Amino acid dipepetide frequency for Mycobacterium heidelbergense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.587AlaAla: 21.587 ± 0.205	1.026AlaCys: 1.026 ± 0.026	8.153AlaAsp: 8.153 ± 0.089	7.542AlaGlu: 7.542 ± 0.087	3.619AlaPhe: 3.619 ± 0.051	12.927AlaGly: 12.927 ± 0.139	2.697AlaHis: 2.697 ± 0.042	5.366AlaIle: 5.366 ± 0.061	3.014AlaLys: 3.014 ± 0.052	13.299AlaLeu: 13.299 ± 0.112	2.809AlaMet: 2.809 ± 0.048	2.962AlaAsn: 2.962 ± 0.049	6.516AlaPro: 6.516 ± 0.089	3.927AlaGln: 3.927 ± 0.048	9.218AlaArg: 9.218 ± 0.093	6.3AlaSer: 6.3 ± 0.073	7.191AlaThr: 7.191 ± 0.081	11.355AlaVal: 11.355 ± 0.104	1.772AlaTrp: 1.772 ± 0.04	2.343AlaTyr: 2.343 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.028	0.1CysCys: 0.1 ± 0.008	0.554CysAsp: 0.554 ± 0.024	0.414CysGlu: 0.414 ± 0.017	0.227CysPhe: 0.227 ± 0.014	0.967CysGly: 0.967 ± 0.029	0.182CysHis: 0.182 ± 0.012	0.228CysIle: 0.228 ± 0.013	0.118CysLys: 0.118 ± 0.009	0.676CysLeu: 0.676 ± 0.023	0.135CysMet: 0.135 ± 0.008	0.166CysAsn: 0.166 ± 0.01	0.534CysPro: 0.534 ± 0.02	0.238CysGln: 0.238 ± 0.012	0.585CysArg: 0.585 ± 0.022	0.453CysSer: 0.453 ± 0.021	0.459CysThr: 0.459 ± 0.02	0.693CysVal: 0.693 ± 0.023	0.128CysTrp: 0.128 ± 0.01	0.178CysTyr: 0.178 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.802AspAla: 7.802 ± 0.091	0.456AspCys: 0.456 ± 0.016	4.132AspAsp: 4.132 ± 0.06	3.962AspGlu: 3.962 ± 0.056	1.851AspPhe: 1.851 ± 0.035	5.825AspGly: 5.825 ± 0.073	1.374AspHis: 1.374 ± 0.032	2.495AspIle: 2.495 ± 0.044	1.248AspLys: 1.248 ± 0.032	5.989AspLeu: 5.989 ± 0.07	0.982AspMet: 0.982 ± 0.022	1.187AspAsn: 1.187 ± 0.029	4.344AspPro: 4.344 ± 0.061	1.621AspGln: 1.621 ± 0.035	4.602AspArg: 4.602 ± 0.058	2.554AspSer: 2.554 ± 0.045	3.019AspThr: 3.019 ± 0.044	5.316AspVal: 5.316 ± 0.058	0.937AspTrp: 0.937 ± 0.027	1.413AspTyr: 1.413 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.118GluAla: 6.118 ± 0.073	0.37GluCys: 0.37 ± 0.015	2.296GluAsp: 2.296 ± 0.042	2.42GluGlu: 2.42 ± 0.054	1.748GluPhe: 1.748 ± 0.037	3.216GluGly: 3.216 ± 0.051	1.512GluHis: 1.512 ± 0.036	2.58GluIle: 2.58 ± 0.051	1.237GluLys: 1.237 ± 0.036	6.409GluLeu: 6.409 ± 0.07	1.046GluMet: 1.046 ± 0.028	1.037GluAsn: 1.037 ± 0.024	3.026GluPro: 3.026 ± 0.049	1.888GluGln: 1.888 ± 0.044	4.544GluArg: 4.544 ± 0.069	2.63GluSer: 2.63 ± 0.045	2.466GluThr: 2.466 ± 0.043	4.179GluVal: 4.179 ± 0.056	0.775GluTrp: 0.775 ± 0.024	1.074GluTyr: 1.074 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.021PheAla: 4.021 ± 0.053	0.32PheCys: 0.32 ± 0.015	2.399PheAsp: 2.399 ± 0.041	1.53PheGlu: 1.53 ± 0.033	0.992PhePhe: 0.992 ± 0.03	3.553PheGly: 3.553 ± 0.058	0.63PheHis: 0.63 ± 0.019	1.006PheIle: 1.006 ± 0.028	0.538PheLys: 0.538 ± 0.02	2.601PheLeu: 2.601 ± 0.045	0.485PheMet: 0.485 ± 0.019	0.767PheAsn: 0.767 ± 0.028	1.499PhePro: 1.499 ± 0.034	0.738PheGln: 0.738 ± 0.022	1.7PheArg: 1.7 ± 0.034	1.757PheSer: 1.757 ± 0.039	1.987PheThr: 1.987 ± 0.038	2.612PheVal: 2.612 ± 0.052	0.441PheTrp: 0.441 ± 0.018	0.723PheTyr: 0.723 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.943GlyAla: 10.943 ± 0.114	0.823GlyCys: 0.823 ± 0.025	5.077GlyAsp: 5.077 ± 0.063	4.326GlyGlu: 4.326 ± 0.058	3.16GlyPhe: 3.16 ± 0.058	8.845GlyGly: 8.845 ± 0.179	2.097GlyHis: 2.097 ± 0.038	4.129GlyIle: 4.129 ± 0.059	2.343GlyLys: 2.343 ± 0.042	9.129GlyLeu: 9.129 ± 0.105	2.166GlyMet: 2.166 ± 0.038	2.249GlyAsn: 2.249 ± 0.063	4.999GlyPro: 4.999 ± 0.058	2.872GlyGln: 2.872 ± 0.049	6.549GlyArg: 6.549 ± 0.071	5.278GlySer: 5.278 ± 0.067	5.068GlyThr: 5.068 ± 0.067	7.605GlyVal: 7.605 ± 0.069	1.694GlyTrp: 1.694 ± 0.035	2.464GlyTyr: 2.464 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.634HisAla: 2.634 ± 0.047	0.215HisCys: 0.215 ± 0.012	1.428HisAsp: 1.428 ± 0.031	1.04HisGlu: 1.04 ± 0.026	0.661HisPhe: 0.661 ± 0.021	2.155HisGly: 2.155 ± 0.037	0.689HisHis: 0.689 ± 0.024	0.851HisIle: 0.851 ± 0.022	0.406HisLys: 0.406 ± 0.016	2.14HisLeu: 2.14 ± 0.036	0.363HisMet: 0.363 ± 0.016	0.514HisAsn: 0.514 ± 0.019	1.697HisPro: 1.697 ± 0.035	0.654HisGln: 0.654 ± 0.027	1.954HisArg: 1.954 ± 0.039	1.074HisSer: 1.074 ± 0.025	1.238HisThr: 1.238 ± 0.033	1.76HisVal: 1.76 ± 0.034	0.395HisTrp: 0.395 ± 0.016	0.579HisTyr: 0.579 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.241IleAla: 6.241 ± 0.068	0.364IleCys: 0.364 ± 0.014	3.349IleAsp: 3.349 ± 0.052	2.481IleGlu: 2.481 ± 0.049	1.013IlePhe: 1.013 ± 0.029	4.441IleGly: 4.441 ± 0.057	0.838IleHis: 0.838 ± 0.024	1.409IleIle: 1.409 ± 0.037	0.917IleLys: 0.917 ± 0.025	3.066IleLeu: 3.066 ± 0.05	0.594IleMet: 0.594 ± 0.02	1.257IleAsn: 1.257 ± 0.036	2.448IlePro: 2.448 ± 0.047	0.974IleGln: 0.974 ± 0.028	2.657IleArg: 2.657 ± 0.045	2.241IleSer: 2.241 ± 0.04	2.784IleThr: 2.784 ± 0.045	3.707IleVal: 3.707 ± 0.05	0.453IleTrp: 0.453 ± 0.017	0.759IleTyr: 0.759 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.681LysAla: 2.681 ± 0.049	0.113LysCys: 0.113 ± 0.008	1.1LysAsp: 1.1 ± 0.031	0.943LysGlu: 0.943 ± 0.029	0.585LysPhe: 0.585 ± 0.02	1.557LysGly: 1.557 ± 0.034	0.508LysHis: 0.508 ± 0.019	0.989LysIle: 0.989 ± 0.026	0.639LysLys: 0.639 ± 0.025	2.172LysLeu: 2.172 ± 0.042	0.434LysMet: 0.434 ± 0.015	0.541LysAsn: 0.541 ± 0.022	1.463LysPro: 1.463 ± 0.033	0.66LysGln: 0.66 ± 0.023	1.643LysArg: 1.643 ± 0.034	1.224LysSer: 1.224 ± 0.029	1.349LysThr: 1.349 ± 0.035	1.871LysVal: 1.871 ± 0.038	0.283LysTrp: 0.283 ± 0.014	0.476LysTyr: 0.476 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.747LeuAla: 14.747 ± 0.114	0.789LeuCys: 0.789 ± 0.025	6.393LeuAsp: 6.393 ± 0.076	4.355LeuGlu: 4.355 ± 0.06	2.707LeuPhe: 2.707 ± 0.048	8.969LeuGly: 8.969 ± 0.091	2.095LeuHis: 2.095 ± 0.041	4.116LeuIle: 4.116 ± 0.055	1.825LeuLys: 1.825 ± 0.033	9.772LeuLeu: 9.772 ± 0.118	1.766LeuMet: 1.766 ± 0.036	2.321LeuAsn: 2.321 ± 0.05	5.821LeuPro: 5.821 ± 0.069	2.587LeuGln: 2.587 ± 0.05	7.921LeuArg: 7.921 ± 0.091	5.805LeuSer: 5.805 ± 0.084	6.256LeuThr: 6.256 ± 0.073	8.222LeuVal: 8.222 ± 0.078	1.203LeuTrp: 1.203 ± 0.032	1.729LeuTyr: 1.729 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.612MetAla: 2.612 ± 0.042	0.179MetCys: 0.179 ± 0.011	0.884MetAsp: 0.884 ± 0.025	0.674MetGlu: 0.674 ± 0.023	0.627MetPhe: 0.627 ± 0.02	1.504MetGly: 1.504 ± 0.037	0.429MetHis: 0.429 ± 0.017	0.888MetIle: 0.888 ± 0.024	0.436MetLys: 0.436 ± 0.016	1.97MetLeu: 1.97 ± 0.04	0.404MetMet: 0.404 ± 0.016	0.508MetAsn: 0.508 ± 0.019	1.22MetPro: 1.22 ± 0.028	0.532MetGln: 0.532 ± 0.019	1.556MetArg: 1.556 ± 0.032	1.526MetSer: 1.526 ± 0.033	1.703MetThr: 1.703 ± 0.03	1.614MetVal: 1.614 ± 0.035	0.256MetTrp: 0.256 ± 0.012	0.343MetTyr: 0.343 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.901AsnAla: 2.901 ± 0.05	0.171AsnCys: 0.171 ± 0.011	1.272AsnAsp: 1.272 ± 0.031	0.978AsnGlu: 0.978 ± 0.027	0.79AsnPhe: 0.79 ± 0.022	2.482AsnGly: 2.482 ± 0.063	0.485AsnHis: 0.485 ± 0.018	1.019AsnIle: 1.019 ± 0.032	0.461AsnLys: 0.461 ± 0.018	2.321AsnLeu: 2.321 ± 0.052	0.43AsnMet: 0.43 ± 0.019	0.633AsnAsn: 0.633 ± 0.023	1.886AsnPro: 1.886 ± 0.04	0.677AsnGln: 0.677 ± 0.026	1.542AsnArg: 1.542 ± 0.036	1.235AsnSer: 1.235 ± 0.034	1.38AsnThr: 1.38 ± 0.03	1.894AsnVal: 1.894 ± 0.036	0.401AsnTrp: 0.401 ± 0.017	0.58AsnTyr: 0.58 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.574ProAla: 7.574 ± 0.092	0.303ProCys: 0.303 ± 0.014	4.347ProAsp: 4.347 ± 0.056	3.614ProGlu: 3.614 ± 0.054	1.691ProPhe: 1.691 ± 0.03	6.174ProGly: 6.174 ± 0.075	1.284ProHis: 1.284 ± 0.031	2.233ProIle: 2.233 ± 0.042	1.275ProLys: 1.275 ± 0.033	4.996ProLeu: 4.996 ± 0.061	1.208ProMet: 1.208 ± 0.027	1.362ProAsn: 1.362 ± 0.032	4.076ProPro: 4.076 ± 0.095	1.758ProGln: 1.758 ± 0.043	3.734ProArg: 3.734 ± 0.056	3.179ProSer: 3.179 ± 0.053	3.446ProThr: 3.446 ± 0.05	5.076ProVal: 5.076 ± 0.068	0.828ProTrp: 0.828 ± 0.021	1.192ProTyr: 1.192 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.67GlnAla: 3.67 ± 0.056	0.205GlnCys: 0.205 ± 0.012	1.153GlnAsp: 1.153 ± 0.028	1.052GlnGlu: 1.052 ± 0.028	0.939GlnPhe: 0.939 ± 0.024	1.974GlnGly: 1.974 ± 0.04	0.779GlnHis: 0.779 ± 0.023	1.443GlnIle: 1.443 ± 0.036	0.586GlnLys: 0.586 ± 0.018	3.534GlnLeu: 3.534 ± 0.053	0.621GlnMet: 0.621 ± 0.02	0.693GlnAsn: 0.693 ± 0.023	1.808GlnPro: 1.808 ± 0.037	1.251GlnGln: 1.251 ± 0.036	2.748GlnArg: 2.748 ± 0.045	1.431GlnSer: 1.431 ± 0.034	1.607GlnThr: 1.607 ± 0.037	2.426GlnVal: 2.426 ± 0.046	0.525GlnTrp: 0.525 ± 0.02	0.631GlnTyr: 0.631 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.845ArgAla: 8.845 ± 0.097	0.637ArgCys: 0.637 ± 0.021	4.349ArgAsp: 4.349 ± 0.053	3.804ArgGlu: 3.804 ± 0.051	2.464ArgPhe: 2.464 ± 0.046	5.537ArgGly: 5.537 ± 0.067	1.907ArgHis: 1.907 ± 0.034	3.398ArgIle: 3.398 ± 0.055	1.517ArgLys: 1.517 ± 0.035	7.927ArgLeu: 7.927 ± 0.084	1.765ArgMet: 1.765 ± 0.033	1.564ArgAsn: 1.564 ± 0.036	4.38ArgPro: 4.38 ± 0.057	2.342ArgGln: 2.342 ± 0.044	7.191ArgArg: 7.191 ± 0.09	3.854ArgSer: 3.854 ± 0.061	3.908ArgThr: 3.908 ± 0.06	5.877ArgVal: 5.877 ± 0.068	1.424ArgTrp: 1.424 ± 0.036	1.924ArgTyr: 1.924 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.9SerAla: 6.9 ± 0.071	0.406SerCys: 0.406 ± 0.017	3.008SerAsp: 3.008 ± 0.049	2.351SerGlu: 2.351 ± 0.044	1.634SerPhe: 1.634 ± 0.037	5.751SerGly: 5.751 ± 0.079	1.06SerHis: 1.06 ± 0.026	2.166SerIle: 2.166 ± 0.041	1.136SerLys: 1.136 ± 0.031	5.066SerLeu: 5.066 ± 0.068	1.274SerMet: 1.274 ± 0.03	1.236SerAsn: 1.236 ± 0.032	3.158SerPro: 3.158 ± 0.047	1.481SerGln: 1.481 ± 0.033	3.729SerArg: 3.729 ± 0.055	3.08SerSer: 3.08 ± 0.056	3.259SerThr: 3.259 ± 0.052	4.434SerVal: 4.434 ± 0.055	0.911SerTrp: 0.911 ± 0.025	1.268SerTyr: 1.268 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.735ThrAla: 7.735 ± 0.08	0.414ThrCys: 0.414 ± 0.014	3.461ThrAsp: 3.461 ± 0.046	2.92ThrGlu: 2.92 ± 0.046	1.778ThrPhe: 1.778 ± 0.043	5.758ThrGly: 5.758 ± 0.063	1.202ThrHis: 1.202 ± 0.031	2.416ThrIle: 2.416 ± 0.045	1.205ThrLys: 1.205 ± 0.03	5.489ThrLeu: 5.489 ± 0.061	1.208ThrMet: 1.208 ± 0.036	1.433ThrAsn: 1.433 ± 0.038	3.759ThrPro: 3.759 ± 0.055	1.546ThrGln: 1.546 ± 0.04	3.625ThrArg: 3.625 ± 0.056	3.024ThrSer: 3.024 ± 0.044	3.713ThrThr: 3.713 ± 0.058	5.404ThrVal: 5.404 ± 0.07	0.841ThrTrp: 0.841 ± 0.023	1.238ThrTyr: 1.238 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.474ValAla: 11.474 ± 0.096	0.811ValCys: 0.811 ± 0.024	5.605ValAsp: 5.605 ± 0.068	4.39ValGlu: 4.39 ± 0.062	2.505ValPhe: 2.505 ± 0.044	7.141ValGly: 7.141 ± 0.073	1.819ValHis: 1.819 ± 0.034	3.972ValIle: 3.972 ± 0.056	1.652ValLys: 1.652 ± 0.034	8.664ValLeu: 8.664 ± 0.084	1.544ValMet: 1.544 ± 0.035	2.177ValAsn: 2.177 ± 0.041	4.57ValPro: 4.57 ± 0.06	2.016ValGln: 2.016 ± 0.033	5.927ValArg: 5.927 ± 0.065	4.635ValSer: 4.635 ± 0.057	5.332ValThr: 5.332 ± 0.062	8.271ValVal: 8.271 ± 0.092	1.047ValTrp: 1.047 ± 0.027	1.603ValTyr: 1.603 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.029	0.178TrpCys: 0.178 ± 0.011	0.783TrpAsp: 0.783 ± 0.023	0.686TrpGlu: 0.686 ± 0.02	0.498TrpPhe: 0.498 ± 0.02	0.982TrpGly: 0.982 ± 0.029	0.375TrpHis: 0.375 ± 0.016	0.685TrpIle: 0.685 ± 0.022	0.317TrpLys: 0.317 ± 0.016	1.812TrpLeu: 1.812 ± 0.04	0.332TrpMet: 0.332 ± 0.017	0.412TrpAsn: 0.412 ± 0.021	0.899TrpPro: 0.899 ± 0.026	0.573TrpGln: 0.573 ± 0.021	1.332TrpArg: 1.332 ± 0.03	0.934TrpSer: 0.934 ± 0.025	0.835TrpThr: 0.835 ± 0.025	1.148TrpVal: 1.148 ± 0.029	0.33TrpTrp: 0.33 ± 0.017	0.301TrpTyr: 0.301 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.049	0.229TyrCys: 0.229 ± 0.012	1.361TyrAsp: 1.361 ± 0.031	1.089TyrGlu: 1.089 ± 0.027	0.81TyrPhe: 0.81 ± 0.021	2.057TyrGly: 2.057 ± 0.039	0.483TyrHis: 0.483 ± 0.016	0.604TyrIle: 0.604 ± 0.02	0.362TyrLys: 0.362 ± 0.017	2.368TyrLeu: 2.368 ± 0.041	0.295TyrMet: 0.295 ± 0.014	0.519TyrAsn: 0.519 ± 0.019	1.248TyrPro: 1.248 ± 0.032	0.738TyrGln: 0.738 ± 0.024	1.862TyrArg: 1.862 ± 0.034	1.096TyrSer: 1.096 ± 0.023	1.168TyrThr: 1.168 ± 0.03	1.69TyrVal: 1.69 ± 0.032	0.349TyrTrp: 0.349 ± 0.015	0.519TyrTyr: 0.519 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4472 proteins (1446619 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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