Amino acid dipepetide frequency for Trifolium-associated circular DNA virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.836AlaAla: 6.836 ± 2.58
0.0AlaCys: 0.0 ± 0.0
9.766AlaAsp: 9.766 ± 2.024
1.953AlaGlu: 1.953 ± 0.607
1.953AlaPhe: 1.953 ± 0.607
6.836AlaGly: 6.836 ± 2.459
0.0AlaHis: 0.0 ± 0.0
1.953AlaIle: 1.953 ± 1.376
7.812AlaLys: 7.812 ± 2.476
5.859AlaLeu: 5.859 ± 2.22
0.0AlaMet: 0.0 ± 0.0
1.953AlaAsn: 1.953 ± 1.376
1.953AlaPro: 1.953 ± 1.376
1.953AlaGln: 1.953 ± 0.607
4.883AlaArg: 4.883 ± 2.501
5.859AlaSer: 5.859 ± 1.779
7.812AlaThr: 7.812 ± 1.88
7.812AlaVal: 7.812 ± 4.142
1.953AlaTrp: 1.953 ± 1.66
1.953AlaTyr: 1.953 ± 1.376
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.977CysCys: 0.977 ± 0.83
0.977CysAsp: 0.977 ± 1.015
1.953CysGlu: 1.953 ± 1.055
1.953CysPhe: 1.953 ± 1.055
0.977CysGly: 0.977 ± 0.83
0.0CysHis: 0.0 ± 0.0
2.93CysIle: 2.93 ± 1.603
0.977CysLys: 0.977 ± 0.688
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
3.906CysArg: 3.906 ± 2.325
0.977CysSer: 0.977 ± 1.015
2.93CysThr: 2.93 ± 1.281
0.977CysVal: 0.977 ± 0.688
0.0CysTrp: 0.0 ± 0.0
1.953CysTyr: 1.953 ± 1.055
0.0CysXaa: 0.0 ± 0.0
Asp
4.883AspAla: 4.883 ± 1.825
1.953AspCys: 1.953 ± 0.607
4.883AspAsp: 4.883 ± 1.706
4.883AspGlu: 4.883 ± 2.584
0.977AspPhe: 0.977 ± 0.83
1.953AspGly: 1.953 ± 0.607
0.0AspHis: 0.0 ± 0.0
4.883AspIle: 4.883 ± 1.247
1.953AspLys: 1.953 ± 1.376
4.883AspLeu: 4.883 ± 3.101
0.0AspMet: 0.0 ± 0.0
2.93AspAsn: 2.93 ± 2.489
3.906AspPro: 3.906 ± 1.214
4.883AspGln: 4.883 ± 2.463
1.953AspArg: 1.953 ± 2.031
3.906AspSer: 3.906 ± 2.854
5.859AspThr: 5.859 ± 2.646
3.906AspVal: 3.906 ± 1.214
0.977AspTrp: 0.977 ± 0.688
1.953AspTyr: 1.953 ± 1.055
0.0AspXaa: 0.0 ± 0.0
Glu
0.977GluAla: 0.977 ± 0.83
0.0GluCys: 0.0 ± 0.0
1.953GluAsp: 1.953 ± 1.055
1.953GluGlu: 1.953 ± 1.055
0.977GluPhe: 0.977 ± 0.83
1.953GluGly: 1.953 ± 1.055
3.906GluHis: 3.906 ± 2.109
1.953GluIle: 1.953 ± 1.66
0.977GluLys: 0.977 ± 0.83
2.93GluLeu: 2.93 ± 2.489
0.0GluMet: 0.0 ± 0.0
0.977GluAsn: 0.977 ± 0.83
4.883GluPro: 4.883 ± 2.897
0.977GluGln: 0.977 ± 1.015
6.836GluArg: 6.836 ± 0.652
0.0GluSer: 0.0 ± 0.0
0.977GluThr: 0.977 ± 0.688
4.883GluVal: 4.883 ± 1.247
0.0GluTrp: 0.0 ± 0.0
1.953GluTyr: 1.953 ± 2.031
0.0GluXaa: 0.0 ± 0.0
Phe
5.859PheAla: 5.859 ± 3.704
1.953PheCys: 1.953 ± 0.607
4.883PheAsp: 4.883 ± 1.825
0.0PheGlu: 0.0 ± 0.0
0.977PhePhe: 0.977 ± 0.83
1.953PheGly: 1.953 ± 1.055
0.977PheHis: 0.977 ± 0.688
1.953PheIle: 1.953 ± 0.607
2.93PheLys: 2.93 ± 0.998
0.977PheLeu: 0.977 ± 0.83
0.977PheMet: 0.977 ± 0.83
0.977PheAsn: 0.977 ± 0.688
0.0PhePro: 0.0 ± 0.0
0.0PheGln: 0.0 ± 0.0
0.977PheArg: 0.977 ± 0.83
2.93PheSer: 2.93 ± 1.323
5.859PheThr: 5.859 ± 1.821
0.977PheVal: 0.977 ± 0.688
0.977PheTrp: 0.977 ± 0.83
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
7.812GlyAla: 7.812 ± 4.486
2.93GlyCys: 2.93 ± 1.897
2.93GlyAsp: 2.93 ± 0.453
3.906GlyGlu: 3.906 ± 1.916
3.906GlyPhe: 3.906 ± 1.603
11.719GlyGly: 11.719 ± 4.941
1.953GlyHis: 1.953 ± 2.031
1.953GlyIle: 1.953 ± 0.607
6.836GlyLys: 6.836 ± 4.528
4.883GlyLeu: 4.883 ± 2.205
1.953GlyMet: 1.953 ± 1.376
2.93GlyAsn: 2.93 ± 0.998
2.93GlyPro: 2.93 ± 0.453
0.977GlyGln: 0.977 ± 1.015
5.859GlyArg: 5.859 ± 2.22
7.812GlySer: 7.812 ± 3.831
5.859GlyThr: 5.859 ± 1.779
3.906GlyVal: 3.906 ± 1.603
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.977HisAla: 0.977 ± 0.83
0.977HisCys: 0.977 ± 0.83
2.93HisAsp: 2.93 ± 1.603
0.0HisGlu: 0.0 ± 0.0
0.977HisPhe: 0.977 ± 0.83
0.0HisGly: 0.0 ± 0.0
3.906HisHis: 3.906 ± 1.879
0.977HisIle: 0.977 ± 0.83
0.977HisLys: 0.977 ± 0.83
0.0HisLeu: 0.0 ± 0.0
1.953HisMet: 1.953 ± 1.397
0.977HisAsn: 0.977 ± 1.015
2.93HisPro: 2.93 ± 1.897
1.953HisGln: 1.953 ± 1.055
0.0HisArg: 0.0 ± 0.0
4.883HisSer: 4.883 ± 2.463
0.977HisThr: 0.977 ± 1.015
4.883HisVal: 4.883 ± 1.247
0.0HisTrp: 0.0 ± 0.0
0.977HisTyr: 0.977 ± 0.688
0.0HisXaa: 0.0 ± 0.0
Ile
3.906IleAla: 3.906 ± 1.214
0.977IleCys: 0.977 ± 1.015
3.906IleAsp: 3.906 ± 2.071
1.953IleGlu: 1.953 ± 1.66
0.977IlePhe: 0.977 ± 0.83
4.883IleGly: 4.883 ± 3.441
2.93IleHis: 2.93 ± 1.603
1.953IleIle: 1.953 ± 1.66
0.0IleLys: 0.0 ± 0.0
3.906IleLeu: 3.906 ± 1.45
0.0IleMet: 0.0 ± 0.0
5.859IleAsn: 5.859 ± 2.516
3.906IlePro: 3.906 ± 1.603
0.0IleGln: 0.0 ± 0.0
2.93IleArg: 2.93 ± 0.998
0.0IleSer: 0.0 ± 0.0
3.906IleThr: 3.906 ± 2.752
0.977IleVal: 0.977 ± 0.83
0.0IleTrp: 0.0 ± 0.0
0.977IleTyr: 0.977 ± 0.688
0.0IleXaa: 0.0 ± 0.0
Lys
0.977LysAla: 0.977 ± 0.688
0.977LysCys: 0.977 ± 0.83
0.977LysAsp: 0.977 ± 1.015
0.0LysGlu: 0.0 ± 0.0
2.93LysPhe: 2.93 ± 1.281
3.906LysGly: 3.906 ± 2.071
0.0LysHis: 0.0 ± 0.0
2.93LysIle: 2.93 ± 1.281
4.883LysLys: 4.883 ± 4.149
5.859LysLeu: 5.859 ± 1.995
0.0LysMet: 0.0 ± 0.0
0.977LysAsn: 0.977 ± 0.83
0.0LysPro: 0.0 ± 0.0
0.977LysGln: 0.977 ± 0.688
5.859LysArg: 5.859 ± 4.129
3.906LysSer: 3.906 ± 1.214
4.883LysThr: 4.883 ± 1.501
0.977LysVal: 0.977 ± 0.688
0.977LysTrp: 0.977 ± 0.83
1.953LysTyr: 1.953 ± 0.607
0.0LysXaa: 0.0 ± 0.0
Leu
3.906LeuAla: 3.906 ± 2.752
0.977LeuCys: 0.977 ± 1.015
4.883LeuAsp: 4.883 ± 1.501
3.906LeuGlu: 3.906 ± 2.827
2.93LeuPhe: 2.93 ± 1.603
3.906LeuGly: 3.906 ± 1.214
2.93LeuHis: 2.93 ± 1.281
1.953LeuIle: 1.953 ± 0.607
0.0LeuLys: 0.0 ± 0.0
3.906LeuLeu: 3.906 ± 1.214
0.0LeuMet: 0.0 ± 0.748
2.93LeuAsn: 2.93 ± 1.281
4.883LeuPro: 4.883 ± 0.34
2.93LeuGln: 2.93 ± 3.046
6.836LeuArg: 6.836 ± 1.208
2.93LeuSer: 2.93 ± 0.998
1.953LeuThr: 1.953 ± 0.607
3.906LeuVal: 3.906 ± 1.45
0.977LeuTrp: 0.977 ± 0.83
5.859LeuTyr: 5.859 ± 0.555
0.0LeuXaa: 0.0 ± 0.0
Met
2.93MetAla: 2.93 ± 1.323
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.977MetGlu: 0.977 ± 0.83
0.977MetPhe: 0.977 ± 0.688
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.977MetIle: 0.977 ± 0.688
0.977MetLys: 0.977 ± 0.688
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.977MetArg: 0.977 ± 0.688
2.93MetSer: 2.93 ± 0.998
0.977MetThr: 0.977 ± 0.688
1.953MetVal: 1.953 ± 1.66
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.906AsnAla: 3.906 ± 0.932
2.93AsnCys: 2.93 ± 1.281
1.953AsnAsp: 1.953 ± 1.055
0.977AsnGlu: 0.977 ± 0.83
2.93AsnPhe: 2.93 ± 0.998
2.93AsnGly: 2.93 ± 1.85
0.977AsnHis: 0.977 ± 0.83
3.906AsnIle: 3.906 ± 1.214
2.93AsnLys: 2.93 ± 0.998
1.953AsnLeu: 1.953 ± 0.607
1.953AsnMet: 1.953 ± 1.376
4.883AsnAsn: 4.883 ± 3.441
2.93AsnPro: 2.93 ± 0.453
4.883AsnGln: 4.883 ± 2.256
0.0AsnArg: 0.0 ± 0.0
1.953AsnSer: 1.953 ± 1.376
4.883AsnThr: 4.883 ± 2.256
1.953AsnVal: 1.953 ± 1.66
0.0AsnTrp: 0.0 ± 0.0
2.93AsnTyr: 2.93 ± 2.489
0.0AsnXaa: 0.0 ± 0.0
Pro
1.953ProAla: 1.953 ± 0.958
0.977ProCys: 0.977 ± 1.015
2.93ProAsp: 2.93 ± 0.998
3.906ProGlu: 3.906 ± 2.325
0.977ProPhe: 0.977 ± 0.688
2.93ProGly: 2.93 ± 1.85
0.977ProHis: 0.977 ± 0.83
0.977ProIle: 0.977 ± 0.688
2.93ProLys: 2.93 ± 2.489
3.906ProLeu: 3.906 ± 0.932
0.977ProMet: 0.977 ± 0.83
3.906ProAsn: 3.906 ± 0.494
3.906ProPro: 3.906 ± 2.827
1.953ProGln: 1.953 ± 0.958
2.93ProArg: 2.93 ± 0.998
2.93ProSer: 2.93 ± 1.897
5.859ProThr: 5.859 ± 0.555
1.953ProVal: 1.953 ± 1.055
0.977ProTrp: 0.977 ± 1.015
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
4.883GlnAla: 4.883 ± 1.109
0.977GlnCys: 0.977 ± 0.83
3.906GlnAsp: 3.906 ± 1.45
0.0GlnGlu: 0.0 ± 0.0
2.93GlnPhe: 2.93 ± 0.998
0.977GlnGly: 0.977 ± 0.688
4.883GlnHis: 4.883 ± 2.463
1.953GlnIle: 1.953 ± 0.607
0.0GlnLys: 0.0 ± 0.0
6.836GlnLeu: 6.836 ± 2.177
0.977GlnMet: 0.977 ± 0.688
0.0GlnAsn: 0.0 ± 0.0
0.0GlnPro: 0.0 ± 0.0
3.906GlnGln: 3.906 ± 4.062
4.883GlnArg: 4.883 ± 2.463
6.836GlnSer: 6.836 ± 3.22
2.93GlnThr: 2.93 ± 1.323
1.953GlnVal: 1.953 ± 0.607
1.953GlnTrp: 1.953 ± 1.055
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.883ArgAla: 4.883 ± 1.501
0.0ArgCys: 0.0 ± 0.0
2.93ArgAsp: 2.93 ± 1.897
2.93ArgGlu: 2.93 ± 0.453
3.906ArgPhe: 3.906 ± 3.319
8.789ArgGly: 8.789 ± 3.124
0.977ArgHis: 0.977 ± 1.015
0.977ArgIle: 0.977 ± 0.688
2.93ArgLys: 2.93 ± 2.064
3.906ArgLeu: 3.906 ± 2.109
0.977ArgMet: 0.977 ± 0.688
4.883ArgAsn: 4.883 ± 2.256
3.906ArgPro: 3.906 ± 0.494
6.836ArgGln: 6.836 ± 1.894
6.836ArgArg: 6.836 ± 2.58
6.836ArgSer: 6.836 ± 2.177
3.906ArgThr: 3.906 ± 0.494
3.906ArgVal: 3.906 ± 2.752
2.93ArgTrp: 2.93 ± 0.453
0.977ArgTyr: 0.977 ± 1.015
0.0ArgXaa: 0.0 ± 0.0
Ser
5.859SerAla: 5.859 ± 0.555
1.953SerCys: 1.953 ± 2.031
2.93SerAsp: 2.93 ± 1.897
0.977SerGlu: 0.977 ± 1.015
2.93SerPhe: 2.93 ± 0.998
10.742SerGly: 10.742 ± 4.822
0.0SerHis: 0.0 ± 0.0
3.906SerIle: 3.906 ± 0.494
0.977SerLys: 0.977 ± 0.688
0.977SerLeu: 0.977 ± 0.688
0.0SerMet: 0.0 ± 0.0
4.883SerAsn: 4.883 ± 1.109
3.906SerPro: 3.906 ± 1.45
9.766SerGln: 9.766 ± 2.341
3.906SerArg: 3.906 ± 1.45
7.812SerSer: 7.812 ± 2.365
4.883SerThr: 4.883 ± 1.247
5.859SerVal: 5.859 ± 0.555
0.977SerTrp: 0.977 ± 0.83
0.977SerTyr: 0.977 ± 1.015
0.0SerXaa: 0.0 ± 0.0
Thr
6.836ThrAla: 6.836 ± 1.817
0.977ThrCys: 0.977 ± 0.83
0.977ThrAsp: 0.977 ± 0.688
1.953ThrGlu: 1.953 ± 1.055
0.977ThrPhe: 0.977 ± 0.688
10.742ThrGly: 10.742 ± 2.311
0.977ThrHis: 0.977 ± 0.83
3.906ThrIle: 3.906 ± 1.603
2.93ThrLys: 2.93 ± 2.064
4.883ThrLeu: 4.883 ± 1.109
0.977ThrMet: 0.977 ± 0.688
6.836ThrAsn: 6.836 ± 1.203
3.906ThrPro: 3.906 ± 0.932
5.859ThrGln: 5.859 ± 2.925
3.906ThrArg: 3.906 ± 1.879
1.953ThrSer: 1.953 ± 1.376
8.789ThrThr: 8.789 ± 0.177
5.859ThrVal: 5.859 ± 1.995
0.977ThrTrp: 0.977 ± 0.83
4.883ThrTyr: 4.883 ± 1.501
0.0ThrXaa: 0.0 ± 0.0
Val
7.812ValAla: 7.812 ± 2.476
0.0ValCys: 0.0 ± 0.0
2.93ValAsp: 2.93 ± 0.998
4.883ValGlu: 4.883 ± 1.706
1.953ValPhe: 1.953 ± 0.607
4.883ValGly: 4.883 ± 1.47
2.93ValHis: 2.93 ± 0.453
0.0ValIle: 0.0 ± 0.0
0.0ValLys: 0.0 ± 0.0
5.859ValLeu: 5.859 ± 1.821
1.953ValMet: 1.953 ± 1.178
3.906ValAsn: 3.906 ± 1.214
0.977ValPro: 0.977 ± 1.015
0.977ValGln: 0.977 ± 0.688
5.859ValArg: 5.859 ± 0.905
3.906ValSer: 3.906 ± 0.932
4.883ValThr: 4.883 ± 2.256
6.836ValVal: 6.836 ± 2.061
1.953ValTrp: 1.953 ± 1.66
0.977ValTyr: 0.977 ± 0.688
0.0ValXaa: 0.0 ± 0.0
Trp
0.977TrpAla: 0.977 ± 0.83
0.977TrpCys: 0.977 ± 0.83
0.0TrpAsp: 0.0 ± 0.0
0.977TrpGlu: 0.977 ± 1.015
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.977TrpHis: 0.977 ± 1.015
2.93TrpIle: 2.93 ± 1.603
0.977TrpLys: 0.977 ± 0.83
0.977TrpLeu: 0.977 ± 0.688
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.953TrpPro: 1.953 ± 1.66
0.0TrpGln: 0.0 ± 0.0
2.93TrpArg: 2.93 ± 1.281
0.977TrpSer: 0.977 ± 0.83
0.977TrpThr: 0.977 ± 0.83
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.93TyrAla: 2.93 ± 1.323
0.977TyrCys: 0.977 ± 0.83
4.883TyrAsp: 4.883 ± 1.247
0.977TyrGlu: 0.977 ± 0.83
0.0TyrPhe: 0.0 ± 0.0
0.977TyrGly: 0.977 ± 0.688
1.953TyrHis: 1.953 ± 1.66
0.977TyrIle: 0.977 ± 0.688
1.953TyrLys: 1.953 ± 0.958
0.977TyrLeu: 0.977 ± 0.688
0.0TyrMet: 0.0 ± 0.0
1.953TyrAsn: 1.953 ± 0.607
0.977TyrPro: 0.977 ± 0.83
1.953TyrGln: 1.953 ± 1.055
1.953TyrArg: 1.953 ± 0.958
4.883TyrSer: 4.883 ± 0.34
0.0TyrThr: 0.0 ± 0.0
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
0.977TyrTyr: 0.977 ± 1.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1025 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski