Amino acid dipepetide frequency for Pseudonocardia endophytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.097AlaAla: 21.097 ± 0.185	1.079AlaCys: 1.079 ± 0.024	9.252AlaAsp: 9.252 ± 0.081	8.093AlaGlu: 8.093 ± 0.063	3.554AlaPhe: 3.554 ± 0.043	14.257AlaGly: 14.257 ± 0.103	2.71AlaHis: 2.71 ± 0.037	3.763AlaIle: 3.763 ± 0.05	1.732AlaLys: 1.732 ± 0.039	13.737AlaLeu: 13.737 ± 0.138	2.599AlaMet: 2.599 ± 0.037	1.831AlaAsn: 1.831 ± 0.031	7.21AlaPro: 7.21 ± 0.077	3.149AlaGln: 3.149 ± 0.038	10.605AlaArg: 10.605 ± 0.084	6.033AlaSer: 6.033 ± 0.057	7.644AlaThr: 7.644 ± 0.068	13.344AlaVal: 13.344 ± 0.102	1.82AlaTrp: 1.82 ± 0.031	2.111AlaTyr: 2.111 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.012CysAla: 1.012 ± 0.022	0.094CysCys: 0.094 ± 0.007	0.512CysAsp: 0.512 ± 0.016	0.371CysGlu: 0.371 ± 0.013	0.188CysPhe: 0.188 ± 0.009	0.935CysGly: 0.935 ± 0.022	0.179CysHis: 0.179 ± 0.009	0.182CysIle: 0.182 ± 0.011	0.083CysLys: 0.083 ± 0.007	0.629CysLeu: 0.629 ± 0.016	0.1CysMet: 0.1 ± 0.006	0.116CysAsn: 0.116 ± 0.007	0.473CysPro: 0.473 ± 0.014	0.139CysGln: 0.139 ± 0.008	0.663CysArg: 0.663 ± 0.019	0.444CysSer: 0.444 ± 0.016	0.481CysThr: 0.481 ± 0.015	0.637CysVal: 0.637 ± 0.017	0.119CysTrp: 0.119 ± 0.007	0.153CysTyr: 0.153 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	9.372AspAla: 9.372 ± 0.095	0.365AspCys: 0.365 ± 0.013	5.227AspAsp: 5.227 ± 0.062	4.624AspGlu: 4.624 ± 0.051	1.314AspPhe: 1.314 ± 0.029	7.837AspGly: 7.837 ± 0.074	1.544AspHis: 1.544 ± 0.027	1.557AspIle: 1.557 ± 0.033	0.828AspLys: 0.828 ± 0.024	6.62AspLeu: 6.62 ± 0.06	0.859AspMet: 0.859 ± 0.02	0.76AspAsn: 0.76 ± 0.022	5.558AspPro: 5.558 ± 0.059	1.494AspGln: 1.494 ± 0.026	6.16AspArg: 6.16 ± 0.073	2.235AspSer: 2.235 ± 0.035	3.291AspThr: 3.291 ± 0.046	6.598AspVal: 6.598 ± 0.058	0.906AspTrp: 0.906 ± 0.023	1.062AspTyr: 1.062 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.094GluAla: 6.094 ± 0.063	0.341GluCys: 0.341 ± 0.012	2.527GluAsp: 2.527 ± 0.041	2.504GluGlu: 2.504 ± 0.04	1.627GluPhe: 1.627 ± 0.028	3.436GluGly: 3.436 ± 0.044	1.735GluHis: 1.735 ± 0.028	2.591GluIle: 2.591 ± 0.037	1.105GluLys: 1.105 ± 0.028	6.864GluLeu: 6.864 ± 0.068	0.99GluMet: 0.99 ± 0.023	1.0GluAsn: 1.0 ± 0.023	3.688GluPro: 3.688 ± 0.054	2.235GluGln: 2.235 ± 0.035	5.765GluArg: 5.765 ± 0.061	2.519GluSer: 2.519 ± 0.036	2.819GluThr: 2.819 ± 0.033	4.409GluVal: 4.409 ± 0.05	0.812GluTrp: 0.812 ± 0.02	0.96GluTyr: 0.96 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.737PheAla: 3.737 ± 0.04	0.297PheCys: 0.297 ± 0.013	2.262PheAsp: 2.262 ± 0.036	1.232PheGlu: 1.232 ± 0.025	0.774PhePhe: 0.774 ± 0.022	3.22PheGly: 3.22 ± 0.038	0.612PheHis: 0.612 ± 0.016	0.471PheIle: 0.471 ± 0.018	0.281PheLys: 0.281 ± 0.011	2.476PheLeu: 2.476 ± 0.038	0.334PheMet: 0.334 ± 0.012	0.397PheAsn: 0.397 ± 0.015	1.352PhePro: 1.352 ± 0.024	0.51PheGln: 0.51 ± 0.017	1.947PheArg: 1.947 ± 0.031	1.445PheSer: 1.445 ± 0.024	1.808PheThr: 1.808 ± 0.032	2.563PheVal: 2.563 ± 0.032	0.406PheTrp: 0.406 ± 0.014	0.53PheTyr: 0.53 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.669GlyAla: 11.669 ± 0.083	0.78GlyCys: 0.78 ± 0.019	5.842GlyAsp: 5.842 ± 0.065	5.118GlyGlu: 5.118 ± 0.054	2.958GlyPhe: 2.958 ± 0.038	9.342GlyGly: 9.342 ± 0.097	2.31GlyHis: 2.31 ± 0.032	3.546GlyIle: 3.546 ± 0.045	1.646GlyLys: 1.646 ± 0.031	9.562GlyLeu: 9.562 ± 0.06	2.213GlyMet: 2.213 ± 0.031	1.615GlyAsn: 1.615 ± 0.031	6.057GlyPro: 6.057 ± 0.072	2.445GlyGln: 2.445 ± 0.048	8.334GlyArg: 8.334 ± 0.061	5.779GlySer: 5.779 ± 0.067	6.461GlyThr: 6.461 ± 0.06	8.673GlyVal: 8.673 ± 0.075	1.767GlyTrp: 1.767 ± 0.032	2.262GlyTyr: 2.262 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.722HisAla: 2.722 ± 0.038	0.195HisCys: 0.195 ± 0.01	1.544HisAsp: 1.544 ± 0.03	1.217HisGlu: 1.217 ± 0.023	0.512HisPhe: 0.512 ± 0.015	2.443HisGly: 2.443 ± 0.037	0.647HisHis: 0.647 ± 0.019	0.48HisIle: 0.48 ± 0.014	0.234HisLys: 0.234 ± 0.009	2.318HisLeu: 2.318 ± 0.033	0.321HisMet: 0.321 ± 0.013	0.328HisAsn: 0.328 ± 0.012	1.81HisPro: 1.81 ± 0.028	0.496HisGln: 0.496 ± 0.016	2.117HisArg: 2.117 ± 0.034	0.879HisSer: 0.879 ± 0.021	1.12HisThr: 1.12 ± 0.02	2.018HisVal: 2.018 ± 0.034	0.339HisTrp: 0.339 ± 0.013	0.45HisTyr: 0.45 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.867IleAla: 4.867 ± 0.055	0.273IleCys: 0.273 ± 0.011	2.377IleAsp: 2.377 ± 0.036	1.897IleGlu: 1.897 ± 0.031	0.64IlePhe: 0.64 ± 0.019	3.841IleGly: 3.841 ± 0.05	0.512IleHis: 0.512 ± 0.015	0.727IleIle: 0.727 ± 0.023	0.469IleLys: 0.469 ± 0.017	2.224IleLeu: 2.224 ± 0.04	0.418IleMet: 0.418 ± 0.017	0.603IleAsn: 0.603 ± 0.022	1.746IlePro: 1.746 ± 0.032	0.607IleGln: 0.607 ± 0.019	2.233IleArg: 2.233 ± 0.03	1.555IleSer: 1.555 ± 0.03	2.102IleThr: 2.102 ± 0.034	3.169IleVal: 3.169 ± 0.044	0.376IleTrp: 0.376 ± 0.014	0.5IleTyr: 0.5 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.829LysAla: 1.829 ± 0.035	0.074LysCys: 0.074 ± 0.005	0.813LysAsp: 0.813 ± 0.02	0.691LysGlu: 0.691 ± 0.023	0.325LysPhe: 0.325 ± 0.013	1.063LysGly: 1.063 ± 0.026	0.309LysHis: 0.309 ± 0.012	0.721LysIle: 0.721 ± 0.021	0.399LysLys: 0.399 ± 0.019	1.445LysLeu: 1.445 ± 0.032	0.274LysMet: 0.274 ± 0.011	0.304LysAsn: 0.304 ± 0.012	0.882LysPro: 0.882 ± 0.023	0.497LysGln: 0.497 ± 0.017	1.123LysArg: 1.123 ± 0.028	0.716LysSer: 0.716 ± 0.019	0.782LysThr: 0.782 ± 0.018	1.283LysVal: 1.283 ± 0.026	0.17LysTrp: 0.17 ± 0.009	0.289LysTyr: 0.289 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	14.83LeuAla: 14.83 ± 0.123	0.801LeuCys: 0.801 ± 0.019	7.55LeuAsp: 7.55 ± 0.065	4.527LeuGlu: 4.527 ± 0.051	2.527LeuPhe: 2.527 ± 0.035	9.534LeuGly: 9.534 ± 0.077	2.206LeuHis: 2.206 ± 0.035	2.705LeuIle: 2.705 ± 0.044	1.125LeuLys: 1.125 ± 0.026	10.463LeuLeu: 10.463 ± 0.104	1.42LeuMet: 1.42 ± 0.027	1.407LeuAsn: 1.407 ± 0.025	6.016LeuPro: 6.016 ± 0.051	2.003LeuGln: 2.003 ± 0.037	8.605LeuArg: 8.605 ± 0.075	5.285LeuSer: 5.285 ± 0.054	6.04LeuThr: 6.04 ± 0.057	10.115LeuVal: 10.115 ± 0.087	1.159LeuTrp: 1.159 ± 0.026	1.541LeuTyr: 1.541 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.194MetAla: 2.194 ± 0.038	0.128MetCys: 0.128 ± 0.007	0.884MetAsp: 0.884 ± 0.024	0.678MetGlu: 0.678 ± 0.018	0.464MetPhe: 0.464 ± 0.013	1.274MetGly: 1.274 ± 0.022	0.35MetHis: 0.35 ± 0.013	0.765MetIle: 0.765 ± 0.021	0.285MetLys: 0.285 ± 0.012	1.792MetLeu: 1.792 ± 0.029	0.288MetMet: 0.288 ± 0.012	0.367MetAsn: 0.367 ± 0.013	1.149MetPro: 1.149 ± 0.025	0.445MetGln: 0.445 ± 0.014	1.453MetArg: 1.453 ± 0.03	1.359MetSer: 1.359 ± 0.025	1.752MetThr: 1.752 ± 0.03	1.419MetVal: 1.419 ± 0.027	0.195MetTrp: 0.195 ± 0.01	0.246MetTyr: 0.246 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.042AsnAla: 2.042 ± 0.033	0.138AsnCys: 0.138 ± 0.007	0.903AsnAsp: 0.903 ± 0.024	0.685AsnGlu: 0.685 ± 0.017	0.421AsnPhe: 0.421 ± 0.015	1.743AsnGly: 1.743 ± 0.037	0.335AsnHis: 0.335 ± 0.013	0.525AsnIle: 0.525 ± 0.018	0.268AsnLys: 0.268 ± 0.013	1.543AsnLeu: 1.543 ± 0.029	0.263AsnMet: 0.263 ± 0.012	0.323AsnAsn: 0.323 ± 0.015	1.289AsnPro: 1.289 ± 0.027	0.463AsnGln: 0.463 ± 0.023	1.239AsnArg: 1.239 ± 0.024	0.738AsnSer: 0.738 ± 0.019	0.834AsnThr: 0.834 ± 0.021	1.346AsnVal: 1.346 ± 0.03	0.245AsnTrp: 0.245 ± 0.011	0.363AsnTyr: 0.363 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.499ProAla: 8.499 ± 0.083	0.324ProCys: 0.324 ± 0.013	5.982ProAsp: 5.982 ± 0.055	4.14ProGlu: 4.14 ± 0.048	1.559ProPhe: 1.559 ± 0.025	6.979ProGly: 6.979 ± 0.09	1.299ProHis: 1.299 ± 0.027	1.602ProIle: 1.602 ± 0.028	0.809ProLys: 0.809 ± 0.02	4.974ProLeu: 4.974 ± 0.044	1.078ProMet: 1.078 ± 0.02	0.918ProAsn: 0.918 ± 0.023	3.812ProPro: 3.812 ± 0.069	1.516ProGln: 1.516 ± 0.028	3.996ProArg: 3.996 ± 0.048	3.72ProSer: 3.72 ± 0.043	3.48ProThr: 3.48 ± 0.039	6.037ProVal: 6.037 ± 0.068	0.919ProTrp: 0.919 ± 0.022	1.08ProTyr: 1.08 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.176GlnAla: 3.176 ± 0.044	0.141GlnCys: 0.141 ± 0.008	1.263GlnAsp: 1.263 ± 0.024	1.119GlnGlu: 1.119 ± 0.024	0.681GlnPhe: 0.681 ± 0.017	1.858GlnGly: 1.858 ± 0.034	0.534GlnHis: 0.534 ± 0.015	1.053GlnIle: 1.053 ± 0.029	0.449GlnLys: 0.449 ± 0.016	2.588GlnLeu: 2.588 ± 0.039	0.465GlnMet: 0.465 ± 0.014	0.509GlnAsn: 0.509 ± 0.021	1.419GlnPro: 1.419 ± 0.044	0.981GlnGln: 0.981 ± 0.035	2.251GlnArg: 2.251 ± 0.034	1.073GlnSer: 1.073 ± 0.022	1.15GlnThr: 1.15 ± 0.026	2.391GlnVal: 2.391 ± 0.037	0.392GlnTrp: 0.392 ± 0.012	0.476GlnTyr: 0.476 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.369ArgAla: 10.369 ± 0.09	0.637ArgCys: 0.637 ± 0.017	5.217ArgAsp: 5.217 ± 0.057	4.698ArgGlu: 4.698 ± 0.049	2.583ArgPhe: 2.583 ± 0.036	6.221ArgGly: 6.221 ± 0.052	2.067ArgHis: 2.067 ± 0.027	3.336ArgIle: 3.336 ± 0.042	1.167ArgLys: 1.167 ± 0.026	8.34ArgLeu: 8.34 ± 0.065	1.915ArgMet: 1.915 ± 0.032	1.357ArgAsn: 1.357 ± 0.026	5.342ArgPro: 5.342 ± 0.06	1.84ArgGln: 1.84 ± 0.032	8.489ArgArg: 8.489 ± 0.087	4.764ArgSer: 4.764 ± 0.051	5.545ArgThr: 5.545 ± 0.054	6.611ArgVal: 6.611 ± 0.063	1.485ArgTrp: 1.485 ± 0.026	1.817ArgTyr: 1.817 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.574SerAla: 6.574 ± 0.062	0.369SerCys: 0.369 ± 0.015	3.329SerAsp: 3.329 ± 0.044	2.553SerGlu: 2.553 ± 0.036	1.418SerPhe: 1.418 ± 0.027	6.392SerGly: 6.392 ± 0.067	0.901SerHis: 0.901 ± 0.019	1.5SerIle: 1.5 ± 0.028	0.703SerLys: 0.703 ± 0.023	4.527SerLeu: 4.527 ± 0.054	1.137SerMet: 1.137 ± 0.022	0.822SerAsn: 0.822 ± 0.023	3.198SerPro: 3.198 ± 0.036	1.105SerGln: 1.105 ± 0.023	3.847SerArg: 3.847 ± 0.051	3.07SerSer: 3.07 ± 0.052	3.336SerThr: 3.336 ± 0.04	4.461SerVal: 4.461 ± 0.042	0.85SerTrp: 0.85 ± 0.019	0.981SerTyr: 0.981 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	8.349ThrAla: 8.349 ± 0.071	0.427ThrCys: 0.427 ± 0.016	4.022ThrAsp: 4.022 ± 0.041	3.089ThrGlu: 3.089 ± 0.042	1.628ThrPhe: 1.628 ± 0.031	6.977ThrGly: 6.977 ± 0.067	1.1ThrHis: 1.1 ± 0.024	1.959ThrIle: 1.959 ± 0.034	0.792ThrLys: 0.792 ± 0.022	5.447ThrLeu: 5.447 ± 0.049	1.018ThrMet: 1.018 ± 0.02	0.93ThrAsn: 0.93 ± 0.021	4.087ThrPro: 4.087 ± 0.047	1.14ThrGln: 1.14 ± 0.024	4.115ThrArg: 4.115 ± 0.041	3.165ThrSer: 3.165 ± 0.042	4.093ThrThr: 4.093 ± 0.058	6.373ThrVal: 6.373 ± 0.057	0.875ThrTrp: 0.875 ± 0.019	1.129ThrTyr: 1.129 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	13.315ValAla: 13.315 ± 0.103	0.743ValCys: 0.743 ± 0.019	6.605ValAsp: 6.605 ± 0.063	5.172ValGlu: 5.172 ± 0.055	2.412ValPhe: 2.412 ± 0.035	8.042ValGly: 8.042 ± 0.067	2.119ValHis: 2.119 ± 0.029	2.726ValIle: 2.726 ± 0.04	1.106ValLys: 1.106 ± 0.024	10.701ValLeu: 10.701 ± 0.09	1.268ValMet: 1.268 ± 0.023	1.481ValAsn: 1.481 ± 0.031	5.793ValPro: 5.793 ± 0.064	2.0ValGln: 2.0 ± 0.028	7.768ValArg: 7.768 ± 0.06	4.451ValSer: 4.451 ± 0.045	5.893ValThr: 5.893 ± 0.054	10.322ValVal: 10.322 ± 0.083	1.094ValTrp: 1.094 ± 0.023	1.365ValTyr: 1.365 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.64TrpAla: 1.64 ± 0.028	0.148TrpCys: 0.148 ± 0.009	0.833TrpAsp: 0.833 ± 0.022	0.7TrpGlu: 0.7 ± 0.021	0.555TrpPhe: 0.555 ± 0.015	1.05TrpGly: 1.05 ± 0.027	0.32TrpHis: 0.32 ± 0.012	0.547TrpIle: 0.547 ± 0.018	0.247TrpLys: 0.247 ± 0.011	1.609TrpLeu: 1.609 ± 0.03	0.292TrpMet: 0.292 ± 0.012	0.345TrpAsn: 0.345 ± 0.013	0.827TrpPro: 0.827 ± 0.018	0.448TrpGln: 0.448 ± 0.014	1.274TrpArg: 1.274 ± 0.026	0.965TrpSer: 0.965 ± 0.025	1.092TrpThr: 1.092 ± 0.025	1.099TrpVal: 1.099 ± 0.021	0.348TrpTrp: 0.348 ± 0.013	0.272TrpTyr: 0.272 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.234TyrAla: 2.234 ± 0.033	0.159TyrCys: 0.159 ± 0.008	1.266TyrAsp: 1.266 ± 0.024	0.915TyrGlu: 0.915 ± 0.02	0.516TyrPhe: 0.516 ± 0.016	1.937TyrGly: 1.937 ± 0.034	0.4TyrHis: 0.4 ± 0.014	0.379TyrIle: 0.379 ± 0.013	0.262TyrLys: 0.262 ± 0.012	1.998TyrLeu: 1.998 ± 0.034	0.235TyrMet: 0.235 ± 0.012	0.292TyrAsn: 0.292 ± 0.013	1.017TyrPro: 1.017 ± 0.024	0.459TyrGln: 0.459 ± 0.014	1.814TyrArg: 1.814 ± 0.03	0.875TyrSer: 0.875 ± 0.022	0.99TyrThr: 0.99 ± 0.021	1.507TyrVal: 1.507 ± 0.034	0.334TyrTrp: 0.334 ± 0.012	0.387TyrTyr: 0.387 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6902 proteins (2267065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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