Amino acid dipepetide frequency for Acidovorax temperans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.603AlaAla: 17.603 ± 0.178
1.258AlaCys: 1.258 ± 0.033
6.301AlaAsp: 6.301 ± 0.068
6.644AlaGlu: 6.644 ± 0.071
3.921AlaPhe: 3.921 ± 0.064
9.887AlaGly: 9.887 ± 0.11
2.95AlaHis: 2.95 ± 0.049
4.987AlaIle: 4.987 ± 0.076
4.32AlaLys: 4.32 ± 0.078
15.257AlaLeu: 15.257 ± 0.144
3.584AlaMet: 3.584 ± 0.044
2.888AlaAsn: 2.888 ± 0.057
6.395AlaPro: 6.395 ± 0.088
7.048AlaGln: 7.048 ± 0.094
8.155AlaArg: 8.155 ± 0.098
6.757AlaSer: 6.757 ± 0.087
6.371AlaThr: 6.371 ± 0.078
9.313AlaVal: 9.313 ± 0.102
1.987AlaTrp: 1.987 ± 0.054
2.417AlaTyr: 2.417 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.114CysAla: 1.114 ± 0.03
0.124CysCys: 0.124 ± 0.011
0.539CysAsp: 0.539 ± 0.021
0.468CysGlu: 0.468 ± 0.021
0.289CysPhe: 0.289 ± 0.017
0.922CysGly: 0.922 ± 0.033
0.289CysHis: 0.289 ± 0.015
0.435CysIle: 0.435 ± 0.02
0.258CysLys: 0.258 ± 0.016
0.8CysLeu: 0.8 ± 0.027
0.24CysMet: 0.24 ± 0.013
0.247CysAsn: 0.247 ± 0.014
0.514CysPro: 0.514 ± 0.023
0.322CysGln: 0.322 ± 0.016
0.501CysArg: 0.501 ± 0.02
0.534CysSer: 0.534 ± 0.024
0.549CysThr: 0.549 ± 0.024
0.758CysVal: 0.758 ± 0.029
0.115CysTrp: 0.115 ± 0.009
0.193CysTyr: 0.193 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.828AspAla: 6.828 ± 0.07
0.446AspCys: 0.446 ± 0.022
2.468AspAsp: 2.468 ± 0.057
3.123AspGlu: 3.123 ± 0.055
2.012AspPhe: 2.012 ± 0.039
4.067AspGly: 4.067 ± 0.063
1.17AspHis: 1.17 ± 0.037
2.354AspIle: 2.354 ± 0.043
1.95AspLys: 1.95 ± 0.047
5.245AspLeu: 5.245 ± 0.063
1.311AspMet: 1.311 ± 0.03
1.207AspAsn: 1.207 ± 0.035
2.712AspPro: 2.712 ± 0.047
1.626AspGln: 1.626 ± 0.038
3.029AspArg: 3.029 ± 0.055
2.278AspSer: 2.278 ± 0.043
2.586AspThr: 2.586 ± 0.05
4.109AspVal: 4.109 ± 0.066
0.904AspTrp: 0.904 ± 0.032
1.357AspTyr: 1.357 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.687GluAla: 6.687 ± 0.086
0.424GluCys: 0.424 ± 0.018
2.29GluAsp: 2.29 ± 0.051
2.654GluGlu: 2.654 ± 0.053
1.795GluPhe: 1.795 ± 0.039
3.895GluGly: 3.895 ± 0.061
1.413GluHis: 1.413 ± 0.035
2.516GluIle: 2.516 ± 0.059
2.116GluLys: 2.116 ± 0.049
5.84GluLeu: 5.84 ± 0.07
1.281GluMet: 1.281 ± 0.034
1.316GluAsn: 1.316 ± 0.034
2.471GluPro: 2.471 ± 0.052
2.873GluGln: 2.873 ± 0.054
4.459GluArg: 4.459 ± 0.073
2.635GluSer: 2.635 ± 0.048
2.455GluThr: 2.455 ± 0.051
4.121GluVal: 4.121 ± 0.061
0.727GluTrp: 0.727 ± 0.026
1.089GluTyr: 1.089 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.229PheAla: 4.229 ± 0.066
0.395PheCys: 0.395 ± 0.019
2.325PheAsp: 2.325 ± 0.047
1.984PheGlu: 1.984 ± 0.045
1.304PhePhe: 1.304 ± 0.038
3.073PheGly: 3.073 ± 0.062
0.683PheHis: 0.683 ± 0.025
1.502PheIle: 1.502 ± 0.038
1.371PheLys: 1.371 ± 0.036
2.878PheLeu: 2.878 ± 0.055
0.822PheMet: 0.822 ± 0.024
1.118PheAsn: 1.118 ± 0.029
1.396PhePro: 1.396 ± 0.036
1.1PheGln: 1.1 ± 0.032
1.774PheArg: 1.774 ± 0.039
2.062PheSer: 2.062 ± 0.051
1.971PheThr: 1.971 ± 0.041
2.723PheVal: 2.723 ± 0.049
0.508PheTrp: 0.508 ± 0.023
0.828PheTyr: 0.828 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.72GlyAla: 8.72 ± 0.106
0.896GlyCys: 0.896 ± 0.034
3.828GlyAsp: 3.828 ± 0.053
4.068GlyGlu: 4.068 ± 0.065
3.103GlyPhe: 3.103 ± 0.055
6.563GlyGly: 6.563 ± 0.117
1.932GlyHis: 1.932 ± 0.041
3.675GlyIle: 3.675 ± 0.058
3.514GlyLys: 3.514 ± 0.064
8.594GlyLeu: 8.594 ± 0.101
2.318GlyMet: 2.318 ± 0.046
2.205GlyAsn: 2.205 ± 0.047
2.944GlyPro: 2.944 ± 0.054
3.58GlyGln: 3.58 ± 0.055
4.917GlyArg: 4.917 ± 0.066
4.462GlySer: 4.462 ± 0.06
4.483GlyThr: 4.483 ± 0.067
6.564GlyVal: 6.564 ± 0.081
1.394GlyTrp: 1.394 ± 0.035
2.265GlyTyr: 2.265 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.856HisAla: 2.856 ± 0.054
0.298HisCys: 0.298 ± 0.017
1.181HisAsp: 1.181 ± 0.034
1.204HisGlu: 1.204 ± 0.035
0.888HisPhe: 0.888 ± 0.028
2.08HisGly: 2.08 ± 0.044
0.712HisHis: 0.712 ± 0.026
1.091HisIle: 1.091 ± 0.033
0.662HisLys: 0.662 ± 0.025
2.441HisLeu: 2.441 ± 0.049
0.575HisMet: 0.575 ± 0.024
0.559HisAsn: 0.559 ± 0.021
1.56HisPro: 1.56 ± 0.035
0.92HisGln: 0.92 ± 0.033
1.483HisArg: 1.483 ± 0.038
1.152HisSer: 1.152 ± 0.032
1.322HisThr: 1.322 ± 0.034
1.548HisVal: 1.548 ± 0.036
0.448HisTrp: 0.448 ± 0.018
0.646HisTyr: 0.646 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.777IleAla: 5.777 ± 0.074
0.412IleCys: 0.412 ± 0.017
2.829IleAsp: 2.829 ± 0.052
2.984IleGlu: 2.984 ± 0.053
1.255IlePhe: 1.255 ± 0.037
3.624IleGly: 3.624 ± 0.059
0.887IleHis: 0.887 ± 0.028
1.583IleIle: 1.583 ± 0.04
1.654IleLys: 1.654 ± 0.049
3.26IleLeu: 3.26 ± 0.059
0.752IleMet: 0.752 ± 0.026
1.403IleAsn: 1.403 ± 0.033
2.059IlePro: 2.059 ± 0.039
1.451IleGln: 1.451 ± 0.038
2.441IleArg: 2.441 ± 0.054
2.356IleSer: 2.356 ± 0.046
2.723IleThr: 2.723 ± 0.053
3.201IleVal: 3.201 ± 0.054
0.45IleTrp: 0.45 ± 0.021
0.973IleTyr: 0.973 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.65LysAla: 4.65 ± 0.065
0.171LysCys: 0.171 ± 0.013
1.869LysAsp: 1.869 ± 0.042
1.772LysGlu: 1.772 ± 0.044
1.052LysPhe: 1.052 ± 0.03
2.723LysGly: 2.723 ± 0.053
0.761LysHis: 0.761 ± 0.028
1.575LysIle: 1.575 ± 0.043
1.637LysLys: 1.637 ± 0.054
3.823LysLeu: 3.823 ± 0.062
0.879LysMet: 0.879 ± 0.03
1.098LysAsn: 1.098 ± 0.031
2.163LysPro: 2.163 ± 0.047
1.382LysGln: 1.382 ± 0.036
2.226LysArg: 2.226 ± 0.05
1.888LysSer: 1.888 ± 0.039
2.099LysThr: 2.099 ± 0.052
2.777LysVal: 2.777 ± 0.056
0.37LysTrp: 0.37 ± 0.02
0.73LysTyr: 0.73 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.552LeuAla: 14.552 ± 0.145
1.036LeuCys: 1.036 ± 0.031
5.504LeuAsp: 5.504 ± 0.071
5.282LeuGlu: 5.282 ± 0.074
3.297LeuPhe: 3.297 ± 0.059
8.489LeuGly: 8.489 ± 0.093
2.553LeuHis: 2.553 ± 0.047
4.233LeuIle: 4.233 ± 0.069
3.796LeuLys: 3.796 ± 0.065
11.272LeuLeu: 11.272 ± 0.142
2.588LeuMet: 2.588 ± 0.05
2.886LeuAsn: 2.886 ± 0.053
6.177LeuPro: 6.177 ± 0.069
5.289LeuGln: 5.289 ± 0.078
7.549LeuArg: 7.549 ± 0.095
5.886LeuSer: 5.886 ± 0.076
5.486LeuThr: 5.486 ± 0.068
7.985LeuVal: 7.985 ± 0.09
1.426LeuTrp: 1.426 ± 0.04
1.984LeuTyr: 1.984 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.309MetAla: 3.309 ± 0.059
0.184MetCys: 0.184 ± 0.014
1.293MetAsp: 1.293 ± 0.032
1.201MetGlu: 1.201 ± 0.031
0.687MetPhe: 0.687 ± 0.025
2.04MetGly: 2.04 ± 0.043
0.584MetHis: 0.584 ± 0.02
0.884MetIle: 0.884 ± 0.027
0.981MetLys: 0.981 ± 0.029
2.653MetLeu: 2.653 ± 0.045
0.557MetMet: 0.557 ± 0.022
0.82MetAsn: 0.82 ± 0.024
1.476MetPro: 1.476 ± 0.036
1.212MetGln: 1.212 ± 0.031
1.67MetArg: 1.67 ± 0.036
1.516MetSer: 1.516 ± 0.039
1.511MetThr: 1.511 ± 0.035
1.909MetVal: 1.909 ± 0.038
0.219MetTrp: 0.219 ± 0.013
0.392MetTyr: 0.392 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.596AsnAla: 3.596 ± 0.054
0.24AsnCys: 0.24 ± 0.015
1.331AsnAsp: 1.331 ± 0.032
1.289AsnGlu: 1.289 ± 0.037
0.952AsnPhe: 0.952 ± 0.026
2.098AsnGly: 2.098 ± 0.046
0.591AsnHis: 0.591 ± 0.024
1.254AsnIle: 1.254 ± 0.035
0.849AsnLys: 0.849 ± 0.029
2.609AsnLeu: 2.609 ± 0.041
0.61AsnMet: 0.61 ± 0.024
0.77AsnAsn: 0.77 ± 0.031
1.92AsnPro: 1.92 ± 0.044
1.012AsnGln: 1.012 ± 0.028
1.656AsnArg: 1.656 ± 0.036
1.198AsnSer: 1.198 ± 0.033
1.556AsnThr: 1.556 ± 0.038
1.999AsnVal: 1.999 ± 0.047
0.432AsnTrp: 0.432 ± 0.019
0.652AsnTyr: 0.652 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.272ProAla: 7.272 ± 0.109
0.374ProCys: 0.374 ± 0.018
2.91ProAsp: 2.91 ± 0.051
3.377ProGlu: 3.377 ± 0.05
1.742ProPhe: 1.742 ± 0.04
4.397ProGly: 4.397 ± 0.056
1.242ProHis: 1.242 ± 0.039
1.787ProIle: 1.787 ± 0.037
1.599ProLys: 1.599 ± 0.04
5.434ProLeu: 5.434 ± 0.069
1.203ProMet: 1.203 ± 0.033
1.26ProAsn: 1.26 ± 0.032
2.626ProPro: 2.626 ± 0.061
2.442ProGln: 2.442 ± 0.047
2.727ProArg: 2.727 ± 0.052
2.835ProSer: 2.835 ± 0.052
2.83ProThr: 2.83 ± 0.05
4.403ProVal: 4.403 ± 0.063
0.834ProTrp: 0.834 ± 0.029
1.145ProTyr: 1.145 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
6.448GlnAla: 6.448 ± 0.104
0.358GlnCys: 0.358 ± 0.017
1.883GlnAsp: 1.883 ± 0.042
2.019GlnGlu: 2.019 ± 0.041
1.396GlnPhe: 1.396 ± 0.032
3.614GlnGly: 3.614 ± 0.067
1.093GlnHis: 1.093 ± 0.031
1.848GlnIle: 1.848 ± 0.035
1.42GlnLys: 1.42 ± 0.033
4.704GlnLeu: 4.704 ± 0.077
1.112GlnMet: 1.112 ± 0.032
0.972GlnAsn: 0.972 ± 0.028
2.658GlnPro: 2.658 ± 0.046
2.363GlnGln: 2.363 ± 0.06
3.817GlnArg: 3.817 ± 0.07
2.296GlnSer: 2.296 ± 0.044
2.165GlnThr: 2.165 ± 0.04
3.387GlnVal: 3.387 ± 0.063
0.913GlnTrp: 0.913 ± 0.03
0.878GlnTyr: 0.878 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
7.302ArgAla: 7.302 ± 0.099
0.545ArgCys: 0.545 ± 0.023
3.296ArgAsp: 3.296 ± 0.054
3.966ArgGlu: 3.966 ± 0.065
2.49ArgPhe: 2.49 ± 0.038
4.237ArgGly: 4.237 ± 0.058
1.697ArgHis: 1.697 ± 0.039
3.206ArgIle: 3.206 ± 0.056
2.276ArgLys: 2.276 ± 0.047
7.322ArgLeu: 7.322 ± 0.1
1.911ArgMet: 1.911 ± 0.04
1.868ArgAsn: 1.868 ± 0.045
2.968ArgPro: 2.968 ± 0.053
2.99ArgGln: 2.99 ± 0.053
4.32ArgArg: 4.32 ± 0.073
3.509ArgSer: 3.509 ± 0.049
3.388ArgThr: 3.388 ± 0.053
4.815ArgVal: 4.815 ± 0.064
1.251ArgTrp: 1.251 ± 0.032
1.725ArgTyr: 1.725 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.771SerAla: 6.771 ± 0.072
0.427SerCys: 0.427 ± 0.021
2.568SerAsp: 2.568 ± 0.045
2.525SerGlu: 2.525 ± 0.052
1.921SerPhe: 1.921 ± 0.043
4.892SerGly: 4.892 ± 0.067
1.254SerHis: 1.254 ± 0.035
2.417SerIle: 2.417 ± 0.049
1.741SerLys: 1.741 ± 0.042
5.595SerLeu: 5.595 ± 0.079
1.376SerMet: 1.376 ± 0.035
1.488SerAsn: 1.488 ± 0.04
2.851SerPro: 2.851 ± 0.048
2.099SerGln: 2.099 ± 0.043
3.268SerArg: 3.268 ± 0.049
3.06SerSer: 3.06 ± 0.058
3.067SerThr: 3.067 ± 0.046
3.985SerVal: 3.985 ± 0.062
0.725SerTrp: 0.725 ± 0.026
1.292SerTyr: 1.292 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.418ThrAla: 6.418 ± 0.087
0.417ThrCys: 0.417 ± 0.022
2.583ThrAsp: 2.583 ± 0.048
2.59ThrGlu: 2.59 ± 0.043
1.744ThrPhe: 1.744 ± 0.038
4.728ThrGly: 4.728 ± 0.072
1.269ThrHis: 1.269 ± 0.033
2.073ThrIle: 2.073 ± 0.037
1.571ThrLys: 1.571 ± 0.037
6.433ThrLeu: 6.433 ± 0.07
1.094ThrMet: 1.094 ± 0.034
1.312ThrAsn: 1.312 ± 0.036
3.721ThrPro: 3.721 ± 0.059
2.341ThrGln: 2.341 ± 0.044
3.198ThrArg: 3.198 ± 0.052
2.877ThrSer: 2.877 ± 0.048
3.139ThrThr: 3.139 ± 0.059
4.399ThrVal: 4.399 ± 0.063
0.685ThrTrp: 0.685 ± 0.026
1.114ThrTyr: 1.114 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.775ValAla: 9.775 ± 0.1
0.751ValCys: 0.751 ± 0.025
3.988ValAsp: 3.988 ± 0.064
4.093ValGlu: 4.093 ± 0.055
2.724ValPhe: 2.724 ± 0.044
5.699ValGly: 5.699 ± 0.083
1.73ValHis: 1.73 ± 0.038
3.203ValIle: 3.203 ± 0.053
2.647ValLys: 2.647 ± 0.046
8.555ValLeu: 8.555 ± 0.105
1.954ValMet: 1.954 ± 0.046
2.163ValAsn: 2.163 ± 0.043
4.018ValPro: 4.018 ± 0.057
3.545ValGln: 3.545 ± 0.059
5.126ValArg: 5.126 ± 0.073
3.97ValSer: 3.97 ± 0.057
4.079ValThr: 4.079 ± 0.062
6.734ValVal: 6.734 ± 0.089
1.069ValTrp: 1.069 ± 0.032
1.569ValTyr: 1.569 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.554TrpAla: 1.554 ± 0.038
0.193TrpCys: 0.193 ± 0.014
0.62TrpAsp: 0.62 ± 0.022
0.593TrpGlu: 0.593 ± 0.023
0.564TrpPhe: 0.564 ± 0.024
1.083TrpGly: 1.083 ± 0.032
0.371TrpHis: 0.371 ± 0.019
0.653TrpIle: 0.653 ± 0.023
0.521TrpLys: 0.521 ± 0.022
2.196TrpLeu: 2.196 ± 0.052
0.479TrpMet: 0.479 ± 0.023
0.44TrpAsn: 0.44 ± 0.022
0.716TrpPro: 0.716 ± 0.029
0.792TrpGln: 0.792 ± 0.025
1.177TrpArg: 1.177 ± 0.033
0.818TrpSer: 0.818 ± 0.03
0.687TrpThr: 0.687 ± 0.025
1.108TrpVal: 1.108 ± 0.028
0.327TrpTrp: 0.327 ± 0.017
0.261TrpTyr: 0.261 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.58TyrAla: 2.58 ± 0.046
0.265TyrCys: 0.265 ± 0.013
1.176TyrAsp: 1.176 ± 0.032
1.221TyrGlu: 1.221 ± 0.03
0.91TyrPhe: 0.91 ± 0.024
1.913TyrGly: 1.913 ± 0.042
0.445TyrHis: 0.445 ± 0.021
0.8TyrIle: 0.8 ± 0.025
0.76TyrLys: 0.76 ± 0.027
2.359TyrLeu: 2.359 ± 0.051
0.45TyrMet: 0.45 ± 0.018
0.595TyrAsn: 0.595 ± 0.022
1.094TyrPro: 1.094 ± 0.033
0.958TyrGln: 0.958 ± 0.029
1.591TyrArg: 1.591 ± 0.031
1.235TyrSer: 1.235 ± 0.033
1.239TyrThr: 1.239 ± 0.031
1.551TyrVal: 1.551 ± 0.034
0.369TyrTrp: 0.369 ± 0.016
0.563TyrTyr: 0.563 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3750 proteins (1212441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski