Amino acid dipepetide frequency for Leptospira phage vB_LbrZ_5399-LE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.159AlaAla: 4.159 ± 0.959
0.432AlaCys: 0.432 ± 0.119
2.707AlaAsp: 2.707 ± 0.376
3.688AlaGlu: 3.688 ± 0.408
2.786AlaPhe: 2.786 ± 0.346
3.845AlaGly: 3.845 ± 0.522
0.863AlaHis: 0.863 ± 0.234
5.454AlaIle: 5.454 ± 0.405
3.767AlaLys: 3.767 ± 0.446
6.004AlaLeu: 6.004 ± 0.48
1.059AlaMet: 1.059 ± 0.194
3.257AlaAsn: 3.257 ± 0.496
1.609AlaPro: 1.609 ± 0.261
1.413AlaGln: 1.413 ± 0.596
2.433AlaArg: 2.433 ± 0.399
4.356AlaSer: 4.356 ± 0.508
2.747AlaThr: 2.747 ± 0.515
3.1AlaVal: 3.1 ± 0.394
0.589AlaTrp: 0.589 ± 0.188
2.433AlaTyr: 2.433 ± 0.409
0.0AlaXaa: 0.0 ± 0.0
Cys
0.471CysAla: 0.471 ± 0.144
0.118CysCys: 0.118 ± 0.072
0.392CysAsp: 0.392 ± 0.123
0.392CysGlu: 0.392 ± 0.149
0.549CysPhe: 0.549 ± 0.162
0.353CysGly: 0.353 ± 0.116
0.0CysHis: 0.0 ± 0.0
0.549CysIle: 0.549 ± 0.123
0.353CysLys: 0.353 ± 0.107
0.51CysLeu: 0.51 ± 0.13
0.078CysMet: 0.078 ± 0.059
0.235CysAsn: 0.235 ± 0.09
0.353CysPro: 0.353 ± 0.151
0.196CysGln: 0.196 ± 0.089
0.196CysArg: 0.196 ± 0.074
0.51CysSer: 0.51 ± 0.151
0.432CysThr: 0.432 ± 0.141
0.314CysVal: 0.314 ± 0.09
0.118CysTrp: 0.118 ± 0.06
0.157CysTyr: 0.157 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
2.394AspAla: 2.394 ± 0.314
0.314AspCys: 0.314 ± 0.113
2.158AspAsp: 2.158 ± 0.326
3.139AspGlu: 3.139 ± 0.373
3.1AspPhe: 3.1 ± 0.312
2.315AspGly: 2.315 ± 0.372
0.628AspHis: 0.628 ± 0.172
3.296AspIle: 3.296 ± 0.323
3.296AspLys: 3.296 ± 0.441
5.533AspLeu: 5.533 ± 0.406
0.902AspMet: 0.902 ± 0.188
1.727AspAsn: 1.727 ± 0.362
3.218AspPro: 3.218 ± 0.287
1.216AspGln: 1.216 ± 0.235
2.59AspArg: 2.59 ± 0.432
4.905AspSer: 4.905 ± 0.455
2.08AspThr: 2.08 ± 0.231
1.727AspVal: 1.727 ± 0.245
0.628AspTrp: 0.628 ± 0.133
2.08AspTyr: 2.08 ± 0.364
0.0AspXaa: 0.0 ± 0.0
Glu
4.042GluAla: 4.042 ± 0.377
0.432GluCys: 0.432 ± 0.127
3.178GluAsp: 3.178 ± 0.281
6.043GluGlu: 6.043 ± 0.766
3.845GluPhe: 3.845 ± 0.446
3.767GluGly: 3.767 ± 0.369
0.589GluHis: 0.589 ± 0.155
7.769GluIle: 7.769 ± 0.887
7.809GluLys: 7.809 ± 0.779
7.063GluLeu: 7.063 ± 0.746
1.413GluMet: 1.413 ± 0.238
4.669GluAsn: 4.669 ± 0.517
1.491GluPro: 1.491 ± 0.269
1.138GluGln: 1.138 ± 0.211
4.002GluArg: 4.002 ± 0.503
5.886GluSer: 5.886 ± 0.445
3.845GluThr: 3.845 ± 0.368
3.414GluVal: 3.414 ± 0.369
0.51GluTrp: 0.51 ± 0.143
2.394GluTyr: 2.394 ± 0.319
0.0GluXaa: 0.0 ± 0.0
Phe
2.668PheAla: 2.668 ± 0.334
0.314PheCys: 0.314 ± 0.128
2.59PheAsp: 2.59 ± 0.263
3.767PheGlu: 3.767 ± 0.392
3.061PhePhe: 3.061 ± 0.424
3.845PheGly: 3.845 ± 0.32
0.746PheHis: 0.746 ± 0.185
4.512PheIle: 4.512 ± 0.49
3.728PheLys: 3.728 ± 0.501
6.396PheLeu: 6.396 ± 0.674
0.785PheMet: 0.785 ± 0.154
1.609PheAsn: 1.609 ± 0.255
2.943PhePro: 2.943 ± 0.403
3.061PheGln: 3.061 ± 0.377
2.433PheArg: 2.433 ± 0.397
4.277PheSer: 4.277 ± 0.426
2.707PheThr: 2.707 ± 0.313
2.943PheVal: 2.943 ± 0.387
0.667PheTrp: 0.667 ± 0.162
2.04PheTyr: 2.04 ± 0.305
0.0PheXaa: 0.0 ± 0.0
Gly
3.218GlyAla: 3.218 ± 0.478
0.196GlyCys: 0.196 ± 0.093
2.943GlyAsp: 2.943 ± 0.35
4.238GlyGlu: 4.238 ± 0.477
3.021GlyPhe: 3.021 ± 0.377
4.434GlyGly: 4.434 ± 0.555
0.706GlyHis: 0.706 ± 0.189
4.905GlyIle: 4.905 ± 0.437
5.023GlyLys: 5.023 ± 0.43
6.2GlyLeu: 6.2 ± 0.545
1.02GlyMet: 1.02 ± 0.169
3.924GlyAsn: 3.924 ± 0.48
2.001GlyPro: 2.001 ± 0.306
1.766GlyGln: 1.766 ± 0.293
2.433GlyArg: 2.433 ± 0.329
4.316GlySer: 4.316 ± 0.701
3.688GlyThr: 3.688 ± 0.606
4.356GlyVal: 4.356 ± 0.448
0.824GlyTrp: 0.824 ± 0.195
2.158GlyTyr: 2.158 ± 0.281
0.0GlyXaa: 0.0 ± 0.0
His
0.549HisAla: 0.549 ± 0.185
0.078HisCys: 0.078 ± 0.062
0.432HisAsp: 0.432 ± 0.119
0.785HisGlu: 0.785 ± 0.177
0.706HisPhe: 0.706 ± 0.175
0.746HisGly: 0.746 ± 0.175
0.196HisHis: 0.196 ± 0.078
0.863HisIle: 0.863 ± 0.168
0.471HisLys: 0.471 ± 0.146
1.609HisLeu: 1.609 ± 0.206
0.078HisMet: 0.078 ± 0.047
0.432HisAsn: 0.432 ± 0.148
0.706HisPro: 0.706 ± 0.135
0.314HisGln: 0.314 ± 0.116
0.942HisArg: 0.942 ± 0.188
1.099HisSer: 1.099 ± 0.206
0.628HisThr: 0.628 ± 0.16
0.981HisVal: 0.981 ± 0.186
0.196HisTrp: 0.196 ± 0.09
0.392HisTyr: 0.392 ± 0.125
0.0HisXaa: 0.0 ± 0.0
Ile
4.944IleAla: 4.944 ± 0.38
0.589IleCys: 0.589 ± 0.195
4.238IleAsp: 4.238 ± 0.314
6.671IleGlu: 6.671 ± 0.685
3.649IlePhe: 3.649 ± 0.536
3.806IleGly: 3.806 ± 0.409
0.981IleHis: 0.981 ± 0.17
4.042IleIle: 4.042 ± 0.491
5.533IleLys: 5.533 ± 0.528
8.436IleLeu: 8.436 ± 0.765
0.51IleMet: 0.51 ± 0.129
3.021IleAsn: 3.021 ± 0.325
4.002IlePro: 4.002 ± 0.419
3.139IleGln: 3.139 ± 0.361
4.434IleArg: 4.434 ± 0.382
7.887IleSer: 7.887 ± 0.792
4.12IleThr: 4.12 ± 0.412
3.885IleVal: 3.885 ± 0.523
0.667IleTrp: 0.667 ± 0.176
2.786IleTyr: 2.786 ± 0.371
0.0IleXaa: 0.0 ± 0.0
Lys
4.787LysAla: 4.787 ± 0.423
0.078LysCys: 0.078 ± 0.048
4.199LysAsp: 4.199 ± 0.461
7.141LysGlu: 7.141 ± 0.715
3.178LysPhe: 3.178 ± 0.419
4.866LysGly: 4.866 ± 0.547
0.549LysHis: 0.549 ± 0.136
6.2LysIle: 6.2 ± 0.725
7.455LysLys: 7.455 ± 0.828
6.71LysLeu: 6.71 ± 0.601
1.413LysMet: 1.413 ± 0.286
4.983LysAsn: 4.983 ± 0.451
2.433LysPro: 2.433 ± 0.313
2.04LysGln: 2.04 ± 0.301
3.806LysArg: 3.806 ± 0.592
6.043LysSer: 6.043 ± 0.5
4.905LysThr: 4.905 ± 0.592
4.316LysVal: 4.316 ± 0.45
0.549LysTrp: 0.549 ± 0.173
2.864LysTyr: 2.864 ± 0.394
0.0LysXaa: 0.0 ± 0.0
Leu
5.807LeuAla: 5.807 ± 0.623
0.746LeuCys: 0.746 ± 0.166
4.395LeuAsp: 4.395 ± 0.437
7.612LeuGlu: 7.612 ± 0.788
5.886LeuPhe: 5.886 ± 0.619
5.533LeuGly: 5.533 ± 0.492
1.53LeuHis: 1.53 ± 0.286
7.22LeuIle: 7.22 ± 0.676
9.025LeuLys: 9.025 ± 0.607
10.398LeuLeu: 10.398 ± 0.883
1.687LeuMet: 1.687 ± 0.241
6.435LeuAsn: 6.435 ± 0.521
4.434LeuPro: 4.434 ± 0.365
2.786LeuGln: 2.786 ± 0.368
5.023LeuArg: 5.023 ± 0.665
9.3LeuSer: 9.3 ± 0.651
5.219LeuThr: 5.219 ± 0.467
5.611LeuVal: 5.611 ± 0.501
0.942LeuTrp: 0.942 ± 0.206
3.335LeuTyr: 3.335 ± 0.369
0.0LeuXaa: 0.0 ± 0.0
Met
1.452MetAla: 1.452 ± 0.259
0.118MetCys: 0.118 ± 0.068
0.824MetAsp: 0.824 ± 0.197
1.138MetGlu: 1.138 ± 0.181
0.746MetPhe: 0.746 ± 0.139
0.51MetGly: 0.51 ± 0.133
0.314MetHis: 0.314 ± 0.122
1.138MetIle: 1.138 ± 0.242
1.648MetLys: 1.648 ± 0.219
1.02MetLeu: 1.02 ± 0.218
0.196MetMet: 0.196 ± 0.114
1.059MetAsn: 1.059 ± 0.209
0.471MetPro: 0.471 ± 0.124
0.235MetGln: 0.235 ± 0.093
0.785MetArg: 0.785 ± 0.199
1.295MetSer: 1.295 ± 0.232
0.706MetThr: 0.706 ± 0.192
0.785MetVal: 0.785 ± 0.212
0.0MetTrp: 0.0 ± 0.0
0.549MetTyr: 0.549 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
3.375AsnAla: 3.375 ± 0.522
0.589AsnCys: 0.589 ± 0.147
2.001AsnAsp: 2.001 ± 0.312
3.257AsnGlu: 3.257 ± 0.38
3.61AsnPhe: 3.61 ± 0.42
2.747AsnGly: 2.747 ± 0.359
0.706AsnHis: 0.706 ± 0.159
3.178AsnIle: 3.178 ± 0.318
3.139AsnLys: 3.139 ± 0.369
6.435AsnLeu: 6.435 ± 0.625
0.589AsnMet: 0.589 ± 0.148
1.687AsnAsn: 1.687 ± 0.261
3.178AsnPro: 3.178 ± 0.422
2.394AsnGln: 2.394 ± 0.526
2.864AsnArg: 2.864 ± 0.273
5.336AsnSer: 5.336 ± 0.542
2.825AsnThr: 2.825 ± 0.356
3.139AsnVal: 3.139 ± 0.373
1.02AsnTrp: 1.02 ± 0.166
1.452AsnTyr: 1.452 ± 0.259
0.0AsnXaa: 0.0 ± 0.0
Pro
1.687ProAla: 1.687 ± 0.213
0.196ProCys: 0.196 ± 0.112
2.472ProAsp: 2.472 ± 0.289
3.649ProGlu: 3.649 ± 0.386
2.551ProPhe: 2.551 ± 0.303
3.375ProGly: 3.375 ± 0.359
0.314ProHis: 0.314 ± 0.115
3.257ProIle: 3.257 ± 0.363
2.825ProLys: 2.825 ± 0.263
4.042ProLeu: 4.042 ± 0.373
0.51ProMet: 0.51 ± 0.148
2.197ProAsn: 2.197 ± 0.263
1.177ProPro: 1.177 ± 0.243
0.863ProGln: 0.863 ± 0.22
1.687ProArg: 1.687 ± 0.317
3.61ProSer: 3.61 ± 0.349
2.08ProThr: 2.08 ± 0.255
3.139ProVal: 3.139 ± 0.376
0.432ProTrp: 0.432 ± 0.11
0.785ProTyr: 0.785 ± 0.169
0.0ProXaa: 0.0 ± 0.0
Gln
2.04GlnAla: 2.04 ± 0.498
0.196GlnCys: 0.196 ± 0.087
1.256GlnAsp: 1.256 ± 0.19
1.962GlnGlu: 1.962 ± 0.262
1.491GlnPhe: 1.491 ± 0.305
2.315GlnGly: 2.315 ± 0.28
0.353GlnHis: 0.353 ± 0.116
3.139GlnIle: 3.139 ± 0.382
2.354GlnLys: 2.354 ± 0.284
2.197GlnLeu: 2.197 ± 0.457
0.353GlnMet: 0.353 ± 0.117
2.511GlnAsn: 2.511 ± 0.522
0.628GlnPro: 0.628 ± 0.183
0.902GlnGln: 0.902 ± 0.374
1.491GlnArg: 1.491 ± 0.241
2.276GlnSer: 2.276 ± 0.369
2.001GlnThr: 2.001 ± 0.423
2.001GlnVal: 2.001 ± 0.315
0.353GlnTrp: 0.353 ± 0.11
1.059GlnTyr: 1.059 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
3.139ArgAla: 3.139 ± 0.347
0.275ArgCys: 0.275 ± 0.081
2.59ArgAsp: 2.59 ± 0.307
3.767ArgGlu: 3.767 ± 0.525
2.354ArgPhe: 2.354 ± 0.325
2.315ArgGly: 2.315 ± 0.32
0.549ArgHis: 0.549 ± 0.147
4.199ArgIle: 4.199 ± 0.509
3.61ArgLys: 3.61 ± 0.442
4.826ArgLeu: 4.826 ± 0.68
1.099ArgMet: 1.099 ± 0.249
2.511ArgAsn: 2.511 ± 0.337
1.766ArgPro: 1.766 ± 0.309
1.609ArgGln: 1.609 ± 0.308
2.864ArgArg: 2.864 ± 0.419
3.453ArgSer: 3.453 ± 0.509
2.864ArgThr: 2.864 ± 0.314
2.825ArgVal: 2.825 ± 0.383
0.353ArgTrp: 0.353 ± 0.13
1.491ArgTyr: 1.491 ± 0.342
0.0ArgXaa: 0.0 ± 0.0
Ser
4.473SerAla: 4.473 ± 0.605
0.432SerCys: 0.432 ± 0.151
4.042SerAsp: 4.042 ± 0.369
6.317SerGlu: 6.317 ± 0.593
5.297SerPhe: 5.297 ± 0.495
6.631SerGly: 6.631 ± 0.627
0.981SerHis: 0.981 ± 0.181
6.671SerIle: 6.671 ± 0.453
7.22SerLys: 7.22 ± 0.582
8.789SerLeu: 8.789 ± 0.682
1.256SerMet: 1.256 ± 0.231
4.63SerAsn: 4.63 ± 0.515
4.002SerPro: 4.002 ± 0.377
3.296SerGln: 3.296 ± 0.738
3.021SerArg: 3.021 ± 0.352
8.358SerSer: 8.358 ± 0.872
4.042SerThr: 4.042 ± 0.523
4.552SerVal: 4.552 ± 0.48
0.275SerTrp: 0.275 ± 0.094
2.825SerTyr: 2.825 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
2.943ThrAla: 2.943 ± 0.482
0.392ThrCys: 0.392 ± 0.121
2.59ThrAsp: 2.59 ± 0.383
3.61ThrGlu: 3.61 ± 0.43
3.218ThrPhe: 3.218 ± 0.378
4.709ThrGly: 4.709 ± 0.623
0.589ThrHis: 0.589 ± 0.129
4.081ThrIle: 4.081 ± 0.366
3.845ThrLys: 3.845 ± 0.416
5.729ThrLeu: 5.729 ± 0.506
0.589ThrMet: 0.589 ± 0.12
2.394ThrAsn: 2.394 ± 0.287
2.707ThrPro: 2.707 ± 0.36
1.57ThrGln: 1.57 ± 0.307
1.962ThrArg: 1.962 ± 0.247
4.512ThrSer: 4.512 ± 0.563
2.59ThrThr: 2.59 ± 0.391
2.511ThrVal: 2.511 ± 0.335
0.471ThrTrp: 0.471 ± 0.144
2.433ThrTyr: 2.433 ± 0.311
0.0ThrXaa: 0.0 ± 0.0
Val
2.668ValAla: 2.668 ± 0.344
0.549ValCys: 0.549 ± 0.142
2.001ValAsp: 2.001 ± 0.278
3.531ValGlu: 3.531 ± 0.336
3.061ValPhe: 3.061 ± 0.324
3.139ValGly: 3.139 ± 0.391
1.099ValHis: 1.099 ± 0.212
3.61ValIle: 3.61 ± 0.463
3.924ValLys: 3.924 ± 0.437
6.004ValLeu: 6.004 ± 0.576
0.589ValMet: 0.589 ± 0.168
3.296ValAsn: 3.296 ± 0.451
1.766ValPro: 1.766 ± 0.295
1.766ValGln: 1.766 ± 0.225
3.571ValArg: 3.571 ± 0.382
5.336ValSer: 5.336 ± 0.577
3.649ValThr: 3.649 ± 0.43
3.649ValVal: 3.649 ± 0.349
0.275ValTrp: 0.275 ± 0.113
2.04ValTyr: 2.04 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
0.392TrpAla: 0.392 ± 0.12
0.039TrpCys: 0.039 ± 0.038
0.589TrpAsp: 0.589 ± 0.171
0.471TrpGlu: 0.471 ± 0.12
0.353TrpPhe: 0.353 ± 0.112
0.432TrpGly: 0.432 ± 0.12
0.118TrpHis: 0.118 ± 0.071
0.981TrpIle: 0.981 ± 0.187
0.432TrpLys: 0.432 ± 0.114
0.785TrpLeu: 0.785 ± 0.162
0.392TrpMet: 0.392 ± 0.123
0.863TrpAsn: 0.863 ± 0.192
0.471TrpPro: 0.471 ± 0.131
0.235TrpGln: 0.235 ± 0.074
0.51TrpArg: 0.51 ± 0.143
0.863TrpSer: 0.863 ± 0.237
0.628TrpThr: 0.628 ± 0.14
0.589TrpVal: 0.589 ± 0.188
0.039TrpTrp: 0.039 ± 0.035
0.235TrpTyr: 0.235 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.491TyrAla: 1.491 ± 0.236
0.196TyrCys: 0.196 ± 0.087
1.648TyrAsp: 1.648 ± 0.249
2.119TyrGlu: 2.119 ± 0.297
2.629TyrPhe: 2.629 ± 0.331
1.687TyrGly: 1.687 ± 0.278
0.392TyrHis: 0.392 ± 0.105
2.276TyrIle: 2.276 ± 0.32
3.061TyrLys: 3.061 ± 0.359
4.238TyrLeu: 4.238 ± 0.457
0.432TyrMet: 0.432 ± 0.121
2.08TyrAsn: 2.08 ± 0.259
1.491TyrPro: 1.491 ± 0.245
0.942TyrGln: 0.942 ± 0.253
1.413TyrArg: 1.413 ± 0.28
3.492TyrSer: 3.492 ± 0.394
1.727TyrThr: 1.727 ± 0.283
1.687TyrVal: 1.687 ± 0.218
0.51TyrTrp: 0.51 ± 0.156
1.334TyrTyr: 1.334 ± 0.196
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 103 proteins (25486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski