Amino acid dipepetide frequency for Ralstonia pickettii (strain 12J)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.554AlaAla: 17.554 ± 0.136	1.288AlaCys: 1.288 ± 0.034	6.819AlaAsp: 6.819 ± 0.075	6.67AlaGlu: 6.67 ± 0.069	4.164AlaPhe: 4.164 ± 0.055	10.408AlaGly: 10.408 ± 0.099	2.77AlaHis: 2.77 ± 0.042	5.724AlaIle: 5.724 ± 0.064	3.975AlaLys: 3.975 ± 0.073	14.129AlaLeu: 14.129 ± 0.118	3.604AlaMet: 3.604 ± 0.051	3.321AlaAsn: 3.321 ± 0.048	6.224AlaPro: 6.224 ± 0.074	5.749AlaGln: 5.749 ± 0.077	8.711AlaArg: 8.711 ± 0.086	6.824AlaSer: 6.824 ± 0.072	6.536AlaThr: 6.536 ± 0.073	9.249AlaVal: 9.249 ± 0.086	1.763AlaTrp: 1.763 ± 0.036	2.794AlaTyr: 2.794 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.227CysAla: 1.227 ± 0.031	0.129CysCys: 0.129 ± 0.009	0.533CysAsp: 0.533 ± 0.021	0.465CysGlu: 0.465 ± 0.017	0.315CysPhe: 0.315 ± 0.014	0.964CysGly: 0.964 ± 0.031	0.28CysHis: 0.28 ± 0.016	0.383CysIle: 0.383 ± 0.015	0.256CysLys: 0.256 ± 0.013	0.791CysLeu: 0.791 ± 0.024	0.215CysMet: 0.215 ± 0.014	0.268CysAsn: 0.268 ± 0.014	0.486CysPro: 0.486 ± 0.02	0.273CysGln: 0.273 ± 0.014	0.591CysArg: 0.591 ± 0.022	0.518CysSer: 0.518 ± 0.021	0.479CysThr: 0.479 ± 0.017	0.72CysVal: 0.72 ± 0.024	0.124CysTrp: 0.124 ± 0.009	0.212CysTyr: 0.212 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.726AspAla: 7.726 ± 0.089	0.487AspCys: 0.487 ± 0.019	2.999AspAsp: 2.999 ± 0.048	2.948AspGlu: 2.948 ± 0.053	1.977AspPhe: 1.977 ± 0.035	4.498AspGly: 4.498 ± 0.053	1.219AspHis: 1.219 ± 0.033	2.526AspIle: 2.526 ± 0.041	1.73AspLys: 1.73 ± 0.036	5.076AspLeu: 5.076 ± 0.064	1.277AspMet: 1.277 ± 0.026	1.325AspAsn: 1.325 ± 0.033	2.839AspPro: 2.839 ± 0.045	1.635AspGln: 1.635 ± 0.032	3.443AspArg: 3.443 ± 0.047	2.175AspSer: 2.175 ± 0.047	2.901AspThr: 2.901 ± 0.046	4.371AspVal: 4.371 ± 0.056	0.938AspTrp: 0.938 ± 0.025	1.395AspTyr: 1.395 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.763GluAla: 6.763 ± 0.083	0.395GluCys: 0.395 ± 0.019	2.386GluAsp: 2.386 ± 0.04	2.435GluGlu: 2.435 ± 0.049	1.681GluPhe: 1.681 ± 0.032	3.521GluGly: 3.521 ± 0.056	1.487GluHis: 1.487 ± 0.036	2.594GluIle: 2.594 ± 0.039	1.742GluLys: 1.742 ± 0.037	5.221GluLeu: 5.221 ± 0.062	1.247GluMet: 1.247 ± 0.027	1.27GluAsn: 1.27 ± 0.032	2.363GluPro: 2.363 ± 0.043	2.526GluGln: 2.526 ± 0.046	4.585GluArg: 4.585 ± 0.066	2.463GluSer: 2.463 ± 0.038	2.705GluThr: 2.705 ± 0.046	3.594GluVal: 3.594 ± 0.051	0.721GluTrp: 0.721 ± 0.021	1.136GluTyr: 1.136 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.389PheAla: 4.389 ± 0.052	0.415PheCys: 0.415 ± 0.016	2.476PheAsp: 2.476 ± 0.041	1.835PheGlu: 1.835 ± 0.036	1.396PhePhe: 1.396 ± 0.037	3.452PheGly: 3.452 ± 0.061	0.792PheHis: 0.792 ± 0.022	1.569PheIle: 1.569 ± 0.031	1.054PheLys: 1.054 ± 0.026	3.053PheLeu: 3.053 ± 0.05	0.74PheMet: 0.74 ± 0.023	1.14PheAsn: 1.14 ± 0.03	1.543PhePro: 1.543 ± 0.032	1.075PheGln: 1.075 ± 0.027	2.0PheArg: 2.0 ± 0.033	2.208PheSer: 2.208 ± 0.036	1.918PheThr: 1.918 ± 0.041	2.807PheVal: 2.807 ± 0.041	0.544PheTrp: 0.544 ± 0.022	0.94PheTyr: 0.94 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.258GlyAla: 9.258 ± 0.095	0.843GlyCys: 0.843 ± 0.026	3.905GlyAsp: 3.905 ± 0.059	4.093GlyGlu: 4.093 ± 0.056	3.225GlyPhe: 3.225 ± 0.05	6.702GlyGly: 6.702 ± 0.102	1.918GlyHis: 1.918 ± 0.039	4.199GlyIle: 4.199 ± 0.059	3.498GlyLys: 3.498 ± 0.053	8.095GlyLeu: 8.095 ± 0.08	2.43GlyMet: 2.43 ± 0.045	2.494GlyAsn: 2.494 ± 0.048	2.866GlyPro: 2.866 ± 0.042	3.047GlyGln: 3.047 ± 0.047	5.012GlyArg: 5.012 ± 0.063	4.279GlySer: 4.279 ± 0.074	4.953GlyThr: 4.953 ± 0.079	6.673GlyVal: 6.673 ± 0.064	1.409GlyTrp: 1.409 ± 0.033	2.387GlyTyr: 2.387 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	3.286HisAla: 3.286 ± 0.052	0.276HisCys: 0.276 ± 0.014	1.36HisAsp: 1.36 ± 0.031	1.097HisGlu: 1.097 ± 0.027	0.883HisPhe: 0.883 ± 0.023	2.244HisGly: 2.244 ± 0.037	0.691HisHis: 0.691 ± 0.024	0.975HisIle: 0.975 ± 0.024	0.558HisLys: 0.558 ± 0.02	2.21HisLeu: 2.21 ± 0.041	0.531HisMet: 0.531 ± 0.018	0.53HisAsn: 0.53 ± 0.019	1.55HisPro: 1.55 ± 0.033	0.711HisGln: 0.711 ± 0.023	1.581HisArg: 1.581 ± 0.031	1.051HisSer: 1.051 ± 0.03	1.195HisThr: 1.195 ± 0.025	1.831HisVal: 1.831 ± 0.034	0.431HisTrp: 0.431 ± 0.019	0.637HisTyr: 0.637 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.447IleAla: 6.447 ± 0.072	0.441IleCys: 0.441 ± 0.018	3.278IleAsp: 3.278 ± 0.049	3.04IleGlu: 3.04 ± 0.047	1.381IlePhe: 1.381 ± 0.031	4.519IleGly: 4.519 ± 0.064	0.915IleHis: 0.915 ± 0.024	1.701IleIle: 1.701 ± 0.034	1.56IleLys: 1.56 ± 0.038	3.563IleLeu: 3.563 ± 0.047	0.724IleMet: 0.724 ± 0.023	1.483IleAsn: 1.483 ± 0.036	2.254IlePro: 2.254 ± 0.045	1.387IleGln: 1.387 ± 0.031	2.829IleArg: 2.829 ± 0.047	2.393IleSer: 2.393 ± 0.044	2.541IleThr: 2.541 ± 0.051	4.044IleVal: 4.044 ± 0.047	0.48IleTrp: 0.48 ± 0.016	1.035IleTyr: 1.035 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.657LysAla: 3.657 ± 0.06	0.167LysCys: 0.167 ± 0.013	1.588LysAsp: 1.588 ± 0.033	1.478LysGlu: 1.478 ± 0.037	0.923LysPhe: 0.923 ± 0.029	2.321LysGly: 2.321 ± 0.044	0.77LysHis: 0.77 ± 0.022	1.506LysIle: 1.506 ± 0.04	1.265LysLys: 1.265 ± 0.039	3.561LysLeu: 3.561 ± 0.059	0.843LysMet: 0.843 ± 0.024	0.929LysAsn: 0.929 ± 0.027	2.115LysPro: 2.115 ± 0.042	1.382LysGln: 1.382 ± 0.035	2.439LysArg: 2.439 ± 0.041	1.655LysSer: 1.655 ± 0.033	2.015LysThr: 2.015 ± 0.038	2.397LysVal: 2.397 ± 0.048	0.392LysTrp: 0.392 ± 0.016	0.714LysTyr: 0.714 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.939LeuAla: 13.939 ± 0.117	0.995LeuCys: 0.995 ± 0.026	5.626LeuAsp: 5.626 ± 0.061	4.927LeuGlu: 4.927 ± 0.073	3.559LeuPhe: 3.559 ± 0.054	8.18LeuGly: 8.18 ± 0.087	2.338LeuHis: 2.338 ± 0.045	4.541LeuIle: 4.541 ± 0.059	3.264LeuLys: 3.264 ± 0.048	10.395LeuLeu: 10.395 ± 0.123	2.383LeuMet: 2.383 ± 0.047	2.771LeuAsn: 2.771 ± 0.042	5.828LeuPro: 5.828 ± 0.066	3.763LeuGln: 3.763 ± 0.048	7.323LeuArg: 7.323 ± 0.078	6.282LeuSer: 6.282 ± 0.06	5.764LeuThr: 5.764 ± 0.063	7.402LeuVal: 7.402 ± 0.091	1.265LeuTrp: 1.265 ± 0.031	2.211LeuTyr: 2.211 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.927MetAla: 2.927 ± 0.048	0.184MetCys: 0.184 ± 0.012	1.11MetAsp: 1.11 ± 0.028	1.11MetGlu: 1.11 ± 0.031	0.745MetPhe: 0.745 ± 0.025	1.74MetGly: 1.74 ± 0.036	0.594MetHis: 0.594 ± 0.02	1.041MetIle: 1.041 ± 0.026	0.874MetLys: 0.874 ± 0.026	2.872MetLeu: 2.872 ± 0.049	0.662MetMet: 0.662 ± 0.023	0.833MetAsn: 0.833 ± 0.024	1.587MetPro: 1.587 ± 0.035	1.173MetGln: 1.173 ± 0.027	1.87MetArg: 1.87 ± 0.037	1.639MetSer: 1.639 ± 0.034	1.767MetThr: 1.767 ± 0.033	1.672MetVal: 1.672 ± 0.034	0.236MetTrp: 0.236 ± 0.013	0.38MetTyr: 0.38 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.663AsnAla: 3.663 ± 0.056	0.271AsnCys: 0.271 ± 0.013	1.426AsnAsp: 1.426 ± 0.03	1.25AsnGlu: 1.25 ± 0.031	0.933AsnPhe: 0.933 ± 0.029	2.559AsnGly: 2.559 ± 0.05	0.576AsnHis: 0.576 ± 0.021	1.303AsnIle: 1.303 ± 0.033	0.857AsnLys: 0.857 ± 0.023	2.759AsnLeu: 2.759 ± 0.044	0.598AsnMet: 0.598 ± 0.02	0.844AsnAsn: 0.844 ± 0.028	1.846AsnPro: 1.846 ± 0.038	0.938AsnGln: 0.938 ± 0.024	1.753AsnArg: 1.753 ± 0.036	1.275AsnSer: 1.275 ± 0.033	1.651AsnThr: 1.651 ± 0.038	2.318AsnVal: 2.318 ± 0.042	0.446AsnTrp: 0.446 ± 0.017	0.751AsnTyr: 0.751 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.057ProAla: 7.057 ± 0.086	0.355ProCys: 0.355 ± 0.016	3.225ProAsp: 3.225 ± 0.048	3.2ProGlu: 3.2 ± 0.044	1.834ProPhe: 1.834 ± 0.038	4.222ProGly: 4.222 ± 0.056	1.248ProHis: 1.248 ± 0.028	2.148ProIle: 2.148 ± 0.034	1.578ProLys: 1.578 ± 0.035	5.023ProLeu: 5.023 ± 0.057	1.319ProMet: 1.319 ± 0.033	1.504ProAsn: 1.504 ± 0.031	2.513ProPro: 2.513 ± 0.052	1.95ProGln: 1.95 ± 0.041	2.931ProArg: 2.931 ± 0.053	2.841ProSer: 2.841 ± 0.045	2.879ProThr: 2.879 ± 0.056	4.386ProVal: 4.386 ± 0.058	0.692ProTrp: 0.692 ± 0.021	1.226ProTyr: 1.226 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.267GlnAla: 5.267 ± 0.074	0.293GlnCys: 0.293 ± 0.014	1.585GlnAsp: 1.585 ± 0.038	1.585GlnGlu: 1.585 ± 0.037	1.284GlnPhe: 1.284 ± 0.028	2.795GlnGly: 2.795 ± 0.052	0.99GlnHis: 0.99 ± 0.024	1.935GlnIle: 1.935 ± 0.037	1.148GlnLys: 1.148 ± 0.029	3.866GlnLeu: 3.866 ± 0.062	1.077GlnMet: 1.077 ± 0.03	0.995GlnAsn: 0.995 ± 0.025	2.314GlnPro: 2.314 ± 0.043	1.883GlnGln: 1.883 ± 0.041	3.172GlnArg: 3.172 ± 0.049	2.084GlnSer: 2.084 ± 0.041	2.198GlnThr: 2.198 ± 0.044	2.7GlnVal: 2.7 ± 0.041	0.612GlnTrp: 0.612 ± 0.022	0.891GlnTyr: 0.891 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.336ArgAla: 8.336 ± 0.09	0.593ArgCys: 0.593 ± 0.023	3.716ArgAsp: 3.716 ± 0.049	4.039ArgGlu: 4.039 ± 0.065	2.8ArgPhe: 2.8 ± 0.047	4.482ArgGly: 4.482 ± 0.059	1.869ArgHis: 1.869 ± 0.037	3.536ArgIle: 3.536 ± 0.049	2.214ArgLys: 2.214 ± 0.038	7.159ArgLeu: 7.159 ± 0.07	1.919ArgMet: 1.919 ± 0.036	1.928ArgAsn: 1.928 ± 0.037	3.128ArgPro: 3.128 ± 0.051	2.812ArgGln: 2.812 ± 0.044	5.109ArgArg: 5.109 ± 0.067	3.21ArgSer: 3.21 ± 0.047	3.563ArgThr: 3.563 ± 0.055	5.211ArgVal: 5.211 ± 0.061	1.127ArgTrp: 1.127 ± 0.03	1.978ArgTyr: 1.978 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.6SerAla: 6.6 ± 0.072	0.421SerCys: 0.421 ± 0.021	2.607SerAsp: 2.607 ± 0.044	2.354SerGlu: 2.354 ± 0.043	1.931SerPhe: 1.931 ± 0.039	5.007SerGly: 5.007 ± 0.073	1.243SerHis: 1.243 ± 0.033	2.534SerIle: 2.534 ± 0.044	1.565SerLys: 1.565 ± 0.037	5.445SerLeu: 5.445 ± 0.061	1.411SerMet: 1.411 ± 0.033	1.609SerAsn: 1.609 ± 0.034	2.894SerPro: 2.894 ± 0.048	1.883SerGln: 1.883 ± 0.037	3.446SerArg: 3.446 ± 0.048	2.994SerSer: 2.994 ± 0.056	3.173SerThr: 3.173 ± 0.051	4.073SerVal: 4.073 ± 0.048	0.694SerTrp: 0.694 ± 0.021	1.231SerTyr: 1.231 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.565ThrAla: 6.565 ± 0.078	0.475ThrCys: 0.475 ± 0.018	2.77ThrAsp: 2.77 ± 0.05	2.561ThrGlu: 2.561 ± 0.041	1.986ThrPhe: 1.986 ± 0.039	4.868ThrGly: 4.868 ± 0.066	1.338ThrHis: 1.338 ± 0.028	2.523ThrIle: 2.523 ± 0.045	1.418ThrLys: 1.418 ± 0.03	6.73ThrLeu: 6.73 ± 0.072	1.191ThrMet: 1.191 ± 0.028	1.491ThrAsn: 1.491 ± 0.034	3.692ThrPro: 3.692 ± 0.054	2.132ThrGln: 2.132 ± 0.039	3.53ThrArg: 3.53 ± 0.053	2.842ThrSer: 2.842 ± 0.057	3.114ThrThr: 3.114 ± 0.059	4.577ThrVal: 4.577 ± 0.056	0.722ThrTrp: 0.722 ± 0.023	1.321ThrTyr: 1.321 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.509ValAla: 9.509 ± 0.085	0.801ValCys: 0.801 ± 0.022	4.186ValAsp: 4.186 ± 0.055	4.062ValGlu: 4.062 ± 0.06	2.791ValPhe: 2.791 ± 0.051	5.733ValGly: 5.733 ± 0.068	1.609ValHis: 1.609 ± 0.033	3.656ValIle: 3.656 ± 0.054	2.393ValLys: 2.393 ± 0.052	8.305ValLeu: 8.305 ± 0.082	1.951ValMet: 1.951 ± 0.038	2.147ValAsn: 2.147 ± 0.04	4.229ValPro: 4.229 ± 0.052	2.698ValGln: 2.698 ± 0.049	5.331ValArg: 5.331 ± 0.07	4.424ValSer: 4.424 ± 0.054	4.395ValThr: 4.395 ± 0.061	6.472ValVal: 6.472 ± 0.073	1.0ValTrp: 1.0 ± 0.029	1.665ValTyr: 1.665 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.267TrpAla: 1.267 ± 0.03	0.156TrpCys: 0.156 ± 0.01	0.568TrpAsp: 0.568 ± 0.017	0.557TrpGlu: 0.557 ± 0.019	0.582TrpPhe: 0.582 ± 0.02	0.944TrpGly: 0.944 ± 0.025	0.446TrpHis: 0.446 ± 0.017	0.736TrpIle: 0.736 ± 0.022	0.459TrpLys: 0.459 ± 0.02	2.013TrpLeu: 2.013 ± 0.04	0.441TrpMet: 0.441 ± 0.017	0.432TrpAsn: 0.432 ± 0.018	0.645TrpPro: 0.645 ± 0.019	0.707TrpGln: 0.707 ± 0.019	1.184TrpArg: 1.184 ± 0.03	0.767TrpSer: 0.767 ± 0.024	0.753TrpThr: 0.753 ± 0.023	0.995TrpVal: 0.995 ± 0.028	0.285TrpTrp: 0.285 ± 0.014	0.326TrpTyr: 0.326 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.838TyrAla: 2.838 ± 0.044	0.242TyrCys: 0.242 ± 0.013	1.322TyrAsp: 1.322 ± 0.034	1.131TyrGlu: 1.131 ± 0.03	0.954TyrPhe: 0.954 ± 0.026	2.127TyrGly: 2.127 ± 0.04	0.532TyrHis: 0.532 ± 0.017	0.885TyrIle: 0.885 ± 0.027	0.709TyrLys: 0.709 ± 0.024	2.487TyrLeu: 2.487 ± 0.041	0.451TyrMet: 0.451 ± 0.016	0.702TyrAsn: 0.702 ± 0.022	1.216TyrPro: 1.216 ± 0.027	0.951TyrGln: 0.951 ± 0.025	1.889TyrArg: 1.889 ± 0.035	1.193TyrSer: 1.193 ± 0.032	1.35TyrThr: 1.35 ± 0.035	1.869TyrVal: 1.869 ± 0.033	0.383TyrTrp: 0.383 ± 0.017	0.647TyrTyr: 0.647 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4890 proteins (1540967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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