Human papillomavirus 43

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 8

Average proteome isoelectric point is 7.2

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 10 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q705I0|Q705I0_HPV43 Protein E6 OS=Human papillomavirus 43 OX=10591 GN=E6 PE=3 SV=1
MM1 pKa = 7.44HH2 pKa = 7.29GKK4 pKa = 10.03KK5 pKa = 8.45PTIRR9 pKa = 11.84DD10 pKa = 3.66YY11 pKa = 11.64VLTMQPEE18 pKa = 4.32PRR20 pKa = 11.84SLTCNEE26 pKa = 4.21QLDD29 pKa = 4.21SSDD32 pKa = 4.24SEE34 pKa = 4.66DD35 pKa = 3.58EE36 pKa = 4.38RR37 pKa = 11.84EE38 pKa = 4.36QPTQQDD44 pKa = 3.33QQVNLQVYY52 pKa = 8.91RR53 pKa = 11.84VVTEE57 pKa = 4.23CTSCLCVIRR66 pKa = 11.84LVVQCSDD73 pKa = 3.23SDD75 pKa = 3.69IKK77 pKa = 11.08KK78 pKa = 10.83LEE80 pKa = 4.3DD81 pKa = 3.86LLLGTLKK88 pKa = 10.13IVCPLCTTTAVV99 pKa = 3.26

Molecular weight: 11.19 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|Q705H5|VL2_HPV43 Minor capsid protein L2 OS=Human papillomavirus 43 OX=10591 GN=L2 PE=3 SV=1
MM1 pKa = 7.66GIVCFFFYY9 pKa = 10.65AGNKK13 pKa = 9.34CSLDD17 pKa = 3.0IFLIKK22 pKa = 10.18LVKK25 pKa = 10.23LATLCLPICILLALIPGPKK44 pKa = 9.68LQIVYY49 pKa = 10.26IFLHH53 pKa = 6.39PVGLWLLLILNCLTNPYY70 pKa = 9.87GYY72 pKa = 10.25KK73 pKa = 9.96RR74 pKa = 11.84PRR76 pKa = 11.84DD77 pKa = 3.45IIMAFVLGISCLLQWW92 pKa = 4.39

Molecular weight: 10.43 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

1

10

3105

92

655

310.5

34.86

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.572 ± 0.403

2.802 ± 0.645

5.314 ± 0.38

4.702 ± 0.559

4.509 ± 0.603

6.087 ± 0.418

2.48 ± 0.415

5.153 ± 0.678

5.443 ± 0.62

8.792 ± 0.761

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.158 ± 0.264

3.768 ± 0.427

6.087 ± 0.82

4.38 ± 0.326

4.734 ± 0.258

7.794 ± 0.526

7.955 ± 0.675

6.795 ± 0.326

1.578 ± 0.256

3.897 ± 0.328
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski