Amino acid dipepetide frequency for Nocardia amikacinitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.834AlaAla: 21.834 ± 0.147	0.979AlaCys: 0.979 ± 0.028	9.028AlaAsp: 9.028 ± 0.083	9.507AlaGlu: 9.507 ± 0.095	3.479AlaPhe: 3.479 ± 0.049	11.713AlaGly: 11.713 ± 0.093	2.717AlaHis: 2.717 ± 0.039	5.092AlaIle: 5.092 ± 0.053	2.96AlaLys: 2.96 ± 0.048	13.803AlaLeu: 13.803 ± 0.108	2.731AlaMet: 2.731 ± 0.038	2.498AlaAsn: 2.498 ± 0.034	6.789AlaPro: 6.789 ± 0.072	3.889AlaGln: 3.889 ± 0.053	9.68AlaArg: 9.68 ± 0.087	5.568AlaSer: 5.568 ± 0.052	7.558AlaThr: 7.558 ± 0.066	11.828AlaVal: 11.828 ± 0.099	1.699AlaTrp: 1.699 ± 0.028	2.4AlaTyr: 2.4 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.087CysAla: 1.087 ± 0.029	0.084CysCys: 0.084 ± 0.007	0.46CysAsp: 0.46 ± 0.015	0.39CysGlu: 0.39 ± 0.016	0.218CysPhe: 0.218 ± 0.01	0.883CysGly: 0.883 ± 0.022	0.175CysHis: 0.175 ± 0.009	0.186CysIle: 0.186 ± 0.009	0.114CysLys: 0.114 ± 0.008	0.671CysLeu: 0.671 ± 0.021	0.108CysMet: 0.108 ± 0.007	0.115CysAsn: 0.115 ± 0.007	0.448CysPro: 0.448 ± 0.015	0.169CysGln: 0.169 ± 0.009	0.546CysArg: 0.546 ± 0.018	0.408CysSer: 0.408 ± 0.015	0.457CysThr: 0.457 ± 0.017	0.602CysVal: 0.602 ± 0.018	0.116CysTrp: 0.116 ± 0.008	0.162CysTyr: 0.162 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.923AspAla: 7.923 ± 0.074	0.404AspCys: 0.404 ± 0.014	3.691AspAsp: 3.691 ± 0.053	4.023AspGlu: 4.023 ± 0.05	1.787AspPhe: 1.787 ± 0.029	5.645AspGly: 5.645 ± 0.051	1.413AspHis: 1.413 ± 0.025	2.453AspIle: 2.453 ± 0.035	1.201AspLys: 1.201 ± 0.026	6.406AspLeu: 6.406 ± 0.067	0.933AspMet: 0.933 ± 0.018	1.145AspAsn: 1.145 ± 0.024	4.644AspPro: 4.644 ± 0.069	1.674AspGln: 1.674 ± 0.028	5.274AspArg: 5.274 ± 0.057	2.911AspSer: 2.911 ± 0.045	3.273AspThr: 3.273 ± 0.043	4.638AspVal: 4.638 ± 0.049	0.973AspTrp: 0.973 ± 0.021	1.404AspTyr: 1.404 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.352GluAla: 6.352 ± 0.064	0.347GluCys: 0.347 ± 0.013	2.46GluAsp: 2.46 ± 0.039	2.637GluGlu: 2.637 ± 0.04	2.081GluPhe: 2.081 ± 0.034	3.539GluGly: 3.539 ± 0.047	1.658GluHis: 1.658 ± 0.028	2.841GluIle: 2.841 ± 0.036	1.223GluLys: 1.223 ± 0.028	7.624GluLeu: 7.624 ± 0.093	1.012GluMet: 1.012 ± 0.025	1.177GluAsn: 1.177 ± 0.025	3.564GluPro: 3.564 ± 0.072	2.381GluGln: 2.381 ± 0.034	5.38GluArg: 5.38 ± 0.055	3.015GluSer: 3.015 ± 0.037	3.026GluThr: 3.026 ± 0.04	4.683GluVal: 4.683 ± 0.052	0.873GluTrp: 0.873 ± 0.022	1.244GluTyr: 1.244 ± 0.024	0.0GluXaa: 0.0 ± 0.001
Phe	4.339PheAla: 4.339 ± 0.048	0.244PheCys: 0.244 ± 0.01	2.494PheAsp: 2.494 ± 0.044	1.681PheGlu: 1.681 ± 0.029	0.878PhePhe: 0.878 ± 0.021	3.422PheGly: 3.422 ± 0.046	0.629PheHis: 0.629 ± 0.018	0.79PheIle: 0.79 ± 0.02	0.392PheLys: 0.392 ± 0.015	2.616PheLeu: 2.616 ± 0.043	0.41PheMet: 0.41 ± 0.015	0.543PheAsn: 0.543 ± 0.018	1.433PhePro: 1.433 ± 0.025	0.748PheGln: 0.748 ± 0.022	1.89PheArg: 1.89 ± 0.031	1.426PheSer: 1.426 ± 0.028	1.996PheThr: 1.996 ± 0.028	2.588PheVal: 2.588 ± 0.042	0.415PheTrp: 0.415 ± 0.012	0.627PheTyr: 0.627 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.912GlyAla: 10.912 ± 0.087	0.769GlyCys: 0.769 ± 0.023	4.776GlyAsp: 4.776 ± 0.049	4.723GlyGlu: 4.723 ± 0.056	2.955GlyPhe: 2.955 ± 0.037	7.779GlyGly: 7.779 ± 0.074	2.033GlyHis: 2.033 ± 0.034	3.967GlyIle: 3.967 ± 0.054	2.307GlyLys: 2.307 ± 0.039	8.6GlyLeu: 8.6 ± 0.078	2.087GlyMet: 2.087 ± 0.03	1.824GlyAsn: 1.824 ± 0.034	4.724GlyPro: 4.724 ± 0.06	2.476GlyGln: 2.476 ± 0.045	6.654GlyArg: 6.654 ± 0.062	5.095GlySer: 5.095 ± 0.054	5.229GlyThr: 5.229 ± 0.06	7.54GlyVal: 7.54 ± 0.07	1.568GlyTrp: 1.568 ± 0.03	2.365GlyTyr: 2.365 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.582HisAla: 2.582 ± 0.038	0.19HisCys: 0.19 ± 0.01	1.265HisAsp: 1.265 ± 0.024	1.138HisGlu: 1.138 ± 0.022	0.631HisPhe: 0.631 ± 0.016	2.156HisGly: 2.156 ± 0.032	0.629HisHis: 0.629 ± 0.019	0.763HisIle: 0.763 ± 0.02	0.313HisLys: 0.313 ± 0.012	2.128HisLeu: 2.128 ± 0.038	0.36HisMet: 0.36 ± 0.011	0.457HisAsn: 0.457 ± 0.015	1.713HisPro: 1.713 ± 0.025	0.563HisGln: 0.563 ± 0.016	2.054HisArg: 2.054 ± 0.033	1.076HisSer: 1.076 ± 0.021	1.207HisThr: 1.207 ± 0.028	1.573HisVal: 1.573 ± 0.028	0.356HisTrp: 0.356 ± 0.013	0.527HisTyr: 0.527 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.427IleAla: 6.427 ± 0.056	0.314IleCys: 0.314 ± 0.014	3.323IleAsp: 3.323 ± 0.042	2.725IleGlu: 2.725 ± 0.035	0.917IlePhe: 0.917 ± 0.024	4.505IleGly: 4.505 ± 0.051	0.666IleHis: 0.666 ± 0.019	1.188IleIle: 1.188 ± 0.029	0.673IleLys: 0.673 ± 0.023	2.928IleLeu: 2.928 ± 0.042	0.552IleMet: 0.552 ± 0.019	0.796IleAsn: 0.796 ± 0.024	2.3IlePro: 2.3 ± 0.031	0.842IleGln: 0.842 ± 0.019	2.673IleArg: 2.673 ± 0.033	2.039IleSer: 2.039 ± 0.032	2.575IleThr: 2.575 ± 0.034	3.567IleVal: 3.567 ± 0.052	0.419IleTrp: 0.419 ± 0.014	0.707IleTyr: 0.707 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.456LysAla: 2.456 ± 0.055	0.109LysCys: 0.109 ± 0.007	0.967LysAsp: 0.967 ± 0.025	0.932LysGlu: 0.932 ± 0.027	0.589LysPhe: 0.589 ± 0.017	1.422LysGly: 1.422 ± 0.027	0.442LysHis: 0.442 ± 0.014	0.924LysIle: 0.924 ± 0.026	0.575LysLys: 0.575 ± 0.022	2.098LysLeu: 2.098 ± 0.039	0.422LysMet: 0.422 ± 0.015	0.458LysAsn: 0.458 ± 0.017	1.331LysPro: 1.331 ± 0.026	0.68LysGln: 0.68 ± 0.018	1.472LysArg: 1.472 ± 0.032	1.183LysSer: 1.183 ± 0.03	1.235LysThr: 1.235 ± 0.023	1.743LysVal: 1.743 ± 0.031	0.28LysTrp: 0.28 ± 0.013	0.489LysTyr: 0.489 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.01LeuAla: 15.01 ± 0.107	0.778LeuCys: 0.778 ± 0.021	7.032LeuAsp: 7.032 ± 0.072	4.843LeuGlu: 4.843 ± 0.053	2.82LeuPhe: 2.82 ± 0.043	9.092LeuGly: 9.092 ± 0.089	2.081LeuHis: 2.081 ± 0.033	4.005LeuIle: 4.005 ± 0.052	1.416LeuLys: 1.416 ± 0.029	10.429LeuLeu: 10.429 ± 0.091	1.547LeuMet: 1.547 ± 0.029	1.835LeuAsn: 1.835 ± 0.029	6.196LeuPro: 6.196 ± 0.064	2.068LeuGln: 2.068 ± 0.034	8.772LeuArg: 8.772 ± 0.082	5.332LeuSer: 5.332 ± 0.05	6.532LeuThr: 6.532 ± 0.057	8.62LeuVal: 8.62 ± 0.072	1.202LeuTrp: 1.202 ± 0.026	1.706LeuTyr: 1.706 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.264MetAla: 2.264 ± 0.044	0.146MetCys: 0.146 ± 0.008	0.895MetAsp: 0.895 ± 0.02	0.685MetGlu: 0.685 ± 0.02	0.567MetPhe: 0.567 ± 0.018	1.305MetGly: 1.305 ± 0.026	0.405MetHis: 0.405 ± 0.015	0.85MetIle: 0.85 ± 0.02	0.401MetLys: 0.401 ± 0.016	1.933MetLeu: 1.933 ± 0.033	0.322MetMet: 0.322 ± 0.014	0.517MetAsn: 0.517 ± 0.015	1.151MetPro: 1.151 ± 0.022	0.465MetGln: 0.465 ± 0.017	1.577MetArg: 1.577 ± 0.025	1.408MetSer: 1.408 ± 0.028	1.622MetThr: 1.622 ± 0.028	1.56MetVal: 1.56 ± 0.028	0.241MetTrp: 0.241 ± 0.011	0.35MetTyr: 0.35 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.485AsnAla: 2.485 ± 0.037	0.151AsnCys: 0.151 ± 0.009	1.044AsnAsp: 1.044 ± 0.025	0.948AsnGlu: 0.948 ± 0.02	0.571AsnPhe: 0.571 ± 0.016	2.026AsnGly: 2.026 ± 0.035	0.407AsnHis: 0.407 ± 0.014	0.849AsnIle: 0.849 ± 0.02	0.434AsnLys: 0.434 ± 0.015	1.895AsnLeu: 1.895 ± 0.032	0.393AsnMet: 0.393 ± 0.015	0.489AsnAsn: 0.489 ± 0.016	1.627AsnPro: 1.627 ± 0.031	0.596AsnGln: 0.596 ± 0.019	1.523AsnArg: 1.523 ± 0.028	1.066AsnSer: 1.066 ± 0.023	1.225AsnThr: 1.225 ± 0.027	1.476AsnVal: 1.476 ± 0.028	0.318AsnTrp: 0.318 ± 0.014	0.479AsnTyr: 0.479 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.808ProAla: 7.808 ± 0.082	0.293ProCys: 0.293 ± 0.012	4.489ProAsp: 4.489 ± 0.066	4.411ProGlu: 4.411 ± 0.075	1.594ProPhe: 1.594 ± 0.026	5.911ProGly: 5.911 ± 0.069	1.198ProHis: 1.198 ± 0.027	2.27ProIle: 2.27 ± 0.03	1.257ProLys: 1.257 ± 0.027	5.053ProLeu: 5.053 ± 0.055	1.12ProMet: 1.12 ± 0.024	1.278ProAsn: 1.278 ± 0.024	3.402ProPro: 3.402 ± 0.077	1.716ProGln: 1.716 ± 0.041	3.832ProArg: 3.832 ± 0.045	3.149ProSer: 3.149 ± 0.045	3.58ProThr: 3.58 ± 0.045	5.17ProVal: 5.17 ± 0.061	0.848ProTrp: 0.848 ± 0.02	1.134ProTyr: 1.134 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.39GlnAla: 3.39 ± 0.05	0.174GlnCys: 0.174 ± 0.01	1.165GlnAsp: 1.165 ± 0.022	1.101GlnGlu: 1.101 ± 0.025	0.84GlnPhe: 0.84 ± 0.019	1.846GlnGly: 1.846 ± 0.04	0.648GlnHis: 0.648 ± 0.016	1.278GlnIle: 1.278 ± 0.026	0.494GlnLys: 0.494 ± 0.018	3.346GlnLeu: 3.346 ± 0.043	0.512GlnMet: 0.512 ± 0.017	0.539GlnAsn: 0.539 ± 0.017	1.86GlnPro: 1.86 ± 0.046	1.266GlnGln: 1.266 ± 0.035	2.762GlnArg: 2.762 ± 0.044	1.283GlnSer: 1.283 ± 0.027	1.395GlnThr: 1.395 ± 0.033	2.5GlnVal: 2.5 ± 0.041	0.5GlnTrp: 0.5 ± 0.015	0.618GlnTyr: 0.618 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.792ArgAla: 9.792 ± 0.1	0.583ArgCys: 0.583 ± 0.019	4.423ArgAsp: 4.423 ± 0.049	4.513ArgGlu: 4.513 ± 0.053	2.583ArgPhe: 2.583 ± 0.032	5.608ArgGly: 5.608 ± 0.059	1.81ArgHis: 1.81 ± 0.03	3.711ArgIle: 3.711 ± 0.046	1.79ArgLys: 1.79 ± 0.036	8.066ArgLeu: 8.066 ± 0.076	1.981ArgMet: 1.981 ± 0.031	1.647ArgAsn: 1.647 ± 0.027	4.505ArgPro: 4.505 ± 0.061	2.209ArgGln: 2.209 ± 0.038	7.146ArgArg: 7.146 ± 0.084	4.134ArgSer: 4.134 ± 0.048	4.947ArgThr: 4.947 ± 0.062	6.061ArgVal: 6.061 ± 0.051	1.431ArgTrp: 1.431 ± 0.026	1.909ArgTyr: 1.909 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.094SerAla: 7.094 ± 0.067	0.375SerCys: 0.375 ± 0.016	2.922SerAsp: 2.922 ± 0.045	2.651SerGlu: 2.651 ± 0.037	1.589SerPhe: 1.589 ± 0.029	5.765SerGly: 5.765 ± 0.065	0.952SerHis: 0.952 ± 0.025	2.043SerIle: 2.043 ± 0.036	1.034SerLys: 1.034 ± 0.025	4.44SerLeu: 4.44 ± 0.049	1.236SerMet: 1.236 ± 0.025	1.002SerAsn: 1.002 ± 0.024	2.92SerPro: 2.92 ± 0.039	1.141SerGln: 1.141 ± 0.026	3.629SerArg: 3.629 ± 0.048	2.823SerSer: 2.823 ± 0.045	3.311SerThr: 3.311 ± 0.041	4.337SerVal: 4.337 ± 0.046	0.851SerTrp: 0.851 ± 0.026	1.166SerTyr: 1.166 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.458ThrAla: 8.458 ± 0.072	0.39ThrCys: 0.39 ± 0.015	3.717ThrAsp: 3.717 ± 0.045	3.733ThrGlu: 3.733 ± 0.045	1.692ThrPhe: 1.692 ± 0.03	5.989ThrGly: 5.989 ± 0.066	1.141ThrHis: 1.141 ± 0.022	2.327ThrIle: 2.327 ± 0.036	1.251ThrLys: 1.251 ± 0.026	5.625ThrLeu: 5.625 ± 0.057	1.068ThrMet: 1.068 ± 0.022	1.15ThrAsn: 1.15 ± 0.025	3.89ThrPro: 3.89 ± 0.055	1.332ThrGln: 1.332 ± 0.032	3.764ThrArg: 3.764 ± 0.046	2.983ThrSer: 2.983 ± 0.043	3.876ThrThr: 3.876 ± 0.059	5.983ThrVal: 5.983 ± 0.054	0.793ThrTrp: 0.793 ± 0.019	1.201ThrTyr: 1.201 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	11.549ValAla: 11.549 ± 0.089	0.735ValCys: 0.735 ± 0.019	5.599ValAsp: 5.599 ± 0.059	4.704ValGlu: 4.704 ± 0.043	2.567ValPhe: 2.567 ± 0.041	6.77ValGly: 6.77 ± 0.073	1.892ValHis: 1.892 ± 0.029	3.375ValIle: 3.375 ± 0.044	1.342ValLys: 1.342 ± 0.033	9.537ValLeu: 9.537 ± 0.081	1.284ValMet: 1.284 ± 0.023	1.723ValAsn: 1.723 ± 0.031	5.015ValPro: 5.015 ± 0.056	2.037ValGln: 2.037 ± 0.034	6.814ValArg: 6.814 ± 0.055	4.361ValSer: 4.361 ± 0.052	5.272ValThr: 5.272 ± 0.051	8.261ValVal: 8.261 ± 0.081	1.036ValTrp: 1.036 ± 0.022	1.539ValTyr: 1.539 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.534TrpAla: 1.534 ± 0.03	0.135TrpCys: 0.135 ± 0.009	0.771TrpAsp: 0.771 ± 0.02	0.673TrpGlu: 0.673 ± 0.021	0.526TrpPhe: 0.526 ± 0.015	0.949TrpGly: 0.949 ± 0.021	0.335TrpHis: 0.335 ± 0.012	0.603TrpIle: 0.603 ± 0.02	0.305TrpLys: 0.305 ± 0.013	1.718TrpLeu: 1.718 ± 0.032	0.315TrpMet: 0.315 ± 0.012	0.39TrpAsn: 0.39 ± 0.015	0.762TrpPro: 0.762 ± 0.023	0.597TrpGln: 0.597 ± 0.017	1.377TrpArg: 1.377 ± 0.026	0.975TrpSer: 0.975 ± 0.022	0.929TrpThr: 0.929 ± 0.024	1.081TrpVal: 1.081 ± 0.022	0.318TrpTrp: 0.318 ± 0.013	0.319TrpTyr: 0.319 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.039	0.202TyrCys: 0.202 ± 0.01	1.295TyrAsp: 1.295 ± 0.027	1.098TyrGlu: 1.098 ± 0.027	0.678TyrPhe: 0.678 ± 0.019	2.057TyrGly: 2.057 ± 0.031	0.451TyrHis: 0.451 ± 0.016	0.62TyrIle: 0.62 ± 0.018	0.326TyrLys: 0.326 ± 0.013	2.4TyrLeu: 2.4 ± 0.036	0.271TyrMet: 0.271 ± 0.011	0.42TyrAsn: 0.42 ± 0.015	1.237TyrPro: 1.237 ± 0.029	0.667TyrGln: 0.667 ± 0.019	2.027TyrArg: 2.027 ± 0.035	1.047TyrSer: 1.047 ± 0.02	1.117TyrThr: 1.117 ± 0.021	1.599TyrVal: 1.599 ± 0.033	0.374TyrTrp: 0.374 ± 0.013	0.46TyrTyr: 0.46 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.006

Statistics based on 6460 proteins (2146072 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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