Amino acid dipepetide frequency for Mycobacterium phage MissWhite

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.024AlaAla: 11.024 ± 0.965
0.897AlaCys: 0.897 ± 0.24
5.512AlaAsp: 5.512 ± 0.632
8.14AlaGlu: 8.14 ± 0.888
3.974AlaPhe: 3.974 ± 0.581
8.589AlaGly: 8.589 ± 0.969
1.474AlaHis: 1.474 ± 0.29
4.358AlaIle: 4.358 ± 0.561
4.294AlaLys: 4.294 ± 0.518
8.845AlaLeu: 8.845 ± 1.231
2.756AlaMet: 2.756 ± 0.415
3.461AlaAsn: 3.461 ± 0.48
4.679AlaPro: 4.679 ± 0.615
4.166AlaGln: 4.166 ± 0.633
6.089AlaArg: 6.089 ± 0.761
3.653AlaSer: 3.653 ± 0.395
4.935AlaThr: 4.935 ± 0.563
7.05AlaVal: 7.05 ± 0.586
1.987AlaTrp: 1.987 ± 0.349
2.884AlaTyr: 2.884 ± 0.481
0.0AlaXaa: 0.0 ± 0.0
Cys
0.833CysAla: 0.833 ± 0.238
0.256CysCys: 0.256 ± 0.196
0.641CysAsp: 0.641 ± 0.223
0.449CysGlu: 0.449 ± 0.156
0.256CysPhe: 0.256 ± 0.154
0.961CysGly: 0.961 ± 0.26
0.256CysHis: 0.256 ± 0.117
0.385CysIle: 0.385 ± 0.156
0.449CysLys: 0.449 ± 0.168
0.641CysLeu: 0.641 ± 0.196
0.192CysMet: 0.192 ± 0.104
0.577CysAsn: 0.577 ± 0.166
0.513CysPro: 0.513 ± 0.224
0.256CysGln: 0.256 ± 0.114
1.026CysArg: 1.026 ± 0.226
0.32CysSer: 0.32 ± 0.13
0.577CysThr: 0.577 ± 0.179
0.449CysVal: 0.449 ± 0.194
0.449CysTrp: 0.449 ± 0.146
0.385CysTyr: 0.385 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
6.153AspAla: 6.153 ± 0.608
0.833AspCys: 0.833 ± 0.26
4.358AspAsp: 4.358 ± 0.604
5.063AspGlu: 5.063 ± 0.678
2.436AspPhe: 2.436 ± 0.45
5.512AspGly: 5.512 ± 0.592
2.051AspHis: 2.051 ± 0.448
3.333AspIle: 3.333 ± 0.437
2.115AspLys: 2.115 ± 0.391
6.025AspLeu: 6.025 ± 0.602
1.795AspMet: 1.795 ± 0.378
1.346AspAsn: 1.346 ± 0.333
5.32AspPro: 5.32 ± 0.655
1.731AspGln: 1.731 ± 0.329
3.397AspArg: 3.397 ± 0.511
2.884AspSer: 2.884 ± 0.434
3.589AspThr: 3.589 ± 0.547
4.615AspVal: 4.615 ± 0.487
1.218AspTrp: 1.218 ± 0.293
2.371AspTyr: 2.371 ± 0.413
0.0AspXaa: 0.0 ± 0.0
Glu
7.371GluAla: 7.371 ± 0.787
0.32GluCys: 0.32 ± 0.126
5.128GluAsp: 5.128 ± 0.742
5.512GluGlu: 5.512 ± 0.825
2.948GluPhe: 2.948 ± 0.426
4.871GluGly: 4.871 ± 0.648
1.602GluHis: 1.602 ± 0.329
4.487GluIle: 4.487 ± 0.709
2.564GluLys: 2.564 ± 0.457
7.307GluLeu: 7.307 ± 0.706
2.051GluMet: 2.051 ± 0.368
1.538GluAsn: 1.538 ± 0.303
2.436GluPro: 2.436 ± 0.398
2.371GluGln: 2.371 ± 0.308
4.551GluArg: 4.551 ± 0.492
2.756GluSer: 2.756 ± 0.402
3.397GluThr: 3.397 ± 0.367
5.576GluVal: 5.576 ± 0.634
1.859GluTrp: 1.859 ± 0.366
2.243GluTyr: 2.243 ± 0.389
0.0GluXaa: 0.0 ± 0.0
Phe
3.205PheAla: 3.205 ± 0.39
0.32PheCys: 0.32 ± 0.143
2.243PheAsp: 2.243 ± 0.402
2.884PheGlu: 2.884 ± 0.341
0.513PhePhe: 0.513 ± 0.156
2.82PheGly: 2.82 ± 0.375
0.769PheHis: 0.769 ± 0.259
1.346PheIle: 1.346 ± 0.284
1.41PheLys: 1.41 ± 0.302
2.5PheLeu: 2.5 ± 0.451
0.769PheMet: 0.769 ± 0.178
1.731PheAsn: 1.731 ± 0.316
2.115PhePro: 2.115 ± 0.319
1.026PheGln: 1.026 ± 0.346
2.436PheArg: 2.436 ± 0.42
2.307PheSer: 2.307 ± 0.453
2.243PheThr: 2.243 ± 0.315
2.5PheVal: 2.5 ± 0.371
0.513PheTrp: 0.513 ± 0.204
0.833PheTyr: 0.833 ± 0.176
0.0PheXaa: 0.0 ± 0.0
Gly
7.243GlyAla: 7.243 ± 1.093
0.641GlyCys: 0.641 ± 0.221
5.961GlyAsp: 5.961 ± 0.709
4.423GlyGlu: 4.423 ± 0.57
3.269GlyPhe: 3.269 ± 0.566
9.422GlyGly: 9.422 ± 1.478
1.859GlyHis: 1.859 ± 0.328
4.358GlyIle: 4.358 ± 0.589
3.846GlyLys: 3.846 ± 0.441
5.576GlyLeu: 5.576 ± 0.813
2.371GlyMet: 2.371 ± 0.417
3.333GlyAsn: 3.333 ± 0.475
3.782GlyPro: 3.782 ± 0.427
3.333GlyGln: 3.333 ± 0.372
3.782GlyArg: 3.782 ± 0.481
3.461GlySer: 3.461 ± 0.558
5.256GlyThr: 5.256 ± 0.783
6.217GlyVal: 6.217 ± 0.65
1.474GlyTrp: 1.474 ± 0.301
2.371GlyTyr: 2.371 ± 0.373
0.0GlyXaa: 0.0 ± 0.0
His
1.218HisAla: 1.218 ± 0.272
0.385HisCys: 0.385 ± 0.144
1.923HisAsp: 1.923 ± 0.417
1.602HisGlu: 1.602 ± 0.343
0.513HisPhe: 0.513 ± 0.177
1.602HisGly: 1.602 ± 0.445
0.577HisHis: 0.577 ± 0.194
1.218HisIle: 1.218 ± 0.266
1.282HisLys: 1.282 ± 0.326
1.218HisLeu: 1.218 ± 0.253
0.449HisMet: 0.449 ± 0.145
0.641HisAsn: 0.641 ± 0.213
1.346HisPro: 1.346 ± 0.253
0.769HisGln: 0.769 ± 0.246
1.795HisArg: 1.795 ± 0.376
0.769HisSer: 0.769 ± 0.191
0.961HisThr: 0.961 ± 0.239
1.282HisVal: 1.282 ± 0.254
0.32HisTrp: 0.32 ± 0.144
0.833HisTyr: 0.833 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
6.217IleAla: 6.217 ± 0.672
0.385IleCys: 0.385 ± 0.17
3.269IleAsp: 3.269 ± 0.456
4.871IleGlu: 4.871 ± 0.562
1.666IlePhe: 1.666 ± 0.358
4.487IleGly: 4.487 ± 0.67
1.346IleHis: 1.346 ± 0.272
1.474IleIle: 1.474 ± 0.329
2.371IleLys: 2.371 ± 0.341
3.461IleLeu: 3.461 ± 0.403
0.577IleMet: 0.577 ± 0.18
1.987IleAsn: 1.987 ± 0.384
3.653IlePro: 3.653 ± 0.481
1.474IleGln: 1.474 ± 0.329
3.205IleArg: 3.205 ± 0.509
2.564IleSer: 2.564 ± 0.516
3.077IleThr: 3.077 ± 0.429
2.371IleVal: 2.371 ± 0.388
0.641IleTrp: 0.641 ± 0.18
0.769IleTyr: 0.769 ± 0.198
0.0IleXaa: 0.0 ± 0.0
Lys
5.128LysAla: 5.128 ± 0.63
0.192LysCys: 0.192 ± 0.118
2.179LysAsp: 2.179 ± 0.327
2.115LysGlu: 2.115 ± 0.324
0.961LysPhe: 0.961 ± 0.214
2.756LysGly: 2.756 ± 0.396
0.577LysHis: 0.577 ± 0.17
2.051LysIle: 2.051 ± 0.306
3.141LysLys: 3.141 ± 0.624
2.692LysLeu: 2.692 ± 0.483
1.666LysMet: 1.666 ± 0.294
1.346LysAsn: 1.346 ± 0.259
2.436LysPro: 2.436 ± 0.464
1.602LysGln: 1.602 ± 0.309
3.846LysArg: 3.846 ± 0.484
1.795LysSer: 1.795 ± 0.316
3.333LysThr: 3.333 ± 0.454
4.166LysVal: 4.166 ± 0.618
0.897LysTrp: 0.897 ± 0.215
0.961LysTyr: 0.961 ± 0.281
0.0LysXaa: 0.0 ± 0.0
Leu
8.909LeuAla: 8.909 ± 1.032
0.897LeuCys: 0.897 ± 0.221
4.679LeuAsp: 4.679 ± 0.606
5.704LeuGlu: 5.704 ± 0.634
2.179LeuPhe: 2.179 ± 0.294
6.73LeuGly: 6.73 ± 1.113
1.602LeuHis: 1.602 ± 0.408
4.743LeuIle: 4.743 ± 0.52
2.884LeuLys: 2.884 ± 0.432
5.704LeuLeu: 5.704 ± 0.649
2.82LeuMet: 2.82 ± 0.481
2.756LeuAsn: 2.756 ± 0.416
4.23LeuPro: 4.23 ± 0.428
2.5LeuGln: 2.5 ± 0.565
5.704LeuArg: 5.704 ± 0.82
4.487LeuSer: 4.487 ± 0.5
4.871LeuThr: 4.871 ± 0.663
4.679LeuVal: 4.679 ± 0.468
1.474LeuTrp: 1.474 ± 0.265
2.179LeuTyr: 2.179 ± 0.46
0.0LeuXaa: 0.0 ± 0.0
Met
2.436MetAla: 2.436 ± 0.357
0.128MetCys: 0.128 ± 0.095
1.538MetAsp: 1.538 ± 0.283
1.346MetGlu: 1.346 ± 0.346
0.449MetPhe: 0.449 ± 0.16
1.923MetGly: 1.923 ± 0.359
0.192MetHis: 0.192 ± 0.111
1.346MetIle: 1.346 ± 0.309
1.731MetLys: 1.731 ± 0.31
1.795MetLeu: 1.795 ± 0.337
0.577MetMet: 0.577 ± 0.192
0.897MetAsn: 0.897 ± 0.27
1.474MetPro: 1.474 ± 0.349
1.154MetGln: 1.154 ± 0.252
1.41MetArg: 1.41 ± 0.324
2.371MetSer: 2.371 ± 0.297
3.141MetThr: 3.141 ± 0.342
1.346MetVal: 1.346 ± 0.341
0.32MetTrp: 0.32 ± 0.134
0.577MetTyr: 0.577 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
3.012AsnAla: 3.012 ± 0.521
0.385AsnCys: 0.385 ± 0.167
2.051AsnAsp: 2.051 ± 0.3
1.795AsnGlu: 1.795 ± 0.377
1.154AsnPhe: 1.154 ± 0.279
3.269AsnGly: 3.269 ± 0.422
1.09AsnHis: 1.09 ± 0.267
1.41AsnIle: 1.41 ± 0.284
1.154AsnLys: 1.154 ± 0.272
2.884AsnLeu: 2.884 ± 0.409
1.154AsnMet: 1.154 ± 0.27
1.026AsnAsn: 1.026 ± 0.296
2.628AsnPro: 2.628 ± 0.427
1.026AsnGln: 1.026 ± 0.23
1.859AsnArg: 1.859 ± 0.375
1.41AsnSer: 1.41 ± 0.322
2.051AsnThr: 2.051 ± 0.46
2.307AsnVal: 2.307 ± 0.366
0.833AsnTrp: 0.833 ± 0.198
1.09AsnTyr: 1.09 ± 0.233
0.0AsnXaa: 0.0 ± 0.0
Pro
4.423ProAla: 4.423 ± 0.44
0.449ProCys: 0.449 ± 0.177
3.653ProAsp: 3.653 ± 0.469
4.423ProGlu: 4.423 ± 0.533
1.923ProPhe: 1.923 ± 0.366
4.615ProGly: 4.615 ± 0.524
0.961ProHis: 0.961 ± 0.22
3.333ProIle: 3.333 ± 0.459
2.564ProLys: 2.564 ± 0.503
3.077ProLeu: 3.077 ± 0.383
1.026ProMet: 1.026 ± 0.28
2.243ProAsn: 2.243 ± 0.365
2.564ProPro: 2.564 ± 0.462
1.859ProGln: 1.859 ± 0.355
3.269ProArg: 3.269 ± 0.577
2.756ProSer: 2.756 ± 0.382
3.91ProThr: 3.91 ± 0.529
3.653ProVal: 3.653 ± 0.511
1.026ProTrp: 1.026 ± 0.367
1.154ProTyr: 1.154 ± 0.302
0.0ProXaa: 0.0 ± 0.0
Gln
4.102GlnAla: 4.102 ± 0.644
0.192GlnCys: 0.192 ± 0.111
1.859GlnAsp: 1.859 ± 0.325
1.602GlnGlu: 1.602 ± 0.333
1.346GlnPhe: 1.346 ± 0.245
2.948GlnGly: 2.948 ± 0.449
0.961GlnHis: 0.961 ± 0.182
2.051GlnIle: 2.051 ± 0.339
1.602GlnLys: 1.602 ± 0.323
3.141GlnLeu: 3.141 ± 0.574
1.154GlnMet: 1.154 ± 0.283
1.154GlnAsn: 1.154 ± 0.25
1.154GlnPro: 1.154 ± 0.312
1.731GlnGln: 1.731 ± 0.338
2.5GlnArg: 2.5 ± 0.405
1.538GlnSer: 1.538 ± 0.361
2.884GlnThr: 2.884 ± 0.434
2.051GlnVal: 2.051 ± 0.351
0.833GlnTrp: 0.833 ± 0.215
1.026GlnTyr: 1.026 ± 0.216
0.0GlnXaa: 0.0 ± 0.0
Arg
5.897ArgAla: 5.897 ± 0.747
0.897ArgCys: 0.897 ± 0.296
4.166ArgAsp: 4.166 ± 0.519
6.153ArgGlu: 6.153 ± 0.674
2.82ArgPhe: 2.82 ± 0.492
3.397ArgGly: 3.397 ± 0.5
1.41ArgHis: 1.41 ± 0.29
3.653ArgIle: 3.653 ± 0.516
3.397ArgLys: 3.397 ± 0.521
4.999ArgLeu: 4.999 ± 0.488
2.115ArgMet: 2.115 ± 0.337
2.436ArgAsn: 2.436 ± 0.389
2.243ArgPro: 2.243 ± 0.376
1.731ArgGln: 1.731 ± 0.285
5.448ArgArg: 5.448 ± 0.653
3.141ArgSer: 3.141 ± 0.58
2.371ArgThr: 2.371 ± 0.418
5.704ArgVal: 5.704 ± 0.672
1.538ArgTrp: 1.538 ± 0.299
2.371ArgTyr: 2.371 ± 0.442
0.0ArgXaa: 0.0 ± 0.0
Ser
4.935SerAla: 4.935 ± 0.511
0.705SerCys: 0.705 ± 0.221
3.653SerAsp: 3.653 ± 0.501
3.141SerGlu: 3.141 ± 0.506
2.179SerPhe: 2.179 ± 0.407
4.23SerGly: 4.23 ± 0.56
0.641SerHis: 0.641 ± 0.193
2.115SerIle: 2.115 ± 0.417
2.243SerLys: 2.243 ± 0.486
4.038SerLeu: 4.038 ± 0.569
1.538SerMet: 1.538 ± 0.272
1.154SerAsn: 1.154 ± 0.255
3.012SerPro: 3.012 ± 0.423
1.666SerGln: 1.666 ± 0.33
3.974SerArg: 3.974 ± 0.429
3.205SerSer: 3.205 ± 0.538
2.243SerThr: 2.243 ± 0.381
3.525SerVal: 3.525 ± 0.544
1.026SerTrp: 1.026 ± 0.304
0.897SerTyr: 0.897 ± 0.219
0.0SerXaa: 0.0 ± 0.0
Thr
6.153ThrAla: 6.153 ± 0.54
0.769ThrCys: 0.769 ± 0.224
4.102ThrAsp: 4.102 ± 0.534
3.461ThrGlu: 3.461 ± 0.445
1.859ThrPhe: 1.859 ± 0.318
5.192ThrGly: 5.192 ± 0.642
1.026ThrHis: 1.026 ± 0.252
2.756ThrIle: 2.756 ± 0.463
2.884ThrLys: 2.884 ± 0.439
5.063ThrLeu: 5.063 ± 0.855
1.218ThrMet: 1.218 ± 0.221
1.987ThrAsn: 1.987 ± 0.37
4.038ThrPro: 4.038 ± 0.488
1.923ThrGln: 1.923 ± 0.342
3.333ThrArg: 3.333 ± 0.431
2.948ThrSer: 2.948 ± 0.473
3.141ThrThr: 3.141 ± 0.457
5.128ThrVal: 5.128 ± 0.598
1.026ThrTrp: 1.026 ± 0.283
1.923ThrTyr: 1.923 ± 0.267
0.0ThrXaa: 0.0 ± 0.0
Val
6.025ValAla: 6.025 ± 0.647
0.641ValCys: 0.641 ± 0.196
5.512ValAsp: 5.512 ± 0.57
4.679ValGlu: 4.679 ± 0.478
2.5ValPhe: 2.5 ± 0.419
4.679ValGly: 4.679 ± 0.468
1.602ValHis: 1.602 ± 0.307
3.077ValIle: 3.077 ± 0.459
2.884ValLys: 2.884 ± 0.396
6.666ValLeu: 6.666 ± 0.661
0.897ValMet: 0.897 ± 0.333
2.692ValAsn: 2.692 ± 0.44
2.948ValPro: 2.948 ± 0.542
2.884ValGln: 2.884 ± 0.401
4.871ValArg: 4.871 ± 0.649
4.551ValSer: 4.551 ± 0.608
4.999ValThr: 4.999 ± 0.519
5.063ValVal: 5.063 ± 0.495
1.282ValTrp: 1.282 ± 0.266
2.436ValTyr: 2.436 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
1.987TrpAla: 1.987 ± 0.474
0.385TrpCys: 0.385 ± 0.168
1.538TrpAsp: 1.538 ± 0.318
1.41TrpGlu: 1.41 ± 0.263
0.833TrpPhe: 0.833 ± 0.231
1.474TrpGly: 1.474 ± 0.298
0.385TrpHis: 0.385 ± 0.137
1.09TrpIle: 1.09 ± 0.255
0.385TrpLys: 0.385 ± 0.162
1.154TrpLeu: 1.154 ± 0.305
0.385TrpMet: 0.385 ± 0.165
0.705TrpAsn: 0.705 ± 0.24
0.833TrpPro: 0.833 ± 0.22
1.218TrpGln: 1.218 ± 0.282
1.282TrpArg: 1.282 ± 0.302
1.218TrpSer: 1.218 ± 0.314
1.218TrpThr: 1.218 ± 0.302
1.346TrpVal: 1.346 ± 0.265
0.513TrpTrp: 0.513 ± 0.2
0.385TrpTyr: 0.385 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.5TyrAla: 2.5 ± 0.388
0.192TyrCys: 0.192 ± 0.113
2.179TyrAsp: 2.179 ± 0.376
2.115TyrGlu: 2.115 ± 0.391
0.705TyrPhe: 0.705 ± 0.195
2.5TyrGly: 2.5 ± 0.407
0.32TyrHis: 0.32 ± 0.143
1.282TyrIle: 1.282 ± 0.302
0.641TyrLys: 0.641 ± 0.214
2.948TyrLeu: 2.948 ± 0.446
0.577TyrMet: 0.577 ± 0.205
0.577TyrAsn: 0.577 ± 0.175
1.474TyrPro: 1.474 ± 0.252
1.41TyrGln: 1.41 ± 0.344
2.115TyrArg: 2.115 ± 0.473
1.987TyrSer: 1.987 ± 0.379
1.731TyrThr: 1.731 ± 0.336
1.923TyrVal: 1.923 ± 0.391
0.513TyrTrp: 0.513 ± 0.194
1.026TyrTyr: 1.026 ± 0.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (15603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski