Amino acid dipepetide frequency for Natronincola peptidivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.516AlaAla: 5.516 ± 0.107	0.626AlaCys: 0.626 ± 0.026	2.861AlaAsp: 2.861 ± 0.055	4.434AlaGlu: 4.434 ± 0.069	2.846AlaPhe: 2.846 ± 0.052	4.726AlaGly: 4.726 ± 0.084	1.013AlaHis: 1.013 ± 0.032	6.619AlaIle: 6.619 ± 0.102	4.525AlaLys: 4.525 ± 0.074	6.838AlaLeu: 6.838 ± 0.094	2.043AlaMet: 2.043 ± 0.044	2.618AlaAsn: 2.618 ± 0.051	1.818AlaPro: 1.818 ± 0.05	1.697AlaGln: 1.697 ± 0.038	2.38AlaArg: 2.38 ± 0.054	3.747AlaSer: 3.747 ± 0.074	3.505AlaThr: 3.505 ± 0.063	5.107AlaVal: 5.107 ± 0.087	0.428AlaTrp: 0.428 ± 0.02	2.426AlaTyr: 2.426 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.023	0.149CysCys: 0.149 ± 0.011	0.469CysAsp: 0.469 ± 0.021	0.544CysGlu: 0.544 ± 0.025	0.376CysPhe: 0.376 ± 0.017	0.878CysGly: 0.878 ± 0.032	0.225CysHis: 0.225 ± 0.015	0.872CysIle: 0.872 ± 0.031	0.694CysLys: 0.694 ± 0.028	0.682CysLeu: 0.682 ± 0.026	0.248CysMet: 0.248 ± 0.016	0.49CysAsn: 0.49 ± 0.024	0.481CysPro: 0.481 ± 0.026	0.294CysGln: 0.294 ± 0.016	0.365CysArg: 0.365 ± 0.019	0.621CysSer: 0.621 ± 0.025	0.449CysThr: 0.449 ± 0.022	0.497CysVal: 0.497 ± 0.02	0.075CysTrp: 0.075 ± 0.009	0.338CysTyr: 0.338 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.214AspAla: 3.214 ± 0.056	0.5AspCys: 0.5 ± 0.025	2.246AspAsp: 2.246 ± 0.053	3.911AspGlu: 3.911 ± 0.08	2.54AspPhe: 2.54 ± 0.052	3.226AspGly: 3.226 ± 0.072	0.935AspHis: 0.935 ± 0.031	5.631AspIle: 5.631 ± 0.083	3.974AspLys: 3.974 ± 0.08	4.973AspLeu: 4.973 ± 0.066	1.48AspMet: 1.48 ± 0.035	2.346AspAsn: 2.346 ± 0.059	1.606AspPro: 1.606 ± 0.049	1.258AspGln: 1.258 ± 0.036	2.059AspArg: 2.059 ± 0.049	2.54AspSer: 2.54 ± 0.058	2.745AspThr: 2.745 ± 0.049	3.453AspVal: 3.453 ± 0.053	0.463AspTrp: 0.463 ± 0.021	2.439AspTyr: 2.439 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.814GluAla: 5.814 ± 0.082	0.43GluCys: 0.43 ± 0.022	4.634GluAsp: 4.634 ± 0.073	8.696GluGlu: 8.696 ± 0.135	2.417GluPhe: 2.417 ± 0.053	5.289GluGly: 5.289 ± 0.078	1.005GluHis: 1.005 ± 0.035	7.935GluIle: 7.935 ± 0.081	7.908GluLys: 7.908 ± 0.099	6.562GluLeu: 6.562 ± 0.084	2.401GluMet: 2.401 ± 0.045	4.258GluAsn: 4.258 ± 0.065	1.611GluPro: 1.611 ± 0.045	1.689GluGln: 1.689 ± 0.038	3.012GluArg: 3.012 ± 0.057	3.164GluSer: 3.164 ± 0.06	3.582GluThr: 3.582 ± 0.065	5.734GluVal: 5.734 ± 0.073	0.501GluTrp: 0.501 ± 0.022	2.527GluTyr: 2.527 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.423PheAla: 2.423 ± 0.057	0.424PheCys: 0.424 ± 0.021	2.183PheAsp: 2.183 ± 0.042	2.406PheGlu: 2.406 ± 0.054	1.951PhePhe: 1.951 ± 0.058	2.745PheGly: 2.745 ± 0.062	0.888PheHis: 0.888 ± 0.028	4.156PheIle: 4.156 ± 0.08	2.652PheLys: 2.652 ± 0.049	3.89PheLeu: 3.89 ± 0.07	1.095PheMet: 1.095 ± 0.033	2.097PheAsn: 2.097 ± 0.043	1.405PhePro: 1.405 ± 0.041	1.512PheGln: 1.512 ± 0.037	1.398PheArg: 1.398 ± 0.038	2.747PheSer: 2.747 ± 0.051	2.361PheThr: 2.361 ± 0.05	2.595PheVal: 2.595 ± 0.05	0.319PheTrp: 0.319 ± 0.019	1.615PheTyr: 1.615 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.553GlyAla: 4.553 ± 0.086	0.842GlyCys: 0.842 ± 0.032	3.337GlyAsp: 3.337 ± 0.06	4.766GlyGlu: 4.766 ± 0.065	3.239GlyPhe: 3.239 ± 0.063	5.091GlyGly: 5.091 ± 0.122	1.198GlyHis: 1.198 ± 0.034	7.046GlyIle: 7.046 ± 0.103	5.179GlyLys: 5.179 ± 0.066	6.315GlyLeu: 6.315 ± 0.092	2.093GlyMet: 2.093 ± 0.043	3.122GlyAsn: 3.122 ± 0.065	1.529GlyPro: 1.529 ± 0.05	1.767GlyGln: 1.767 ± 0.051	2.651GlyArg: 2.651 ± 0.046	3.573GlySer: 3.573 ± 0.068	3.826GlyThr: 3.826 ± 0.079	4.853GlyVal: 4.853 ± 0.08	0.586GlyTrp: 0.586 ± 0.026	3.055GlyTyr: 3.055 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.965HisAla: 0.965 ± 0.027	0.224HisCys: 0.224 ± 0.015	0.814HisAsp: 0.814 ± 0.028	1.159HisGlu: 1.159 ± 0.033	0.852HisPhe: 0.852 ± 0.029	1.281HisGly: 1.281 ± 0.034	0.57HisHis: 0.57 ± 0.031	1.666HisIle: 1.666 ± 0.044	1.153HisLys: 1.153 ± 0.036	1.749HisLeu: 1.749 ± 0.042	0.449HisMet: 0.449 ± 0.021	0.874HisAsn: 0.874 ± 0.03	0.892HisPro: 0.892 ± 0.029	0.792HisGln: 0.792 ± 0.025	0.833HisArg: 0.833 ± 0.029	1.013HisSer: 1.013 ± 0.031	0.902HisThr: 0.902 ± 0.029	1.019HisVal: 1.019 ± 0.03	0.195HisTrp: 0.195 ± 0.013	0.757HisTyr: 0.757 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.806IleAla: 6.806 ± 0.093	0.903IleCys: 0.903 ± 0.026	5.414IleAsp: 5.414 ± 0.082	7.625IleGlu: 7.625 ± 0.09	3.655IlePhe: 3.655 ± 0.068	6.563IleGly: 6.563 ± 0.103	1.792IleHis: 1.792 ± 0.037	8.707IleIle: 8.707 ± 0.115	7.043IleLys: 7.043 ± 0.092	8.557IleLeu: 8.557 ± 0.099	2.382IleMet: 2.382 ± 0.047	4.719IleAsn: 4.719 ± 0.073	3.621IlePro: 3.621 ± 0.061	3.037IleGln: 3.037 ± 0.056	3.395IleArg: 3.395 ± 0.06	5.754IleSer: 5.754 ± 0.079	5.401IleThr: 5.401 ± 0.091	6.091IleVal: 6.091 ± 0.076	0.611IleTrp: 0.611 ± 0.026	3.238IleTyr: 3.238 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.197LysAla: 5.197 ± 0.075	0.535LysCys: 0.535 ± 0.025	4.585LysAsp: 4.585 ± 0.084	8.245LysGlu: 8.245 ± 0.112	1.958LysPhe: 1.958 ± 0.043	4.912LysGly: 4.912 ± 0.073	1.342LysHis: 1.342 ± 0.033	7.092LysIle: 7.092 ± 0.097	7.248LysLys: 7.248 ± 0.11	6.405LysLeu: 6.405 ± 0.087	2.158LysMet: 2.158 ± 0.044	4.384LysAsn: 4.384 ± 0.065	2.077LysPro: 2.077 ± 0.045	2.404LysGln: 2.404 ± 0.058	3.05LysArg: 3.05 ± 0.058	3.839LysSer: 3.839 ± 0.064	3.997LysThr: 3.997 ± 0.068	4.865LysVal: 4.865 ± 0.07	0.56LysTrp: 0.56 ± 0.023	2.883LysTyr: 2.883 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.116LeuAla: 6.116 ± 0.086	0.849LeuCys: 0.849 ± 0.029	4.84LeuAsp: 4.84 ± 0.069	7.416LeuGlu: 7.416 ± 0.102	3.825LeuPhe: 3.825 ± 0.081	6.651LeuGly: 6.651 ± 0.098	1.622LeuHis: 1.622 ± 0.043	7.504LeuIle: 7.504 ± 0.097	7.548LeuLys: 7.548 ± 0.104	9.285LeuLeu: 9.285 ± 0.127	2.76LeuMet: 2.76 ± 0.056	4.409LeuAsn: 4.409 ± 0.066	3.326LeuPro: 3.326 ± 0.057	3.508LeuGln: 3.508 ± 0.059	3.514LeuArg: 3.514 ± 0.057	5.884LeuSer: 5.884 ± 0.082	4.713LeuThr: 4.713 ± 0.072	5.721LeuVal: 5.721 ± 0.074	0.686LeuTrp: 0.686 ± 0.031	3.236LeuTyr: 3.236 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.087MetAla: 2.087 ± 0.049	0.176MetCys: 0.176 ± 0.011	1.593MetAsp: 1.593 ± 0.037	2.46MetGlu: 2.46 ± 0.043	0.919MetPhe: 0.919 ± 0.03	2.019MetGly: 2.019 ± 0.049	0.396MetHis: 0.396 ± 0.018	2.539MetIle: 2.539 ± 0.048	2.689MetLys: 2.689 ± 0.047	2.581MetLeu: 2.581 ± 0.055	1.019MetMet: 1.019 ± 0.034	1.489MetAsn: 1.489 ± 0.036	1.034MetPro: 1.034 ± 0.033	0.881MetGln: 0.881 ± 0.028	1.08MetArg: 1.08 ± 0.03	1.357MetSer: 1.357 ± 0.033	1.393MetThr: 1.393 ± 0.03	1.951MetVal: 1.951 ± 0.039	0.132MetTrp: 0.132 ± 0.012	0.773MetTyr: 0.773 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.799AsnAla: 2.799 ± 0.053	0.503AsnCys: 0.503 ± 0.025	2.206AsnAsp: 2.206 ± 0.05	3.131AsnGlu: 3.131 ± 0.066	1.84AsnPhe: 1.84 ± 0.044	2.84AsnGly: 2.84 ± 0.072	1.17AsnHis: 1.17 ± 0.037	5.159AsnIle: 5.159 ± 0.077	3.982AsnLys: 3.982 ± 0.076	4.578AsnLeu: 4.578 ± 0.063	1.283AsnMet: 1.283 ± 0.029	3.055AsnAsn: 3.055 ± 0.071	2.22AsnPro: 2.22 ± 0.049	2.0AsnGln: 2.0 ± 0.046	2.143AsnArg: 2.143 ± 0.047	2.523AsnSer: 2.523 ± 0.05	2.8AsnThr: 2.8 ± 0.054	2.802AsnVal: 2.802 ± 0.052	0.418AsnTrp: 0.418 ± 0.021	2.114AsnTyr: 2.114 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.015ProAla: 2.015 ± 0.056	0.309ProCys: 0.309 ± 0.017	1.596ProAsp: 1.596 ± 0.041	2.635ProGlu: 2.635 ± 0.053	1.454ProPhe: 1.454 ± 0.039	2.116ProGly: 2.116 ± 0.048	0.694ProHis: 0.694 ± 0.027	3.06ProIle: 3.06 ± 0.054	2.148ProLys: 2.148 ± 0.05	3.023ProLeu: 3.023 ± 0.052	0.879ProMet: 0.879 ± 0.031	1.561ProAsn: 1.561 ± 0.039	1.025ProPro: 1.025 ± 0.034	1.241ProGln: 1.241 ± 0.037	1.065ProArg: 1.065 ± 0.035	1.899ProSer: 1.899 ± 0.044	1.733ProThr: 1.733 ± 0.046	2.374ProVal: 2.374 ± 0.056	0.303ProTrp: 0.303 ± 0.019	1.323ProTyr: 1.323 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.818GlnAla: 1.818 ± 0.041	0.293GlnCys: 0.293 ± 0.019	1.584GlnAsp: 1.584 ± 0.042	3.194GlnGlu: 3.194 ± 0.059	1.084GlnPhe: 1.084 ± 0.035	2.022GlnGly: 2.022 ± 0.05	0.691GlnHis: 0.691 ± 0.025	2.28GlnIle: 2.28 ± 0.046	2.275GlnLys: 2.275 ± 0.049	3.291GlnLeu: 3.291 ± 0.055	1.015GlnMet: 1.015 ± 0.031	1.405GlnAsn: 1.405 ± 0.039	0.942GlnPro: 0.942 ± 0.03	1.801GlnGln: 1.801 ± 0.05	1.375GlnArg: 1.375 ± 0.036	1.629GlnSer: 1.629 ± 0.038	1.279GlnThr: 1.279 ± 0.037	1.946GlnVal: 1.946 ± 0.04	0.369GlnTrp: 0.369 ± 0.02	1.406GlnTyr: 1.406 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.155ArgAla: 2.155 ± 0.041	0.346ArgCys: 0.346 ± 0.018	2.032ArgAsp: 2.032 ± 0.047	3.32ArgGlu: 3.32 ± 0.063	1.586ArgPhe: 1.586 ± 0.038	2.497ArgGly: 2.497 ± 0.056	0.635ArgHis: 0.635 ± 0.023	3.554ArgIle: 3.554 ± 0.06	3.151ArgLys: 3.151 ± 0.059	3.536ArgLeu: 3.536 ± 0.06	1.152ArgMet: 1.152 ± 0.03	2.062ArgAsn: 2.062 ± 0.043	1.153ArgPro: 1.153 ± 0.035	1.334ArgGln: 1.334 ± 0.036	1.831ArgArg: 1.831 ± 0.05	1.817ArgSer: 1.817 ± 0.045	1.732ArgThr: 1.732 ± 0.038	2.564ArgVal: 2.564 ± 0.053	0.324ArgTrp: 0.324 ± 0.019	1.535ArgTyr: 1.535 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	2.957SerAla: 2.957 ± 0.06	0.547SerCys: 0.547 ± 0.023	2.367SerAsp: 2.367 ± 0.057	3.183SerGlu: 3.183 ± 0.063	2.948SerPhe: 2.948 ± 0.054	3.75SerGly: 3.75 ± 0.082	1.099SerHis: 1.099 ± 0.034	5.956SerIle: 5.956 ± 0.09	4.026SerLys: 4.026 ± 0.072	5.515SerLeu: 5.515 ± 0.074	1.682SerMet: 1.682 ± 0.042	2.809SerAsn: 2.809 ± 0.055	1.845SerPro: 1.845 ± 0.044	1.778SerGln: 1.778 ± 0.043	2.118SerArg: 2.118 ± 0.047	3.464SerSer: 3.464 ± 0.071	3.036SerThr: 3.036 ± 0.057	3.336SerVal: 3.336 ± 0.064	0.433SerTrp: 0.433 ± 0.021	2.233SerTyr: 2.233 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.793ThrAla: 3.793 ± 0.073	0.427ThrCys: 0.427 ± 0.02	2.438ThrAsp: 2.438 ± 0.05	3.539ThrGlu: 3.539 ± 0.054	2.208ThrPhe: 2.208 ± 0.045	4.129ThrGly: 4.129 ± 0.072	0.846ThrHis: 0.846 ± 0.027	5.303ThrIle: 5.303 ± 0.073	3.5ThrLys: 3.5 ± 0.06	5.037ThrLeu: 5.037 ± 0.074	1.413ThrMet: 1.413 ± 0.038	2.46ThrAsn: 2.46 ± 0.054	2.081ThrPro: 2.081 ± 0.049	1.375ThrGln: 1.375 ± 0.042	1.773ThrArg: 1.773 ± 0.043	3.077ThrSer: 3.077 ± 0.055	3.086ThrThr: 3.086 ± 0.064	3.846ThrVal: 3.846 ± 0.081	0.382ThrTrp: 0.382 ± 0.02	1.87ThrTyr: 1.87 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.62ValAla: 4.62 ± 0.078	0.613ValCys: 0.613 ± 0.023	3.789ValAsp: 3.789 ± 0.062	5.335ValGlu: 5.335 ± 0.082	3.013ValPhe: 3.013 ± 0.056	4.553ValGly: 4.553 ± 0.073	1.009ValHis: 1.009 ± 0.036	6.03ValIle: 6.03 ± 0.078	4.814ValLys: 4.814 ± 0.071	6.377ValLeu: 6.377 ± 0.08	1.834ValMet: 1.834 ± 0.042	2.994ValAsn: 2.994 ± 0.057	2.216ValPro: 2.216 ± 0.046	1.612ValGln: 1.612 ± 0.037	2.196ValArg: 2.196 ± 0.046	3.814ValSer: 3.814 ± 0.065	3.691ValThr: 3.691 ± 0.072	4.984ValVal: 4.984 ± 0.074	0.43ValTrp: 0.43 ± 0.016	2.295ValTyr: 2.295 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.443TrpAla: 0.443 ± 0.023	0.084TrpCys: 0.084 ± 0.009	0.412TrpAsp: 0.412 ± 0.021	0.552TrpGlu: 0.552 ± 0.026	0.328TrpPhe: 0.328 ± 0.017	0.624TrpGly: 0.624 ± 0.026	0.154TrpHis: 0.154 ± 0.012	0.664TrpIle: 0.664 ± 0.025	0.524TrpLys: 0.524 ± 0.023	0.694TrpLeu: 0.694 ± 0.028	0.246TrpMet: 0.246 ± 0.015	0.412TrpAsn: 0.412 ± 0.022	0.182TrpPro: 0.182 ± 0.016	0.313TrpGln: 0.313 ± 0.019	0.371TrpArg: 0.371 ± 0.019	0.413TrpSer: 0.413 ± 0.021	0.331TrpThr: 0.331 ± 0.016	0.481TrpVal: 0.481 ± 0.022	0.096TrpTrp: 0.096 ± 0.011	0.287TrpTyr: 0.287 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.033TyrAla: 2.033 ± 0.048	0.415TyrCys: 0.415 ± 0.02	2.138TyrAsp: 2.138 ± 0.048	2.618TyrGlu: 2.618 ± 0.055	1.823TyrPhe: 1.823 ± 0.047	2.708TyrGly: 2.708 ± 0.051	0.874TyrHis: 0.874 ± 0.03	3.543TyrIle: 3.543 ± 0.063	2.703TyrLys: 2.703 ± 0.052	3.525TyrLeu: 3.525 ± 0.059	0.937TyrMet: 0.937 ± 0.03	2.002TyrAsn: 2.002 ± 0.046	1.388TyrPro: 1.388 ± 0.036	1.404TyrGln: 1.404 ± 0.037	1.707TyrArg: 1.707 ± 0.042	2.208TyrSer: 2.208 ± 0.047	2.022TyrThr: 2.022 ± 0.046	2.001TyrVal: 2.001 ± 0.039	0.3TyrTrp: 0.3 ± 0.016	1.771TyrTyr: 1.771 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3528 proteins (1074561 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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