Amino acid dipepetide frequency for Pseudolysobacter antarcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.999AlaAla: 15.999 ± 0.154	1.183AlaCys: 1.183 ± 0.036	6.598AlaAsp: 6.598 ± 0.082	6.11AlaGlu: 6.11 ± 0.092	3.827AlaPhe: 3.827 ± 0.061	9.264AlaGly: 9.264 ± 0.109	2.75AlaHis: 2.75 ± 0.05	6.399AlaIle: 6.399 ± 0.072	3.929AlaLys: 3.929 ± 0.068	14.077AlaLeu: 14.077 ± 0.17	2.863AlaMet: 2.863 ± 0.053	4.012AlaAsn: 4.012 ± 0.075	5.59AlaPro: 5.59 ± 0.086	5.393AlaGln: 5.393 ± 0.069	7.456AlaArg: 7.456 ± 0.098	7.319AlaSer: 7.319 ± 0.106	7.18AlaThr: 7.18 ± 0.15	7.679AlaVal: 7.679 ± 0.096	1.597AlaTrp: 1.597 ± 0.043	2.552AlaTyr: 2.552 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.304CysAla: 1.304 ± 0.037	0.12CysCys: 0.12 ± 0.01	0.548CysAsp: 0.548 ± 0.02	0.468CysGlu: 0.468 ± 0.018	0.317CysPhe: 0.317 ± 0.016	0.971CysGly: 0.971 ± 0.03	0.269CysHis: 0.269 ± 0.016	0.46CysIle: 0.46 ± 0.019	0.24CysLys: 0.24 ± 0.016	0.834CysLeu: 0.834 ± 0.02	0.179CysMet: 0.179 ± 0.012	0.306CysAsn: 0.306 ± 0.016	0.459CysPro: 0.459 ± 0.026	0.279CysGln: 0.279 ± 0.014	0.552CysArg: 0.552 ± 0.025	0.649CysSer: 0.649 ± 0.025	0.617CysThr: 0.617 ± 0.042	0.753CysVal: 0.753 ± 0.027	0.154CysTrp: 0.154 ± 0.017	0.243CysTyr: 0.243 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.222AspAla: 7.222 ± 0.09	0.478AspCys: 0.478 ± 0.02	2.975AspAsp: 2.975 ± 0.05	2.86AspGlu: 2.86 ± 0.058	2.308AspPhe: 2.308 ± 0.045	5.023AspGly: 5.023 ± 0.086	1.243AspHis: 1.243 ± 0.031	2.908AspIle: 2.908 ± 0.049	1.722AspLys: 1.722 ± 0.046	5.523AspLeu: 5.523 ± 0.087	1.018AspMet: 1.018 ± 0.033	1.711AspAsn: 1.711 ± 0.035	3.0AspPro: 3.0 ± 0.054	1.871AspGln: 1.871 ± 0.031	3.038AspArg: 3.038 ± 0.052	3.104AspSer: 3.104 ± 0.051	2.894AspThr: 2.894 ± 0.049	3.86AspVal: 3.86 ± 0.052	0.899AspTrp: 0.899 ± 0.026	1.674AspTyr: 1.674 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.81GluAla: 4.81 ± 0.075	0.383GluCys: 0.383 ± 0.017	1.909GluAsp: 1.909 ± 0.044	1.888GluGlu: 1.888 ± 0.049	2.005GluPhe: 2.005 ± 0.036	2.739GluGly: 2.739 ± 0.052	1.481GluHis: 1.481 ± 0.036	3.019GluIle: 3.019 ± 0.059	2.029GluLys: 2.029 ± 0.041	5.721GluLeu: 5.721 ± 0.091	1.098GluMet: 1.098 ± 0.03	1.731GluAsn: 1.731 ± 0.042	1.944GluPro: 1.944 ± 0.045	2.367GluGln: 2.367 ± 0.048	3.88GluArg: 3.88 ± 0.063	2.765GluSer: 2.765 ± 0.05	2.583GluThr: 2.583 ± 0.046	3.117GluVal: 3.117 ± 0.059	0.616GluTrp: 0.616 ± 0.022	1.074GluTyr: 1.074 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.992PheAla: 4.992 ± 0.071	0.456PheCys: 0.456 ± 0.016	2.679PheAsp: 2.679 ± 0.044	1.879PheGlu: 1.879 ± 0.03	1.442PhePhe: 1.442 ± 0.04	3.485PheGly: 3.485 ± 0.06	0.815PheHis: 0.815 ± 0.027	1.613PheIle: 1.613 ± 0.034	0.991PheLys: 0.991 ± 0.028	3.225PheLeu: 3.225 ± 0.053	0.649PheMet: 0.649 ± 0.02	1.329PheAsn: 1.329 ± 0.035	1.501PhePro: 1.501 ± 0.033	1.029PheGln: 1.029 ± 0.028	2.079PheArg: 2.079 ± 0.041	2.744PheSer: 2.744 ± 0.05	2.08PheThr: 2.08 ± 0.058	2.915PheVal: 2.915 ± 0.048	0.475PheTrp: 0.475 ± 0.02	1.003PheTyr: 1.003 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.737GlyAla: 8.737 ± 0.127	0.842GlyCys: 0.842 ± 0.026	4.218GlyAsp: 4.218 ± 0.058	3.773GlyGlu: 3.773 ± 0.056	3.379GlyPhe: 3.379 ± 0.053	6.966GlyGly: 6.966 ± 0.124	1.799GlyHis: 1.799 ± 0.036	4.601GlyIle: 4.601 ± 0.062	3.345GlyLys: 3.345 ± 0.064	7.687GlyLeu: 7.687 ± 0.089	1.94GlyMet: 1.94 ± 0.042	3.185GlyAsn: 3.185 ± 0.071	2.585GlyPro: 2.585 ± 0.05	2.71GlyGln: 2.71 ± 0.049	4.083GlyArg: 4.083 ± 0.06	5.384GlySer: 5.384 ± 0.106	4.85GlyThr: 4.85 ± 0.128	5.809GlyVal: 5.809 ± 0.079	1.317GlyTrp: 1.317 ± 0.04	2.4GlyTyr: 2.4 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.243HisAla: 3.243 ± 0.054	0.267HisCys: 0.267 ± 0.016	1.433HisAsp: 1.433 ± 0.037	1.269HisGlu: 1.269 ± 0.036	0.944HisPhe: 0.944 ± 0.029	2.137HisGly: 2.137 ± 0.047	0.608HisHis: 0.608 ± 0.026	1.087HisIle: 1.087 ± 0.031	0.54HisLys: 0.54 ± 0.019	2.314HisLeu: 2.314 ± 0.041	0.536HisMet: 0.536 ± 0.019	0.645HisAsn: 0.645 ± 0.02	1.306HisPro: 1.306 ± 0.032	0.712HisGln: 0.712 ± 0.022	1.377HisArg: 1.377 ± 0.034	1.26HisSer: 1.26 ± 0.032	1.21HisThr: 1.21 ± 0.036	1.678HisVal: 1.678 ± 0.033	0.411HisTrp: 0.411 ± 0.018	0.673HisTyr: 0.673 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.718IleAla: 7.718 ± 0.077	0.532IleCys: 0.532 ± 0.02	3.81IleAsp: 3.81 ± 0.056	3.439IleGlu: 3.439 ± 0.061	1.888IlePhe: 1.888 ± 0.04	4.931IleGly: 4.931 ± 0.075	1.027IleHis: 1.027 ± 0.028	1.968IleIle: 1.968 ± 0.044	1.683IleLys: 1.683 ± 0.035	4.049IleLeu: 4.049 ± 0.059	0.697IleMet: 0.697 ± 0.022	1.879IleAsn: 1.879 ± 0.044	2.309IlePro: 2.309 ± 0.053	1.379IleGln: 1.379 ± 0.032	2.714IleArg: 2.714 ± 0.049	3.507IleSer: 3.507 ± 0.052	3.305IleThr: 3.305 ± 0.056	4.082IleVal: 4.082 ± 0.069	0.587IleTrp: 0.587 ± 0.021	1.313IleTyr: 1.313 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.193LysAla: 3.193 ± 0.062	0.182LysCys: 0.182 ± 0.013	1.616LysAsp: 1.616 ± 0.044	1.223LysGlu: 1.223 ± 0.036	1.089LysPhe: 1.089 ± 0.032	1.814LysGly: 1.814 ± 0.042	0.806LysHis: 0.806 ± 0.024	1.852LysIle: 1.852 ± 0.042	1.344LysLys: 1.344 ± 0.044	3.757LysLeu: 3.757 ± 0.06	0.729LysMet: 0.729 ± 0.024	1.275LysAsn: 1.275 ± 0.034	2.132LysPro: 2.132 ± 0.046	1.317LysGln: 1.317 ± 0.038	2.253LysArg: 2.253 ± 0.042	2.086LysSer: 2.086 ± 0.052	2.041LysThr: 2.041 ± 0.038	2.177LysVal: 2.177 ± 0.05	0.279LysTrp: 0.279 ± 0.015	0.738LysTyr: 0.738 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.498LeuAla: 13.498 ± 0.15	1.107LeuCys: 1.107 ± 0.026	6.268LeuAsp: 6.268 ± 0.081	4.528LeuGlu: 4.528 ± 0.073	3.64LeuPhe: 3.64 ± 0.065	8.079LeuGly: 8.079 ± 0.095	2.62LeuHis: 2.62 ± 0.053	5.585LeuIle: 5.585 ± 0.069	3.52LeuLys: 3.52 ± 0.056	12.014LeuLeu: 12.014 ± 0.184	1.887LeuMet: 1.887 ± 0.04	3.258LeuAsn: 3.258 ± 0.06	6.075LeuPro: 6.075 ± 0.084	3.947LeuGln: 3.947 ± 0.069	7.599LeuArg: 7.599 ± 0.101	6.913LeuSer: 6.913 ± 0.083	5.614LeuThr: 5.614 ± 0.095	7.044LeuVal: 7.044 ± 0.087	1.315LeuTrp: 1.315 ± 0.039	2.252LeuTyr: 2.252 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.095MetAla: 2.095 ± 0.038	0.167MetCys: 0.167 ± 0.012	0.909MetAsp: 0.909 ± 0.025	0.684MetGlu: 0.684 ± 0.022	0.718MetPhe: 0.718 ± 0.024	1.197MetGly: 1.197 ± 0.032	0.577MetHis: 0.577 ± 0.021	1.066MetIle: 1.066 ± 0.031	0.764MetLys: 0.764 ± 0.026	2.571MetLeu: 2.571 ± 0.05	0.373MetMet: 0.373 ± 0.019	0.759MetAsn: 0.759 ± 0.025	1.287MetPro: 1.287 ± 0.029	1.074MetGln: 1.074 ± 0.029	1.704MetArg: 1.704 ± 0.04	1.532MetSer: 1.532 ± 0.034	1.244MetThr: 1.244 ± 0.029	1.193MetVal: 1.193 ± 0.031	0.192MetTrp: 0.192 ± 0.011	0.396MetTyr: 0.396 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.305AsnAla: 4.305 ± 0.073	0.341AsnCys: 0.341 ± 0.021	1.78AsnAsp: 1.78 ± 0.036	1.383AsnGlu: 1.383 ± 0.037	1.343AsnPhe: 1.343 ± 0.035	3.351AsnGly: 3.351 ± 0.086	0.67AsnHis: 0.67 ± 0.023	1.817AsnIle: 1.817 ± 0.038	0.872AsnLys: 0.872 ± 0.026	3.202AsnLeu: 3.202 ± 0.048	0.566AsnMet: 0.566 ± 0.02	1.452AsnAsn: 1.452 ± 0.05	2.086AsnPro: 2.086 ± 0.044	1.162AsnGln: 1.162 ± 0.028	1.769AsnArg: 1.769 ± 0.045	2.215AsnSer: 2.215 ± 0.057	2.331AsnThr: 2.331 ± 0.07	2.394AsnVal: 2.394 ± 0.048	0.466AsnTrp: 0.466 ± 0.021	1.087AsnTyr: 1.087 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.054ProAla: 6.054 ± 0.094	0.351ProCys: 0.351 ± 0.017	2.975ProAsp: 2.975 ± 0.052	2.591ProGlu: 2.591 ± 0.047	1.653ProPhe: 1.653 ± 0.028	3.897ProGly: 3.897 ± 0.067	1.073ProHis: 1.073 ± 0.031	2.483ProIle: 2.483 ± 0.047	1.498ProLys: 1.498 ± 0.039	4.987ProLeu: 4.987 ± 0.065	1.129ProMet: 1.129 ± 0.029	1.771ProAsn: 1.771 ± 0.056	2.406ProPro: 2.406 ± 0.065	2.089ProGln: 2.089 ± 0.04	2.581ProArg: 2.581 ± 0.052	3.014ProSer: 3.014 ± 0.062	2.847ProThr: 2.847 ± 0.053	3.52ProVal: 3.52 ± 0.06	0.673ProTrp: 0.673 ± 0.023	1.163ProTyr: 1.163 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.401GlnAla: 4.401 ± 0.065	0.291GlnCys: 0.291 ± 0.016	1.484GlnAsp: 1.484 ± 0.04	1.288GlnGlu: 1.288 ± 0.039	1.355GlnPhe: 1.355 ± 0.03	2.451GlnGly: 2.451 ± 0.046	1.093GlnHis: 1.093 ± 0.028	2.166GlnIle: 2.166 ± 0.038	1.198GlnLys: 1.198 ± 0.034	4.157GlnLeu: 4.157 ± 0.058	0.845GlnMet: 0.845 ± 0.026	1.313GlnAsn: 1.313 ± 0.03	1.989GlnPro: 1.989 ± 0.046	1.997GlnGln: 1.997 ± 0.046	3.471GlnArg: 3.471 ± 0.056	2.289GlnSer: 2.289 ± 0.046	2.177GlnThr: 2.177 ± 0.042	2.519GlnVal: 2.519 ± 0.045	0.498GlnTrp: 0.498 ± 0.021	0.896GlnTyr: 0.896 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.039ArgAla: 7.039 ± 0.09	0.657ArgCys: 0.657 ± 0.025	3.829ArgAsp: 3.829 ± 0.054	3.751ArgGlu: 3.751 ± 0.059	2.577ArgPhe: 2.577 ± 0.048	4.345ArgGly: 4.345 ± 0.064	1.586ArgHis: 1.586 ± 0.038	3.824ArgIle: 3.824 ± 0.062	1.926ArgLys: 1.926 ± 0.038	6.977ArgLeu: 6.977 ± 0.099	1.461ArgMet: 1.461 ± 0.033	2.042ArgAsn: 2.042 ± 0.042	2.336ArgPro: 2.336 ± 0.048	2.301ArgGln: 2.301 ± 0.048	4.426ArgArg: 4.426 ± 0.067	3.609ArgSer: 3.609 ± 0.064	2.813ArgThr: 2.813 ± 0.045	4.364ArgVal: 4.364 ± 0.074	1.105ArgTrp: 1.105 ± 0.031	2.082ArgTyr: 2.082 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	8.032SerAla: 8.032 ± 0.102	0.625SerCys: 0.625 ± 0.031	3.43SerAsp: 3.43 ± 0.053	2.79SerGlu: 2.79 ± 0.049	2.374SerPhe: 2.374 ± 0.051	6.382SerGly: 6.382 ± 0.115	1.329SerHis: 1.329 ± 0.032	3.26SerIle: 3.26 ± 0.063	1.867SerLys: 1.867 ± 0.037	6.192SerLeu: 6.192 ± 0.075	1.323SerMet: 1.323 ± 0.032	2.349SerAsn: 2.349 ± 0.06	2.859SerPro: 2.859 ± 0.047	1.92SerGln: 1.92 ± 0.033	3.358SerArg: 3.358 ± 0.052	4.256SerSer: 4.256 ± 0.068	3.741SerThr: 3.741 ± 0.069	4.608SerVal: 4.608 ± 0.075	0.853SerTrp: 0.853 ± 0.026	1.61SerTyr: 1.61 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.62ThrAla: 6.62 ± 0.142	0.613ThrCys: 0.613 ± 0.044	2.88ThrAsp: 2.88 ± 0.053	2.239ThrGlu: 2.239 ± 0.043	2.128ThrPhe: 2.128 ± 0.055	4.724ThrGly: 4.724 ± 0.123	1.371ThrHis: 1.371 ± 0.03	3.076ThrIle: 3.076 ± 0.089	1.301ThrLys: 1.301 ± 0.032	6.895ThrLeu: 6.895 ± 0.099	0.99ThrMet: 0.99 ± 0.028	1.875ThrAsn: 1.875 ± 0.068	3.709ThrPro: 3.709 ± 0.08	2.196ThrGln: 2.196 ± 0.034	3.392ThrArg: 3.392 ± 0.053	3.547ThrSer: 3.547 ± 0.077	3.719ThrThr: 3.719 ± 0.115	4.19ThrVal: 4.19 ± 0.105	0.715ThrTrp: 0.715 ± 0.029	1.3ThrTyr: 1.3 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.373ValAla: 8.373 ± 0.086	0.712ValCys: 0.712 ± 0.025	3.937ValAsp: 3.937 ± 0.062	3.43ValGlu: 3.43 ± 0.059	2.68ValPhe: 2.68 ± 0.049	5.004ValGly: 5.004 ± 0.077	1.545ValHis: 1.545 ± 0.032	3.861ValIle: 3.861 ± 0.061	2.013ValLys: 2.013 ± 0.049	7.909ValLeu: 7.909 ± 0.088	1.489ValMet: 1.489 ± 0.032	2.309ValAsn: 2.309 ± 0.052	3.371ValPro: 3.371 ± 0.058	2.412ValGln: 2.412 ± 0.046	4.184ValArg: 4.184 ± 0.055	4.504ValSer: 4.504 ± 0.072	4.149ValThr: 4.149 ± 0.109	5.277ValVal: 5.277 ± 0.071	0.845ValTrp: 0.845 ± 0.028	1.663ValTyr: 1.663 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.042TrpAla: 1.042 ± 0.032	0.161TrpCys: 0.161 ± 0.011	0.563TrpAsp: 0.563 ± 0.02	0.458TrpGlu: 0.458 ± 0.02	0.564TrpPhe: 0.564 ± 0.024	0.813TrpGly: 0.813 ± 0.031	0.4TrpHis: 0.4 ± 0.017	0.799TrpIle: 0.799 ± 0.027	0.434TrpLys: 0.434 ± 0.019	1.992TrpLeu: 1.992 ± 0.05	0.318TrpMet: 0.318 ± 0.015	0.544TrpAsn: 0.544 ± 0.019	0.592TrpPro: 0.592 ± 0.023	0.778TrpGln: 0.778 ± 0.026	1.206TrpArg: 1.206 ± 0.035	0.92TrpSer: 0.92 ± 0.027	0.676TrpThr: 0.676 ± 0.028	0.788TrpVal: 0.788 ± 0.025	0.256TrpTrp: 0.256 ± 0.016	0.345TrpTyr: 0.345 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.099TyrAla: 3.099 ± 0.055	0.251TyrCys: 0.251 ± 0.014	1.492TyrAsp: 1.492 ± 0.045	1.111TyrGlu: 1.111 ± 0.026	1.149TyrPhe: 1.149 ± 0.029	2.032TyrGly: 2.032 ± 0.044	0.584TyrHis: 0.584 ± 0.026	0.976TyrIle: 0.976 ± 0.028	0.688TyrLys: 0.688 ± 0.025	2.68TyrLeu: 2.68 ± 0.047	0.412TyrMet: 0.412 ± 0.018	0.848TyrAsn: 0.848 ± 0.032	1.218TyrPro: 1.218 ± 0.031	0.946TyrGln: 0.946 ± 0.03	1.93TyrArg: 1.93 ± 0.041	1.543TyrSer: 1.543 ± 0.036	1.409TyrThr: 1.409 ± 0.04	1.701TyrVal: 1.701 ± 0.04	0.395TyrTrp: 0.395 ± 0.017	0.683TyrTyr: 0.683 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3894 proteins (1372272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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