Amino acid dipepetide frequency for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.856AlaAla: 8.856 ± 0.059	1.095AlaCys: 1.095 ± 0.016	4.276AlaAsp: 4.276 ± 0.03	5.334AlaGlu: 5.334 ± 0.048	3.12AlaPhe: 3.12 ± 0.027	5.828AlaGly: 5.828 ± 0.043	1.791AlaHis: 1.791 ± 0.018	4.344AlaIle: 4.344 ± 0.032	3.823AlaLys: 3.823 ± 0.033	7.941AlaLeu: 7.941 ± 0.046	1.917AlaMet: 1.917 ± 0.018	2.914AlaAsn: 2.914 ± 0.024	4.527AlaPro: 4.527 ± 0.042	3.386AlaGln: 3.386 ± 0.034	5.021AlaArg: 5.021 ± 0.034	7.244AlaSer: 7.244 ± 0.045	5.167AlaThr: 5.167 ± 0.035	5.509AlaVal: 5.509 ± 0.035	1.146AlaTrp: 1.146 ± 0.02	2.274AlaTyr: 2.274 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.013	0.252CysCys: 0.252 ± 0.008	0.683CysAsp: 0.683 ± 0.015	0.612CysGlu: 0.612 ± 0.013	0.539CysPhe: 0.539 ± 0.012	0.944CysGly: 0.944 ± 0.016	0.339CysHis: 0.339 ± 0.009	0.726CysIle: 0.726 ± 0.012	0.471CysLys: 0.471 ± 0.011	1.337CysLeu: 1.337 ± 0.017	0.28CysMet: 0.28 ± 0.007	0.421CysAsn: 0.421 ± 0.011	0.675CysPro: 0.675 ± 0.012	0.466CysGln: 0.466 ± 0.01	0.805CysArg: 0.805 ± 0.014	0.977CysSer: 0.977 ± 0.014	0.712CysThr: 0.712 ± 0.013	0.807CysVal: 0.807 ± 0.015	0.206CysTrp: 0.206 ± 0.006	0.363CysTyr: 0.363 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.569AspAla: 4.569 ± 0.033	0.622AspCys: 0.622 ± 0.012	3.857AspAsp: 3.857 ± 0.042	4.29AspGlu: 4.29 ± 0.037	2.145AspPhe: 2.145 ± 0.023	3.947AspGly: 3.947 ± 0.03	1.233AspHis: 1.233 ± 0.019	3.181AspIle: 3.181 ± 0.025	2.207AspLys: 2.207 ± 0.026	5.048AspLeu: 5.048 ± 0.036	1.179AspMet: 1.179 ± 0.015	1.883AspAsn: 1.883 ± 0.02	3.279AspPro: 3.279 ± 0.027	1.847AspGln: 1.847 ± 0.019	3.119AspArg: 3.119 ± 0.03	4.228AspSer: 4.228 ± 0.031	2.966AspThr: 2.966 ± 0.026	3.498AspVal: 3.498 ± 0.026	0.881AspTrp: 0.881 ± 0.014	1.67AspTyr: 1.67 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.287GluAla: 5.287 ± 0.047	0.636GluCys: 0.636 ± 0.012	3.976GluAsp: 3.976 ± 0.035	5.323GluGlu: 5.323 ± 0.052	1.966GluPhe: 1.966 ± 0.019	3.707GluGly: 3.707 ± 0.03	1.389GluHis: 1.389 ± 0.018	3.153GluIle: 3.153 ± 0.029	3.585GluLys: 3.585 ± 0.033	5.328GluLeu: 5.328 ± 0.041	1.377GluMet: 1.377 ± 0.017	2.406GluAsn: 2.406 ± 0.021	2.864GluPro: 2.864 ± 0.038	2.567GluGln: 2.567 ± 0.027	4.033GluArg: 4.033 ± 0.039	4.451GluSer: 4.451 ± 0.034	3.667GluThr: 3.667 ± 0.035	3.49GluVal: 3.49 ± 0.027	0.878GluTrp: 0.878 ± 0.015	1.799GluTyr: 1.799 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.074PheAla: 3.074 ± 0.025	0.57PheCys: 0.57 ± 0.011	2.211PheAsp: 2.211 ± 0.022	2.107PheGlu: 2.107 ± 0.02	1.66PhePhe: 1.66 ± 0.024	2.788PheGly: 2.788 ± 0.031	0.906PheHis: 0.906 ± 0.013	1.847PheIle: 1.847 ± 0.024	1.416PheLys: 1.416 ± 0.016	3.571PheLeu: 3.571 ± 0.035	0.767PheMet: 0.767 ± 0.012	1.414PheAsn: 1.414 ± 0.017	1.992PhePro: 1.992 ± 0.02	1.385PheGln: 1.385 ± 0.016	2.031PheArg: 2.031 ± 0.023	3.091PheSer: 3.091 ± 0.03	2.163PheThr: 2.163 ± 0.02	2.37PheVal: 2.37 ± 0.025	0.655PheTrp: 0.655 ± 0.013	1.148PheTyr: 1.148 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.249GlyAla: 5.249 ± 0.037	0.913GlyCys: 0.913 ± 0.016	3.548GlyAsp: 3.548 ± 0.03	3.628GlyGlu: 3.628 ± 0.031	2.819GlyPhe: 2.819 ± 0.028	5.379GlyGly: 5.379 ± 0.05	1.678GlyHis: 1.678 ± 0.021	3.632GlyIle: 3.632 ± 0.029	3.268GlyLys: 3.268 ± 0.034	6.298GlyLeu: 6.298 ± 0.043	1.493GlyMet: 1.493 ± 0.02	2.528GlyAsn: 2.528 ± 0.023	3.352GlyPro: 3.352 ± 0.032	2.538GlyGln: 2.538 ± 0.027	4.078GlyArg: 4.078 ± 0.033	5.718GlySer: 5.718 ± 0.049	3.921GlyThr: 3.921 ± 0.033	4.436GlyVal: 4.436 ± 0.036	1.17GlyTrp: 1.17 ± 0.016	2.232GlyTyr: 2.232 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.803HisAla: 1.803 ± 0.022	0.33HisCys: 0.33 ± 0.009	1.269HisAsp: 1.269 ± 0.018	1.319HisGlu: 1.319 ± 0.016	0.928HisPhe: 0.928 ± 0.013	1.717HisGly: 1.717 ± 0.021	0.793HisHis: 0.793 ± 0.015	1.258HisIle: 1.258 ± 0.015	0.863HisLys: 0.863 ± 0.014	2.262HisLeu: 2.262 ± 0.022	0.463HisMet: 0.463 ± 0.01	0.826HisAsn: 0.826 ± 0.013	1.682HisPro: 1.682 ± 0.021	0.947HisGln: 0.947 ± 0.014	1.564HisArg: 1.564 ± 0.02	1.929HisSer: 1.929 ± 0.02	1.274HisThr: 1.274 ± 0.016	1.372HisVal: 1.372 ± 0.017	0.361HisTrp: 0.361 ± 0.008	0.727HisTyr: 0.727 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.265IleAla: 4.265 ± 0.034	0.785IleCys: 0.785 ± 0.013	2.852IleAsp: 2.852 ± 0.026	2.906IleGlu: 2.906 ± 0.026	2.011IlePhe: 2.011 ± 0.022	3.196IleGly: 3.196 ± 0.029	1.213IleHis: 1.213 ± 0.013	2.585IleIle: 2.585 ± 0.027	2.086IleLys: 2.086 ± 0.026	4.828IleLeu: 4.828 ± 0.035	0.991IleMet: 0.991 ± 0.016	1.856IleAsn: 1.856 ± 0.021	3.193IlePro: 3.193 ± 0.028	2.0IleGln: 2.0 ± 0.019	2.95IleArg: 2.95 ± 0.026	4.048IleSer: 4.048 ± 0.033	2.902IleThr: 2.902 ± 0.026	3.21IleVal: 3.21 ± 0.025	0.723IleTrp: 0.723 ± 0.013	1.523IleTyr: 1.523 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.007LysAla: 4.007 ± 0.035	0.483LysCys: 0.483 ± 0.01	2.595LysAsp: 2.595 ± 0.024	3.258LysGlu: 3.258 ± 0.035	1.323LysPhe: 1.323 ± 0.017	2.901LysGly: 2.901 ± 0.03	1.057LysHis: 1.057 ± 0.015	2.184LysIle: 2.184 ± 0.022	2.946LysLys: 2.946 ± 0.038	3.976LysLeu: 3.976 ± 0.033	0.893LysMet: 0.893 ± 0.013	1.673LysAsn: 1.673 ± 0.02	2.596LysPro: 2.596 ± 0.028	1.86LysGln: 1.86 ± 0.023	3.35LysArg: 3.35 ± 0.032	3.287LysSer: 3.287 ± 0.027	2.652LysThr: 2.652 ± 0.024	2.624LysVal: 2.624 ± 0.025	0.622LysTrp: 0.622 ± 0.012	1.371LysTyr: 1.371 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.025LeuAla: 8.025 ± 0.041	1.258LeuCys: 1.258 ± 0.018	5.279LeuAsp: 5.279 ± 0.032	5.678LeuGlu: 5.678 ± 0.039	3.402LeuPhe: 3.402 ± 0.028	6.084LeuGly: 6.084 ± 0.042	2.257LeuHis: 2.257 ± 0.023	4.161LeuIle: 4.161 ± 0.034	4.098LeuLys: 4.098 ± 0.036	8.681LeuLeu: 8.681 ± 0.061	1.762LeuMet: 1.762 ± 0.02	3.319LeuAsn: 3.319 ± 0.024	5.57LeuPro: 5.57 ± 0.038	3.964LeuGln: 3.964 ± 0.036	6.018LeuArg: 6.018 ± 0.043	7.702LeuSer: 7.702 ± 0.048	5.022LeuThr: 5.022 ± 0.034	5.566LeuVal: 5.566 ± 0.041	1.233LeuTrp: 1.233 ± 0.017	2.54LeuTyr: 2.54 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.1MetAla: 2.1 ± 0.019	0.243MetCys: 0.243 ± 0.006	1.181MetAsp: 1.181 ± 0.015	1.217MetGlu: 1.217 ± 0.016	0.682MetPhe: 0.682 ± 0.011	1.409MetGly: 1.409 ± 0.017	0.477MetHis: 0.477 ± 0.01	0.985MetIle: 0.985 ± 0.016	0.944MetLys: 0.944 ± 0.013	1.804MetLeu: 1.804 ± 0.019	0.498MetMet: 0.498 ± 0.011	0.779MetAsn: 0.779 ± 0.013	1.203MetPro: 1.203 ± 0.018	0.827MetGln: 0.827 ± 0.014	1.219MetArg: 1.219 ± 0.016	1.757MetSer: 1.757 ± 0.019	1.232MetThr: 1.232 ± 0.015	1.288MetVal: 1.288 ± 0.018	0.239MetTrp: 0.239 ± 0.007	0.531MetTyr: 0.531 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.176AsnAla: 3.176 ± 0.028	0.461AsnCys: 0.461 ± 0.011	1.907AsnAsp: 1.907 ± 0.019	2.108AsnGlu: 2.108 ± 0.022	1.283AsnPhe: 1.283 ± 0.017	2.889AsnGly: 2.889 ± 0.026	0.852AsnHis: 0.852 ± 0.012	2.085AsnIle: 2.085 ± 0.023	1.483AsnLys: 1.483 ± 0.021	3.276AsnLeu: 3.276 ± 0.023	0.807AsnMet: 0.807 ± 0.014	1.452AsnAsn: 1.452 ± 0.02	2.525AsnPro: 2.525 ± 0.023	1.396AsnGln: 1.396 ± 0.02	2.071AsnArg: 2.071 ± 0.021	2.815AsnSer: 2.815 ± 0.023	2.217AsnThr: 2.217 ± 0.021	2.296AsnVal: 2.296 ± 0.025	0.597AsnTrp: 0.597 ± 0.012	1.089AsnTyr: 1.089 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.19ProAla: 5.19 ± 0.045	0.575ProCys: 0.575 ± 0.012	3.241ProAsp: 3.241 ± 0.032	3.885ProGlu: 3.885 ± 0.032	2.102ProPhe: 2.102 ± 0.025	3.999ProGly: 3.999 ± 0.035	1.29ProHis: 1.29 ± 0.017	2.543ProIle: 2.543 ± 0.024	2.465ProLys: 2.465 ± 0.025	4.845ProLeu: 4.845 ± 0.035	0.998ProMet: 0.998 ± 0.013	2.178ProAsn: 2.178 ± 0.02	4.695ProPro: 4.695 ± 0.068	2.423ProGln: 2.423 ± 0.033	3.438ProArg: 3.438 ± 0.033	6.086ProSer: 6.086 ± 0.046	3.91ProThr: 3.91 ± 0.035	3.685ProVal: 3.685 ± 0.033	0.754ProTrp: 0.754 ± 0.014	1.573ProTyr: 1.573 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.433GlnAla: 3.433 ± 0.038	0.459GlnCys: 0.459 ± 0.009	2.038GlnAsp: 2.038 ± 0.02	2.431GlnGlu: 2.431 ± 0.029	1.314GlnPhe: 1.314 ± 0.017	2.412GlnGly: 2.412 ± 0.025	1.049GlnHis: 1.049 ± 0.014	1.924GlnIle: 1.924 ± 0.021	1.966GlnLys: 1.966 ± 0.025	3.606GlnLeu: 3.606 ± 0.031	0.853GlnMet: 0.853 ± 0.014	1.551GlnAsn: 1.551 ± 0.021	2.548GlnPro: 2.548 ± 0.033	2.3GlnGln: 2.3 ± 0.047	2.737GlnArg: 2.737 ± 0.026	3.24GlnSer: 3.24 ± 0.03	2.388GlnThr: 2.388 ± 0.024	2.175GlnVal: 2.175 ± 0.021	0.56GlnTrp: 0.56 ± 0.011	1.217GlnTyr: 1.217 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.885ArgAla: 4.885 ± 0.032	0.756ArgCys: 0.756 ± 0.014	3.354ArgAsp: 3.354 ± 0.032	3.935ArgGlu: 3.935 ± 0.039	2.267ArgPhe: 2.267 ± 0.022	3.691ArgGly: 3.691 ± 0.031	1.579ArgHis: 1.579 ± 0.02	3.028ArgIle: 3.028 ± 0.029	3.415ArgLys: 3.415 ± 0.029	5.846ArgLeu: 5.846 ± 0.04	1.313ArgMet: 1.313 ± 0.018	2.342ArgAsn: 2.342 ± 0.024	3.532ArgPro: 3.532 ± 0.032	2.634ArgGln: 2.634 ± 0.026	5.234ArgArg: 5.234 ± 0.048	4.941ArgSer: 4.941 ± 0.041	3.464ArgThr: 3.464 ± 0.028	3.546ArgVal: 3.546 ± 0.027	0.982ArgTrp: 0.982 ± 0.013	1.781ArgTyr: 1.781 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.811SerAla: 6.811 ± 0.043	0.935SerCys: 0.935 ± 0.017	4.304SerAsp: 4.304 ± 0.031	4.332SerGlu: 4.332 ± 0.031	3.077SerPhe: 3.077 ± 0.024	5.62SerGly: 5.62 ± 0.034	1.993SerHis: 1.993 ± 0.022	4.102SerIle: 4.102 ± 0.031	3.523SerLys: 3.523 ± 0.028	7.569SerLeu: 7.569 ± 0.048	1.651SerMet: 1.651 ± 0.018	3.037SerAsn: 3.037 ± 0.026	5.541SerPro: 5.541 ± 0.05	3.422SerGln: 3.422 ± 0.032	5.281SerArg: 5.281 ± 0.041	8.834SerSer: 8.834 ± 0.071	5.658SerThr: 5.658 ± 0.046	4.765SerVal: 4.765 ± 0.028	1.153SerTrp: 1.153 ± 0.017	2.186SerTyr: 2.186 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.299ThrAla: 5.299 ± 0.036	0.745ThrCys: 0.745 ± 0.013	2.904ThrAsp: 2.904 ± 0.026	3.278ThrGlu: 3.278 ± 0.032	2.228ThrPhe: 2.228 ± 0.019	4.315ThrGly: 4.315 ± 0.032	1.259ThrHis: 1.259 ± 0.015	3.054ThrIle: 3.054 ± 0.026	2.461ThrLys: 2.461 ± 0.023	5.371ThrLeu: 5.371 ± 0.034	1.136ThrMet: 1.136 ± 0.017	2.097ThrAsn: 2.097 ± 0.023	4.301ThrPro: 4.301 ± 0.038	2.11ThrGln: 2.11 ± 0.023	3.212ThrArg: 3.212 ± 0.03	5.316ThrSer: 5.316 ± 0.039	4.134ThrThr: 4.134 ± 0.046	3.885ThrVal: 3.885 ± 0.028	0.856ThrTrp: 0.856 ± 0.014	1.658ThrTyr: 1.658 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.112ValAla: 5.112 ± 0.035	0.835ValCys: 0.835 ± 0.014	3.637ValAsp: 3.637 ± 0.03	3.793ValGlu: 3.793 ± 0.03	2.518ValPhe: 2.518 ± 0.028	3.95ValGly: 3.95 ± 0.033	1.408ValHis: 1.408 ± 0.017	3.042ValIle: 3.042 ± 0.026	2.725ValLys: 2.725 ± 0.024	5.769ValLeu: 5.769 ± 0.039	1.243ValMet: 1.243 ± 0.015	2.29ValAsn: 2.29 ± 0.024	3.572ValPro: 3.572 ± 0.029	2.447ValGln: 2.447 ± 0.023	3.611ValArg: 3.611 ± 0.03	4.872ValSer: 4.872 ± 0.032	3.525ValThr: 3.525 ± 0.03	4.167ValVal: 4.167 ± 0.032	0.868ValTrp: 0.868 ± 0.014	1.85ValTyr: 1.85 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.136TrpAla: 1.136 ± 0.016	0.19TrpCys: 0.19 ± 0.006	0.876TrpAsp: 0.876 ± 0.015	0.855TrpGlu: 0.855 ± 0.013	0.547TrpPhe: 0.547 ± 0.01	0.928TrpGly: 0.928 ± 0.015	0.35TrpHis: 0.35 ± 0.008	0.771TrpIle: 0.771 ± 0.012	0.795TrpLys: 0.795 ± 0.014	1.418TrpLeu: 1.418 ± 0.017	0.363TrpMet: 0.363 ± 0.008	0.644TrpAsn: 0.644 ± 0.012	0.608TrpPro: 0.608 ± 0.01	0.551TrpGln: 0.551 ± 0.011	0.984TrpArg: 0.984 ± 0.014	1.08TrpSer: 1.08 ± 0.015	0.923TrpThr: 0.923 ± 0.015	0.901TrpVal: 0.901 ± 0.015	0.278TrpTrp: 0.278 ± 0.008	0.431TrpTyr: 0.431 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.272TyrAla: 2.272 ± 0.024	0.434TyrCys: 0.434 ± 0.01	1.662TyrAsp: 1.662 ± 0.018	1.594TyrGlu: 1.594 ± 0.018	1.238TyrPhe: 1.238 ± 0.019	2.174TyrGly: 2.174 ± 0.024	0.777TyrHis: 0.777 ± 0.012	1.515TyrIle: 1.515 ± 0.019	1.118TyrLys: 1.118 ± 0.016	2.845TyrLeu: 2.845 ± 0.027	0.631TyrMet: 0.631 ± 0.012	1.176TyrAsn: 1.176 ± 0.018	1.619TyrPro: 1.619 ± 0.021	1.13TyrGln: 1.13 ± 0.016	1.769TyrArg: 1.769 ± 0.016	2.177TyrSer: 2.177 ± 0.023	1.721TyrThr: 1.721 ± 0.018	1.645TyrVal: 1.645 ± 0.019	0.469TyrTrp: 0.469 ± 0.01	1.004TyrTyr: 1.004 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10559 proteins (5092340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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