Amino acid dipepetide frequency for Rhodanobacter sp. 115

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.203AlaAla: 16.203 ± 0.164	1.332AlaCys: 1.332 ± 0.036	6.864AlaAsp: 6.864 ± 0.082	6.334AlaGlu: 6.334 ± 0.084	3.971AlaPhe: 3.971 ± 0.059	10.508AlaGly: 10.508 ± 0.111	3.203AlaHis: 3.203 ± 0.062	5.344AlaIle: 5.344 ± 0.076	3.776AlaLys: 3.776 ± 0.075	14.562AlaLeu: 14.562 ± 0.13	3.504AlaMet: 3.504 ± 0.063	3.071AlaAsn: 3.071 ± 0.055	5.824AlaPro: 5.824 ± 0.067	5.068AlaGln: 5.068 ± 0.073	8.816AlaArg: 8.816 ± 0.101	6.838AlaSer: 6.838 ± 0.094	6.431AlaThr: 6.431 ± 0.081	8.308AlaVal: 8.308 ± 0.098	2.115AlaTrp: 2.115 ± 0.043	2.49AlaTyr: 2.49 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.171CysAla: 1.171 ± 0.031	0.141CysCys: 0.141 ± 0.014	0.513CysAsp: 0.513 ± 0.022	0.446CysGlu: 0.446 ± 0.02	0.305CysPhe: 0.305 ± 0.015	0.93CysGly: 0.93 ± 0.031	0.294CysHis: 0.294 ± 0.019	0.374CysIle: 0.374 ± 0.019	0.191CysLys: 0.191 ± 0.013	0.855CysLeu: 0.855 ± 0.028	0.219CysMet: 0.219 ± 0.015	0.222CysAsn: 0.222 ± 0.015	0.458CysPro: 0.458 ± 0.021	0.24CysGln: 0.24 ± 0.014	0.716CysArg: 0.716 ± 0.027	0.503CysSer: 0.503 ± 0.02	0.462CysThr: 0.462 ± 0.02	0.676CysVal: 0.676 ± 0.024	0.173CysTrp: 0.173 ± 0.013	0.227CysTyr: 0.227 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.802AspAla: 7.802 ± 0.105	0.437AspCys: 0.437 ± 0.02	3.517AspAsp: 3.517 ± 0.081	3.226AspGlu: 3.226 ± 0.06	2.209AspPhe: 2.209 ± 0.05	5.442AspGly: 5.442 ± 0.07	1.491AspHis: 1.491 ± 0.043	2.483AspIle: 2.483 ± 0.049	1.794AspLys: 1.794 ± 0.047	5.28AspLeu: 5.28 ± 0.065	1.252AspMet: 1.252 ± 0.035	1.465AspAsn: 1.465 ± 0.039	3.324AspPro: 3.324 ± 0.052	1.756AspGln: 1.756 ± 0.047	3.427AspArg: 3.427 ± 0.058	2.558AspSer: 2.558 ± 0.051	2.99AspThr: 2.99 ± 0.057	4.234AspVal: 4.234 ± 0.053	1.112AspTrp: 1.112 ± 0.032	1.71AspTyr: 1.71 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.132GluAla: 6.132 ± 0.079	0.365GluCys: 0.365 ± 0.018	2.103GluAsp: 2.103 ± 0.044	1.918GluGlu: 1.918 ± 0.046	1.484GluPhe: 1.484 ± 0.037	3.439GluGly: 3.439 ± 0.065	1.67GluHis: 1.67 ± 0.044	2.133GluIle: 2.133 ± 0.042	1.6GluLys: 1.6 ± 0.042	5.987GluLeu: 5.987 ± 0.083	0.995GluMet: 0.995 ± 0.03	1.14GluAsn: 1.14 ± 0.034	2.369GluPro: 2.369 ± 0.052	2.513GluGln: 2.513 ± 0.046	4.524GluArg: 4.524 ± 0.075	2.441GluSer: 2.441 ± 0.048	2.38GluThr: 2.38 ± 0.046	3.472GluVal: 3.472 ± 0.064	0.674GluTrp: 0.674 ± 0.025	1.049GluTyr: 1.049 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.243PheAla: 4.243 ± 0.066	0.345PheCys: 0.345 ± 0.018	2.56PheAsp: 2.56 ± 0.048	1.748PheGlu: 1.748 ± 0.042	1.204PhePhe: 1.204 ± 0.034	3.372PheGly: 3.372 ± 0.059	0.933PheHis: 0.933 ± 0.031	1.274PheIle: 1.274 ± 0.036	0.99PheLys: 0.99 ± 0.031	2.894PheLeu: 2.894 ± 0.061	0.689PheMet: 0.689 ± 0.025	1.093PheAsn: 1.093 ± 0.032	1.522PhePro: 1.522 ± 0.04	1.022PheGln: 1.022 ± 0.03	2.199PheArg: 2.199 ± 0.05	1.914PheSer: 1.914 ± 0.038	1.822PheThr: 1.822 ± 0.041	2.679PheVal: 2.679 ± 0.049	0.521PheTrp: 0.521 ± 0.025	0.891PheTyr: 0.891 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.596GlyAla: 8.596 ± 0.097	0.849GlyCys: 0.849 ± 0.029	4.594GlyAsp: 4.594 ± 0.07	4.424GlyGlu: 4.424 ± 0.07	3.3GlyPhe: 3.3 ± 0.06	6.929GlyGly: 6.929 ± 0.108	2.606GlyHis: 2.606 ± 0.045	4.078GlyIle: 4.078 ± 0.074	3.48GlyLys: 3.48 ± 0.071	8.427GlyLeu: 8.427 ± 0.086	2.483GlyMet: 2.483 ± 0.055	2.508GlyAsn: 2.508 ± 0.056	3.015GlyPro: 3.015 ± 0.059	3.237GlyGln: 3.237 ± 0.058	5.572GlyArg: 5.572 ± 0.071	4.847GlySer: 4.847 ± 0.07	4.508GlyThr: 4.508 ± 0.077	6.458GlyVal: 6.458 ± 0.074	1.715GlyTrp: 1.715 ± 0.041	2.442GlyTyr: 2.442 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	3.894HisAla: 3.894 ± 0.063	0.288HisCys: 0.288 ± 0.016	1.744HisAsp: 1.744 ± 0.038	1.38HisGlu: 1.38 ± 0.038	1.074HisPhe: 1.074 ± 0.031	2.877HisGly: 2.877 ± 0.053	0.954HisHis: 0.954 ± 0.033	0.984HisIle: 0.984 ± 0.034	0.621HisLys: 0.621 ± 0.024	2.597HisLeu: 2.597 ± 0.048	0.659HisMet: 0.659 ± 0.024	0.546HisAsn: 0.546 ± 0.021	1.794HisPro: 1.794 ± 0.043	0.839HisGln: 0.839 ± 0.028	2.083HisArg: 2.083 ± 0.046	1.259HisSer: 1.259 ± 0.031	1.208HisThr: 1.208 ± 0.03	2.045HisVal: 2.045 ± 0.041	0.582HisTrp: 0.582 ± 0.023	0.827HisTyr: 0.827 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.824IleAla: 5.824 ± 0.076	0.393IleCys: 0.393 ± 0.017	3.327IleAsp: 3.327 ± 0.058	2.751IleGlu: 2.751 ± 0.051	1.215IlePhe: 1.215 ± 0.033	4.355IleGly: 4.355 ± 0.069	1.061IleHis: 1.061 ± 0.031	1.464IleIle: 1.464 ± 0.037	1.258IleLys: 1.258 ± 0.041	3.149IleLeu: 3.149 ± 0.056	0.607IleMet: 0.607 ± 0.024	1.321IleAsn: 1.321 ± 0.035	2.126IlePro: 2.126 ± 0.043	1.077IleGln: 1.077 ± 0.03	2.712IleArg: 2.712 ± 0.062	2.238IleSer: 2.238 ± 0.049	2.406IleThr: 2.406 ± 0.046	3.261IleVal: 3.261 ± 0.055	0.497IleTrp: 0.497 ± 0.02	0.971IleTyr: 0.971 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.731LysAla: 3.731 ± 0.079	0.165LysCys: 0.165 ± 0.013	1.538LysAsp: 1.538 ± 0.038	1.186LysGlu: 1.186 ± 0.037	0.805LysPhe: 0.805 ± 0.026	2.197LysGly: 2.197 ± 0.052	0.857LysHis: 0.857 ± 0.026	1.204LysIle: 1.204 ± 0.037	1.164LysLys: 1.164 ± 0.049	3.691LysLeu: 3.691 ± 0.057	0.652LysMet: 0.652 ± 0.026	0.817LysAsn: 0.817 ± 0.027	2.172LysPro: 2.172 ± 0.049	1.359LysGln: 1.359 ± 0.034	2.219LysArg: 2.219 ± 0.043	1.608LysSer: 1.608 ± 0.04	1.693LysThr: 1.693 ± 0.045	2.385LysVal: 2.385 ± 0.052	0.329LysTrp: 0.329 ± 0.016	0.689LysTyr: 0.689 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.125LeuAla: 15.125 ± 0.146	1.018LeuCys: 1.018 ± 0.033	6.928LeuAsp: 6.928 ± 0.078	4.86LeuGlu: 4.86 ± 0.079	3.453LeuPhe: 3.453 ± 0.061	8.969LeuGly: 8.969 ± 0.094	2.884LeuHis: 2.884 ± 0.056	4.144LeuIle: 4.144 ± 0.071	3.452LeuLys: 3.452 ± 0.062	12.421LeuLeu: 12.421 ± 0.139	2.196LeuMet: 2.196 ± 0.043	2.437LeuAsn: 2.437 ± 0.047	6.636LeuPro: 6.636 ± 0.088	3.842LeuGln: 3.842 ± 0.06	8.301LeuArg: 8.301 ± 0.115	5.821LeuSer: 5.821 ± 0.065	5.138LeuThr: 5.138 ± 0.071	7.648LeuVal: 7.648 ± 0.084	1.464LeuTrp: 1.464 ± 0.043	2.297LeuTyr: 2.297 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.85MetAla: 2.85 ± 0.051	0.143MetCys: 0.143 ± 0.01	1.199MetAsp: 1.199 ± 0.036	0.935MetGlu: 0.935 ± 0.028	0.695MetPhe: 0.695 ± 0.026	1.568MetGly: 1.568 ± 0.037	0.677MetHis: 0.677 ± 0.022	0.943MetIle: 0.943 ± 0.028	0.831MetLys: 0.831 ± 0.031	2.703MetLeu: 2.703 ± 0.049	0.482MetMet: 0.482 ± 0.024	0.776MetAsn: 0.776 ± 0.026	1.6MetPro: 1.6 ± 0.042	1.02MetGln: 1.02 ± 0.029	1.82MetArg: 1.82 ± 0.04	1.578MetSer: 1.578 ± 0.033	1.342MetThr: 1.342 ± 0.031	1.592MetVal: 1.592 ± 0.042	0.219MetTrp: 0.219 ± 0.016	0.412MetTyr: 0.412 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.256AsnAla: 3.256 ± 0.056	0.206AsnCys: 0.206 ± 0.013	1.528AsnAsp: 1.528 ± 0.033	1.149AsnGlu: 1.149 ± 0.03	0.904AsnPhe: 0.904 ± 0.029	2.54AsnGly: 2.54 ± 0.053	0.686AsnHis: 0.686 ± 0.027	1.101AsnIle: 1.101 ± 0.031	0.655AsnLys: 0.655 ± 0.025	2.71AsnLeu: 2.71 ± 0.048	0.487AsnMet: 0.487 ± 0.02	0.755AsnAsn: 0.755 ± 0.029	1.732AsnPro: 1.732 ± 0.038	0.887AsnGln: 0.887 ± 0.03	1.637AsnArg: 1.637 ± 0.037	1.16AsnSer: 1.16 ± 0.032	1.4AsnThr: 1.4 ± 0.039	1.93AsnVal: 1.93 ± 0.045	0.436AsnTrp: 0.436 ± 0.02	0.834AsnTyr: 0.834 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	7.183ProAla: 7.183 ± 0.088	0.437ProCys: 0.437 ± 0.02	3.487ProAsp: 3.487 ± 0.06	2.777ProGlu: 2.777 ± 0.049	1.727ProPhe: 1.727 ± 0.03	4.799ProGly: 4.799 ± 0.073	1.39ProHis: 1.39 ± 0.035	1.942ProIle: 1.942 ± 0.042	1.528ProLys: 1.528 ± 0.04	5.477ProLeu: 5.477 ± 0.078	1.339ProMet: 1.339 ± 0.033	1.305ProAsn: 1.305 ± 0.037	2.821ProPro: 2.821 ± 0.061	2.075ProGln: 2.075 ± 0.043	3.365ProArg: 3.365 ± 0.061	2.915ProSer: 2.915 ± 0.057	2.564ProThr: 2.564 ± 0.046	4.14ProVal: 4.14 ± 0.077	0.977ProTrp: 0.977 ± 0.032	1.261ProTyr: 1.261 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.126GlnAla: 5.126 ± 0.08	0.29GlnCys: 0.29 ± 0.017	1.457GlnAsp: 1.457 ± 0.033	1.233GlnGlu: 1.233 ± 0.033	1.134GlnPhe: 1.134 ± 0.031	2.876GlnGly: 2.876 ± 0.057	1.201GlnHis: 1.201 ± 0.033	1.558GlnIle: 1.558 ± 0.039	1.026GlnLys: 1.026 ± 0.032	4.384GlnLeu: 4.384 ± 0.062	0.847GlnMet: 0.847 ± 0.028	0.818GlnAsn: 0.818 ± 0.027	2.415GlnPro: 2.415 ± 0.042	2.047GlnGln: 2.047 ± 0.056	3.559GlnArg: 3.559 ± 0.057	1.971GlnSer: 1.971 ± 0.046	1.715GlnThr: 1.715 ± 0.042	2.873GlnVal: 2.873 ± 0.056	0.651GlnTrp: 0.651 ± 0.025	0.823GlnTyr: 0.823 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.713ArgAla: 7.713 ± 0.095	0.714ArgCys: 0.714 ± 0.028	4.032ArgAsp: 4.032 ± 0.061	4.308ArgGlu: 4.308 ± 0.074	2.757ArgPhe: 2.757 ± 0.052	4.982ArgGly: 4.982 ± 0.077	2.494ArgHis: 2.494 ± 0.053	3.52ArgIle: 3.52 ± 0.059	2.156ArgLys: 2.156 ± 0.044	8.141ArgLeu: 8.141 ± 0.094	1.897ArgMet: 1.897 ± 0.042	1.828ArgAsn: 1.828 ± 0.038	3.353ArgPro: 3.353 ± 0.058	3.068ArgGln: 3.068 ± 0.055	6.089ArgArg: 6.089 ± 0.107	3.764ArgSer: 3.764 ± 0.068	3.296ArgThr: 3.296 ± 0.053	4.957ArgVal: 4.957 ± 0.064	1.475ArgTrp: 1.475 ± 0.037	2.219ArgTyr: 2.219 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.318SerAla: 6.318 ± 0.084	0.474SerCys: 0.474 ± 0.02	2.815SerAsp: 2.815 ± 0.052	2.297SerGlu: 2.297 ± 0.05	1.952SerPhe: 1.952 ± 0.042	5.128SerGly: 5.128 ± 0.078	1.443SerHis: 1.443 ± 0.036	2.383SerIle: 2.383 ± 0.048	1.526SerLys: 1.526 ± 0.04	5.764SerLeu: 5.764 ± 0.073	1.43SerMet: 1.43 ± 0.039	1.425SerAsn: 1.425 ± 0.045	2.902SerPro: 2.902 ± 0.049	1.854SerGln: 1.854 ± 0.04	3.601SerArg: 3.601 ± 0.065	3.192SerSer: 3.192 ± 0.061	2.976SerThr: 2.976 ± 0.054	3.928SerVal: 3.928 ± 0.059	0.854SerTrp: 0.854 ± 0.028	1.393SerTyr: 1.393 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.89ThrAla: 5.89 ± 0.074	0.444ThrCys: 0.444 ± 0.022	2.737ThrAsp: 2.737 ± 0.052	2.062ThrGlu: 2.062 ± 0.045	1.589ThrPhe: 1.589 ± 0.04	4.501ThrGly: 4.501 ± 0.082	1.423ThrHis: 1.423 ± 0.038	2.11ThrIle: 2.11 ± 0.048	1.204ThrLys: 1.204 ± 0.036	6.548ThrLeu: 6.548 ± 0.082	1.072ThrMet: 1.072 ± 0.034	1.159ThrAsn: 1.159 ± 0.039	3.539ThrPro: 3.539 ± 0.057	1.743ThrGln: 1.743 ± 0.039	3.571ThrArg: 3.571 ± 0.056	2.758ThrSer: 2.758 ± 0.057	2.813ThrThr: 2.813 ± 0.051	4.02ThrVal: 4.02 ± 0.066	0.809ThrTrp: 0.809 ± 0.023	1.16ThrTyr: 1.16 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.167ValAla: 9.167 ± 0.088	0.651ValCys: 0.651 ± 0.023	4.44ValAsp: 4.44 ± 0.068	3.831ValGlu: 3.831 ± 0.068	2.543ValPhe: 2.543 ± 0.048	5.41ValGly: 5.41 ± 0.071	1.786ValHis: 1.786 ± 0.043	3.451ValIle: 3.451 ± 0.057	2.06ValLys: 2.06 ± 0.048	8.447ValLeu: 8.447 ± 0.101	1.681ValMet: 1.681 ± 0.043	2.018ValAsn: 2.018 ± 0.044	3.841ValPro: 3.841 ± 0.058	2.559ValGln: 2.559 ± 0.052	5.015ValArg: 5.015 ± 0.068	4.081ValSer: 4.081 ± 0.064	3.934ValThr: 3.934 ± 0.06	5.9ValVal: 5.9 ± 0.092	0.976ValTrp: 0.976 ± 0.031	1.595ValTyr: 1.595 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.323TrpAla: 1.323 ± 0.033	0.193TrpCys: 0.193 ± 0.015	0.677TrpAsp: 0.677 ± 0.026	0.471TrpGlu: 0.471 ± 0.022	0.636TrpPhe: 0.636 ± 0.025	0.989TrpGly: 0.989 ± 0.032	0.561TrpHis: 0.561 ± 0.024	0.71TrpIle: 0.71 ± 0.025	0.526TrpLys: 0.526 ± 0.022	2.429TrpLeu: 2.429 ± 0.059	0.463TrpMet: 0.463 ± 0.021	0.589TrpAsn: 0.589 ± 0.024	0.873TrpPro: 0.873 ± 0.03	0.873TrpGln: 0.873 ± 0.03	1.453TrpArg: 1.453 ± 0.035	0.967TrpSer: 0.967 ± 0.033	0.798TrpThr: 0.798 ± 0.027	1.027TrpVal: 1.027 ± 0.028	0.356TrpTrp: 0.356 ± 0.02	0.429TrpTyr: 0.429 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.017TyrAla: 3.017 ± 0.058	0.23TyrCys: 0.23 ± 0.015	1.449TyrAsp: 1.449 ± 0.041	1.048TyrGlu: 1.048 ± 0.031	0.957TyrPhe: 0.957 ± 0.03	2.258TyrGly: 2.258 ± 0.046	0.643TyrHis: 0.643 ± 0.023	0.814TyrIle: 0.814 ± 0.028	0.622TyrLys: 0.622 ± 0.027	2.572TyrLeu: 2.572 ± 0.051	0.429TyrMet: 0.429 ± 0.02	0.697TyrAsn: 0.697 ± 0.03	1.195TyrPro: 1.195 ± 0.036	0.926TyrGln: 0.926 ± 0.032	2.085TyrArg: 2.085 ± 0.046	1.242TyrSer: 1.242 ± 0.032	1.276TyrThr: 1.276 ± 0.037	1.854TyrVal: 1.854 ± 0.038	0.407TyrTrp: 0.407 ± 0.021	0.769TyrTyr: 0.769 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3918 proteins (1152151 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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