Amino acid dipepetide frequency for Coniophora puteana (strain RWD-64-598) (Brown rot fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.157AlaAla: 9.157 ± 0.069	1.194AlaCys: 1.194 ± 0.017	4.518AlaAsp: 4.518 ± 0.029	5.01AlaGlu: 5.01 ± 0.04	3.402AlaPhe: 3.402 ± 0.026	6.023AlaGly: 6.023 ± 0.037	2.276AlaHis: 2.276 ± 0.02	4.085AlaIle: 4.085 ± 0.028	3.663AlaLys: 3.663 ± 0.033	8.952AlaLeu: 8.952 ± 0.045	2.031AlaMet: 2.031 ± 0.02	2.901AlaAsn: 2.901 ± 0.026	5.537AlaPro: 5.537 ± 0.046	3.525AlaGln: 3.525 ± 0.026	5.656AlaArg: 5.656 ± 0.036	8.229AlaSer: 8.229 ± 0.046	5.131AlaThr: 5.131 ± 0.032	5.659AlaVal: 5.659 ± 0.035	1.272AlaTrp: 1.272 ± 0.016	2.417AlaTyr: 2.417 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.015	0.261CysCys: 0.261 ± 0.008	0.688CysAsp: 0.688 ± 0.012	0.618CysGlu: 0.618 ± 0.011	0.527CysPhe: 0.527 ± 0.01	0.923CysGly: 0.923 ± 0.016	0.33CysHis: 0.33 ± 0.009	0.719CysIle: 0.719 ± 0.012	0.517CysLys: 0.517 ± 0.009	1.286CysLeu: 1.286 ± 0.019	0.314CysMet: 0.314 ± 0.008	0.463CysAsn: 0.463 ± 0.01	0.829CysPro: 0.829 ± 0.016	0.463CysGln: 0.463 ± 0.008	0.802CysArg: 0.802 ± 0.013	1.042CysSer: 1.042 ± 0.016	0.768CysThr: 0.768 ± 0.011	0.858CysVal: 0.858 ± 0.013	0.221CysTrp: 0.221 ± 0.006	0.334CysTyr: 0.334 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.478AspAla: 5.478 ± 0.03	0.633AspCys: 0.633 ± 0.011	4.315AspAsp: 4.315 ± 0.04	4.355AspGlu: 4.355 ± 0.032	2.072AspPhe: 2.072 ± 0.019	4.301AspGly: 4.301 ± 0.026	1.273AspHis: 1.273 ± 0.019	3.002AspIle: 3.002 ± 0.023	2.191AspLys: 2.191 ± 0.02	4.743AspLeu: 4.743 ± 0.025	1.279AspMet: 1.279 ± 0.013	1.755AspAsn: 1.755 ± 0.019	3.298AspPro: 3.298 ± 0.026	1.641AspGln: 1.641 ± 0.016	2.866AspArg: 2.866 ± 0.024	3.989AspSer: 3.989 ± 0.03	3.096AspThr: 3.096 ± 0.025	4.316AspVal: 4.316 ± 0.027	0.941AspTrp: 0.941 ± 0.012	1.485AspTyr: 1.485 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.022GluAla: 5.022 ± 0.036	0.648GluCys: 0.648 ± 0.011	4.222GluAsp: 4.222 ± 0.033	5.062GluGlu: 5.062 ± 0.051	1.775GluPhe: 1.775 ± 0.016	3.9GluGly: 3.9 ± 0.031	1.526GluHis: 1.526 ± 0.016	2.55GluIle: 2.55 ± 0.024	2.857GluLys: 2.857 ± 0.031	5.279GluLeu: 5.279 ± 0.031	1.317GluMet: 1.317 ± 0.015	1.87GluAsn: 1.87 ± 0.018	2.666GluPro: 2.666 ± 0.024	2.179GluGln: 2.179 ± 0.02	4.132GluArg: 4.132 ± 0.036	3.847GluSer: 3.847 ± 0.028	3.03GluThr: 3.03 ± 0.02	3.648GluVal: 3.648 ± 0.027	0.944GluTrp: 0.944 ± 0.013	1.555GluTyr: 1.555 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.252PheAla: 3.252 ± 0.02	0.57PheCys: 0.57 ± 0.01	2.236PheAsp: 2.236 ± 0.02	1.99PheGlu: 1.99 ± 0.019	1.533PhePhe: 1.533 ± 0.019	2.705PheGly: 2.705 ± 0.023	0.886PheHis: 0.886 ± 0.012	1.746PheIle: 1.746 ± 0.02	1.444PheLys: 1.444 ± 0.016	3.376PheLeu: 3.376 ± 0.027	0.77PheMet: 0.77 ± 0.011	1.317PheAsn: 1.317 ± 0.015	2.032PhePro: 2.032 ± 0.02	1.141PheGln: 1.141 ± 0.014	1.924PheArg: 1.924 ± 0.02	3.185PheSer: 3.185 ± 0.028	2.173PheThr: 2.173 ± 0.02	2.562PheVal: 2.562 ± 0.024	0.582PheTrp: 0.582 ± 0.01	1.038PheTyr: 1.038 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	5.861GlyAla: 5.861 ± 0.044	0.879GlyCys: 0.879 ± 0.013	3.726GlyAsp: 3.726 ± 0.031	3.7GlyGlu: 3.7 ± 0.028	2.496GlyPhe: 2.496 ± 0.025	6.069GlyGly: 6.069 ± 0.064	1.784GlyHis: 1.784 ± 0.022	3.175GlyIle: 3.175 ± 0.025	3.175GlyLys: 3.175 ± 0.03	5.726GlyLeu: 5.726 ± 0.036	1.561GlyMet: 1.561 ± 0.017	2.307GlyAsn: 2.307 ± 0.024	3.494GlyPro: 3.494 ± 0.028	2.435GlyGln: 2.435 ± 0.026	4.146GlyArg: 4.146 ± 0.029	5.927GlySer: 5.927 ± 0.044	4.069GlyThr: 4.069 ± 0.033	4.473GlyVal: 4.473 ± 0.033	1.147GlyTrp: 1.147 ± 0.015	1.957GlyTyr: 1.957 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.315HisAla: 2.315 ± 0.019	0.363HisCys: 0.363 ± 0.008	1.373HisAsp: 1.373 ± 0.019	1.301HisGlu: 1.301 ± 0.018	0.981HisPhe: 0.981 ± 0.014	1.764HisGly: 1.764 ± 0.019	0.908HisHis: 0.908 ± 0.018	1.308HisIle: 1.308 ± 0.016	0.887HisLys: 0.887 ± 0.012	2.545HisLeu: 2.545 ± 0.026	0.508HisMet: 0.508 ± 0.009	0.807HisAsn: 0.807 ± 0.01	1.943HisPro: 1.943 ± 0.02	0.953HisGln: 0.953 ± 0.015	1.639HisArg: 1.639 ± 0.016	2.079HisSer: 2.079 ± 0.022	1.525HisThr: 1.525 ± 0.016	1.789HisVal: 1.789 ± 0.017	0.369HisTrp: 0.369 ± 0.007	0.687HisTyr: 0.687 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.187IleAla: 4.187 ± 0.029	0.737IleCys: 0.737 ± 0.012	2.711IleAsp: 2.711 ± 0.021	2.542IleGlu: 2.542 ± 0.023	1.751IlePhe: 1.751 ± 0.018	2.883IleGly: 2.883 ± 0.026	1.175IleHis: 1.175 ± 0.015	2.308IleIle: 2.308 ± 0.022	1.885IleLys: 1.885 ± 0.02	4.235IleLeu: 4.235 ± 0.033	0.963IleMet: 0.963 ± 0.012	1.617IleAsn: 1.617 ± 0.018	3.022IlePro: 3.022 ± 0.022	1.696IleGln: 1.696 ± 0.017	2.77IleArg: 2.77 ± 0.023	3.743IleSer: 3.743 ± 0.031	2.685IleThr: 2.685 ± 0.024	3.235IleVal: 3.235 ± 0.027	0.761IleTrp: 0.761 ± 0.012	1.255IleTyr: 1.255 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.95LysAla: 3.95 ± 0.036	0.482LysCys: 0.482 ± 0.01	2.446LysAsp: 2.446 ± 0.026	2.868LysGlu: 2.868 ± 0.025	1.276LysPhe: 1.276 ± 0.015	2.751LysGly: 2.751 ± 0.024	1.12LysHis: 1.12 ± 0.015	1.779LysIle: 1.779 ± 0.021	2.58LysLys: 2.58 ± 0.035	3.717LysLeu: 3.717 ± 0.026	0.855LysMet: 0.855 ± 0.012	1.38LysAsn: 1.38 ± 0.015	2.334LysPro: 2.334 ± 0.027	1.542LysGln: 1.542 ± 0.018	3.164LysArg: 3.164 ± 0.027	2.911LysSer: 2.911 ± 0.027	2.371LysThr: 2.371 ± 0.021	2.634LysVal: 2.634 ± 0.024	0.607LysTrp: 0.607 ± 0.01	1.177LysTyr: 1.177 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.628LeuAla: 8.628 ± 0.043	1.346LeuCys: 1.346 ± 0.018	5.223LeuAsp: 5.223 ± 0.026	5.195LeuGlu: 5.195 ± 0.034	3.325LeuPhe: 3.325 ± 0.028	5.762LeuGly: 5.762 ± 0.035	2.459LeuHis: 2.459 ± 0.021	3.752LeuIle: 3.752 ± 0.026	3.751LeuLys: 3.751 ± 0.028	8.505LeuLeu: 8.505 ± 0.057	1.774LeuMet: 1.774 ± 0.02	2.984LeuAsn: 2.984 ± 0.025	6.024LeuPro: 6.024 ± 0.035	3.532LeuGln: 3.532 ± 0.028	6.2LeuArg: 6.2 ± 0.041	7.947LeuSer: 7.947 ± 0.044	5.193LeuThr: 5.193 ± 0.03	5.968LeuVal: 5.968 ± 0.041	1.295LeuTrp: 1.295 ± 0.018	2.437LeuTyr: 2.437 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.017	0.271MetCys: 0.271 ± 0.007	1.25MetAsp: 1.25 ± 0.016	1.151MetGlu: 1.151 ± 0.013	0.831MetPhe: 0.831 ± 0.012	1.369MetGly: 1.369 ± 0.016	0.614MetHis: 0.614 ± 0.01	0.921MetIle: 0.921 ± 0.013	0.868MetLys: 0.868 ± 0.013	1.946MetLeu: 1.946 ± 0.019	0.536MetMet: 0.536 ± 0.01	0.756MetAsn: 0.756 ± 0.012	1.299MetPro: 1.299 ± 0.017	0.836MetGln: 0.836 ± 0.012	1.356MetArg: 1.356 ± 0.016	2.043MetSer: 2.043 ± 0.019	1.245MetThr: 1.245 ± 0.015	1.261MetVal: 1.261 ± 0.017	0.284MetTrp: 0.284 ± 0.006	0.577MetTyr: 0.577 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.281AsnAla: 3.281 ± 0.021	0.388AsnCys: 0.388 ± 0.009	1.797AsnAsp: 1.797 ± 0.019	1.743AsnGlu: 1.743 ± 0.018	1.24AsnPhe: 1.24 ± 0.016	2.693AsnGly: 2.693 ± 0.028	0.805AsnHis: 0.805 ± 0.013	1.833AsnIle: 1.833 ± 0.02	1.297AsnLys: 1.297 ± 0.016	2.98AsnLeu: 2.98 ± 0.026	0.768AsnMet: 0.768 ± 0.012	1.282AsnAsn: 1.282 ± 0.019	2.148AsnPro: 2.148 ± 0.021	1.086AsnGln: 1.086 ± 0.016	1.639AsnArg: 1.639 ± 0.02	2.491AsnSer: 2.491 ± 0.021	2.082AsnThr: 2.082 ± 0.018	2.521AsnVal: 2.521 ± 0.021	0.481AsnTrp: 0.481 ± 0.01	0.903AsnTyr: 0.903 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.699ProAla: 5.699 ± 0.04	0.594ProCys: 0.594 ± 0.011	3.339ProAsp: 3.339 ± 0.025	3.611ProGlu: 3.611 ± 0.032	2.161ProPhe: 2.161 ± 0.022	3.901ProGly: 3.901 ± 0.037	1.654ProHis: 1.654 ± 0.019	2.494ProIle: 2.494 ± 0.023	2.291ProLys: 2.291 ± 0.02	5.152ProLeu: 5.152 ± 0.034	1.098ProMet: 1.098 ± 0.013	2.097ProAsn: 2.097 ± 0.02	6.08ProPro: 6.08 ± 0.075	2.323ProGln: 2.323 ± 0.025	3.652ProArg: 3.652 ± 0.032	7.264ProSer: 7.264 ± 0.06	4.085ProThr: 4.085 ± 0.033	3.686ProVal: 3.686 ± 0.028	0.777ProTrp: 0.777 ± 0.011	1.61ProTyr: 1.61 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.381GlnAla: 3.381 ± 0.031	0.462GlnCys: 0.462 ± 0.01	1.901GlnAsp: 1.901 ± 0.018	2.1GlnGlu: 2.1 ± 0.02	1.137GlnPhe: 1.137 ± 0.015	2.378GlnGly: 2.378 ± 0.024	1.086GlnHis: 1.086 ± 0.015	1.605GlnIle: 1.605 ± 0.016	1.516GlnLys: 1.516 ± 0.018	3.418GlnLeu: 3.418 ± 0.026	0.78GlnMet: 0.78 ± 0.012	1.287GlnAsn: 1.287 ± 0.015	2.37GlnPro: 2.37 ± 0.029	2.051GlnGln: 2.051 ± 0.036	2.496GlnArg: 2.496 ± 0.025	2.895GlnSer: 2.895 ± 0.025	2.182GlnThr: 2.182 ± 0.02	2.202GlnVal: 2.202 ± 0.019	0.567GlnTrp: 0.567 ± 0.011	1.101GlnTyr: 1.101 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.449ArgAla: 5.449 ± 0.033	0.856ArgCys: 0.856 ± 0.014	3.336ArgAsp: 3.336 ± 0.027	3.821ArgGlu: 3.821 ± 0.034	2.22ArgPhe: 2.22 ± 0.022	3.741ArgGly: 3.741 ± 0.029	1.631ArgHis: 1.631 ± 0.019	2.892ArgIle: 2.892 ± 0.024	3.106ArgLys: 3.106 ± 0.025	5.745ArgLeu: 5.745 ± 0.036	1.408ArgMet: 1.408 ± 0.016	2.018ArgAsn: 2.018 ± 0.018	3.6ArgPro: 3.6 ± 0.037	2.34ArgGln: 2.34 ± 0.022	5.29ArgArg: 5.29 ± 0.04	5.093ArgSer: 5.093 ± 0.041	3.585ArgThr: 3.585 ± 0.022	3.976ArgVal: 3.976 ± 0.029	1.069ArgTrp: 1.069 ± 0.016	1.655ArgTyr: 1.655 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.699SerAla: 7.699 ± 0.048	0.978SerCys: 0.978 ± 0.017	4.476SerAsp: 4.476 ± 0.031	4.073SerGlu: 4.073 ± 0.031	3.085SerPhe: 3.085 ± 0.027	5.931SerGly: 5.931 ± 0.036	2.133SerHis: 2.133 ± 0.025	3.874SerIle: 3.874 ± 0.027	3.26SerLys: 3.26 ± 0.027	7.786SerLeu: 7.786 ± 0.047	1.806SerMet: 1.806 ± 0.019	2.798SerAsn: 2.798 ± 0.023	6.268SerPro: 6.268 ± 0.066	3.178SerGln: 3.178 ± 0.028	5.196SerArg: 5.196 ± 0.041	9.903SerSer: 9.903 ± 0.093	5.867SerThr: 5.867 ± 0.044	5.187SerVal: 5.187 ± 0.033	1.108SerTrp: 1.108 ± 0.016	2.061SerTyr: 2.061 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.06ThrAla: 5.06 ± 0.033	0.819ThrCys: 0.819 ± 0.013	2.763ThrAsp: 2.763 ± 0.024	2.775ThrGlu: 2.775 ± 0.021	2.434ThrPhe: 2.434 ± 0.02	3.998ThrGly: 3.998 ± 0.03	1.529ThrHis: 1.529 ± 0.015	2.93ThrIle: 2.93 ± 0.025	2.229ThrLys: 2.229 ± 0.023	5.849ThrLeu: 5.849 ± 0.033	1.201ThrMet: 1.201 ± 0.014	1.948ThrAsn: 1.948 ± 0.019	4.408ThrPro: 4.408 ± 0.037	2.049ThrGln: 2.049 ± 0.018	3.425ThrArg: 3.425 ± 0.025	5.736ThrSer: 5.736 ± 0.039	3.909ThrThr: 3.909 ± 0.032	3.717ThrVal: 3.717 ± 0.03	0.858ThrTrp: 0.858 ± 0.012	1.618ThrTyr: 1.618 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.582ValAla: 5.582 ± 0.035	0.96ValCys: 0.96 ± 0.013	3.964ValAsp: 3.964 ± 0.026	3.797ValGlu: 3.797 ± 0.03	2.593ValPhe: 2.593 ± 0.025	4.089ValGly: 4.089 ± 0.031	1.747ValHis: 1.747 ± 0.019	3.094ValIle: 3.094 ± 0.025	2.689ValLys: 2.689 ± 0.025	6.231ValLeu: 6.231 ± 0.036	1.356ValMet: 1.356 ± 0.014	2.238ValAsn: 2.238 ± 0.019	4.002ValPro: 4.002 ± 0.027	2.434ValGln: 2.434 ± 0.021	3.861ValArg: 3.861 ± 0.025	5.142ValSer: 5.142 ± 0.032	3.609ValThr: 3.609 ± 0.028	4.72ValVal: 4.72 ± 0.035	1.074ValTrp: 1.074 ± 0.016	1.876ValTyr: 1.876 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.253TrpAla: 1.253 ± 0.015	0.228TrpCys: 0.228 ± 0.006	1.041TrpAsp: 1.041 ± 0.015	0.846TrpGlu: 0.846 ± 0.011	0.55TrpPhe: 0.55 ± 0.009	0.918TrpGly: 0.918 ± 0.016	0.369TrpHis: 0.369 ± 0.007	0.751TrpIle: 0.751 ± 0.013	0.74TrpLys: 0.74 ± 0.011	1.325TrpLeu: 1.325 ± 0.016	0.394TrpMet: 0.394 ± 0.008	0.621TrpAsn: 0.621 ± 0.012	0.668TrpPro: 0.668 ± 0.011	0.521TrpGln: 0.521 ± 0.01	1.073TrpArg: 1.073 ± 0.013	1.164TrpSer: 1.164 ± 0.016	0.988TrpThr: 0.988 ± 0.013	0.887TrpVal: 0.887 ± 0.012	0.314TrpTrp: 0.314 ± 0.008	0.442TrpTyr: 0.442 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.369TyrAla: 2.369 ± 0.024	0.407TyrCys: 0.407 ± 0.008	1.705TyrAsp: 1.705 ± 0.019	1.47TyrGlu: 1.47 ± 0.014	1.075TyrPhe: 1.075 ± 0.014	2.008TyrGly: 2.008 ± 0.022	0.737TyrHis: 0.737 ± 0.01	1.344TyrIle: 1.344 ± 0.016	0.999TyrLys: 0.999 ± 0.013	2.505TyrLeu: 2.505 ± 0.025	0.597TyrMet: 0.597 ± 0.01	1.012TyrAsn: 1.012 ± 0.015	1.546TyrPro: 1.546 ± 0.021	0.992TyrGln: 0.992 ± 0.015	1.545TyrArg: 1.545 ± 0.017	2.035TyrSer: 2.035 ± 0.022	1.661TyrThr: 1.661 ± 0.018	1.76TyrVal: 1.76 ± 0.018	0.42TyrTrp: 0.42 ± 0.008	0.864TyrTyr: 0.864 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13735 proteins (6006140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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