Amino acid dipepetide frequency for Butyricimonas sp. An62

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.453AlaAla: 4.453 ± 0.063
0.887AlaCys: 0.887 ± 0.022
3.482AlaAsp: 3.482 ± 0.048
4.26AlaGlu: 4.26 ± 0.059
2.917AlaPhe: 2.917 ± 0.047
4.563AlaGly: 4.563 ± 0.064
0.95AlaHis: 0.95 ± 0.023
4.578AlaIle: 4.578 ± 0.064
3.904AlaLys: 3.904 ± 0.06
6.161AlaLeu: 6.161 ± 0.078
1.666AlaMet: 1.666 ± 0.034
3.033AlaAsn: 3.033 ± 0.045
1.944AlaPro: 1.944 ± 0.033
2.144AlaGln: 2.144 ± 0.044
3.018AlaArg: 3.018 ± 0.05
3.879AlaSer: 3.879 ± 0.056
3.468AlaThr: 3.468 ± 0.054
4.171AlaVal: 4.171 ± 0.057
0.775AlaTrp: 0.775 ± 0.021
2.969AlaTyr: 2.969 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.594CysAla: 0.594 ± 0.02
0.188CysCys: 0.188 ± 0.011
0.603CysAsp: 0.603 ± 0.02
0.586CysGlu: 0.586 ± 0.021
0.651CysPhe: 0.651 ± 0.021
0.954CysGly: 0.954 ± 0.026
0.208CysHis: 0.208 ± 0.012
0.74CysIle: 0.74 ± 0.021
0.656CysLys: 0.656 ± 0.023
1.053CysLeu: 1.053 ± 0.025
0.32CysMet: 0.32 ± 0.012
0.524CysAsn: 0.524 ± 0.017
0.421CysPro: 0.421 ± 0.019
0.297CysGln: 0.297 ± 0.015
0.577CysArg: 0.577 ± 0.019
0.738CysSer: 0.738 ± 0.023
0.557CysThr: 0.557 ± 0.019
0.762CysVal: 0.762 ± 0.023
0.123CysTrp: 0.123 ± 0.009
0.482CysTyr: 0.482 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.515AspAla: 3.515 ± 0.051
0.541AspCys: 0.541 ± 0.022
2.74AspAsp: 2.74 ± 0.048
4.098AspGlu: 4.098 ± 0.056
3.028AspPhe: 3.028 ± 0.04
3.853AspGly: 3.853 ± 0.055
0.845AspHis: 0.845 ± 0.023
4.123AspIle: 4.123 ± 0.056
3.882AspLys: 3.882 ± 0.049
4.984AspLeu: 4.984 ± 0.06
1.649AspMet: 1.649 ± 0.035
2.563AspAsn: 2.563 ± 0.044
2.204AspPro: 2.204 ± 0.037
1.586AspGln: 1.586 ± 0.038
2.676AspArg: 2.676 ± 0.042
3.034AspSer: 3.034 ± 0.05
2.563AspThr: 2.563 ± 0.051
4.22AspVal: 4.22 ± 0.058
0.754AspTrp: 0.754 ± 0.024
2.946AspTyr: 2.946 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
4.299GluAla: 4.299 ± 0.064
0.616GluCys: 0.616 ± 0.023
3.611GluAsp: 3.611 ± 0.049
5.718GluGlu: 5.718 ± 0.083
2.889GluPhe: 2.889 ± 0.047
4.405GluGly: 4.405 ± 0.052
1.122GluHis: 1.122 ± 0.027
5.143GluIle: 5.143 ± 0.065
5.79GluLys: 5.79 ± 0.069
6.475GluLeu: 6.475 ± 0.077
2.103GluMet: 2.103 ± 0.041
3.982GluAsn: 3.982 ± 0.051
1.653GluPro: 1.653 ± 0.03
2.707GluGln: 2.707 ± 0.046
3.811GluArg: 3.811 ± 0.06
3.422GluSer: 3.422 ± 0.046
3.364GluThr: 3.364 ± 0.05
4.934GluVal: 4.934 ± 0.059
0.845GluTrp: 0.845 ± 0.025
2.985GluTyr: 2.985 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.939PheAla: 2.939 ± 0.045
0.57PheCys: 0.57 ± 0.019
2.825PheAsp: 2.825 ± 0.04
2.785PheGlu: 2.785 ± 0.045
2.286PhePhe: 2.286 ± 0.046
3.095PheGly: 3.095 ± 0.05
0.724PheHis: 0.724 ± 0.023
3.254PheIle: 3.254 ± 0.053
2.711PheLys: 2.711 ± 0.042
4.205PheLeu: 4.205 ± 0.063
1.467PheMet: 1.467 ± 0.031
2.488PheAsn: 2.488 ± 0.039
1.725PhePro: 1.725 ± 0.029
1.377PheGln: 1.377 ± 0.028
2.124PheArg: 2.124 ± 0.037
3.771PheSer: 3.771 ± 0.051
3.007PheThr: 3.007 ± 0.046
3.394PheVal: 3.394 ± 0.046
0.595PheTrp: 0.595 ± 0.019
2.159PheTyr: 2.159 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
3.828GlyAla: 3.828 ± 0.056
0.855GlyCys: 0.855 ± 0.027
3.535GlyAsp: 3.535 ± 0.049
4.912GlyGlu: 4.912 ± 0.074
3.231GlyPhe: 3.231 ± 0.055
4.492GlyGly: 4.492 ± 0.065
1.076GlyHis: 1.076 ± 0.031
5.211GlyIle: 5.211 ± 0.072
5.387GlyLys: 5.387 ± 0.067
5.556GlyLeu: 5.556 ± 0.064
2.126GlyMet: 2.126 ± 0.037
3.636GlyAsn: 3.636 ± 0.046
1.2GlyPro: 1.2 ± 0.031
2.042GlyGln: 2.042 ± 0.037
2.878GlyArg: 2.878 ± 0.046
3.964GlySer: 3.964 ± 0.067
4.08GlyThr: 4.08 ± 0.06
5.136GlyVal: 5.136 ± 0.055
0.853GlyTrp: 0.853 ± 0.023
3.202GlyTyr: 3.202 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
0.968HisAla: 0.968 ± 0.026
0.215HisCys: 0.215 ± 0.012
0.874HisAsp: 0.874 ± 0.024
0.982HisGlu: 0.982 ± 0.026
0.977HisPhe: 0.977 ± 0.029
0.978HisGly: 0.978 ± 0.025
0.337HisHis: 0.337 ± 0.016
1.045HisIle: 1.045 ± 0.033
0.874HisLys: 0.874 ± 0.025
1.609HisLeu: 1.609 ± 0.033
0.364HisMet: 0.364 ± 0.018
0.768HisAsn: 0.768 ± 0.021
0.867HisPro: 0.867 ± 0.028
0.508HisGln: 0.508 ± 0.017
0.849HisArg: 0.849 ± 0.024
0.969HisSer: 0.969 ± 0.027
0.857HisThr: 0.857 ± 0.021
1.099HisVal: 1.099 ± 0.03
0.188HisTrp: 0.188 ± 0.01
0.796HisTyr: 0.796 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.664IleAla: 4.664 ± 0.064
0.854IleCys: 0.854 ± 0.024
4.065IleAsp: 4.065 ± 0.053
4.456IleGlu: 4.456 ± 0.055
2.914IlePhe: 2.914 ± 0.055
4.352IleGly: 4.352 ± 0.065
1.211IleHis: 1.211 ± 0.029
4.512IleIle: 4.512 ± 0.064
4.047IleLys: 4.047 ± 0.06
6.293IleLeu: 6.293 ± 0.064
1.658IleMet: 1.658 ± 0.035
3.425IleAsn: 3.425 ± 0.051
3.155IlePro: 3.155 ± 0.04
2.225IleGln: 2.225 ± 0.043
3.537IleArg: 3.537 ± 0.048
4.639IleSer: 4.639 ± 0.059
4.063IleThr: 4.063 ± 0.065
4.836IleVal: 4.836 ± 0.066
0.659IleTrp: 0.659 ± 0.018
2.827IleTyr: 2.827 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.532LysAla: 4.532 ± 0.064
0.515LysCys: 0.515 ± 0.022
4.279LysAsp: 4.279 ± 0.059
5.859LysGlu: 5.859 ± 0.072
2.403LysPhe: 2.403 ± 0.038
4.48LysGly: 4.48 ± 0.048
1.096LysHis: 1.096 ± 0.031
4.693LysIle: 4.693 ± 0.066
5.079LysLys: 5.079 ± 0.061
5.527LysLeu: 5.527 ± 0.062
2.161LysMet: 2.161 ± 0.038
3.8LysAsn: 3.8 ± 0.053
1.952LysPro: 1.952 ± 0.03
2.511LysGln: 2.511 ± 0.049
3.3LysArg: 3.3 ± 0.037
3.465LysSer: 3.465 ± 0.043
3.492LysThr: 3.492 ± 0.05
4.574LysVal: 4.574 ± 0.051
0.794LysTrp: 0.794 ± 0.022
3.156LysTyr: 3.156 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
5.896LeuAla: 5.896 ± 0.076
1.143LeuCys: 1.143 ± 0.028
4.952LeuAsp: 4.952 ± 0.05
5.954LeuGlu: 5.954 ± 0.081
4.774LeuPhe: 4.774 ± 0.062
5.885LeuGly: 5.885 ± 0.068
1.564LeuHis: 1.564 ± 0.037
5.446LeuIle: 5.446 ± 0.071
6.889LeuLys: 6.889 ± 0.064
9.055LeuLeu: 9.055 ± 0.103
2.287LeuMet: 2.287 ± 0.041
5.045LeuAsn: 5.045 ± 0.054
3.941LeuPro: 3.941 ± 0.05
3.216LeuGln: 3.216 ± 0.052
4.574LeuArg: 4.574 ± 0.059
6.826LeuSer: 6.826 ± 0.076
5.061LeuThr: 5.061 ± 0.057
5.602LeuVal: 5.602 ± 0.074
0.94LeuTrp: 0.94 ± 0.025
3.96LeuTyr: 3.96 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.875MetAla: 1.875 ± 0.032
0.211MetCys: 0.211 ± 0.012
1.593MetAsp: 1.593 ± 0.032
2.018MetGlu: 2.018 ± 0.036
1.121MetPhe: 1.121 ± 0.026
1.806MetGly: 1.806 ± 0.033
0.376MetHis: 0.376 ± 0.017
1.805MetIle: 1.805 ± 0.03
2.641MetLys: 2.641 ± 0.04
2.51MetLeu: 2.51 ± 0.038
0.819MetMet: 0.819 ± 0.026
1.662MetAsn: 1.662 ± 0.035
1.062MetPro: 1.062 ± 0.026
0.975MetGln: 0.975 ± 0.024
1.319MetArg: 1.319 ± 0.028
1.594MetSer: 1.594 ± 0.031
1.449MetThr: 1.449 ± 0.027
1.651MetVal: 1.651 ± 0.033
0.239MetTrp: 0.239 ± 0.013
0.977MetTyr: 0.977 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.205AsnAla: 3.205 ± 0.049
0.403AsnCys: 0.403 ± 0.015
2.549AsnAsp: 2.549 ± 0.036
3.215AsnGlu: 3.215 ± 0.056
2.379AsnPhe: 2.379 ± 0.045
3.596AsnGly: 3.596 ± 0.057
0.863AsnHis: 0.863 ± 0.028
3.935AsnIle: 3.935 ± 0.056
3.243AsnLys: 3.243 ± 0.047
4.631AsnLeu: 4.631 ± 0.059
1.499AsnMet: 1.499 ± 0.038
2.562AsnAsn: 2.562 ± 0.048
2.359AsnPro: 2.359 ± 0.038
1.708AsnGln: 1.708 ± 0.03
2.651AsnArg: 2.651 ± 0.042
2.961AsnSer: 2.961 ± 0.045
2.979AsnThr: 2.979 ± 0.046
3.726AsnVal: 3.726 ± 0.055
0.646AsnTrp: 0.646 ± 0.021
2.585AsnTyr: 2.585 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.227ProAla: 2.227 ± 0.039
0.394ProCys: 0.394 ± 0.018
2.39ProAsp: 2.39 ± 0.038
3.405ProGlu: 3.405 ± 0.052
1.67ProPhe: 1.67 ± 0.035
2.461ProGly: 2.461 ± 0.042
0.546ProHis: 0.546 ± 0.022
2.084ProIle: 2.084 ± 0.041
1.867ProLys: 1.867 ± 0.034
3.249ProLeu: 3.249 ± 0.043
0.838ProMet: 0.838 ± 0.023
1.599ProAsn: 1.599 ± 0.033
0.752ProPro: 0.752 ± 0.025
1.087ProGln: 1.087 ± 0.031
1.341ProArg: 1.341 ± 0.03
2.057ProSer: 2.057 ± 0.041
1.835ProThr: 1.835 ± 0.034
2.98ProVal: 2.98 ± 0.043
0.4ProTrp: 0.4 ± 0.017
1.699ProTyr: 1.699 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.29GlnAla: 2.29 ± 0.039
0.25GlnCys: 0.25 ± 0.013
1.718GlnAsp: 1.718 ± 0.034
2.662GlnGlu: 2.662 ± 0.043
1.32GlnPhe: 1.32 ± 0.028
2.052GlnGly: 2.052 ± 0.035
0.544GlnHis: 0.544 ± 0.019
2.176GlnIle: 2.176 ± 0.042
2.447GlnLys: 2.447 ± 0.043
3.18GlnLeu: 3.18 ± 0.049
0.99GlnMet: 0.99 ± 0.024
1.663GlnAsn: 1.663 ± 0.034
1.043GlnPro: 1.043 ± 0.025
1.531GlnGln: 1.531 ± 0.036
1.612GlnArg: 1.612 ± 0.03
1.647GlnSer: 1.647 ± 0.031
1.802GlnThr: 1.802 ± 0.034
2.445GlnVal: 2.445 ± 0.042
0.408GlnTrp: 0.408 ± 0.016
1.366GlnTyr: 1.366 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.677ArgAla: 2.677 ± 0.047
0.416ArgCys: 0.416 ± 0.017
2.561ArgAsp: 2.561 ± 0.038
3.967ArgGlu: 3.967 ± 0.06
2.537ArgPhe: 2.537 ± 0.042
2.98ArgGly: 2.98 ± 0.046
0.844ArgHis: 0.844 ± 0.025
3.13ArgIle: 3.13 ± 0.05
3.284ArgLys: 3.284 ± 0.046
4.813ArgLeu: 4.813 ± 0.061
1.456ArgMet: 1.456 ± 0.032
2.438ArgAsn: 2.438 ± 0.041
1.425ArgPro: 1.425 ± 0.028
1.678ArgGln: 1.678 ± 0.035
2.238ArgArg: 2.238 ± 0.046
2.256ArgSer: 2.256 ± 0.039
2.16ArgThr: 2.16 ± 0.037
3.662ArgVal: 3.662 ± 0.051
0.828ArgTrp: 0.828 ± 0.025
2.529ArgTyr: 2.529 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.644SerAla: 3.644 ± 0.057
0.816SerCys: 0.816 ± 0.025
3.354SerAsp: 3.354 ± 0.045
3.639SerGlu: 3.639 ± 0.052
3.545SerPhe: 3.545 ± 0.053
4.626SerGly: 4.626 ± 0.063
0.978SerHis: 0.978 ± 0.025
4.239SerIle: 4.239 ± 0.059
3.328SerLys: 3.328 ± 0.05
6.183SerLeu: 6.183 ± 0.071
1.638SerMet: 1.638 ± 0.029
2.696SerAsn: 2.696 ± 0.047
2.159SerPro: 2.159 ± 0.036
1.807SerGln: 1.807 ± 0.038
2.81SerArg: 2.81 ± 0.04
4.022SerSer: 4.022 ± 0.066
3.288SerThr: 3.288 ± 0.046
4.578SerVal: 4.578 ± 0.059
0.882SerTrp: 0.882 ± 0.022
3.089SerTyr: 3.089 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.348ThrAla: 3.348 ± 0.046
0.544ThrCys: 0.544 ± 0.019
3.155ThrAsp: 3.155 ± 0.048
3.221ThrGlu: 3.221 ± 0.053
2.673ThrPhe: 2.673 ± 0.043
4.363ThrGly: 4.363 ± 0.068
0.834ThrHis: 0.834 ± 0.025
3.946ThrIle: 3.946 ± 0.054
2.957ThrLys: 2.957 ± 0.042
5.55ThrLeu: 5.55 ± 0.059
1.186ThrMet: 1.186 ± 0.026
2.503ThrAsn: 2.503 ± 0.047
2.498ThrPro: 2.498 ± 0.045
1.544ThrGln: 1.544 ± 0.033
2.386ThrArg: 2.386 ± 0.04
3.575ThrSer: 3.575 ± 0.047
3.315ThrThr: 3.315 ± 0.049
3.917ThrVal: 3.917 ± 0.051
0.669ThrTrp: 0.669 ± 0.022
2.557ThrTyr: 2.557 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.675ValAla: 4.675 ± 0.054
0.874ValCys: 0.874 ± 0.024
4.065ValAsp: 4.065 ± 0.057
4.64ValGlu: 4.64 ± 0.069
3.311ValPhe: 3.311 ± 0.048
4.322ValGly: 4.322 ± 0.059
1.025ValHis: 1.025 ± 0.026
4.866ValIle: 4.866 ± 0.059
4.963ValLys: 4.963 ± 0.062
6.528ValLeu: 6.528 ± 0.065
1.861ValMet: 1.861 ± 0.034
3.745ValAsn: 3.745 ± 0.054
2.492ValPro: 2.492 ± 0.047
2.084ValGln: 2.084 ± 0.038
3.253ValArg: 3.253 ± 0.049
4.659ValSer: 4.659 ± 0.06
4.002ValThr: 4.002 ± 0.05
5.244ValVal: 5.244 ± 0.068
0.766ValTrp: 0.766 ± 0.021
3.035ValTyr: 3.035 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.693TrpAla: 0.693 ± 0.021
0.224TrpCys: 0.224 ± 0.011
0.651TrpAsp: 0.651 ± 0.021
0.828TrpGlu: 0.828 ± 0.023
0.559TrpPhe: 0.559 ± 0.02
0.932TrpGly: 0.932 ± 0.026
0.19TrpHis: 0.19 ± 0.011
0.709TrpIle: 0.709 ± 0.021
0.863TrpLys: 0.863 ± 0.023
1.232TrpLeu: 1.232 ± 0.03
0.414TrpMet: 0.414 ± 0.016
0.742TrpAsn: 0.742 ± 0.022
0.218TrpPro: 0.218 ± 0.012
0.533TrpGln: 0.533 ± 0.016
0.603TrpArg: 0.603 ± 0.02
0.703TrpSer: 0.703 ± 0.023
0.559TrpThr: 0.559 ± 0.021
0.729TrpVal: 0.729 ± 0.022
0.177TrpTrp: 0.177 ± 0.012
0.567TrpTyr: 0.567 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.902TyrAla: 2.902 ± 0.046
0.519TyrCys: 0.519 ± 0.02
2.8TyrAsp: 2.8 ± 0.046
2.671TyrGlu: 2.671 ± 0.042
2.313TyrPhe: 2.313 ± 0.042
3.01TyrGly: 3.01 ± 0.046
0.791TyrHis: 0.791 ± 0.022
2.759TyrIle: 2.759 ± 0.049
2.858TyrLys: 2.858 ± 0.046
4.214TyrLeu: 4.214 ± 0.057
1.199TyrMet: 1.199 ± 0.026
2.819TyrAsn: 2.819 ± 0.054
1.814TyrPro: 1.814 ± 0.036
1.586TyrGln: 1.586 ± 0.03
2.319TyrArg: 2.319 ± 0.039
3.142TyrSer: 3.142 ± 0.05
2.838TyrThr: 2.838 ± 0.047
2.751TyrVal: 2.751 ± 0.042
0.583TyrTrp: 0.583 ± 0.019
2.374TyrTyr: 2.374 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3969 proteins (1544925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski