Amino acid dipepetide frequency for Sodalis sp. 159R

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.626AlaAla: 12.626 ± 0.109
1.156AlaCys: 1.156 ± 0.026
5.583AlaAsp: 5.583 ± 0.059
5.561AlaGlu: 5.561 ± 0.074
3.62AlaPhe: 3.62 ± 0.047
9.368AlaGly: 9.368 ± 0.106
1.87AlaHis: 1.87 ± 0.036
5.937AlaIle: 5.937 ± 0.063
3.541AlaLys: 3.541 ± 0.049
12.643AlaLeu: 12.643 ± 0.094
2.982AlaMet: 2.982 ± 0.04
2.976AlaAsn: 2.976 ± 0.046
4.127AlaPro: 4.127 ± 0.058
4.244AlaGln: 4.244 ± 0.054
6.158AlaArg: 6.158 ± 0.075
5.346AlaSer: 5.346 ± 0.062
4.648AlaThr: 4.648 ± 0.059
7.362AlaVal: 7.362 ± 0.073
1.375AlaTrp: 1.375 ± 0.031
2.425AlaTyr: 2.425 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.011CysAla: 1.011 ± 0.027
0.176CysCys: 0.176 ± 0.011
0.59CysAsp: 0.59 ± 0.018
0.503CysGlu: 0.503 ± 0.019
0.414CysPhe: 0.414 ± 0.016
1.095CysGly: 1.095 ± 0.027
0.311CysHis: 0.311 ± 0.014
0.594CysIle: 0.594 ± 0.018
0.274CysLys: 0.274 ± 0.013
1.139CysLeu: 1.139 ± 0.028
0.23CysMet: 0.23 ± 0.012
0.306CysAsn: 0.306 ± 0.013
0.517CysPro: 0.517 ± 0.017
0.386CysGln: 0.386 ± 0.016
0.772CysArg: 0.772 ± 0.022
0.605CysSer: 0.605 ± 0.019
0.465CysThr: 0.465 ± 0.017
0.675CysVal: 0.675 ± 0.02
0.172CysTrp: 0.172 ± 0.009
0.341CysTyr: 0.341 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.148AspAla: 5.148 ± 0.059
0.483AspCys: 0.483 ± 0.018
2.791AspAsp: 2.791 ± 0.041
3.245AspGlu: 3.245 ± 0.047
2.166AspPhe: 2.166 ± 0.038
4.201AspGly: 4.201 ± 0.064
1.029AspHis: 1.029 ± 0.025
3.785AspIle: 3.785 ± 0.047
2.194AspLys: 2.194 ± 0.04
4.786AspLeu: 4.786 ± 0.058
1.382AspMet: 1.382 ± 0.027
2.141AspAsn: 2.141 ± 0.034
2.532AspPro: 2.532 ± 0.042
1.664AspGln: 1.664 ± 0.032
3.082AspArg: 3.082 ± 0.04
2.898AspSer: 2.898 ± 0.045
2.5AspThr: 2.5 ± 0.035
3.671AspVal: 3.671 ± 0.054
0.797AspTrp: 0.797 ± 0.022
1.852AspTyr: 1.852 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.784GluAla: 4.784 ± 0.068
0.432GluCys: 0.432 ± 0.014
2.33GluAsp: 2.33 ± 0.04
2.894GluGlu: 2.894 ± 0.05
1.699GluPhe: 1.699 ± 0.035
3.277GluGly: 3.277 ± 0.043
1.343GluHis: 1.343 ± 0.031
3.268GluIle: 3.268 ± 0.044
2.633GluLys: 2.633 ± 0.043
5.564GluLeu: 5.564 ± 0.056
1.534GluMet: 1.534 ± 0.027
2.143GluAsn: 2.143 ± 0.037
2.121GluPro: 2.121 ± 0.041
2.987GluGln: 2.987 ± 0.045
3.626GluArg: 3.626 ± 0.049
2.763GluSer: 2.763 ± 0.041
2.659GluThr: 2.659 ± 0.036
3.279GluVal: 3.279 ± 0.049
0.662GluTrp: 0.662 ± 0.02
1.368GluTyr: 1.368 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.749PheAla: 3.749 ± 0.053
0.508PheCys: 0.508 ± 0.017
2.274PheAsp: 2.274 ± 0.036
1.594PheGlu: 1.594 ± 0.032
1.771PhePhe: 1.771 ± 0.042
3.28PheGly: 3.28 ± 0.049
0.871PheHis: 0.871 ± 0.023
2.723PheIle: 2.723 ± 0.047
1.187PheLys: 1.187 ± 0.027
3.457PheLeu: 3.457 ± 0.049
0.966PheMet: 0.966 ± 0.026
1.673PheAsn: 1.673 ± 0.032
1.645PhePro: 1.645 ± 0.032
1.149PheGln: 1.149 ± 0.026
1.939PheArg: 1.939 ± 0.038
2.977PheSer: 2.977 ± 0.045
2.249PheThr: 2.249 ± 0.04
2.366PheVal: 2.366 ± 0.044
0.548PheTrp: 0.548 ± 0.021
1.225PheTyr: 1.225 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.224GlyAla: 7.224 ± 0.095
1.012GlyCys: 1.012 ± 0.028
3.912GlyAsp: 3.912 ± 0.071
4.448GlyGlu: 4.448 ± 0.058
3.368GlyPhe: 3.368 ± 0.05
6.345GlyGly: 6.345 ± 0.108
1.78GlyHis: 1.78 ± 0.032
5.538GlyIle: 5.538 ± 0.068
3.659GlyLys: 3.659 ± 0.05
8.281GlyLeu: 8.281 ± 0.083
2.373GlyMet: 2.373 ± 0.037
2.893GlyAsn: 2.893 ± 0.05
2.511GlyPro: 2.511 ± 0.04
3.181GlyGln: 3.181 ± 0.046
4.602GlyArg: 4.602 ± 0.057
4.605GlySer: 4.605 ± 0.07
4.014GlyThr: 4.014 ± 0.073
5.764GlyVal: 5.764 ± 0.062
1.292GlyTrp: 1.292 ± 0.03
2.655GlyTyr: 2.655 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.84HisAla: 1.84 ± 0.033
0.334HisCys: 0.334 ± 0.015
1.218HisAsp: 1.218 ± 0.029
1.082HisGlu: 1.082 ± 0.027
1.014HisPhe: 1.014 ± 0.025
1.812HisGly: 1.812 ± 0.033
0.721HisHis: 0.721 ± 0.024
1.424HisIle: 1.424 ± 0.028
0.712HisLys: 0.712 ± 0.022
2.343HisLeu: 2.343 ± 0.039
0.567HisMet: 0.567 ± 0.018
0.795HisAsn: 0.795 ± 0.024
1.375HisPro: 1.375 ± 0.029
1.054HisGln: 1.054 ± 0.021
1.491HisArg: 1.491 ± 0.029
1.245HisSer: 1.245 ± 0.025
1.015HisThr: 1.015 ± 0.024
1.264HisVal: 1.264 ± 0.024
0.419HisTrp: 0.419 ± 0.018
0.872HisTyr: 0.872 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.798IleAla: 6.798 ± 0.068
0.719IleCys: 0.719 ± 0.024
3.636IleAsp: 3.636 ± 0.048
3.168IleGlu: 3.168 ± 0.049
2.166IlePhe: 2.166 ± 0.046
5.136IleGly: 5.136 ± 0.065
1.237IleHis: 1.237 ± 0.03
3.821IleIle: 3.821 ± 0.061
2.467IleLys: 2.467 ± 0.043
5.503IleLeu: 5.503 ± 0.066
1.357IleMet: 1.357 ± 0.029
2.612IleAsn: 2.612 ± 0.043
2.888IlePro: 2.888 ± 0.04
1.784IleGln: 1.784 ± 0.032
3.286IleArg: 3.286 ± 0.049
3.949IleSer: 3.949 ± 0.057
3.584IleThr: 3.584 ± 0.041
3.851IleVal: 3.851 ± 0.055
0.659IleTrp: 0.659 ± 0.023
1.659IleTyr: 1.659 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.596LysAla: 3.596 ± 0.049
0.233LysCys: 0.233 ± 0.011
1.78LysAsp: 1.78 ± 0.036
2.059LysGlu: 2.059 ± 0.041
1.056LysPhe: 1.056 ± 0.026
2.675LysGly: 2.675 ± 0.044
0.805LysHis: 0.805 ± 0.02
2.449LysIle: 2.449 ± 0.044
1.937LysLys: 1.937 ± 0.042
3.654LysLeu: 3.654 ± 0.047
1.055LysMet: 1.055 ± 0.027
1.613LysAsn: 1.613 ± 0.034
1.863LysPro: 1.863 ± 0.035
1.688LysGln: 1.688 ± 0.038
2.352LysArg: 2.352 ± 0.036
2.192LysSer: 2.192 ± 0.037
2.347LysThr: 2.347 ± 0.038
2.544LysVal: 2.544 ± 0.043
0.405LysTrp: 0.405 ± 0.018
1.005LysTyr: 1.005 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.763LeuAla: 12.763 ± 0.102
1.335LeuCys: 1.335 ± 0.028
5.742LeuAsp: 5.742 ± 0.055
5.142LeuGlu: 5.142 ± 0.06
4.324LeuPhe: 4.324 ± 0.06
8.108LeuGly: 8.108 ± 0.076
2.293LeuHis: 2.293 ± 0.043
6.163LeuIle: 6.163 ± 0.074
4.063LeuLys: 4.063 ± 0.052
12.488LeuLeu: 12.488 ± 0.133
2.929LeuMet: 2.929 ± 0.048
3.892LeuAsn: 3.892 ± 0.06
6.124LeuPro: 6.124 ± 0.065
3.957LeuGln: 3.957 ± 0.049
6.418LeuArg: 6.418 ± 0.065
7.766LeuSer: 7.766 ± 0.069
6.368LeuThr: 6.368 ± 0.058
7.067LeuVal: 7.067 ± 0.075
1.326LeuTrp: 1.326 ± 0.029
2.728LeuTyr: 2.728 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.046MetAla: 3.046 ± 0.045
0.181MetCys: 0.181 ± 0.01
1.224MetAsp: 1.224 ± 0.025
1.159MetGlu: 1.159 ± 0.027
0.802MetPhe: 0.802 ± 0.025
1.843MetGly: 1.843 ± 0.039
0.52MetHis: 0.52 ± 0.018
1.525MetIle: 1.525 ± 0.03
1.158MetLys: 1.158 ± 0.028
3.059MetLeu: 3.059 ± 0.044
0.77MetMet: 0.77 ± 0.02
1.038MetAsn: 1.038 ± 0.022
1.412MetPro: 1.412 ± 0.03
1.017MetGln: 1.017 ± 0.028
1.429MetArg: 1.429 ± 0.029
1.793MetSer: 1.793 ± 0.031
1.683MetThr: 1.683 ± 0.03
1.821MetVal: 1.821 ± 0.037
0.198MetTrp: 0.198 ± 0.01
0.491MetTyr: 0.491 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.393AsnAla: 3.393 ± 0.047
0.337AsnCys: 0.337 ± 0.013
1.89AsnAsp: 1.89 ± 0.04
1.75AsnGlu: 1.75 ± 0.033
1.268AsnPhe: 1.268 ± 0.033
2.922AsnGly: 2.922 ± 0.044
0.828AsnHis: 0.828 ± 0.023
2.446AsnIle: 2.446 ± 0.045
1.423AsnLys: 1.423 ± 0.033
3.478AsnLeu: 3.478 ± 0.047
0.824AsnMet: 0.824 ± 0.023
1.54AsnAsn: 1.54 ± 0.036
2.109AsnPro: 2.109 ± 0.038
1.456AsnGln: 1.456 ± 0.031
2.044AsnArg: 2.044 ± 0.037
1.92AsnSer: 1.92 ± 0.036
1.827AsnThr: 1.827 ± 0.034
2.311AsnVal: 2.311 ± 0.042
0.47AsnTrp: 0.47 ± 0.019
1.098AsnTyr: 1.098 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.678ProAla: 5.678 ± 0.07
0.391ProCys: 0.391 ± 0.015
2.987ProAsp: 2.987 ± 0.05
2.995ProGlu: 2.995 ± 0.043
1.884ProPhe: 1.884 ± 0.034
3.853ProGly: 3.853 ± 0.054
1.093ProHis: 1.093 ± 0.026
2.167ProIle: 2.167 ± 0.038
1.395ProLys: 1.395 ± 0.03
5.606ProLeu: 5.606 ± 0.055
1.085ProMet: 1.085 ± 0.025
1.263ProAsn: 1.263 ± 0.029
2.153ProPro: 2.153 ± 0.05
2.0ProGln: 2.0 ± 0.035
2.448ProArg: 2.448 ± 0.042
2.578ProSer: 2.578 ± 0.039
2.155ProThr: 2.155 ± 0.035
3.909ProVal: 3.909 ± 0.043
0.727ProTrp: 0.727 ± 0.023
1.37ProTyr: 1.37 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.485GlnAla: 4.485 ± 0.06
0.358GlnCys: 0.358 ± 0.015
1.817GlnAsp: 1.817 ± 0.031
1.881GlnGlu: 1.881 ± 0.034
1.35GlnPhe: 1.35 ± 0.029
3.239GlnGly: 3.239 ± 0.048
1.028GlnHis: 1.028 ± 0.023
2.184GlnIle: 2.184 ± 0.041
1.482GlnLys: 1.482 ± 0.032
4.517GlnLeu: 4.517 ± 0.051
1.045GlnMet: 1.045 ± 0.024
1.314GlnAsn: 1.314 ± 0.028
2.107GlnPro: 2.107 ± 0.041
2.675GlnGln: 2.675 ± 0.052
3.135GlnArg: 3.135 ± 0.054
2.336GlnSer: 2.336 ± 0.035
2.054GlnThr: 2.054 ± 0.032
2.781GlnVal: 2.781 ± 0.042
0.656GlnTrp: 0.656 ± 0.019
1.061GlnTyr: 1.061 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
5.222ArgAla: 5.222 ± 0.059
0.639ArgCys: 0.639 ± 0.021
3.249ArgAsp: 3.249 ± 0.047
3.577ArgGlu: 3.577 ± 0.047
2.555ArgPhe: 2.555 ± 0.037
3.859ArgGly: 3.859 ± 0.046
1.844ArgHis: 1.844 ± 0.038
3.576ArgIle: 3.576 ± 0.047
2.071ArgLys: 2.071 ± 0.034
7.414ArgLeu: 7.414 ± 0.089
1.546ArgMet: 1.546 ± 0.027
1.856ArgAsn: 1.856 ± 0.034
2.753ArgPro: 2.753 ± 0.04
3.584ArgGln: 3.584 ± 0.049
4.559ArgArg: 4.559 ± 0.058
2.953ArgSer: 2.953 ± 0.038
2.663ArgThr: 2.663 ± 0.037
3.987ArgVal: 3.987 ± 0.054
0.973ArgTrp: 0.973 ± 0.026
2.187ArgTyr: 2.187 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.046SerAla: 6.046 ± 0.061
0.572SerCys: 0.572 ± 0.018
2.925SerAsp: 2.925 ± 0.043
2.69SerGlu: 2.69 ± 0.043
2.36SerPhe: 2.36 ± 0.035
5.644SerGly: 5.644 ± 0.072
1.367SerHis: 1.367 ± 0.031
3.256SerIle: 3.256 ± 0.052
1.796SerLys: 1.796 ± 0.032
7.153SerLeu: 7.153 ± 0.078
1.514SerMet: 1.514 ± 0.032
1.728SerAsn: 1.728 ± 0.035
3.051SerPro: 3.051 ± 0.035
2.284SerGln: 2.284 ± 0.039
3.656SerArg: 3.656 ± 0.052
3.629SerSer: 3.629 ± 0.055
2.959SerThr: 2.959 ± 0.044
4.229SerVal: 4.229 ± 0.05
0.883SerTrp: 0.883 ± 0.021
1.623SerTyr: 1.623 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
5.521ThrAla: 5.521 ± 0.066
0.443ThrCys: 0.443 ± 0.017
2.681ThrAsp: 2.681 ± 0.041
2.465ThrGlu: 2.465 ± 0.038
1.902ThrPhe: 1.902 ± 0.038
4.739ThrGly: 4.739 ± 0.067
1.219ThrHis: 1.219 ± 0.03
2.624ThrIle: 2.624 ± 0.044
1.386ThrLys: 1.386 ± 0.032
7.168ThrLeu: 7.168 ± 0.072
1.014ThrMet: 1.014 ± 0.024
1.452ThrAsn: 1.452 ± 0.029
3.167ThrPro: 3.167 ± 0.046
1.822ThrGln: 1.822 ± 0.035
2.928ThrArg: 2.928 ± 0.04
2.793ThrSer: 2.793 ± 0.045
2.589ThrThr: 2.589 ± 0.048
4.0ThrVal: 4.0 ± 0.048
0.647ThrTrp: 0.647 ± 0.02
1.23ThrTyr: 1.23 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
7.183ValAla: 7.183 ± 0.075
0.727ValCys: 0.727 ± 0.02
3.598ValAsp: 3.598 ± 0.048
3.469ValGlu: 3.469 ± 0.046
2.603ValPhe: 2.603 ± 0.043
4.856ValGly: 4.856 ± 0.06
1.243ValHis: 1.243 ± 0.026
4.572ValIle: 4.572 ± 0.057
2.749ValLys: 2.749 ± 0.041
7.386ValLeu: 7.386 ± 0.078
2.068ValMet: 2.068 ± 0.037
2.715ValAsn: 2.715 ± 0.045
3.151ValPro: 3.151 ± 0.041
2.12ValGln: 2.12 ± 0.042
3.844ValArg: 3.844 ± 0.053
4.489ValSer: 4.489 ± 0.053
4.067ValThr: 4.067 ± 0.051
5.194ValVal: 5.194 ± 0.076
0.799ValTrp: 0.799 ± 0.023
1.741ValTyr: 1.741 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
0.954TrpAla: 0.954 ± 0.022
0.166TrpCys: 0.166 ± 0.01
0.586TrpAsp: 0.586 ± 0.016
0.481TrpGlu: 0.481 ± 0.018
0.594TrpPhe: 0.594 ± 0.019
0.901TrpGly: 0.901 ± 0.026
0.434TrpHis: 0.434 ± 0.019
0.716TrpIle: 0.716 ± 0.019
0.381TrpLys: 0.381 ± 0.015
2.105TrpLeu: 2.105 ± 0.041
0.359TrpMet: 0.359 ± 0.014
0.412TrpAsn: 0.412 ± 0.017
0.649TrpPro: 0.649 ± 0.02
0.961TrpGln: 0.961 ± 0.023
1.152TrpArg: 1.152 ± 0.031
0.8TrpSer: 0.8 ± 0.021
0.56TrpThr: 0.56 ± 0.021
0.843TrpVal: 0.843 ± 0.024
0.223TrpTrp: 0.223 ± 0.013
0.364TrpTyr: 0.364 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.481TyrAla: 2.481 ± 0.036
0.376TyrCys: 0.376 ± 0.016
1.535TyrAsp: 1.535 ± 0.028
1.205TyrGlu: 1.205 ± 0.028
1.236TyrPhe: 1.236 ± 0.028
2.304TyrGly: 2.304 ± 0.04
0.763TyrHis: 0.763 ± 0.02
1.509TyrIle: 1.509 ± 0.03
0.802TyrLys: 0.802 ± 0.024
3.251TyrLeu: 3.251 ± 0.054
0.564TyrMet: 0.564 ± 0.018
0.973TyrAsn: 0.973 ± 0.024
1.482TyrPro: 1.482 ± 0.033
1.491TyrGln: 1.491 ± 0.033
2.144TyrArg: 2.144 ± 0.037
1.729TyrSer: 1.729 ± 0.032
1.384TyrThr: 1.384 ± 0.03
1.654TyrVal: 1.654 ± 0.032
0.411TyrTrp: 0.411 ± 0.013
0.894TyrTyr: 0.894 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5491 proteins (1783851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski