Amino acid dipepetide frequency for Serratia symbiotica str. Tucson

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.667AlaAla: 9.667 ± 0.162
1.19AlaCys: 1.19 ± 0.051
4.986AlaAsp: 4.986 ± 0.105
6.097AlaGlu: 6.097 ± 0.132
3.37AlaPhe: 3.37 ± 0.084
6.959AlaGly: 6.959 ± 0.143
1.917AlaHis: 1.917 ± 0.063
5.746AlaIle: 5.746 ± 0.122
4.278AlaLys: 4.278 ± 0.079
11.559AlaLeu: 11.559 ± 0.16
2.865AlaMet: 2.865 ± 0.092
3.023AlaAsn: 3.023 ± 0.077
3.32AlaPro: 3.32 ± 0.072
4.566AlaGln: 4.566 ± 0.098
5.27AlaArg: 5.27 ± 0.112
5.024AlaSer: 5.024 ± 0.103
4.501AlaThr: 4.501 ± 0.091
6.374AlaVal: 6.374 ± 0.124
1.123AlaTrp: 1.123 ± 0.055
2.341AlaTyr: 2.341 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.096CysAla: 1.096 ± 0.047
0.248CysCys: 0.248 ± 0.023
0.643CysAsp: 0.643 ± 0.038
0.593CysGlu: 0.593 ± 0.031
0.455CysPhe: 0.455 ± 0.026
1.113CysGly: 1.113 ± 0.049
0.401CysHis: 0.401 ± 0.032
0.681CysIle: 0.681 ± 0.039
0.439CysLys: 0.439 ± 0.032
1.146CysLeu: 1.146 ± 0.047
0.263CysMet: 0.263 ± 0.022
0.37CysAsn: 0.37 ± 0.024
0.512CysPro: 0.512 ± 0.032
0.518CysGln: 0.518 ± 0.03
0.691CysArg: 0.691 ± 0.039
0.739CysSer: 0.739 ± 0.041
0.53CysThr: 0.53 ± 0.03
0.806CysVal: 0.806 ± 0.039
0.194CysTrp: 0.194 ± 0.019
0.424CysTyr: 0.424 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.955AspAla: 4.955 ± 0.107
0.61AspCys: 0.61 ± 0.038
2.883AspAsp: 2.883 ± 0.082
3.403AspGlu: 3.403 ± 0.086
2.109AspPhe: 2.109 ± 0.065
3.629AspGly: 3.629 ± 0.102
1.1AspHis: 1.1 ± 0.044
3.435AspIle: 3.435 ± 0.088
2.556AspLys: 2.556 ± 0.075
5.065AspLeu: 5.065 ± 0.119
1.414AspMet: 1.414 ± 0.052
2.215AspAsn: 2.215 ± 0.065
2.082AspPro: 2.082 ± 0.06
1.875AspGln: 1.875 ± 0.059
2.942AspArg: 2.942 ± 0.067
2.844AspSer: 2.844 ± 0.069
2.48AspThr: 2.48 ± 0.073
3.771AspVal: 3.771 ± 0.09
0.796AspTrp: 0.796 ± 0.04
1.846AspTyr: 1.846 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.261GluAla: 5.261 ± 0.116
0.532GluCys: 0.532 ± 0.034
2.529GluAsp: 2.529 ± 0.083
3.272GluGlu: 3.272 ± 0.106
1.829GluPhe: 1.829 ± 0.057
3.337GluGly: 3.337 ± 0.09
1.47GluHis: 1.47 ± 0.058
3.343GluIle: 3.343 ± 0.099
3.199GluLys: 3.199 ± 0.083
6.201GluLeu: 6.201 ± 0.133
1.802GluMet: 1.802 ± 0.057
2.268GluAsn: 2.268 ± 0.063
2.042GluPro: 2.042 ± 0.067
3.725GluGln: 3.725 ± 0.108
3.961GluArg: 3.961 ± 0.1
2.625GluSer: 2.625 ± 0.067
2.792GluThr: 2.792 ± 0.073
4.009GluVal: 4.009 ± 0.098
0.672GluTrp: 0.672 ± 0.033
1.437GluTyr: 1.437 ± 0.059
0.002GluXaa: 0.002 ± 0.002
Phe
3.293PheAla: 3.293 ± 0.081
0.572PheCys: 0.572 ± 0.031
2.253PheAsp: 2.253 ± 0.063
1.796PheGlu: 1.796 ± 0.058
1.497PhePhe: 1.497 ± 0.062
3.071PheGly: 3.071 ± 0.083
0.841PheHis: 0.841 ± 0.041
2.57PheIle: 2.57 ± 0.078
1.507PheLys: 1.507 ± 0.055
3.205PheLeu: 3.205 ± 0.094
0.938PheMet: 0.938 ± 0.045
1.785PheAsn: 1.785 ± 0.059
1.384PhePro: 1.384 ± 0.048
1.132PheGln: 1.132 ± 0.037
1.892PheArg: 1.892 ± 0.062
3.025PheSer: 3.025 ± 0.078
2.196PheThr: 2.196 ± 0.068
2.316PheVal: 2.316 ± 0.079
0.493PheTrp: 0.493 ± 0.034
1.232PheTyr: 1.232 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.706GlyAla: 5.706 ± 0.126
1.034GlyCys: 1.034 ± 0.043
3.698GlyAsp: 3.698 ± 0.101
4.481GlyGlu: 4.481 ± 0.095
3.05GlyPhe: 3.05 ± 0.086
5.337GlyGly: 5.337 ± 0.131
1.725GlyHis: 1.725 ± 0.054
4.938GlyIle: 4.938 ± 0.112
4.153GlyLys: 4.153 ± 0.091
7.141GlyLeu: 7.141 ± 0.129
2.32GlyMet: 2.32 ± 0.061
2.842GlyAsn: 2.842 ± 0.083
1.743GlyPro: 1.743 ± 0.059
3.013GlyGln: 3.013 ± 0.082
4.059GlyArg: 4.059 ± 0.098
4.257GlySer: 4.257 ± 0.089
3.56GlyThr: 3.56 ± 0.088
5.575GlyVal: 5.575 ± 0.115
1.132GlyTrp: 1.132 ± 0.053
2.478GlyTyr: 2.478 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
2.011HisAla: 2.011 ± 0.055
0.474HisCys: 0.474 ± 0.03
1.148HisAsp: 1.148 ± 0.048
1.056HisGlu: 1.056 ± 0.047
1.104HisPhe: 1.104 ± 0.049
1.825HisGly: 1.825 ± 0.061
0.827HisHis: 0.827 ± 0.045
1.484HisIle: 1.484 ± 0.054
0.818HisLys: 0.818 ± 0.046
2.526HisLeu: 2.526 ± 0.072
0.601HisMet: 0.601 ± 0.028
0.95HisAsn: 0.95 ± 0.05
1.436HisPro: 1.436 ± 0.057
1.449HisGln: 1.449 ± 0.061
1.487HisArg: 1.487 ± 0.053
1.347HisSer: 1.347 ± 0.049
1.092HisThr: 1.092 ± 0.041
1.313HisVal: 1.313 ± 0.057
0.409HisTrp: 0.409 ± 0.028
0.904HisTyr: 0.904 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.333IleAla: 6.333 ± 0.119
0.729IleCys: 0.729 ± 0.042
3.748IleAsp: 3.748 ± 0.083
3.577IleGlu: 3.577 ± 0.083
2.017IlePhe: 2.017 ± 0.062
4.898IleGly: 4.898 ± 0.106
1.265IleHis: 1.265 ± 0.06
3.222IleIle: 3.222 ± 0.096
2.595IleLys: 2.595 ± 0.079
4.948IleLeu: 4.948 ± 0.12
1.244IleMet: 1.244 ± 0.057
2.737IleAsn: 2.737 ± 0.071
2.503IlePro: 2.503 ± 0.073
1.984IleGln: 1.984 ± 0.06
3.163IleArg: 3.163 ± 0.079
4.028IleSer: 4.028 ± 0.081
3.664IleThr: 3.664 ± 0.088
3.925IleVal: 3.925 ± 0.095
0.649IleTrp: 0.649 ± 0.037
1.589IleTyr: 1.589 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.19LysAla: 4.19 ± 0.094
0.338LysCys: 0.338 ± 0.023
2.19LysAsp: 2.19 ± 0.073
2.464LysGlu: 2.464 ± 0.071
1.238LysPhe: 1.238 ± 0.058
3.107LysGly: 3.107 ± 0.09
0.948LysHis: 0.948 ± 0.042
2.549LysIle: 2.549 ± 0.072
2.572LysLys: 2.572 ± 0.079
4.879LysLeu: 4.879 ± 0.108
1.343LysMet: 1.343 ± 0.06
1.858LysAsn: 1.858 ± 0.058
2.247LysPro: 2.247 ± 0.073
2.207LysGln: 2.207 ± 0.066
3.027LysArg: 3.027 ± 0.076
2.568LysSer: 2.568 ± 0.066
2.547LysThr: 2.547 ± 0.076
3.443LysVal: 3.443 ± 0.094
0.416LysTrp: 0.416 ± 0.027
1.136LysTyr: 1.136 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
11.479LeuAla: 11.479 ± 0.157
1.37LeuCys: 1.37 ± 0.053
5.754LeuAsp: 5.754 ± 0.114
5.648LeuGlu: 5.648 ± 0.129
4.038LeuPhe: 4.038 ± 0.101
7.299LeuGly: 7.299 ± 0.129
2.551LeuHis: 2.551 ± 0.077
5.928LeuIle: 5.928 ± 0.114
4.802LeuLys: 4.802 ± 0.108
12.298LeuLeu: 12.298 ± 0.218
3.172LeuMet: 3.172 ± 0.091
4.178LeuAsn: 4.178 ± 0.096
5.604LeuPro: 5.604 ± 0.113
4.445LeuGln: 4.445 ± 0.09
6.677LeuArg: 6.677 ± 0.141
7.383LeuSer: 7.383 ± 0.137
5.792LeuThr: 5.792 ± 0.1
7.636LeuVal: 7.636 ± 0.141
1.169LeuTrp: 1.169 ± 0.052
2.814LeuTyr: 2.814 ± 0.083
0.002LeuXaa: 0.002 ± 0.002
Met
3.052MetAla: 3.052 ± 0.069
0.253MetCys: 0.253 ± 0.024
1.169MetAsp: 1.169 ± 0.05
1.263MetGlu: 1.263 ± 0.054
0.839MetPhe: 0.839 ± 0.043
1.873MetGly: 1.873 ± 0.068
0.582MetHis: 0.582 ± 0.036
1.566MetIle: 1.566 ± 0.051
1.349MetLys: 1.349 ± 0.049
3.322MetLeu: 3.322 ± 0.082
0.894MetMet: 0.894 ± 0.042
1.067MetAsn: 1.067 ± 0.048
1.443MetPro: 1.443 ± 0.059
1.374MetGln: 1.374 ± 0.053
1.599MetArg: 1.599 ± 0.059
1.764MetSer: 1.764 ± 0.066
1.622MetThr: 1.622 ± 0.06
2.061MetVal: 2.061 ± 0.062
0.234MetTrp: 0.234 ± 0.023
0.551MetTyr: 0.551 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.533AsnAla: 3.533 ± 0.093
0.384AsnCys: 0.384 ± 0.027
2.046AsnAsp: 2.046 ± 0.069
1.942AsnGlu: 1.942 ± 0.057
1.251AsnPhe: 1.251 ± 0.051
2.844AsnGly: 2.844 ± 0.09
0.929AsnHis: 0.929 ± 0.043
2.418AsnIle: 2.418 ± 0.082
1.729AsnLys: 1.729 ± 0.063
3.664AsnLeu: 3.664 ± 0.084
1.008AsnMet: 1.008 ± 0.044
1.591AsnAsn: 1.591 ± 0.055
2.067AsnPro: 2.067 ± 0.069
1.748AsnGln: 1.748 ± 0.061
2.132AsnArg: 2.132 ± 0.065
2.113AsnSer: 2.113 ± 0.071
2.002AsnThr: 2.002 ± 0.062
2.554AsnVal: 2.554 ± 0.075
0.522AsnTrp: 0.522 ± 0.034
1.142AsnTyr: 1.142 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.982ProAla: 3.982 ± 0.106
0.439ProCys: 0.439 ± 0.03
2.487ProAsp: 2.487 ± 0.071
2.996ProGlu: 2.996 ± 0.075
1.704ProPhe: 1.704 ± 0.055
3.101ProGly: 3.101 ± 0.068
1.077ProHis: 1.077 ± 0.047
2.182ProIle: 2.182 ± 0.065
1.698ProLys: 1.698 ± 0.062
5.04ProLeu: 5.04 ± 0.098
1.159ProMet: 1.159 ± 0.047
1.397ProAsn: 1.397 ± 0.05
1.752ProPro: 1.752 ± 0.057
2.393ProGln: 2.393 ± 0.068
2.048ProArg: 2.048 ± 0.057
2.267ProSer: 2.267 ± 0.074
2.194ProThr: 2.194 ± 0.062
3.37ProVal: 3.37 ± 0.085
0.639ProTrp: 0.639 ± 0.038
1.332ProTyr: 1.332 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
4.879GlnAla: 4.879 ± 0.109
0.451GlnCys: 0.451 ± 0.032
2.086GlnAsp: 2.086 ± 0.065
2.316GlnGlu: 2.316 ± 0.073
1.558GlnPhe: 1.558 ± 0.058
3.253GlnGly: 3.253 ± 0.07
1.461GlnHis: 1.461 ± 0.056
2.336GlnIle: 2.336 ± 0.07
1.85GlnLys: 1.85 ± 0.061
5.479GlnLeu: 5.479 ± 0.113
1.255GlnMet: 1.255 ± 0.051
1.399GlnAsn: 1.399 ± 0.051
2.401GlnPro: 2.401 ± 0.09
3.875GlnGln: 3.875 ± 0.134
3.556GlnArg: 3.556 ± 0.103
2.355GlnSer: 2.355 ± 0.07
1.984GlnThr: 1.984 ± 0.069
3.497GlnVal: 3.497 ± 0.089
0.697GlnTrp: 0.697 ± 0.035
1.184GlnTyr: 1.184 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
4.681ArgAla: 4.681 ± 0.107
0.718ArgCys: 0.718 ± 0.039
3.098ArgAsp: 3.098 ± 0.081
3.871ArgGlu: 3.871 ± 0.11
2.637ArgPhe: 2.637 ± 0.071
3.62ArgGly: 3.62 ± 0.083
1.764ArgHis: 1.764 ± 0.059
3.66ArgIle: 3.66 ± 0.098
2.608ArgLys: 2.608 ± 0.083
6.915ArgLeu: 6.915 ± 0.111
1.62ArgMet: 1.62 ± 0.047
2.117ArgAsn: 2.117 ± 0.066
2.349ArgPro: 2.349 ± 0.073
3.433ArgGln: 3.433 ± 0.106
3.829ArgArg: 3.829 ± 0.094
3.165ArgSer: 3.165 ± 0.072
2.545ArgThr: 2.545 ± 0.08
4.142ArgVal: 4.142 ± 0.091
0.967ArgTrp: 0.967 ± 0.045
2.046ArgTyr: 2.046 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
5.355SerAla: 5.355 ± 0.102
0.67SerCys: 0.67 ± 0.041
2.911SerAsp: 2.911 ± 0.082
3.176SerGlu: 3.176 ± 0.08
2.232SerPhe: 2.232 ± 0.062
5.049SerGly: 5.049 ± 0.107
1.551SerHis: 1.551 ± 0.056
3.259SerIle: 3.259 ± 0.072
2.464SerLys: 2.464 ± 0.074
6.456SerLeu: 6.456 ± 0.106
1.599SerMet: 1.599 ± 0.054
2.023SerAsn: 2.023 ± 0.067
2.458SerPro: 2.458 ± 0.073
2.595SerGln: 2.595 ± 0.062
3.393SerArg: 3.393 ± 0.073
3.483SerSer: 3.483 ± 0.087
2.965SerThr: 2.965 ± 0.083
4.17SerVal: 4.17 ± 0.099
0.781SerTrp: 0.781 ± 0.036
1.76SerTyr: 1.76 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.664ThrAla: 4.664 ± 0.091
0.484ThrCys: 0.484 ± 0.029
2.681ThrAsp: 2.681 ± 0.088
2.554ThrGlu: 2.554 ± 0.073
1.885ThrPhe: 1.885 ± 0.064
4.144ThrGly: 4.144 ± 0.099
1.24ThrHis: 1.24 ± 0.049
2.838ThrIle: 2.838 ± 0.083
1.768ThrLys: 1.768 ± 0.055
7.122ThrLeu: 7.122 ± 0.128
1.157ThrMet: 1.157 ± 0.053
1.533ThrAsn: 1.533 ± 0.057
2.971ThrPro: 2.971 ± 0.075
2.136ThrGln: 2.136 ± 0.066
2.971ThrArg: 2.971 ± 0.076
2.648ThrSer: 2.648 ± 0.066
2.814ThrThr: 2.814 ± 0.067
3.656ThrVal: 3.656 ± 0.081
0.587ThrTrp: 0.587 ± 0.031
1.236ThrTyr: 1.236 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
6.683ValAla: 6.683 ± 0.115
0.731ValCys: 0.731 ± 0.044
3.723ValAsp: 3.723 ± 0.083
4.195ValGlu: 4.195 ± 0.11
2.503ValPhe: 2.503 ± 0.076
4.913ValGly: 4.913 ± 0.106
1.357ValHis: 1.357 ± 0.053
4.646ValIle: 4.646 ± 0.099
3.43ValLys: 3.43 ± 0.089
7.583ValLeu: 7.583 ± 0.112
2.174ValMet: 2.174 ± 0.063
2.796ValAsn: 2.796 ± 0.076
2.946ValPro: 2.946 ± 0.073
2.61ValGln: 2.61 ± 0.073
3.957ValArg: 3.957 ± 0.078
4.347ValSer: 4.347 ± 0.088
4.08ValThr: 4.08 ± 0.096
5.602ValVal: 5.602 ± 0.117
0.754ValTrp: 0.754 ± 0.04
1.787ValTyr: 1.787 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.925TrpAla: 0.925 ± 0.043
0.19TrpCys: 0.19 ± 0.023
0.487TrpAsp: 0.487 ± 0.03
0.474TrpGlu: 0.474 ± 0.032
0.528TrpPhe: 0.528 ± 0.033
0.772TrpGly: 0.772 ± 0.043
0.378TrpHis: 0.378 ± 0.028
0.576TrpIle: 0.576 ± 0.037
0.474TrpLys: 0.474 ± 0.034
2.102TrpLeu: 2.102 ± 0.079
0.374TrpMet: 0.374 ± 0.026
0.451TrpAsn: 0.451 ± 0.038
0.614TrpPro: 0.614 ± 0.04
1.063TrpGln: 1.063 ± 0.043
1.002TrpArg: 1.002 ± 0.041
0.633TrpSer: 0.633 ± 0.039
0.367TrpThr: 0.367 ± 0.029
0.915TrpVal: 0.915 ± 0.045
0.188TrpTrp: 0.188 ± 0.021
0.322TrpTyr: 0.322 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.434TyrAla: 2.434 ± 0.068
0.445TyrCys: 0.445 ± 0.031
1.491TyrAsp: 1.491 ± 0.058
1.134TyrGlu: 1.134 ± 0.041
1.155TyrPhe: 1.155 ± 0.048
2.1TyrGly: 2.1 ± 0.064
0.877TyrHis: 0.877 ± 0.043
1.439TyrIle: 1.439 ± 0.056
0.977TyrLys: 0.977 ± 0.042
3.387TyrLeu: 3.387 ± 0.092
0.67TyrMet: 0.67 ± 0.039
1.019TyrAsn: 1.019 ± 0.046
1.386TyrPro: 1.386 ± 0.049
1.727TyrGln: 1.727 ± 0.065
2.126TyrArg: 2.126 ± 0.065
1.735TyrSer: 1.735 ± 0.066
1.365TyrThr: 1.365 ± 0.059
1.681TyrVal: 1.681 ± 0.057
0.413TyrTrp: 0.413 ± 0.027
0.933TyrTyr: 0.933 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.012XaaXaa: 0.012 ± 0.012
Statistics based on 2157 proteins (521053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski