Amino acid dipepetide frequency for Limosa lapponica baueri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.974AlaAla: 5.974 ± 0.04	1.36AlaCys: 1.36 ± 0.015	3.022AlaAsp: 3.022 ± 0.022	4.7AlaGlu: 4.7 ± 0.031	2.586AlaPhe: 2.586 ± 0.02	4.179AlaGly: 4.179 ± 0.029	1.334AlaHis: 1.334 ± 0.014	2.893AlaIle: 2.893 ± 0.024	3.703AlaLys: 3.703 ± 0.026	6.599AlaLeu: 6.599 ± 0.038	1.544AlaMet: 1.544 ± 0.014	2.448AlaAsn: 2.448 ± 0.019	3.17AlaPro: 3.17 ± 0.028	2.854AlaGln: 2.854 ± 0.019	2.983AlaArg: 2.983 ± 0.023	5.183AlaSer: 5.183 ± 0.033	3.452AlaThr: 3.452 ± 0.026	4.667AlaVal: 4.667 ± 0.035	0.714AlaTrp: 0.714 ± 0.011	1.477AlaTyr: 1.477 ± 0.014	0.003AlaXaa: 0.003 ± 0.001
Cys	1.35CysAla: 1.35 ± 0.017	0.635CysCys: 0.635 ± 0.01	0.958CysAsp: 0.958 ± 0.017	1.193CysGlu: 1.193 ± 0.018	0.819CysPhe: 0.819 ± 0.011	1.457CysGly: 1.457 ± 0.018	0.605CysHis: 0.605 ± 0.01	1.355CysIle: 1.355 ± 0.016	1.325CysLys: 1.325 ± 0.016	2.224CysLeu: 2.224 ± 0.02	0.479CysMet: 0.479 ± 0.008	0.827CysAsn: 0.827 ± 0.011	1.264CysPro: 1.264 ± 0.018	1.061CysGln: 1.061 ± 0.018	1.34CysArg: 1.34 ± 0.014	1.999CysSer: 1.999 ± 0.02	1.296CysThr: 1.296 ± 0.015	1.459CysVal: 1.459 ± 0.015	0.366CysTrp: 0.366 ± 0.007	0.626CysTyr: 0.626 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	2.791AspAla: 2.791 ± 0.019	1.023AspCys: 1.023 ± 0.014	2.699AspAsp: 2.699 ± 0.022	3.553AspGlu: 3.553 ± 0.027	2.106AspPhe: 2.106 ± 0.018	3.298AspGly: 3.298 ± 0.027	1.109AspHis: 1.109 ± 0.012	2.823AspIle: 2.823 ± 0.019	2.702AspLys: 2.702 ± 0.022	5.545AspLeu: 5.545 ± 0.03	1.344AspMet: 1.344 ± 0.015	1.852AspAsn: 1.852 ± 0.018	2.521AspPro: 2.521 ± 0.02	1.746AspGln: 1.746 ± 0.017	2.705AspArg: 2.705 ± 0.023	3.923AspSer: 3.923 ± 0.024	2.765AspThr: 2.765 ± 0.019	3.054AspVal: 3.054 ± 0.022	0.687AspTrp: 0.687 ± 0.009	1.39AspTyr: 1.39 ± 0.015	0.001AspXaa: 0.001 ± 0.0
Glu	4.482GluAla: 4.482 ± 0.036	1.407GluCys: 1.407 ± 0.022	4.371GluAsp: 4.371 ± 0.027	7.923GluGlu: 7.923 ± 0.059	1.876GluPhe: 1.876 ± 0.017	4.409GluGly: 4.409 ± 0.028	1.603GluHis: 1.603 ± 0.016	3.094GluIle: 3.094 ± 0.026	6.067GluLys: 6.067 ± 0.044	6.144GluLeu: 6.144 ± 0.041	1.785GluMet: 1.785 ± 0.019	3.159GluAsn: 3.159 ± 0.024	2.633GluPro: 2.633 ± 0.028	3.124GluGln: 3.124 ± 0.025	4.296GluArg: 4.296 ± 0.037	4.589GluSer: 4.589 ± 0.027	3.375GluThr: 3.375 ± 0.026	4.582GluVal: 4.582 ± 0.025	0.852GluTrp: 0.852 ± 0.011	1.765GluTyr: 1.765 ± 0.017	0.001GluXaa: 0.001 ± 0.0
Phe	2.123PheAla: 2.123 ± 0.02	0.91PheCys: 0.91 ± 0.012	1.712PheAsp: 1.712 ± 0.015	1.846PheGlu: 1.846 ± 0.016	1.65PhePhe: 1.65 ± 0.018	2.064PheGly: 2.064 ± 0.02	0.983PheHis: 0.983 ± 0.012	1.9PheIle: 1.9 ± 0.017	2.012PheLys: 2.012 ± 0.019	3.765PheLeu: 3.765 ± 0.028	0.812PheMet: 0.812 ± 0.01	1.698PheAsn: 1.698 ± 0.016	1.805PhePro: 1.805 ± 0.016	1.671PheGln: 1.671 ± 0.016	1.79PheArg: 1.79 ± 0.016	3.515PheSer: 3.515 ± 0.018	2.124PheThr: 2.124 ± 0.019	2.102PheVal: 2.102 ± 0.017	0.615PheTrp: 0.615 ± 0.01	1.25PheTyr: 1.25 ± 0.016	0.001PheXaa: 0.001 ± 0.0
Gly	3.822GlyAla: 3.822 ± 0.028	1.55GlyCys: 1.55 ± 0.015	3.16GlyAsp: 3.16 ± 0.022	3.993GlyGlu: 3.993 ± 0.029	2.415GlyPhe: 2.415 ± 0.02	4.427GlyGly: 4.427 ± 0.034	1.658GlyHis: 1.658 ± 0.015	3.026GlyIle: 3.026 ± 0.024	4.125GlyLys: 4.125 ± 0.023	5.77GlyLeu: 5.77 ± 0.033	1.575GlyMet: 1.575 ± 0.019	2.743GlyAsn: 2.743 ± 0.019	3.117GlyPro: 3.117 ± 0.046	2.581GlyGln: 2.581 ± 0.018	3.709GlyArg: 3.709 ± 0.028	5.212GlySer: 5.212 ± 0.034	3.451GlyThr: 3.451 ± 0.026	3.836GlyVal: 3.836 ± 0.026	0.907GlyTrp: 0.907 ± 0.012	1.697GlyTyr: 1.697 ± 0.019	0.003GlyXaa: 0.003 ± 0.001
His	1.233HisAla: 1.233 ± 0.015	0.654HisCys: 0.654 ± 0.01	0.882HisAsp: 0.882 ± 0.011	1.254HisGlu: 1.254 ± 0.014	0.944HisPhe: 0.944 ± 0.011	1.64HisGly: 1.64 ± 0.018	0.847HisHis: 0.847 ± 0.014	1.197HisIle: 1.197 ± 0.013	1.465HisLys: 1.465 ± 0.015	3.171HisLeu: 3.171 ± 0.022	0.642HisMet: 0.642 ± 0.01	0.926HisAsn: 0.926 ± 0.01	1.502HisPro: 1.502 ± 0.017	1.205HisGln: 1.205 ± 0.016	1.459HisArg: 1.459 ± 0.015	2.089HisSer: 2.089 ± 0.018	1.224HisThr: 1.224 ± 0.016	1.431HisVal: 1.431 ± 0.013	0.432HisTrp: 0.432 ± 0.008	0.776HisTyr: 0.776 ± 0.01	0.001HisXaa: 0.001 ± 0.0
Ile	2.682IleAla: 2.682 ± 0.021	1.108IleCys: 1.108 ± 0.015	2.073IleAsp: 2.073 ± 0.021	2.756IleGlu: 2.756 ± 0.023	2.068IlePhe: 2.068 ± 0.019	2.197IleGly: 2.197 ± 0.021	1.247IleHis: 1.247 ± 0.012	2.444IleIle: 2.444 ± 0.023	2.833IleLys: 2.833 ± 0.02	5.047IleLeu: 5.047 ± 0.027	1.059IleMet: 1.059 ± 0.011	1.979IleAsn: 1.979 ± 0.018	2.593IlePro: 2.593 ± 0.02	2.372IleGln: 2.372 ± 0.021	2.582IleArg: 2.582 ± 0.02	3.779IleSer: 3.779 ± 0.026	2.57IleThr: 2.57 ± 0.023	2.604IleVal: 2.604 ± 0.019	0.527IleTrp: 0.527 ± 0.008	1.405IleTyr: 1.405 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.444LysAla: 4.444 ± 0.027	1.412LysCys: 1.412 ± 0.016	3.577LysAsp: 3.577 ± 0.026	5.485LysGlu: 5.485 ± 0.046	2.054LysPhe: 2.054 ± 0.018	3.888LysGly: 3.888 ± 0.034	1.463LysHis: 1.463 ± 0.014	2.774LysIle: 2.774 ± 0.021	5.712LysLys: 5.712 ± 0.057	5.771LysLeu: 5.771 ± 0.034	1.657LysMet: 1.657 ± 0.017	2.523LysAsn: 2.523 ± 0.021	2.845LysPro: 2.845 ± 0.028	2.643LysGln: 2.643 ± 0.021	3.779LysArg: 3.779 ± 0.026	4.26LysSer: 4.26 ± 0.028	3.151LysThr: 3.151 ± 0.023	3.662LysVal: 3.662 ± 0.023	0.732LysTrp: 0.732 ± 0.011	1.719LysTyr: 1.719 ± 0.017	0.005LysXaa: 0.005 ± 0.001
Leu	6.269LeuAla: 6.269 ± 0.036	2.246LeuCys: 2.246 ± 0.018	5.106LeuAsp: 5.106 ± 0.03	8.048LeuGlu: 8.048 ± 0.049	3.629LeuPhe: 3.629 ± 0.024	6.448LeuGly: 6.448 ± 0.038	2.713LeuHis: 2.713 ± 0.02	3.981LeuIle: 3.981 ± 0.025	5.924LeuLys: 5.924 ± 0.033	9.984LeuLeu: 9.984 ± 0.056	2.294LeuMet: 2.294 ± 0.02	3.64LeuAsn: 3.64 ± 0.023	5.381LeuPro: 5.381 ± 0.033	5.321LeuGln: 5.321 ± 0.036	5.554LeuArg: 5.554 ± 0.034	7.717LeuSer: 7.717 ± 0.039	4.725LeuThr: 4.725 ± 0.029	6.01LeuVal: 6.01 ± 0.034	1.228LeuTrp: 1.228 ± 0.013	2.716LeuTyr: 2.716 ± 0.021	0.004LeuXaa: 0.004 ± 0.001
Met	1.76MetAla: 1.76 ± 0.016	0.43MetCys: 0.43 ± 0.008	1.429MetAsp: 1.429 ± 0.015	2.086MetGlu: 2.086 ± 0.018	0.776MetPhe: 0.776 ± 0.011	1.468MetGly: 1.468 ± 0.016	0.551MetHis: 0.551 ± 0.009	1.033MetIle: 1.033 ± 0.011	1.765MetLys: 1.765 ± 0.018	2.123MetLeu: 2.123 ± 0.017	0.639MetMet: 0.639 ± 0.01	0.958MetAsn: 0.958 ± 0.013	1.116MetPro: 1.116 ± 0.015	1.022MetGln: 1.022 ± 0.013	1.292MetArg: 1.292 ± 0.014	1.903MetSer: 1.903 ± 0.016	1.189MetThr: 1.189 ± 0.012	1.534MetVal: 1.534 ± 0.018	0.267MetTrp: 0.267 ± 0.005	0.58MetTyr: 0.58 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.132AsnAla: 2.132 ± 0.018	0.929AsnCys: 0.929 ± 0.013	1.643AsnAsp: 1.643 ± 0.015	2.259AsnGlu: 2.259 ± 0.021	1.502AsnPhe: 1.502 ± 0.017	2.757AsnGly: 2.757 ± 0.025	0.94AsnHis: 0.94 ± 0.012	2.298AsnIle: 2.298 ± 0.018	2.616AsnLys: 2.616 ± 0.024	3.929AsnLeu: 3.929 ± 0.024	1.146AsnMet: 1.146 ± 0.012	1.698AsnAsn: 1.698 ± 0.017	2.24AsnPro: 2.24 ± 0.015	1.599AsnGln: 1.599 ± 0.017	1.976AsnArg: 1.976 ± 0.017	3.266AsnSer: 3.266 ± 0.027	2.066AsnThr: 2.066 ± 0.017	2.295AsnVal: 2.295 ± 0.018	0.562AsnTrp: 0.562 ± 0.009	1.197AsnTyr: 1.197 ± 0.014	0.001AsnXaa: 0.001 ± 0.0
Pro	3.939ProAla: 3.939 ± 0.036	1.062ProCys: 1.062 ± 0.016	2.426ProAsp: 2.426 ± 0.019	3.826ProGlu: 3.826 ± 0.032	1.743ProPhe: 1.743 ± 0.018	4.081ProGly: 4.081 ± 0.061	1.46ProHis: 1.46 ± 0.015	1.818ProIle: 1.818 ± 0.02	2.571ProLys: 2.571 ± 0.028	4.767ProLeu: 4.767 ± 0.031	1.109ProMet: 1.109 ± 0.013	1.655ProAsn: 1.655 ± 0.018	4.306ProPro: 4.306 ± 0.059	2.561ProGln: 2.561 ± 0.024	2.693ProArg: 2.693 ± 0.022	4.784ProSer: 4.784 ± 0.036	2.571ProThr: 2.571 ± 0.025	3.832ProVal: 3.832 ± 0.028	0.644ProTrp: 0.644 ± 0.011	1.368ProTyr: 1.368 ± 0.016	0.003ProXaa: 0.003 ± 0.001
Gln	3.015GlnAla: 3.015 ± 0.026	1.148GlnCys: 1.148 ± 0.015	2.136GlnAsp: 2.136 ± 0.018	3.566GlnGlu: 3.566 ± 0.031	1.467GlnPhe: 1.467 ± 0.016	2.728GlnGly: 2.728 ± 0.021	1.407GlnHis: 1.407 ± 0.016	1.955GlnIle: 1.955 ± 0.019	2.993GlnLys: 2.993 ± 0.024	4.35GlnLeu: 4.35 ± 0.03	1.063GlnMet: 1.063 ± 0.012	1.796GlnAsn: 1.796 ± 0.017	2.363GlnPro: 2.363 ± 0.024	3.021GlnGln: 3.021 ± 0.035	3.044GlnArg: 3.044 ± 0.021	3.021GlnSer: 3.021 ± 0.022	2.151GlnThr: 2.151 ± 0.018	2.818GlnVal: 2.818 ± 0.019	0.553GlnTrp: 0.553 ± 0.009	1.318GlnTyr: 1.318 ± 0.013	0.001GlnXaa: 0.001 ± 0.0
Arg	3.504ArgAla: 3.504 ± 0.023	1.092ArgCys: 1.092 ± 0.017	3.011ArgAsp: 3.011 ± 0.024	4.364ArgGlu: 4.364 ± 0.032	1.851ArgPhe: 1.851 ± 0.018	3.567ArgGly: 3.567 ± 0.033	1.477ArgHis: 1.477 ± 0.016	2.319ArgIle: 2.319 ± 0.018	4.052ArgLys: 4.052 ± 0.029	5.672ArgLeu: 5.672 ± 0.037	1.291ArgMet: 1.291 ± 0.016	2.281ArgAsn: 2.281 ± 0.02	2.703ArgPro: 2.703 ± 0.024	2.455ArgGln: 2.455 ± 0.019	4.235ArgArg: 4.235 ± 0.037	4.157ArgSer: 4.157 ± 0.033	2.732ArgThr: 2.732 ± 0.02	3.278ArgVal: 3.278 ± 0.021	0.804ArgTrp: 0.804 ± 0.01	1.465ArgTyr: 1.465 ± 0.015	0.002ArgXaa: 0.002 ± 0.0
Ser	5.02SerAla: 5.02 ± 0.028	1.955SerCys: 1.955 ± 0.018	3.729SerAsp: 3.729 ± 0.028	4.733SerGlu: 4.733 ± 0.033	2.903SerPhe: 2.903 ± 0.018	5.025SerGly: 5.025 ± 0.033	2.017SerHis: 2.017 ± 0.017	3.409SerIle: 3.409 ± 0.022	4.524SerLys: 4.524 ± 0.032	7.924SerLeu: 7.924 ± 0.043	1.781SerMet: 1.781 ± 0.016	2.795SerAsn: 2.795 ± 0.022	5.289SerPro: 5.289 ± 0.04	3.802SerGln: 3.802 ± 0.024	4.479SerArg: 4.479 ± 0.034	8.795SerSer: 8.795 ± 0.071	4.247SerThr: 4.247 ± 0.028	5.21SerVal: 5.21 ± 0.027	1.174SerTrp: 1.174 ± 0.012	2.113SerTyr: 2.113 ± 0.02	0.002SerXaa: 0.002 ± 0.0
Thr	3.652ThrAla: 3.652 ± 0.026	1.225ThrCys: 1.225 ± 0.02	2.483ThrAsp: 2.483 ± 0.019	3.577ThrGlu: 3.577 ± 0.03	1.937ThrPhe: 1.937 ± 0.015	3.403ThrGly: 3.403 ± 0.025	1.121ThrHis: 1.121 ± 0.016	2.301ThrIle: 2.301 ± 0.018	3.085ThrLys: 3.085 ± 0.022	5.104ThrLeu: 5.104 ± 0.026	1.211ThrMet: 1.211 ± 0.012	1.89ThrAsn: 1.89 ± 0.016	3.016ThrPro: 3.016 ± 0.027	2.071ThrGln: 2.071 ± 0.019	2.46ThrArg: 2.46 ± 0.021	4.593ThrSer: 4.593 ± 0.034	2.898ThrThr: 2.898 ± 0.037	3.919ThrVal: 3.919 ± 0.027	0.715ThrTrp: 0.715 ± 0.01	1.316ThrTyr: 1.316 ± 0.017	0.002ThrXaa: 0.002 ± 0.0
Val	4.323ValAla: 4.323 ± 0.028	1.417ValCys: 1.417 ± 0.015	3.247ValAsp: 3.247 ± 0.024	3.855ValGlu: 3.855 ± 0.027	2.445ValPhe: 2.445 ± 0.02	3.364ValGly: 3.364 ± 0.024	1.44ValHis: 1.44 ± 0.014	3.255ValIle: 3.255 ± 0.02	3.53ValLys: 3.53 ± 0.027	6.825ValLeu: 6.825 ± 0.033	1.516ValMet: 1.516 ± 0.015	2.436ValAsn: 2.436 ± 0.018	3.686ValPro: 3.686 ± 0.029	3.018ValGln: 3.018 ± 0.018	3.18ValArg: 3.18 ± 0.022	4.87ValSer: 4.87 ± 0.026	3.843ValThr: 3.843 ± 0.03	4.4ValVal: 4.4 ± 0.065	0.709ValTrp: 0.709 ± 0.011	1.642ValTyr: 1.642 ± 0.015	0.001ValXaa: 0.001 ± 0.0
Trp	0.998TrpAla: 0.998 ± 0.012	0.254TrpCys: 0.254 ± 0.006	0.66TrpAsp: 0.66 ± 0.01	0.79TrpGlu: 0.79 ± 0.011	0.412TrpPhe: 0.412 ± 0.008	0.749TrpGly: 0.749 ± 0.012	0.294TrpHis: 0.294 ± 0.007	0.685TrpIle: 0.685 ± 0.009	0.933TrpLys: 0.933 ± 0.012	1.415TrpLeu: 1.415 ± 0.016	0.347TrpMet: 0.347 ± 0.007	0.592TrpAsn: 0.592 ± 0.008	0.473TrpPro: 0.473 ± 0.008	0.608TrpGln: 0.608 ± 0.009	0.839TrpArg: 0.839 ± 0.011	0.949TrpSer: 0.949 ± 0.013	0.737TrpThr: 0.737 ± 0.011	0.792TrpVal: 0.792 ± 0.012	0.248TrpTrp: 0.248 ± 0.006	0.332TrpTyr: 0.332 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.328TyrAla: 1.328 ± 0.013	0.823TyrCys: 0.823 ± 0.01	1.313TyrAsp: 1.313 ± 0.014	1.728TyrGlu: 1.728 ± 0.014	1.163TyrPhe: 1.163 ± 0.014	1.626TyrGly: 1.626 ± 0.017	0.706TyrHis: 0.706 ± 0.009	1.366TyrIle: 1.366 ± 0.015	1.616TyrLys: 1.616 ± 0.019	2.804TyrLeu: 2.804 ± 0.022	0.624TyrMet: 0.624 ± 0.01	1.152TyrAsn: 1.152 ± 0.015	1.196TyrPro: 1.196 ± 0.014	1.177TyrGln: 1.177 ± 0.012	1.915TyrArg: 1.915 ± 0.019	2.319TyrSer: 2.319 ± 0.02	1.409TyrThr: 1.409 ± 0.017	1.514TyrVal: 1.514 ± 0.014	0.373TyrTrp: 0.373 ± 0.009	0.901TyrTyr: 0.901 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.003XaaLys: 0.003 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	4.312XaaXaa: 4.312 ± 0.411

Statistics based on 22950 proteins (7942202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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