Amino acid dipepetide frequency for Sphaeroforma arctica JP610

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.258AlaAla: 7.258 ± 0.049
1.53AlaCys: 1.53 ± 0.027
4.826AlaAsp: 4.826 ± 0.033
5.091AlaGlu: 5.091 ± 0.044
2.426AlaPhe: 2.426 ± 0.026
5.12AlaGly: 5.12 ± 0.038
2.492AlaHis: 2.492 ± 0.033
3.709AlaIle: 3.709 ± 0.038
4.348AlaLys: 4.348 ± 0.035
6.854AlaLeu: 6.854 ± 0.041
2.28AlaMet: 2.28 ± 0.023
3.558AlaAsn: 3.558 ± 0.03
3.775AlaPro: 3.775 ± 0.039
3.926AlaGln: 3.926 ± 0.053
4.261AlaArg: 4.261 ± 0.035
6.454AlaSer: 6.454 ± 0.046
5.655AlaThr: 5.655 ± 0.034
5.571AlaVal: 5.571 ± 0.038
0.722AlaTrp: 0.722 ± 0.012
2.202AlaTyr: 2.202 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
1.516CysAla: 1.516 ± 0.033
0.471CysCys: 0.471 ± 0.029
1.22CysAsp: 1.22 ± 0.027
1.113CysGlu: 1.113 ± 0.027
0.549CysPhe: 0.549 ± 0.011
1.414CysGly: 1.414 ± 0.029
0.4CysHis: 0.4 ± 0.009
0.891CysIle: 0.891 ± 0.013
0.827CysLys: 0.827 ± 0.016
1.427CysLeu: 1.427 ± 0.016
0.482CysMet: 0.482 ± 0.01
0.702CysAsn: 0.702 ± 0.014
0.803CysPro: 0.803 ± 0.016
0.583CysGln: 0.583 ± 0.013
0.876CysArg: 0.876 ± 0.014
1.284CysSer: 1.284 ± 0.027
1.365CysThr: 1.365 ± 0.026
1.467CysVal: 1.467 ± 0.021
0.165CysTrp: 0.165 ± 0.006
0.443CysTyr: 0.443 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
4.903AspAla: 4.903 ± 0.04
1.018AspCys: 1.018 ± 0.025
4.48AspAsp: 4.48 ± 0.052
4.324AspGlu: 4.324 ± 0.03
1.949AspPhe: 1.949 ± 0.024
4.485AspGly: 4.485 ± 0.041
1.283AspHis: 1.283 ± 0.018
3.225AspIle: 3.225 ± 0.033
2.955AspLys: 2.955 ± 0.033
4.534AspLeu: 4.534 ± 0.031
1.805AspMet: 1.805 ± 0.019
2.56AspAsn: 2.56 ± 0.022
2.423AspPro: 2.423 ± 0.023
1.831AspGln: 1.831 ± 0.02
3.165AspArg: 3.165 ± 0.033
4.951AspSer: 4.951 ± 0.042
4.795AspThr: 4.795 ± 0.045
4.437AspVal: 4.437 ± 0.033
0.671AspTrp: 0.671 ± 0.013
1.639AspTyr: 1.639 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
4.953GluAla: 4.953 ± 0.036
1.209GluCys: 1.209 ± 0.022
3.856GluAsp: 3.856 ± 0.035
4.378GluGlu: 4.378 ± 0.043
1.781GluPhe: 1.781 ± 0.022
3.89GluGly: 3.89 ± 0.032
1.539GluHis: 1.539 ± 0.016
2.699GluIle: 2.699 ± 0.026
3.618GluLys: 3.618 ± 0.031
4.946GluLeu: 4.946 ± 0.033
1.768GluMet: 1.768 ± 0.021
2.594GluAsn: 2.594 ± 0.025
2.291GluPro: 2.291 ± 0.024
2.375GluGln: 2.375 ± 0.026
3.734GluArg: 3.734 ± 0.036
4.725GluSer: 4.725 ± 0.034
3.746GluThr: 3.746 ± 0.03
3.898GluVal: 3.898 ± 0.034
0.69GluTrp: 0.69 ± 0.014
1.84GluTyr: 1.84 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.367PheAla: 2.367 ± 0.022
0.597PheCys: 0.597 ± 0.011
2.061PheAsp: 2.061 ± 0.02
1.854PheGlu: 1.854 ± 0.02
1.139PhePhe: 1.139 ± 0.018
2.384PheGly: 2.384 ± 0.034
0.715PheHis: 0.715 ± 0.012
1.468PheIle: 1.468 ± 0.021
1.57PheLys: 1.57 ± 0.017
2.531PheLeu: 2.531 ± 0.027
0.835PheMet: 0.835 ± 0.013
1.395PheAsn: 1.395 ± 0.018
1.193PhePro: 1.193 ± 0.016
1.055PheGln: 1.055 ± 0.015
1.457PheArg: 1.457 ± 0.017
2.384PheSer: 2.384 ± 0.023
1.92PheThr: 1.92 ± 0.02
2.29PheVal: 2.29 ± 0.024
0.368PheTrp: 0.368 ± 0.009
0.947PheTyr: 0.947 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
5.236GlyAla: 5.236 ± 0.041
1.202GlyCys: 1.202 ± 0.018
4.246GlyAsp: 4.246 ± 0.03
3.868GlyGlu: 3.868 ± 0.034
2.18GlyPhe: 2.18 ± 0.025
5.49GlyGly: 5.49 ± 0.066
1.691GlyHis: 1.691 ± 0.02
2.97GlyIle: 2.97 ± 0.028
3.381GlyLys: 3.381 ± 0.029
5.243GlyLeu: 5.243 ± 0.036
1.927GlyMet: 1.927 ± 0.022
2.844GlyAsn: 2.844 ± 0.027
2.606GlyPro: 2.606 ± 0.031
2.51GlyGln: 2.51 ± 0.028
3.598GlyArg: 3.598 ± 0.034
5.804GlySer: 5.804 ± 0.042
4.578GlyThr: 4.578 ± 0.034
5.116GlyVal: 5.116 ± 0.04
0.692GlyTrp: 0.692 ± 0.014
1.986GlyTyr: 1.986 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
2.383HisAla: 2.383 ± 0.031
0.423HisCys: 0.423 ± 0.01
1.326HisAsp: 1.326 ± 0.015
1.384HisGlu: 1.384 ± 0.018
0.802HisPhe: 0.802 ± 0.012
1.725HisGly: 1.725 ± 0.021
0.811HisHis: 0.811 ± 0.014
1.316HisIle: 1.316 ± 0.019
1.291HisLys: 1.291 ± 0.018
2.064HisLeu: 2.064 ± 0.023
0.759HisMet: 0.759 ± 0.013
1.186HisAsn: 1.186 ± 0.016
1.444HisPro: 1.444 ± 0.02
1.014HisGln: 1.014 ± 0.02
1.619HisArg: 1.619 ± 0.019
2.419HisSer: 2.419 ± 0.029
3.002HisThr: 3.002 ± 0.045
1.852HisVal: 1.852 ± 0.02
0.24HisTrp: 0.24 ± 0.007
0.675HisTyr: 0.675 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.839IleAla: 3.839 ± 0.034
0.835IleCys: 0.835 ± 0.014
3.054IleAsp: 3.054 ± 0.031
2.788IleGlu: 2.788 ± 0.023
1.37IlePhe: 1.37 ± 0.019
2.907IleGly: 2.907 ± 0.028
1.203IleHis: 1.203 ± 0.015
2.021IleIle: 2.021 ± 0.021
2.296IleLys: 2.296 ± 0.024
3.501IleLeu: 3.501 ± 0.034
1.072IleMet: 1.072 ± 0.014
2.05IleAsn: 2.05 ± 0.021
2.43IlePro: 2.43 ± 0.023
1.804IleGln: 1.804 ± 0.021
2.404IleArg: 2.404 ± 0.023
3.572IleSer: 3.572 ± 0.03
2.881IleThr: 2.881 ± 0.027
3.199IleVal: 3.199 ± 0.033
0.414IleTrp: 0.414 ± 0.009
1.229IleTyr: 1.229 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
4.386LysAla: 4.386 ± 0.038
0.888LysCys: 0.888 ± 0.018
3.107LysAsp: 3.107 ± 0.027
3.366LysGlu: 3.366 ± 0.031
1.442LysPhe: 1.442 ± 0.017
3.264LysGly: 3.264 ± 0.027
1.489LysHis: 1.489 ± 0.018
2.135LysIle: 2.135 ± 0.024
3.787LysLys: 3.787 ± 0.043
3.976LysLeu: 3.976 ± 0.033
1.251LysMet: 1.251 ± 0.016
2.192LysAsn: 2.192 ± 0.021
2.482LysPro: 2.482 ± 0.023
2.202LysGln: 2.202 ± 0.02
3.478LysArg: 3.478 ± 0.032
3.824LysSer: 3.824 ± 0.032
3.105LysThr: 3.105 ± 0.026
3.23LysVal: 3.23 ± 0.026
0.561LysTrp: 0.561 ± 0.01
1.627LysTyr: 1.627 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
6.45LeuAla: 6.45 ± 0.046
1.583LeuCys: 1.583 ± 0.018
4.742LeuAsp: 4.742 ± 0.035
4.736LeuGlu: 4.736 ± 0.034
2.647LeuPhe: 2.647 ± 0.026
4.888LeuGly: 4.888 ± 0.035
2.225LeuHis: 2.225 ± 0.021
3.264LeuIle: 3.264 ± 0.03
4.262LeuLys: 4.262 ± 0.033
7.155LeuLeu: 7.155 ± 0.055
2.009LeuMet: 2.009 ± 0.023
3.353LeuAsn: 3.353 ± 0.026
4.133LeuPro: 4.133 ± 0.029
3.649LeuGln: 3.649 ± 0.031
4.732LeuArg: 4.732 ± 0.032
6.678LeuSer: 6.678 ± 0.042
4.933LeuThr: 4.933 ± 0.033
5.243LeuVal: 5.243 ± 0.039
0.854LeuTrp: 0.854 ± 0.013
2.336LeuTyr: 2.336 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
2.218MetAla: 2.218 ± 0.022
0.532MetCys: 0.532 ± 0.011
1.6MetAsp: 1.6 ± 0.018
1.504MetGlu: 1.504 ± 0.016
0.898MetPhe: 0.898 ± 0.015
1.859MetGly: 1.859 ± 0.02
0.761MetHis: 0.761 ± 0.013
1.027MetIle: 1.027 ± 0.014
1.327MetLys: 1.327 ± 0.015
2.163MetLeu: 2.163 ± 0.022
0.702MetMet: 0.702 ± 0.011
1.163MetAsn: 1.163 ± 0.016
1.265MetPro: 1.265 ± 0.016
1.151MetGln: 1.151 ± 0.016
1.522MetArg: 1.522 ± 0.016
2.293MetSer: 2.293 ± 0.023
1.541MetThr: 1.541 ± 0.018
1.691MetVal: 1.691 ± 0.023
0.295MetTrp: 0.295 ± 0.008
0.897MetTyr: 0.897 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.636AsnAla: 3.636 ± 0.03
0.69AsnCys: 0.69 ± 0.019
2.437AsnAsp: 2.437 ± 0.026
2.531AsnGlu: 2.531 ± 0.023
1.196AsnPhe: 1.196 ± 0.018
3.221AsnGly: 3.221 ± 0.027
0.982AsnHis: 0.982 ± 0.014
2.209AsnIle: 2.209 ± 0.022
2.214AsnLys: 2.214 ± 0.023
3.07AsnLeu: 3.07 ± 0.029
1.171AsnMet: 1.171 ± 0.015
2.325AsnAsn: 2.325 ± 0.04
2.131AsnPro: 2.131 ± 0.023
1.598AsnGln: 1.598 ± 0.021
2.244AsnArg: 2.244 ± 0.021
3.619AsnSer: 3.619 ± 0.032
3.692AsnThr: 3.692 ± 0.036
2.914AsnVal: 2.914 ± 0.025
0.412AsnTrp: 0.412 ± 0.007
1.121AsnTyr: 1.121 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
3.87ProAla: 3.87 ± 0.033
0.64ProCys: 0.64 ± 0.015
2.621ProAsp: 2.621 ± 0.024
2.997ProGlu: 2.997 ± 0.027
1.406ProPhe: 1.406 ± 0.018
2.896ProGly: 2.896 ± 0.028
1.426ProHis: 1.426 ± 0.022
2.17ProIle: 2.17 ± 0.023
2.353ProLys: 2.353 ± 0.023
3.629ProLeu: 3.629 ± 0.03
1.186ProMet: 1.186 ± 0.015
2.124ProAsn: 2.124 ± 0.025
3.161ProPro: 3.161 ± 0.05
2.255ProGln: 2.255 ± 0.038
2.472ProArg: 2.472 ± 0.028
4.258ProSer: 4.258 ± 0.041
3.857ProThr: 3.857 ± 0.036
3.357ProVal: 3.357 ± 0.031
0.435ProTrp: 0.435 ± 0.01
1.31ProTyr: 1.31 ± 0.016
0.0ProXaa: 0.0 ± 0.0
Gln
3.622GlnAla: 3.622 ± 0.047
0.66GlnCys: 0.66 ± 0.012
1.89GlnAsp: 1.89 ± 0.021
2.167GlnGlu: 2.167 ± 0.026
1.133GlnPhe: 1.133 ± 0.017
2.37GlnGly: 2.37 ± 0.032
1.34GlnHis: 1.34 ± 0.023
1.794GlnIle: 1.794 ± 0.018
2.08GlnLys: 2.08 ± 0.02
3.52GlnLeu: 3.52 ± 0.033
1.191GlnMet: 1.191 ± 0.017
1.699GlnAsn: 1.699 ± 0.019
2.459GlnPro: 2.459 ± 0.041
3.431GlnGln: 3.431 ± 0.111
2.621GlnArg: 2.621 ± 0.028
3.501GlnSer: 3.501 ± 0.032
2.918GlnThr: 2.918 ± 0.034
2.346GlnVal: 2.346 ± 0.023
0.473GlnTrp: 0.473 ± 0.011
1.275GlnTyr: 1.275 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
4.355ArgAla: 4.355 ± 0.033
0.88ArgCys: 0.88 ± 0.015
3.43ArgAsp: 3.43 ± 0.04
3.434ArgGlu: 3.434 ± 0.036
1.632ArgPhe: 1.632 ± 0.019
3.407ArgGly: 3.407 ± 0.034
1.539ArgHis: 1.539 ± 0.019
2.455ArgIle: 2.455 ± 0.021
3.255ArgLys: 3.255 ± 0.031
4.533ArgLeu: 4.533 ± 0.037
1.559ArgMet: 1.559 ± 0.018
2.396ArgAsn: 2.396 ± 0.025
2.526ArgPro: 2.526 ± 0.026
2.415ArgGln: 2.415 ± 0.026
4.089ArgArg: 4.089 ± 0.042
4.548ArgSer: 4.548 ± 0.05
3.807ArgThr: 3.807 ± 0.028
3.618ArgVal: 3.618 ± 0.027
0.58ArgTrp: 0.58 ± 0.01
1.622ArgTyr: 1.622 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
6.888SerAla: 6.888 ± 0.042
1.146SerCys: 1.146 ± 0.022
5.214SerAsp: 5.214 ± 0.041
4.847SerGlu: 4.847 ± 0.042
2.337SerPhe: 2.337 ± 0.025
6.032SerGly: 6.032 ± 0.045
2.219SerHis: 2.219 ± 0.024
3.753SerIle: 3.753 ± 0.029
3.873SerLys: 3.873 ± 0.033
6.192SerLeu: 6.192 ± 0.036
2.059SerMet: 2.059 ± 0.023
3.505SerAsn: 3.505 ± 0.033
4.119SerPro: 4.119 ± 0.038
3.297SerGln: 3.297 ± 0.034
4.396SerArg: 4.396 ± 0.044
7.593SerSer: 7.593 ± 0.061
6.307SerThr: 6.307 ± 0.046
5.645SerVal: 5.645 ± 0.038
0.688SerTrp: 0.688 ± 0.011
1.967SerTyr: 1.967 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
5.735ThrAla: 5.735 ± 0.044
1.292ThrCys: 1.292 ± 0.041
4.366ThrAsp: 4.366 ± 0.038
3.876ThrGlu: 3.876 ± 0.032
1.959ThrPhe: 1.959 ± 0.024
4.71ThrGly: 4.71 ± 0.036
2.677ThrHis: 2.677 ± 0.041
3.064ThrIle: 3.064 ± 0.031
3.191ThrLys: 3.191 ± 0.03
5.416ThrLeu: 5.416 ± 0.039
1.53ThrMet: 1.53 ± 0.019
3.153ThrAsn: 3.153 ± 0.027
4.235ThrPro: 4.235 ± 0.041
3.187ThrGln: 3.187 ± 0.038
3.648ThrArg: 3.648 ± 0.037
5.868ThrSer: 5.868 ± 0.045
5.422ThrThr: 5.422 ± 0.052
4.554ThrVal: 4.554 ± 0.036
0.61ThrTrp: 0.61 ± 0.01
1.936ThrTyr: 1.936 ± 0.022
0.0ThrXaa: 0.0 ± 0.0
Val
5.561ValAla: 5.561 ± 0.038
1.641ValCys: 1.641 ± 0.027
4.539ValAsp: 4.539 ± 0.036
4.043ValGlu: 4.043 ± 0.036
2.284ValPhe: 2.284 ± 0.024
4.513ValGly: 4.513 ± 0.037
1.947ValHis: 1.947 ± 0.02
2.806ValIle: 2.806 ± 0.033
3.223ValLys: 3.223 ± 0.031
5.803ValLeu: 5.803 ± 0.044
1.707ValMet: 1.707 ± 0.018
2.731ValAsn: 2.731 ± 0.026
3.393ValPro: 3.393 ± 0.028
2.781ValGln: 2.781 ± 0.025
3.642ValArg: 3.642 ± 0.027
5.424ValSer: 5.424 ± 0.041
4.048ValThr: 4.048 ± 0.035
5.23ValVal: 5.23 ± 0.043
0.758ValTrp: 0.758 ± 0.012
2.114ValTyr: 2.114 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
0.741TrpAla: 0.741 ± 0.011
0.22TrpCys: 0.22 ± 0.007
0.647TrpAsp: 0.647 ± 0.012
0.583TrpGlu: 0.583 ± 0.012
0.38TrpPhe: 0.38 ± 0.009
0.649TrpGly: 0.649 ± 0.012
0.273TrpHis: 0.273 ± 0.008
0.45TrpIle: 0.45 ± 0.011
0.537TrpLys: 0.537 ± 0.011
0.929TrpLeu: 0.929 ± 0.012
0.315TrpMet: 0.315 ± 0.009
0.448TrpAsn: 0.448 ± 0.009
0.372TrpPro: 0.372 ± 0.009
0.401TrpGln: 0.401 ± 0.009
0.583TrpArg: 0.583 ± 0.01
0.751TrpSer: 0.751 ± 0.016
0.629TrpThr: 0.629 ± 0.012
0.684TrpVal: 0.684 ± 0.011
0.157TrpTrp: 0.157 ± 0.006
0.334TrpTyr: 0.334 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.142TyrAla: 2.142 ± 0.021
0.541TyrCys: 0.541 ± 0.011
1.771TyrAsp: 1.771 ± 0.02
1.646TyrGlu: 1.646 ± 0.015
1.02TyrPhe: 1.02 ± 0.016
1.945TyrGly: 1.945 ± 0.024
0.724TyrHis: 0.724 ± 0.013
1.438TyrIle: 1.438 ± 0.017
1.403TyrLys: 1.403 ± 0.019
2.389TyrLeu: 2.389 ± 0.025
0.803TyrMet: 0.803 ± 0.012
1.433TyrAsn: 1.433 ± 0.018
1.181TyrPro: 1.181 ± 0.014
1.027TyrGln: 1.027 ± 0.014
1.536TyrArg: 1.536 ± 0.018
2.127TyrSer: 2.127 ± 0.023
2.228TyrThr: 2.228 ± 0.027
1.846TyrVal: 1.846 ± 0.02
0.297TyrTrp: 0.297 ± 0.008
0.927TyrTyr: 0.927 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18649 proteins (5628458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski