Amino acid dipepetide frequency for Ramlibacter rhizophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.242AlaAla: 19.242 ± 0.188
1.557AlaCys: 1.557 ± 0.039
6.327AlaAsp: 6.327 ± 0.068
6.907AlaGlu: 6.907 ± 0.089
4.204AlaPhe: 4.204 ± 0.063
11.958AlaGly: 11.958 ± 0.13
2.845AlaHis: 2.845 ± 0.052
4.68AlaIle: 4.68 ± 0.061
2.983AlaLys: 2.983 ± 0.067
15.606AlaLeu: 15.606 ± 0.154
3.39AlaMet: 3.39 ± 0.054
2.36AlaAsn: 2.36 ± 0.044
7.206AlaPro: 7.206 ± 0.102
6.438AlaGln: 6.438 ± 0.071
11.351AlaArg: 11.351 ± 0.114
6.991AlaSer: 6.991 ± 0.074
5.842AlaThr: 5.842 ± 0.065
9.488AlaVal: 9.488 ± 0.093
2.292AlaTrp: 2.292 ± 0.052
2.299AlaTyr: 2.299 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.251CysAla: 1.251 ± 0.032
0.121CysCys: 0.121 ± 0.01
0.521CysAsp: 0.521 ± 0.019
0.612CysGlu: 0.612 ± 0.022
0.284CysPhe: 0.284 ± 0.014
1.061CysGly: 1.061 ± 0.029
0.27CysHis: 0.27 ± 0.016
0.428CysIle: 0.428 ± 0.018
0.194CysLys: 0.194 ± 0.011
0.884CysLeu: 0.884 ± 0.027
0.187CysMet: 0.187 ± 0.011
0.212CysAsn: 0.212 ± 0.012
0.51CysPro: 0.51 ± 0.022
0.248CysGln: 0.248 ± 0.014
0.7CysArg: 0.7 ± 0.027
0.469CysSer: 0.469 ± 0.019
0.489CysThr: 0.489 ± 0.021
0.753CysVal: 0.753 ± 0.023
0.133CysTrp: 0.133 ± 0.01
0.171CysTyr: 0.171 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.19AspAla: 7.19 ± 0.082
0.475AspCys: 0.475 ± 0.018
2.256AspAsp: 2.256 ± 0.055
3.235AspGlu: 3.235 ± 0.055
1.995AspPhe: 1.995 ± 0.047
4.367AspGly: 4.367 ± 0.07
1.082AspHis: 1.082 ± 0.027
2.178AspIle: 2.178 ± 0.044
1.42AspLys: 1.42 ± 0.04
5.375AspLeu: 5.375 ± 0.064
1.122AspMet: 1.122 ± 0.03
1.012AspAsn: 1.012 ± 0.033
3.148AspPro: 3.148 ± 0.05
1.418AspGln: 1.418 ± 0.035
3.658AspArg: 3.658 ± 0.054
2.068AspSer: 2.068 ± 0.037
2.396AspThr: 2.396 ± 0.037
3.816AspVal: 3.816 ± 0.053
1.015AspTrp: 1.015 ± 0.028
1.253AspTyr: 1.253 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.946GluAla: 7.946 ± 0.086
0.456GluCys: 0.456 ± 0.018
2.539GluAsp: 2.539 ± 0.048
2.726GluGlu: 2.726 ± 0.049
1.835GluPhe: 1.835 ± 0.032
4.365GluGly: 4.365 ± 0.064
1.459GluHis: 1.459 ± 0.036
2.391GluIle: 2.391 ± 0.049
1.463GluLys: 1.463 ± 0.037
6.524GluLeu: 6.524 ± 0.074
1.223GluMet: 1.223 ± 0.031
1.107GluAsn: 1.107 ± 0.028
3.128GluPro: 3.128 ± 0.054
2.704GluGln: 2.704 ± 0.044
5.598GluArg: 5.598 ± 0.072
2.541GluSer: 2.541 ± 0.049
2.318GluThr: 2.318 ± 0.035
4.388GluVal: 4.388 ± 0.065
0.796GluTrp: 0.796 ± 0.027
0.908GluTyr: 0.908 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.222PheAla: 4.222 ± 0.062
0.389PheCys: 0.389 ± 0.015
2.341PheAsp: 2.341 ± 0.044
2.225PheGlu: 2.225 ± 0.044
1.276PhePhe: 1.276 ± 0.035
3.248PheGly: 3.248 ± 0.059
0.77PheHis: 0.77 ± 0.024
1.337PheIle: 1.337 ± 0.036
0.916PheLys: 0.916 ± 0.028
2.985PheLeu: 2.985 ± 0.054
0.783PheMet: 0.783 ± 0.029
0.908PheAsn: 0.908 ± 0.026
1.541PhePro: 1.541 ± 0.035
1.041PheGln: 1.041 ± 0.028
2.102PheArg: 2.102 ± 0.04
1.873PheSer: 1.873 ± 0.035
1.876PheThr: 1.876 ± 0.039
2.703PheVal: 2.703 ± 0.047
0.513PheTrp: 0.513 ± 0.02
0.783PheTyr: 0.783 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.931GlyAla: 9.931 ± 0.101
0.933GlyCys: 0.933 ± 0.027
3.894GlyAsp: 3.894 ± 0.055
5.027GlyGlu: 5.027 ± 0.065
3.26GlyPhe: 3.26 ± 0.053
7.488GlyGly: 7.488 ± 0.112
2.091GlyHis: 2.091 ± 0.043
3.745GlyIle: 3.745 ± 0.056
2.665GlyLys: 2.665 ± 0.06
9.398GlyLeu: 9.398 ± 0.091
2.273GlyMet: 2.273 ± 0.041
1.842GlyAsn: 1.842 ± 0.038
3.824GlyPro: 3.824 ± 0.066
3.487GlyGln: 3.487 ± 0.056
6.734GlyArg: 6.734 ± 0.082
4.638GlySer: 4.638 ± 0.071
4.461GlyThr: 4.461 ± 0.072
6.589GlyVal: 6.589 ± 0.078
1.58GlyTrp: 1.58 ± 0.035
2.061GlyTyr: 2.061 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
3.117HisAla: 3.117 ± 0.056
0.283HisCys: 0.283 ± 0.013
1.126HisAsp: 1.126 ± 0.034
1.408HisGlu: 1.408 ± 0.036
0.843HisPhe: 0.843 ± 0.024
2.234HisGly: 2.234 ± 0.041
0.612HisHis: 0.612 ± 0.023
0.806HisIle: 0.806 ± 0.024
0.463HisLys: 0.463 ± 0.019
2.427HisLeu: 2.427 ± 0.035
0.472HisMet: 0.472 ± 0.018
0.447HisAsn: 0.447 ± 0.018
1.652HisPro: 1.652 ± 0.037
0.707HisGln: 0.707 ± 0.024
1.738HisArg: 1.738 ± 0.04
0.96HisSer: 0.96 ± 0.027
1.017HisThr: 1.017 ± 0.026
1.71HisVal: 1.71 ± 0.036
0.444HisTrp: 0.444 ± 0.017
0.59HisTyr: 0.59 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.671IleAla: 5.671 ± 0.062
0.349IleCys: 0.349 ± 0.013
2.731IleAsp: 2.731 ± 0.047
2.985IleGlu: 2.985 ± 0.053
1.083IlePhe: 1.083 ± 0.034
3.696IleGly: 3.696 ± 0.062
0.754IleHis: 0.754 ± 0.025
1.142IleIle: 1.142 ± 0.039
1.061IleLys: 1.061 ± 0.032
2.871IleLeu: 2.871 ± 0.054
0.672IleMet: 0.672 ± 0.023
1.025IleAsn: 1.025 ± 0.029
1.844IlePro: 1.844 ± 0.035
1.078IleGln: 1.078 ± 0.028
2.59IleArg: 2.59 ± 0.045
1.887IleSer: 1.887 ± 0.039
2.131IleThr: 2.131 ± 0.033
3.229IleVal: 3.229 ± 0.05
0.354IleTrp: 0.354 ± 0.017
0.789IleTyr: 0.789 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
3.341LysAla: 3.341 ± 0.062
0.128LysCys: 0.128 ± 0.011
1.375LysAsp: 1.375 ± 0.041
1.236LysGlu: 1.236 ± 0.034
0.738LysPhe: 0.738 ± 0.024
2.003LysGly: 2.003 ± 0.043
0.55LysHis: 0.55 ± 0.02
1.06LysIle: 1.06 ± 0.031
0.952LysLys: 0.952 ± 0.044
2.933LysLeu: 2.933 ± 0.054
0.611LysMet: 0.611 ± 0.024
0.639LysAsn: 0.639 ± 0.025
1.745LysPro: 1.745 ± 0.041
0.948LysGln: 0.948 ± 0.027
1.868LysArg: 1.868 ± 0.038
1.354LysSer: 1.354 ± 0.032
1.368LysThr: 1.368 ± 0.034
2.133LysVal: 2.133 ± 0.054
0.262LysTrp: 0.262 ± 0.015
0.522LysTyr: 0.522 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.505LeuAla: 16.505 ± 0.177
1.029LeuCys: 1.029 ± 0.026
5.921LeuAsp: 5.921 ± 0.066
5.64LeuGlu: 5.64 ± 0.064
3.251LeuPhe: 3.251 ± 0.055
9.213LeuGly: 9.213 ± 0.108
2.521LeuHis: 2.521 ± 0.046
3.514LeuIle: 3.514 ± 0.062
2.882LeuLys: 2.882 ± 0.055
11.806LeuLeu: 11.806 ± 0.134
2.496LeuMet: 2.496 ± 0.045
2.239LeuAsn: 2.239 ± 0.047
6.505LeuPro: 6.505 ± 0.091
4.54LeuGln: 4.54 ± 0.062
9.337LeuArg: 9.337 ± 0.101
5.858LeuSer: 5.858 ± 0.075
4.754LeuThr: 4.754 ± 0.063
8.781LeuVal: 8.781 ± 0.105
1.421LeuTrp: 1.421 ± 0.038
1.919LeuTyr: 1.919 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.011MetAla: 3.011 ± 0.049
0.161MetCys: 0.161 ± 0.011
1.18MetAsp: 1.18 ± 0.029
1.061MetGlu: 1.061 ± 0.029
0.656MetPhe: 0.656 ± 0.023
1.804MetGly: 1.804 ± 0.036
0.563MetHis: 0.563 ± 0.02
0.797MetIle: 0.797 ± 0.022
0.909MetLys: 0.909 ± 0.027
2.487MetLeu: 2.487 ± 0.05
0.512MetMet: 0.512 ± 0.021
0.852MetAsn: 0.852 ± 0.024
1.524MetPro: 1.524 ± 0.033
1.005MetGln: 1.005 ± 0.024
1.793MetArg: 1.793 ± 0.04
1.473MetSer: 1.473 ± 0.03
1.308MetThr: 1.308 ± 0.031
1.642MetVal: 1.642 ± 0.035
0.18MetTrp: 0.18 ± 0.01
0.346MetTyr: 0.346 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.855AsnAla: 2.855 ± 0.046
0.227AsnCys: 0.227 ± 0.013
1.081AsnAsp: 1.081 ± 0.028
1.066AsnGlu: 1.066 ± 0.028
0.799AsnPhe: 0.799 ± 0.027
1.716AsnGly: 1.716 ± 0.04
0.437AsnHis: 0.437 ± 0.018
0.989AsnIle: 0.989 ± 0.034
0.63AsnLys: 0.63 ± 0.023
2.277AsnLeu: 2.277 ± 0.046
0.469AsnMet: 0.469 ± 0.019
0.575AsnAsn: 0.575 ± 0.022
1.61AsnPro: 1.61 ± 0.033
0.684AsnGln: 0.684 ± 0.023
1.526AsnArg: 1.526 ± 0.034
0.931AsnSer: 0.931 ± 0.031
1.081AsnThr: 1.081 ± 0.035
1.714AsnVal: 1.714 ± 0.044
0.344AsnTrp: 0.344 ± 0.016
0.526AsnTyr: 0.526 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
8.14ProAla: 8.14 ± 0.095
0.375ProCys: 0.375 ± 0.015
3.177ProAsp: 3.177 ± 0.049
3.773ProGlu: 3.773 ± 0.066
1.809ProPhe: 1.809 ± 0.045
5.552ProGly: 5.552 ± 0.078
1.243ProHis: 1.243 ± 0.027
1.755ProIle: 1.755 ± 0.036
1.19ProLys: 1.19 ± 0.033
5.68ProLeu: 5.68 ± 0.081
1.292ProMet: 1.292 ± 0.034
1.118ProAsn: 1.118 ± 0.028
3.431ProPro: 3.431 ± 0.067
2.598ProGln: 2.598 ± 0.044
3.933ProArg: 3.933 ± 0.064
2.916ProSer: 2.916 ± 0.049
2.536ProThr: 2.536 ± 0.046
4.777ProVal: 4.777 ± 0.064
0.888ProTrp: 0.888 ± 0.027
1.155ProTyr: 1.155 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
6.467GlnAla: 6.467 ± 0.084
0.301GlnCys: 0.301 ± 0.016
1.809GlnAsp: 1.809 ± 0.036
1.789GlnGlu: 1.789 ± 0.037
1.12GlnPhe: 1.12 ± 0.03
3.356GlnGly: 3.356 ± 0.049
0.879GlnHis: 0.879 ± 0.028
1.352GlnIle: 1.352 ± 0.033
0.907GlnLys: 0.907 ± 0.028
4.427GlnLeu: 4.427 ± 0.053
0.9GlnMet: 0.9 ± 0.027
0.649GlnAsn: 0.649 ± 0.022
2.48GlnPro: 2.48 ± 0.048
1.831GlnGln: 1.831 ± 0.041
3.645GlnArg: 3.645 ± 0.052
1.785GlnSer: 1.785 ± 0.036
1.51GlnThr: 1.51 ± 0.037
3.413GlnVal: 3.413 ± 0.05
0.636GlnTrp: 0.636 ± 0.021
0.631GlnTyr: 0.631 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.35ArgAla: 9.35 ± 0.106
0.73ArgCys: 0.73 ± 0.025
3.699ArgAsp: 3.699 ± 0.049
5.656ArgGlu: 5.656 ± 0.076
3.036ArgPhe: 3.036 ± 0.057
5.598ArgGly: 5.598 ± 0.073
2.229ArgHis: 2.229 ± 0.048
3.643ArgIle: 3.643 ± 0.051
1.964ArgLys: 1.964 ± 0.046
9.492ArgLeu: 9.492 ± 0.099
2.091ArgMet: 2.091 ± 0.041
1.7ArgAsn: 1.7 ± 0.038
4.156ArgPro: 4.156 ± 0.064
3.212ArgGln: 3.212 ± 0.058
6.67ArgArg: 6.67 ± 0.088
4.086ArgSer: 4.086 ± 0.06
3.561ArgThr: 3.561 ± 0.05
5.784ArgVal: 5.784 ± 0.071
1.484ArgTrp: 1.484 ± 0.034
1.75ArgTyr: 1.75 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.409SerAla: 6.409 ± 0.093
0.449SerCys: 0.449 ± 0.02
2.393SerAsp: 2.393 ± 0.042
2.556SerGlu: 2.556 ± 0.051
1.959SerPhe: 1.959 ± 0.037
4.994SerGly: 4.994 ± 0.067
1.096SerHis: 1.096 ± 0.031
1.997SerIle: 1.997 ± 0.041
1.131SerLys: 1.131 ± 0.032
5.601SerLeu: 5.601 ± 0.065
1.266SerMet: 1.266 ± 0.031
1.102SerAsn: 1.102 ± 0.028
3.109SerPro: 3.109 ± 0.055
1.729SerGln: 1.729 ± 0.032
3.925SerArg: 3.925 ± 0.055
2.711SerSer: 2.711 ± 0.058
2.691SerThr: 2.691 ± 0.051
3.697SerVal: 3.697 ± 0.055
0.747SerTrp: 0.747 ± 0.024
1.11SerTyr: 1.11 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.557ThrAla: 5.557 ± 0.068
0.385ThrCys: 0.385 ± 0.019
2.2ThrAsp: 2.2 ± 0.04
2.259ThrGlu: 2.259 ± 0.04
1.547ThrPhe: 1.547 ± 0.034
4.593ThrGly: 4.593 ± 0.067
1.088ThrHis: 1.088 ± 0.027
1.69ThrIle: 1.69 ± 0.042
0.889ThrLys: 0.889 ± 0.028
6.006ThrLeu: 6.006 ± 0.068
0.959ThrMet: 0.959 ± 0.028
0.909ThrAsn: 0.909 ± 0.031
3.546ThrPro: 3.546 ± 0.056
1.753ThrGln: 1.753 ± 0.039
3.562ThrArg: 3.562 ± 0.051
2.396ThrSer: 2.396 ± 0.048
2.356ThrThr: 2.356 ± 0.045
4.012ThrVal: 4.012 ± 0.062
0.679ThrTrp: 0.679 ± 0.023
0.916ThrTyr: 0.916 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
9.889ValAla: 9.889 ± 0.1
0.711ValCys: 0.711 ± 0.025
4.102ValAsp: 4.102 ± 0.062
4.394ValGlu: 4.394 ± 0.059
2.775ValPhe: 2.775 ± 0.047
5.731ValGly: 5.731 ± 0.073
1.758ValHis: 1.758 ± 0.036
3.178ValIle: 3.178 ± 0.055
2.173ValLys: 2.173 ± 0.053
9.087ValLeu: 9.087 ± 0.099
1.752ValMet: 1.752 ± 0.038
1.965ValAsn: 1.965 ± 0.038
4.536ValPro: 4.536 ± 0.056
3.059ValGln: 3.059 ± 0.049
6.079ValArg: 6.079 ± 0.065
3.917ValSer: 3.917 ± 0.055
3.785ValThr: 3.785 ± 0.057
6.698ValVal: 6.698 ± 0.081
0.946ValTrp: 0.946 ± 0.025
1.371ValTyr: 1.371 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.471TrpAla: 1.471 ± 0.036
0.201TrpCys: 0.201 ± 0.014
0.692TrpAsp: 0.692 ± 0.027
0.646TrpGlu: 0.646 ± 0.022
0.55TrpPhe: 0.55 ± 0.02
1.112TrpGly: 1.112 ± 0.028
0.381TrpHis: 0.381 ± 0.018
0.62TrpIle: 0.62 ± 0.02
0.409TrpLys: 0.409 ± 0.017
2.124TrpLeu: 2.124 ± 0.046
0.4TrpMet: 0.4 ± 0.019
0.414TrpAsn: 0.414 ± 0.017
0.789TrpPro: 0.789 ± 0.026
0.745TrpGln: 0.745 ± 0.021
1.51TrpArg: 1.51 ± 0.036
0.856TrpSer: 0.856 ± 0.028
0.759TrpThr: 0.759 ± 0.026
1.098TrpVal: 1.098 ± 0.031
0.322TrpTrp: 0.322 ± 0.014
0.263TrpTyr: 0.263 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.4TyrAla: 2.4 ± 0.044
0.24TyrCys: 0.24 ± 0.013
1.116TyrAsp: 1.116 ± 0.028
1.214TyrGlu: 1.214 ± 0.027
0.811TyrPhe: 0.811 ± 0.022
1.831TyrGly: 1.831 ± 0.04
0.43TyrHis: 0.43 ± 0.022
0.641TyrIle: 0.641 ± 0.024
0.563TyrLys: 0.563 ± 0.022
2.142TyrLeu: 2.142 ± 0.039
0.395TyrMet: 0.395 ± 0.019
0.46TyrAsn: 0.46 ± 0.02
1.052TyrPro: 1.052 ± 0.024
0.665TyrGln: 0.665 ± 0.023
1.571TyrArg: 1.571 ± 0.033
0.966TyrSer: 0.966 ± 0.027
1.062TyrThr: 1.062 ± 0.033
1.479TyrVal: 1.479 ± 0.032
0.324TyrTrp: 0.324 ± 0.017
0.479TyrTyr: 0.479 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4252 proteins (1393763 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski