1.82GlnAsp: 1.82 ± 0.182
2.22GlnGlu: 2.22 ± 0.196
1.599GlnPhe: 1.599 ± 0.155
2.068GlnGly: 2.068 ± 0.189
0.758GlnHis: 0.758 ± 0.099
2.95GlnIle: 2.95 ± 0.196
2.082GlnLys: 2.082 ± 0.201
2.564GlnLeu: 2.564 ± 0.195
1.461GlnMet: 1.461 ± 0.15
1.668GlnAsn: 1.668 ± 0.154
1.006GlnPro: 1.006 ± 0.135
1.323GlnGln: 1.323 ± 0.139
1.765GlnArg: 1.765 ± 0.164
2.123GlnSer: 2.123 ± 0.167
1.944GlnThr: 1.944 ± 0.16
2.537GlnVal: 2.537 ± 0.177
0.538GlnTrp: 0.538 ± 0.09
1.392GlnTyr: 1.392 ± 0.141
0.0GlnXaa: 0.0 ± 0.0
Arg
2.936ArgAla: 2.936 ± 0.213
0.565ArgCys: 0.565 ± 0.087
3.157ArgAsp: 3.157 ± 0.212
3.24ArgGlu: 3.24 ± 0.227
2.261ArgPhe: 2.261 ± 0.173
3.088ArgGly: 3.088 ± 0.221
1.199ArgHis: 1.199 ± 0.116
3.612ArgIle: 3.612 ± 0.285
3.157ArgLys: 3.157 ± 0.222
3.626ArgLeu: 3.626 ± 0.219
1.82ArgMet: 1.82 ± 0.143
2.606ArgAsn: 2.606 ± 0.196
1.461ArgPro: 1.461 ± 0.158
1.806ArgGln: 1.806 ± 0.153
2.151ArgArg: 2.151 ± 0.212
2.757ArgSer: 2.757 ± 0.2
2.413ArgThr: 2.413 ± 0.161
3.764ArgVal: 3.764 ± 0.237
0.924ArgTrp: 0.924 ± 0.105
2.702ArgTyr: 2.702 ± 0.2
0.0ArgXaa: 0.0 ± 0.0
Ser
3.584SerAla: 3.584 ± 0.269
0.662SerCys: 0.662 ± 0.109
3.584SerAsp: 3.584 ± 0.253
3.888SerGlu: 3.888 ± 0.257
2.757SerPhe: 2.757 ± 0.187
4.536SerGly: 4.536 ± 0.319
1.103SerHis: 1.103 ± 0.11
3.901SerIle: 3.901 ± 0.21
4.191SerLys: 4.191 ± 0.243
4.108SerLeu: 4.108 ± 0.234
2.095SerMet: 2.095 ± 0.176
3.309SerAsn: 3.309 ± 0.238
1.792SerPro: 1.792 ± 0.155
1.93SerGln: 1.93 ± 0.145
3.171SerArg: 3.171 ± 0.219
3.915SerSer: 3.915 ± 0.238
3.474SerThr: 3.474 ± 0.28
5.032SerVal: 5.032 ± 0.264
0.786SerTrp: 0.786 ± 0.125
2.523SerTyr: 2.523 ± 0.203
0.0SerXaa: 0.0 ± 0.0
Thr
4.412ThrAla: 4.412 ± 0.34
0.648ThrCys: 0.648 ± 0.116
4.122ThrAsp: 4.122 ± 0.281
3.46ThrGlu: 3.46 ± 0.211
2.592ThrPhe: 2.592 ± 0.194
4.549ThrGly: 4.549 ± 0.422
1.186ThrHis: 1.186 ± 0.131
3.653ThrIle: 3.653 ± 0.195
3.874ThrLys: 3.874 ± 0.243
4.301ThrLeu: 4.301 ± 0.265
1.461ThrMet: 1.461 ± 0.15
2.812ThrAsn: 2.812 ± 0.211
2.468ThrPro: 2.468 ± 0.231
2.027ThrGln: 2.027 ± 0.181
3.005ThrArg: 3.005 ± 0.207
3.309ThrSer: 3.309 ± 0.24
3.488ThrThr: 3.488 ± 0.37
5.046ThrVal: 5.046 ± 0.292
0.855ThrTrp: 0.855 ± 0.126
2.247ThrTyr: 2.247 ± 0.179
0.0ThrXaa: 0.0 ± 0.0
Val
5.487ValAla: 5.487 ± 0.235
1.02ValCys: 1.02 ± 0.12
5.666ValAsp: 5.666 ± 0.273
5.087ValGlu: 5.087 ± 0.334
3.24ValPhe: 3.24 ± 0.209
4.508ValGly: 4.508 ± 0.291
1.199ValHis: 1.199 ± 0.121
5.115ValIle: 5.115 ± 0.267
5.197ValLys: 5.197 ± 0.261
4.673ValLeu: 4.673 ± 0.258
1.875ValMet: 1.875 ± 0.132
4.122ValAsn: 4.122 ± 0.232
2.606ValPro: 2.606 ± 0.23
2.22ValGln: 2.22 ± 0.168
3.64ValArg: 3.64 ± 0.253
4.673ValSer: 4.673 ± 0.255
4.536ValThr: 4.536 ± 0.303
5.666ValVal: 5.666 ± 0.287
0.813ValTrp: 0.813 ± 0.114
3.405ValTyr: 3.405 ± 0.217
0.0ValXaa: 0.0 ± 0.0
Trp
0.951TrpAla: 0.951 ± 0.126
0.234TrpCys: 0.234 ± 0.049
0.993TrpAsp: 0.993 ± 0.117
1.02TrpGlu: 1.02 ± 0.111
0.676TrpPhe: 0.676 ± 0.086
0.524TrpGly: 0.524 ± 0.099
0.303TrpHis: 0.303 ± 0.065
0.91TrpIle: 0.91 ± 0.119
1.323TrpLys: 1.323 ± 0.163
0.827TrpLeu: 0.827 ± 0.103
0.483TrpMet: 0.483 ± 0.074
0.717TrpAsn: 0.717 ± 0.089
0.11TrpPro: 0.11 ± 0.035
0.579TrpGln: 0.579 ± 0.092
0.662TrpArg: 0.662 ± 0.102
0.607TrpSer: 0.607 ± 0.1
0.565TrpThr: 0.565 ± 0.108
0.951TrpVal: 0.951 ± 0.123
0.193TrpTrp: 0.193 ± 0.052
0.648TrpTyr: 0.648 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.688TyrAla: 2.688 ± 0.195
0.607TyrCys: 0.607 ± 0.09
2.702TyrAsp: 2.702 ± 0.203
2.22TyrGlu: 2.22 ± 0.205
1.544TyrPhe: 1.544 ± 0.149
2.909TyrGly: 2.909 ± 0.213
0.91TyrHis: 0.91 ± 0.111
2.578TyrIle: 2.578 ± 0.181
2.84TyrLys: 2.84 ± 0.228
3.005TyrLeu: 3.005 ± 0.191
1.048TyrMet: 1.048 ± 0.099
2.275TyrAsn: 2.275 ± 0.19
1.475TyrPro: 1.475 ± 0.158
1.765TyrGln: 1.765 ± 0.175
2.206TyrArg: 2.206 ± 0.185
2.688TyrSer: 2.688 ± 0.192
2.385TyrThr: 2.385 ± 0.206
3.391TyrVal: 3.391 ± 0.23
0.593TyrTrp: 0.593 ± 0.084
1.668TyrTyr: 1.668 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 352 proteins (72538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski