Amino acid dipepetide frequency for Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.37AlaAla: 14.37 ± 0.15	1.141AlaCys: 1.141 ± 0.03	5.493AlaAsp: 5.493 ± 0.082	6.97AlaGlu: 6.97 ± 0.091	3.785AlaPhe: 3.785 ± 0.056	9.674AlaGly: 9.674 ± 0.097	2.056AlaHis: 2.056 ± 0.047	5.081AlaIle: 5.081 ± 0.064	2.74AlaLys: 2.74 ± 0.052	13.466AlaLeu: 13.466 ± 0.129	2.215AlaMet: 2.215 ± 0.045	2.809AlaAsn: 2.809 ± 0.052	5.358AlaPro: 5.358 ± 0.088	4.85AlaGln: 4.85 ± 0.065	7.792AlaArg: 7.792 ± 0.084	5.639AlaSer: 5.639 ± 0.075	5.104AlaThr: 5.104 ± 0.066	9.286AlaVal: 9.286 ± 0.107	1.341AlaTrp: 1.341 ± 0.033	2.552AlaTyr: 2.552 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.017CysAla: 1.017 ± 0.028	0.186CysCys: 0.186 ± 0.014	0.509CysAsp: 0.509 ± 0.021	0.635CysGlu: 0.635 ± 0.022	0.403CysPhe: 0.403 ± 0.017	0.946CysGly: 0.946 ± 0.033	0.252CysHis: 0.252 ± 0.013	0.389CysIle: 0.389 ± 0.019	0.239CysLys: 0.239 ± 0.013	1.214CysLeu: 1.214 ± 0.036	0.15CysMet: 0.15 ± 0.011	0.25CysAsn: 0.25 ± 0.014	0.643CysPro: 0.643 ± 0.025	0.301CysGln: 0.301 ± 0.015	0.894CysArg: 0.894 ± 0.032	0.547CysSer: 0.547 ± 0.021	0.582CysThr: 0.582 ± 0.02	0.624CysVal: 0.624 ± 0.023	0.176CysTrp: 0.176 ± 0.01	0.285CysTyr: 0.285 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.738AspAla: 4.738 ± 0.064	0.53AspCys: 0.53 ± 0.02	2.129AspAsp: 2.129 ± 0.048	2.838AspGlu: 2.838 ± 0.047	2.159AspPhe: 2.159 ± 0.039	4.745AspGly: 4.745 ± 0.086	0.846AspHis: 0.846 ± 0.027	2.349AspIle: 2.349 ± 0.044	1.37AspLys: 1.37 ± 0.035	6.207AspLeu: 6.207 ± 0.09	0.658AspMet: 0.658 ± 0.022	1.419AspAsn: 1.419 ± 0.037	3.685AspPro: 3.685 ± 0.055	1.628AspGln: 1.628 ± 0.037	3.87AspArg: 3.87 ± 0.056	2.536AspSer: 2.536 ± 0.047	2.321AspThr: 2.321 ± 0.045	2.871AspVal: 2.871 ± 0.057	0.966AspTrp: 0.966 ± 0.028	1.542AspTyr: 1.542 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.662GluAla: 7.662 ± 0.088	0.51GluCys: 0.51 ± 0.019	2.474GluAsp: 2.474 ± 0.048	3.567GluGlu: 3.567 ± 0.07	1.903GluPhe: 1.903 ± 0.039	4.258GluGly: 4.258 ± 0.061	1.286GluHis: 1.286 ± 0.032	2.962GluIle: 2.962 ± 0.052	2.099GluLys: 2.099 ± 0.047	6.495GluLeu: 6.495 ± 0.082	1.113GluMet: 1.113 ± 0.027	1.577GluAsn: 1.577 ± 0.037	3.228GluPro: 3.228 ± 0.077	3.597GluGln: 3.597 ± 0.06	6.337GluArg: 6.337 ± 0.073	2.92GluSer: 2.92 ± 0.045	2.781GluThr: 2.781 ± 0.057	4.419GluVal: 4.419 ± 0.064	0.772GluTrp: 0.772 ± 0.025	1.495GluTyr: 1.495 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.484PheAla: 4.484 ± 0.059	0.451PheCys: 0.451 ± 0.016	2.458PheAsp: 2.458 ± 0.045	2.531PheGlu: 2.531 ± 0.049	1.499PhePhe: 1.499 ± 0.036	3.449PheGly: 3.449 ± 0.056	0.658PheHis: 0.658 ± 0.023	1.437PheIle: 1.437 ± 0.034	1.111PheLys: 1.111 ± 0.029	3.495PheLeu: 3.495 ± 0.055	0.562PheMet: 0.562 ± 0.019	1.25PheAsn: 1.25 ± 0.037	1.5PhePro: 1.5 ± 0.032	1.222PheGln: 1.222 ± 0.029	2.158PheArg: 2.158 ± 0.04	2.279PheSer: 2.279 ± 0.043	2.05PheThr: 2.05 ± 0.043	2.879PheVal: 2.879 ± 0.042	0.672PheTrp: 0.672 ± 0.024	1.19PheTyr: 1.19 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.025GlyAla: 8.025 ± 0.102	0.952GlyCys: 0.952 ± 0.027	4.181GlyAsp: 4.181 ± 0.101	5.403GlyGlu: 5.403 ± 0.069	3.319GlyPhe: 3.319 ± 0.052	7.207GlyGly: 7.207 ± 0.105	1.561GlyHis: 1.561 ± 0.044	4.081GlyIle: 4.081 ± 0.057	3.004GlyLys: 3.004 ± 0.054	8.787GlyLeu: 8.787 ± 0.089	1.603GlyMet: 1.603 ± 0.037	2.373GlyAsn: 2.373 ± 0.042	3.367GlyPro: 3.367 ± 0.051	3.233GlyGln: 3.233 ± 0.05	6.499GlyArg: 6.499 ± 0.076	5.026GlySer: 5.026 ± 0.068	4.827GlyThr: 4.827 ± 0.08	5.906GlyVal: 5.906 ± 0.074	1.534GlyTrp: 1.534 ± 0.04	2.424GlyTyr: 2.424 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.508HisAla: 1.508 ± 0.038	0.298HisCys: 0.298 ± 0.017	0.765HisAsp: 0.765 ± 0.025	0.838HisGlu: 0.838 ± 0.032	0.878HisPhe: 0.878 ± 0.024	1.426HisGly: 1.426 ± 0.035	0.536HisHis: 0.536 ± 0.025	0.838HisIle: 0.838 ± 0.024	0.49HisLys: 0.49 ± 0.019	2.456HisLeu: 2.456 ± 0.045	0.272HisMet: 0.272 ± 0.014	0.523HisAsn: 0.523 ± 0.022	1.487HisPro: 1.487 ± 0.038	0.732HisGln: 0.732 ± 0.026	1.688HisArg: 1.688 ± 0.033	1.047HisSer: 1.047 ± 0.03	0.992HisThr: 0.992 ± 0.028	0.886HisVal: 0.886 ± 0.025	0.403HisTrp: 0.403 ± 0.018	0.639HisTyr: 0.639 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.701IleAla: 5.701 ± 0.072	0.463IleCys: 0.463 ± 0.019	3.158IleAsp: 3.158 ± 0.054	3.459IleGlu: 3.459 ± 0.057	1.646IlePhe: 1.646 ± 0.039	3.705IleGly: 3.705 ± 0.06	0.867IleHis: 0.867 ± 0.025	1.46IleIle: 1.46 ± 0.036	1.24IleLys: 1.24 ± 0.034	4.397IleLeu: 4.397 ± 0.064	0.432IleMet: 0.432 ± 0.02	1.325IleAsn: 1.325 ± 0.037	2.366IlePro: 2.366 ± 0.042	1.489IleGln: 1.489 ± 0.033	2.896IleArg: 2.896 ± 0.051	2.144IleSer: 2.144 ± 0.043	2.236IleThr: 2.236 ± 0.046	3.504IleVal: 3.504 ± 0.052	0.598IleTrp: 0.598 ± 0.024	1.243IleTyr: 1.243 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.222LysAla: 3.222 ± 0.054	0.181LysCys: 0.181 ± 0.012	1.368LysAsp: 1.368 ± 0.038	1.487LysGlu: 1.487 ± 0.038	0.878LysPhe: 0.878 ± 0.03	1.987LysGly: 1.987 ± 0.041	0.507LysHis: 0.507 ± 0.022	1.535LysIle: 1.535 ± 0.035	1.061LysLys: 1.061 ± 0.033	3.442LysLeu: 3.442 ± 0.058	0.578LysMet: 0.578 ± 0.02	0.913LysAsn: 0.913 ± 0.029	1.945LysPro: 1.945 ± 0.042	1.302LysGln: 1.302 ± 0.038	1.96LysArg: 1.96 ± 0.04	1.704LysSer: 1.704 ± 0.033	1.704LysThr: 1.704 ± 0.036	2.145LysVal: 2.145 ± 0.046	0.252LysTrp: 0.252 ± 0.014	0.716LysTyr: 0.716 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.233LeuAla: 14.233 ± 0.132	1.174LeuCys: 1.174 ± 0.03	5.844LeuAsp: 5.844 ± 0.074	7.338LeuGlu: 7.338 ± 0.082	3.781LeuPhe: 3.781 ± 0.059	9.618LeuGly: 9.618 ± 0.1	2.008LeuHis: 2.008 ± 0.037	4.611LeuIle: 4.611 ± 0.068	3.777LeuLys: 3.777 ± 0.056	12.331LeuLeu: 12.331 ± 0.13	1.894LeuMet: 1.894 ± 0.043	2.84LeuAsn: 2.84 ± 0.046	6.663LeuPro: 6.663 ± 0.075	4.61LeuGln: 4.61 ± 0.07	7.86LeuArg: 7.86 ± 0.093	6.586LeuSer: 6.586 ± 0.071	5.763LeuThr: 5.763 ± 0.065	8.826LeuVal: 8.826 ± 0.09	1.794LeuTrp: 1.794 ± 0.047	2.644LeuTyr: 2.644 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.14MetAla: 2.14 ± 0.039	0.11MetCys: 0.11 ± 0.009	0.782MetAsp: 0.782 ± 0.025	0.938MetGlu: 0.938 ± 0.03	0.494MetPhe: 0.494 ± 0.018	1.47MetGly: 1.47 ± 0.037	0.387MetHis: 0.387 ± 0.018	0.737MetIle: 0.737 ± 0.025	0.553MetLys: 0.553 ± 0.021	1.91MetLeu: 1.91 ± 0.04	0.277MetMet: 0.277 ± 0.015	0.563MetAsn: 0.563 ± 0.024	1.114MetPro: 1.114 ± 0.032	0.769MetGln: 0.769 ± 0.023	1.239MetArg: 1.239 ± 0.033	1.093MetSer: 1.093 ± 0.029	0.973MetThr: 0.973 ± 0.026	1.364MetVal: 1.364 ± 0.033	0.123MetTrp: 0.123 ± 0.01	0.297MetTyr: 0.297 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.578AsnAla: 2.578 ± 0.048	0.307AsnCys: 0.307 ± 0.017	1.126AsnAsp: 1.126 ± 0.03	1.058AsnGlu: 1.058 ± 0.03	1.276AsnPhe: 1.276 ± 0.039	2.315AsnGly: 2.315 ± 0.06	0.51AsnHis: 0.51 ± 0.023	1.243AsnIle: 1.243 ± 0.029	0.638AsnLys: 0.638 ± 0.025	3.479AsnLeu: 3.479 ± 0.067	0.397AsnMet: 0.397 ± 0.018	0.903AsnAsn: 0.903 ± 0.029	2.058AsnPro: 2.058 ± 0.037	1.007AsnGln: 1.007 ± 0.028	2.234AsnArg: 2.234 ± 0.045	1.392AsnSer: 1.392 ± 0.042	1.458AsnThr: 1.458 ± 0.033	1.796AsnVal: 1.796 ± 0.035	0.512AsnTrp: 0.512 ± 0.021	0.812AsnTyr: 0.812 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.396ProAla: 6.396 ± 0.088	0.408ProCys: 0.408 ± 0.016	3.467ProAsp: 3.467 ± 0.055	4.544ProGlu: 4.544 ± 0.081	1.96ProPhe: 1.96 ± 0.037	4.974ProGly: 4.974 ± 0.069	0.928ProHis: 0.928 ± 0.025	2.102ProIle: 2.102 ± 0.04	1.548ProLys: 1.548 ± 0.036	5.787ProLeu: 5.787 ± 0.081	1.145ProMet: 1.145 ± 0.031	1.535ProAsn: 1.535 ± 0.035	3.624ProPro: 3.624 ± 0.083	2.353ProGln: 2.353 ± 0.048	3.068ProArg: 3.068 ± 0.045	2.861ProSer: 2.861 ± 0.058	2.983ProThr: 2.983 ± 0.055	4.765ProVal: 4.765 ± 0.07	0.737ProTrp: 0.737 ± 0.023	1.354ProTyr: 1.354 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.942GlnAla: 4.942 ± 0.067	0.315GlnCys: 0.315 ± 0.017	1.522GlnAsp: 1.522 ± 0.031	2.17GlnGlu: 2.17 ± 0.048	1.447GlnPhe: 1.447 ± 0.03	2.898GlnGly: 2.898 ± 0.049	0.591GlnHis: 0.591 ± 0.021	2.31GlnIle: 2.31 ± 0.045	1.415GlnLys: 1.415 ± 0.032	4.904GlnLeu: 4.904 ± 0.067	0.965GlnMet: 0.965 ± 0.03	1.037GlnAsn: 1.037 ± 0.032	2.522GlnPro: 2.522 ± 0.056	2.228GlnGln: 2.228 ± 0.054	2.848GlnArg: 2.848 ± 0.045	2.347GlnSer: 2.347 ± 0.04	2.367GlnThr: 2.367 ± 0.041	3.489GlnVal: 3.489 ± 0.058	0.59GlnTrp: 0.59 ± 0.023	0.907GlnTyr: 0.907 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.071ArgAla: 7.071 ± 0.092	0.818ArgCys: 0.818 ± 0.029	3.121ArgAsp: 3.121 ± 0.048	4.41ArgGlu: 4.41 ± 0.066	3.214ArgPhe: 3.214 ± 0.05	4.771ArgGly: 4.771 ± 0.062	1.482ArgHis: 1.482 ± 0.029	3.588ArgIle: 3.588 ± 0.049	1.965ArgLys: 1.965 ± 0.043	9.477ArgLeu: 9.477 ± 0.105	1.447ArgMet: 1.447 ± 0.034	1.836ArgAsn: 1.836 ± 0.042	4.055ArgPro: 4.055 ± 0.066	3.335ArgGln: 3.335 ± 0.057	6.176ArgArg: 6.176 ± 0.087	4.38ArgSer: 4.38 ± 0.054	4.074ArgThr: 4.074 ± 0.05	5.268ArgVal: 5.268 ± 0.066	1.291ArgTrp: 1.291 ± 0.037	2.323ArgTyr: 2.323 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.703SerAla: 5.703 ± 0.073	0.543SerCys: 0.543 ± 0.022	2.692SerAsp: 2.692 ± 0.051	3.379SerGlu: 3.379 ± 0.052	2.113SerPhe: 2.113 ± 0.043	5.432SerGly: 5.432 ± 0.082	0.996SerHis: 0.996 ± 0.027	2.257SerIle: 2.257 ± 0.044	1.479SerLys: 1.479 ± 0.036	6.228SerLeu: 6.228 ± 0.077	1.026SerMet: 1.026 ± 0.026	1.465SerAsn: 1.465 ± 0.036	3.319SerPro: 3.319 ± 0.059	2.149SerGln: 2.149 ± 0.039	3.702SerArg: 3.702 ± 0.055	2.996SerSer: 2.996 ± 0.06	3.067SerThr: 3.067 ± 0.053	4.029SerVal: 4.029 ± 0.062	0.798SerTrp: 0.798 ± 0.024	1.481SerTyr: 1.481 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.844ThrAla: 5.844 ± 0.066	0.48ThrCys: 0.48 ± 0.02	2.53ThrAsp: 2.53 ± 0.05	2.601ThrGlu: 2.601 ± 0.048	2.099ThrPhe: 2.099 ± 0.04	5.025ThrGly: 5.025 ± 0.08	0.925ThrHis: 0.925 ± 0.026	2.356ThrIle: 2.356 ± 0.045	1.158ThrLys: 1.158 ± 0.03	6.036ThrLeu: 6.036 ± 0.07	0.785ThrMet: 0.785 ± 0.021	1.36ThrAsn: 1.36 ± 0.033	3.385ThrPro: 3.385 ± 0.053	1.803ThrGln: 1.803 ± 0.04	3.342ThrArg: 3.342 ± 0.052	2.681ThrSer: 2.681 ± 0.053	2.739ThrThr: 2.739 ± 0.052	4.608ThrVal: 4.608 ± 0.062	0.651ThrTrp: 0.651 ± 0.024	1.376ThrTyr: 1.376 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.477ValAla: 8.477 ± 0.087	0.838ValCys: 0.838 ± 0.025	3.723ValAsp: 3.723 ± 0.052	5.03ValGlu: 5.03 ± 0.068	2.771ValPhe: 2.771 ± 0.05	6.244ValGly: 6.244 ± 0.084	1.535ValHis: 1.535 ± 0.035	3.249ValIle: 3.249 ± 0.053	1.871ValLys: 1.871 ± 0.044	8.77ValLeu: 8.77 ± 0.086	1.156ValMet: 1.156 ± 0.035	1.936ValAsn: 1.936 ± 0.044	4.066ValPro: 4.066 ± 0.064	3.089ValGln: 3.089 ± 0.05	5.736ValArg: 5.736 ± 0.075	4.328ValSer: 4.328 ± 0.053	3.659ValThr: 3.659 ± 0.06	6.089ValVal: 6.089 ± 0.081	1.039ValTrp: 1.039 ± 0.034	1.875ValTyr: 1.875 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.178TrpAla: 1.178 ± 0.031	0.174TrpCys: 0.174 ± 0.012	0.62TrpAsp: 0.62 ± 0.026	0.852TrpGlu: 0.852 ± 0.026	0.565TrpPhe: 0.565 ± 0.022	0.996TrpGly: 0.996 ± 0.028	0.288TrpHis: 0.288 ± 0.013	0.67TrpIle: 0.67 ± 0.023	0.475TrpLys: 0.475 ± 0.019	2.143TrpLeu: 2.143 ± 0.05	0.314TrpMet: 0.314 ± 0.016	0.436TrpAsn: 0.436 ± 0.016	0.661TrpPro: 0.661 ± 0.023	1.055TrpGln: 1.055 ± 0.026	1.307TrpArg: 1.307 ± 0.041	0.892TrpSer: 0.892 ± 0.029	0.687TrpThr: 0.687 ± 0.022	1.071TrpVal: 1.071 ± 0.028	0.306TrpTrp: 0.306 ± 0.017	0.339TrpTyr: 0.339 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.432TyrAla: 2.432 ± 0.047	0.36TyrCys: 0.36 ± 0.017	1.446TyrAsp: 1.446 ± 0.037	1.407TyrGlu: 1.407 ± 0.031	1.148TyrPhe: 1.148 ± 0.032	2.17TyrGly: 2.17 ± 0.041	0.483TyrHis: 0.483 ± 0.018	1.073TyrIle: 1.073 ± 0.031	0.655TyrLys: 0.655 ± 0.024	3.172TyrLeu: 3.172 ± 0.047	0.342TyrMet: 0.342 ± 0.017	0.748TyrAsn: 0.748 ± 0.024	1.494TyrPro: 1.494 ± 0.036	1.065TyrGln: 1.065 ± 0.029	2.497TyrArg: 2.497 ± 0.048	1.453TyrSer: 1.453 ± 0.036	1.417TyrThr: 1.417 ± 0.029	1.655TyrVal: 1.655 ± 0.038	0.476TyrTrp: 0.476 ± 0.018	0.883TyrTyr: 0.883 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4406 proteins (1377677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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