Amino acid dipepetide frequency for Paraburkholderia piptadeniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.051AlaAla: 16.051 ± 0.122	1.448AlaCys: 1.448 ± 0.023	6.4AlaAsp: 6.4 ± 0.051	5.619AlaGlu: 5.619 ± 0.052	4.355AlaPhe: 4.355 ± 0.043	9.749AlaGly: 9.749 ± 0.067	2.923AlaHis: 2.923 ± 0.036	5.825AlaIle: 5.825 ± 0.05	3.857AlaLys: 3.857 ± 0.047	13.373AlaLeu: 13.373 ± 0.09	3.335AlaMet: 3.335 ± 0.039	3.399AlaAsn: 3.399 ± 0.042	5.547AlaPro: 5.547 ± 0.061	5.131AlaGln: 5.131 ± 0.058	8.933AlaArg: 8.933 ± 0.078	7.796AlaSer: 7.796 ± 0.061	6.319AlaThr: 6.319 ± 0.056	8.577AlaVal: 8.577 ± 0.058	1.647AlaTrp: 1.647 ± 0.03	2.664AlaTyr: 2.664 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.415CysAla: 1.415 ± 0.021	0.171CysCys: 0.171 ± 0.008	0.612CysAsp: 0.612 ± 0.015	0.568CysGlu: 0.568 ± 0.014	0.378CysPhe: 0.378 ± 0.012	1.127CysGly: 1.127 ± 0.024	0.27CysHis: 0.27 ± 0.01	0.478CysIle: 0.478 ± 0.013	0.272CysLys: 0.272 ± 0.011	0.865CysLeu: 0.865 ± 0.018	0.246CysMet: 0.246 ± 0.009	0.316CysAsn: 0.316 ± 0.012	0.501CysPro: 0.501 ± 0.017	0.255CysGln: 0.255 ± 0.011	0.752CysArg: 0.752 ± 0.019	0.661CysSer: 0.661 ± 0.016	0.552CysThr: 0.552 ± 0.013	0.934CysVal: 0.934 ± 0.02	0.145CysTrp: 0.145 ± 0.008	0.258CysTyr: 0.258 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.629AspAla: 7.629 ± 0.069	0.514AspCys: 0.514 ± 0.014	3.199AspAsp: 3.199 ± 0.036	3.495AspGlu: 3.495 ± 0.04	1.928AspPhe: 1.928 ± 0.023	4.533AspGly: 4.533 ± 0.047	1.19AspHis: 1.19 ± 0.019	2.578AspIle: 2.578 ± 0.034	1.572AspLys: 1.572 ± 0.025	4.985AspLeu: 4.985 ± 0.047	1.227AspMet: 1.227 ± 0.025	1.383AspAsn: 1.383 ± 0.022	2.813AspPro: 2.813 ± 0.035	1.57AspGln: 1.57 ± 0.024	3.51AspArg: 3.51 ± 0.038	2.607AspSer: 2.607 ± 0.034	2.778AspThr: 2.778 ± 0.029	4.441AspVal: 4.441 ± 0.042	0.892AspTrp: 0.892 ± 0.017	1.474AspTyr: 1.474 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.328GluAla: 6.328 ± 0.058	0.463GluCys: 0.463 ± 0.015	2.09GluAsp: 2.09 ± 0.027	2.46GluGlu: 2.46 ± 0.033	1.786GluPhe: 1.786 ± 0.024	3.402GluGly: 3.402 ± 0.041	1.459GluHis: 1.459 ± 0.024	2.734GluIle: 2.734 ± 0.036	1.871GluLys: 1.871 ± 0.028	5.341GluLeu: 5.341 ± 0.043	1.233GluMet: 1.233 ± 0.024	1.408GluAsn: 1.408 ± 0.023	2.484GluPro: 2.484 ± 0.035	2.341GluGln: 2.341 ± 0.034	4.886GluArg: 4.886 ± 0.051	2.852GluSer: 2.852 ± 0.033	2.823GluThr: 2.823 ± 0.032	3.432GluVal: 3.432 ± 0.043	0.761GluTrp: 0.761 ± 0.018	1.159GluTyr: 1.159 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	4.685PheAla: 4.685 ± 0.044	0.468PheCys: 0.468 ± 0.013	2.752PheAsp: 2.752 ± 0.027	2.069PheGlu: 2.069 ± 0.031	1.506PhePhe: 1.506 ± 0.023	3.631PheGly: 3.631 ± 0.042	0.808PheHis: 0.808 ± 0.017	1.665PheIle: 1.665 ± 0.025	1.011PheLys: 1.011 ± 0.02	2.933PheLeu: 2.933 ± 0.034	0.821PheMet: 0.821 ± 0.018	1.148PheAsn: 1.148 ± 0.019	1.639PhePro: 1.639 ± 0.029	0.962PheGln: 0.962 ± 0.02	2.186PheArg: 2.186 ± 0.029	2.344PheSer: 2.344 ± 0.031	1.956PheThr: 1.956 ± 0.027	3.099PheVal: 3.099 ± 0.035	0.49PheTrp: 0.49 ± 0.015	0.973PheTyr: 0.973 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.035GlyAla: 9.035 ± 0.072	0.954GlyCys: 0.954 ± 0.02	3.903GlyAsp: 3.903 ± 0.047	4.162GlyGlu: 4.162 ± 0.042	3.377GlyPhe: 3.377 ± 0.032	6.569GlyGly: 6.569 ± 0.078	2.015GlyHis: 2.015 ± 0.028	4.361GlyIle: 4.361 ± 0.044	3.262GlyLys: 3.262 ± 0.04	7.664GlyLeu: 7.664 ± 0.065	2.229GlyMet: 2.229 ± 0.03	2.396GlyAsn: 2.396 ± 0.043	2.972GlyPro: 2.972 ± 0.034	2.633GlyGln: 2.633 ± 0.033	5.262GlyArg: 5.262 ± 0.048	4.651GlySer: 4.651 ± 0.047	4.603GlyThr: 4.603 ± 0.063	6.575GlyVal: 6.575 ± 0.05	1.322GlyTrp: 1.322 ± 0.025	2.421GlyTyr: 2.421 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	3.222HisAla: 3.222 ± 0.04	0.3HisCys: 0.3 ± 0.01	1.428HisAsp: 1.428 ± 0.023	1.266HisGlu: 1.266 ± 0.022	1.005HisPhe: 1.005 ± 0.021	2.193HisGly: 2.193 ± 0.031	0.669HisHis: 0.669 ± 0.018	1.009HisIle: 1.009 ± 0.018	0.588HisLys: 0.588 ± 0.016	2.172HisLeu: 2.172 ± 0.027	0.575HisMet: 0.575 ± 0.014	0.565HisAsn: 0.565 ± 0.013	1.494HisPro: 1.494 ± 0.023	0.712HisGln: 0.712 ± 0.017	1.735HisArg: 1.735 ± 0.026	1.199HisSer: 1.199 ± 0.023	1.111HisThr: 1.111 ± 0.022	1.862HisVal: 1.862 ± 0.03	0.403HisTrp: 0.403 ± 0.011	0.691HisTyr: 0.691 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.054IleAla: 7.054 ± 0.053	0.5IleCys: 0.5 ± 0.014	3.625IleAsp: 3.625 ± 0.036	3.327IleGlu: 3.327 ± 0.041	1.521IlePhe: 1.521 ± 0.026	4.808IleGly: 4.808 ± 0.047	0.968IleHis: 0.968 ± 0.021	1.666IleIle: 1.666 ± 0.026	1.338IleLys: 1.338 ± 0.025	3.364IleLeu: 3.364 ± 0.041	0.805IleMet: 0.805 ± 0.019	1.421IleAsn: 1.421 ± 0.024	2.174IlePro: 2.174 ± 0.026	1.238IleGln: 1.238 ± 0.022	3.016IleArg: 3.016 ± 0.035	2.61IleSer: 2.61 ± 0.032	2.432IleThr: 2.432 ± 0.03	4.511IleVal: 4.511 ± 0.045	0.523IleTrp: 0.523 ± 0.013	1.068IleTyr: 1.068 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.679LysAla: 3.679 ± 0.039	0.223LysCys: 0.223 ± 0.01	1.512LysAsp: 1.512 ± 0.026	1.534LysGlu: 1.534 ± 0.025	0.908LysPhe: 0.908 ± 0.02	2.246LysGly: 2.246 ± 0.031	0.752LysHis: 0.752 ± 0.017	1.586LysIle: 1.586 ± 0.027	1.329LysLys: 1.329 ± 0.029	3.432LysLeu: 3.432 ± 0.031	0.843LysMet: 0.843 ± 0.016	0.938LysAsn: 0.938 ± 0.022	2.007LysPro: 2.007 ± 0.033	1.267LysGln: 1.267 ± 0.024	2.54LysArg: 2.54 ± 0.036	1.879LysSer: 1.879 ± 0.027	1.957LysThr: 1.957 ± 0.025	2.383LysVal: 2.383 ± 0.035	0.394LysTrp: 0.394 ± 0.012	0.72LysTyr: 0.72 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	12.947LeuAla: 12.947 ± 0.089	1.131LeuCys: 1.131 ± 0.02	5.716LeuAsp: 5.716 ± 0.055	4.854LeuGlu: 4.854 ± 0.045	3.569LeuPhe: 3.569 ± 0.045	7.682LeuGly: 7.682 ± 0.064	2.323LeuHis: 2.323 ± 0.032	4.69LeuIle: 4.69 ± 0.054	3.383LeuLys: 3.383 ± 0.036	9.548LeuLeu: 9.548 ± 0.086	2.336LeuMet: 2.336 ± 0.034	2.823LeuAsn: 2.823 ± 0.037	5.489LeuPro: 5.489 ± 0.052	3.24LeuGln: 3.24 ± 0.039	7.05LeuArg: 7.05 ± 0.058	6.31LeuSer: 6.31 ± 0.049	5.62LeuThr: 5.62 ± 0.044	7.117LeuVal: 7.117 ± 0.05	1.088LeuTrp: 1.088 ± 0.025	2.142LeuTyr: 2.142 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.462MetAla: 2.462 ± 0.029	0.231MetCys: 0.231 ± 0.01	0.971MetAsp: 0.971 ± 0.019	0.961MetGlu: 0.961 ± 0.018	0.807MetPhe: 0.807 ± 0.016	1.591MetGly: 1.591 ± 0.029	0.665MetHis: 0.665 ± 0.017	1.181MetIle: 1.181 ± 0.021	1.119MetLys: 1.119 ± 0.023	2.718MetLeu: 2.718 ± 0.035	0.65MetMet: 0.65 ± 0.018	0.977MetAsn: 0.977 ± 0.017	1.529MetPro: 1.529 ± 0.026	1.064MetGln: 1.064 ± 0.021	2.008MetArg: 2.008 ± 0.025	1.899MetSer: 1.899 ± 0.025	1.763MetThr: 1.763 ± 0.025	1.485MetVal: 1.485 ± 0.025	0.249MetTrp: 0.249 ± 0.01	0.432MetTyr: 0.432 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.695AsnAla: 3.695 ± 0.046	0.292AsnCys: 0.292 ± 0.012	1.557AsnAsp: 1.557 ± 0.024	1.468AsnGlu: 1.468 ± 0.024	1.018AsnPhe: 1.018 ± 0.019	2.737AsnGly: 2.737 ± 0.044	0.581AsnHis: 0.581 ± 0.014	1.268AsnIle: 1.268 ± 0.021	0.71AsnLys: 0.71 ± 0.015	2.693AsnLeu: 2.693 ± 0.036	0.638AsnMet: 0.638 ± 0.015	0.857AsnAsn: 0.857 ± 0.023	1.818AsnPro: 1.818 ± 0.023	0.927AsnGln: 0.927 ± 0.02	1.956AsnArg: 1.956 ± 0.027	1.419AsnSer: 1.419 ± 0.027	1.556AsnThr: 1.556 ± 0.029	2.42AsnVal: 2.42 ± 0.036	0.447AsnTrp: 0.447 ± 0.013	0.725AsnTyr: 0.725 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.145ProAla: 6.145 ± 0.064	0.443ProCys: 0.443 ± 0.014	3.237ProAsp: 3.237 ± 0.032	2.901ProGlu: 2.901 ± 0.034	1.936ProPhe: 1.936 ± 0.024	4.077ProGly: 4.077 ± 0.042	1.283ProHis: 1.283 ± 0.02	2.093ProIle: 2.093 ± 0.029	1.499ProLys: 1.499 ± 0.024	4.978ProLeu: 4.978 ± 0.048	1.192ProMet: 1.192 ± 0.021	1.471ProAsn: 1.471 ± 0.024	2.445ProPro: 2.445 ± 0.034	1.812ProGln: 1.812 ± 0.031	2.971ProArg: 2.971 ± 0.035	3.035ProSer: 3.035 ± 0.034	2.608ProThr: 2.608 ± 0.033	4.271ProVal: 4.271 ± 0.041	0.653ProTrp: 0.653 ± 0.018	1.255ProTyr: 1.255 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.186GlnAla: 4.186 ± 0.043	0.344GlnCys: 0.344 ± 0.011	1.315GlnAsp: 1.315 ± 0.025	1.364GlnGlu: 1.364 ± 0.027	1.296GlnPhe: 1.296 ± 0.022	2.401GlnGly: 2.401 ± 0.033	0.955GlnHis: 0.955 ± 0.017	1.982GlnIle: 1.982 ± 0.025	1.17GlnLys: 1.17 ± 0.022	3.655GlnLeu: 3.655 ± 0.036	1.047GlnMet: 1.047 ± 0.023	0.929GlnAsn: 0.929 ± 0.017	2.034GlnPro: 2.034 ± 0.032	1.839GlnGln: 1.839 ± 0.032	2.978GlnArg: 2.978 ± 0.038	2.11GlnSer: 2.11 ± 0.025	2.033GlnThr: 2.033 ± 0.03	2.376GlnVal: 2.376 ± 0.03	0.553GlnTrp: 0.553 ± 0.016	0.899GlnTyr: 0.899 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.245ArgAla: 8.245 ± 0.065	0.79ArgCys: 0.79 ± 0.018	3.992ArgAsp: 3.992 ± 0.044	4.303ArgGlu: 4.303 ± 0.045	3.015ArgPhe: 3.015 ± 0.032	4.707ArgGly: 4.707 ± 0.044	2.045ArgHis: 2.045 ± 0.027	3.757ArgIle: 3.757 ± 0.038	2.333ArgLys: 2.333 ± 0.029	7.17ArgLeu: 7.17 ± 0.063	1.954ArgMet: 1.954 ± 0.026	2.075ArgAsn: 2.075 ± 0.028	3.124ArgPro: 3.124 ± 0.034	2.591ArgGln: 2.591 ± 0.031	5.66ArgArg: 5.66 ± 0.055	3.869ArgSer: 3.869 ± 0.044	3.624ArgThr: 3.624 ± 0.037	5.388ArgVal: 5.388 ± 0.053	1.099ArgTrp: 1.099 ± 0.022	2.006ArgTyr: 2.006 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.025SerAla: 7.025 ± 0.053	0.574SerCys: 0.574 ± 0.015	3.003SerAsp: 3.003 ± 0.039	2.748SerGlu: 2.748 ± 0.035	2.273SerPhe: 2.273 ± 0.031	5.438SerGly: 5.438 ± 0.051	1.39SerHis: 1.39 ± 0.024	2.926SerIle: 2.926 ± 0.032	1.815SerLys: 1.815 ± 0.029	5.891SerLeu: 5.891 ± 0.048	1.62SerMet: 1.62 ± 0.024	1.802SerAsn: 1.802 ± 0.029	2.935SerPro: 2.935 ± 0.03	1.893SerGln: 1.893 ± 0.027	4.103SerArg: 4.103 ± 0.039	3.716SerSer: 3.716 ± 0.047	3.395SerThr: 3.395 ± 0.045	4.575SerVal: 4.575 ± 0.043	0.735SerTrp: 0.735 ± 0.017	1.361SerTyr: 1.361 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.867ThrAla: 5.867 ± 0.046	0.526ThrCys: 0.526 ± 0.016	2.726ThrAsp: 2.726 ± 0.035	2.313ThrGlu: 2.313 ± 0.035	2.045ThrPhe: 2.045 ± 0.031	4.903ThrGly: 4.903 ± 0.053	1.337ThrHis: 1.337 ± 0.021	2.684ThrIle: 2.684 ± 0.029	1.404ThrLys: 1.404 ± 0.022	6.286ThrLeu: 6.286 ± 0.051	1.316ThrMet: 1.316 ± 0.024	1.48ThrAsn: 1.48 ± 0.032	3.416ThrPro: 3.416 ± 0.036	1.995ThrGln: 1.995 ± 0.03	3.742ThrArg: 3.742 ± 0.036	3.256ThrSer: 3.256 ± 0.038	3.074ThrThr: 3.074 ± 0.047	4.416ThrVal: 4.416 ± 0.044	0.709ThrTrp: 0.709 ± 0.017	1.272ThrTyr: 1.272 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.312ValAla: 9.312 ± 0.057	0.926ValCys: 0.926 ± 0.019	4.32ValAsp: 4.32 ± 0.043	4.121ValGlu: 4.121 ± 0.047	2.848ValPhe: 2.848 ± 0.03	5.534ValGly: 5.534 ± 0.046	1.618ValHis: 1.618 ± 0.025	3.892ValIle: 3.892 ± 0.042	2.519ValLys: 2.519 ± 0.035	7.718ValLeu: 7.718 ± 0.059	1.824ValMet: 1.824 ± 0.027	2.282ValAsn: 2.282 ± 0.04	3.957ValPro: 3.957 ± 0.04	2.501ValGln: 2.501 ± 0.028	5.249ValArg: 5.249 ± 0.05	4.823ValSer: 4.823 ± 0.051	4.572ValThr: 4.572 ± 0.047	6.185ValVal: 6.185 ± 0.053	0.967ValTrp: 0.967 ± 0.017	1.677ValTyr: 1.677 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.02	0.178TrpCys: 0.178 ± 0.009	0.596TrpAsp: 0.596 ± 0.016	0.514TrpGlu: 0.514 ± 0.014	0.548TrpPhe: 0.548 ± 0.015	0.866TrpGly: 0.866 ± 0.018	0.414TrpHis: 0.414 ± 0.011	0.716TrpIle: 0.716 ± 0.02	0.459TrpLys: 0.459 ± 0.015	1.847TrpLeu: 1.847 ± 0.031	0.391TrpMet: 0.391 ± 0.011	0.475TrpAsn: 0.475 ± 0.014	0.667TrpPro: 0.667 ± 0.016	0.64TrpGln: 0.64 ± 0.015	1.219TrpArg: 1.219 ± 0.022	0.839TrpSer: 0.839 ± 0.018	0.74TrpThr: 0.74 ± 0.017	0.883TrpVal: 0.883 ± 0.019	0.219TrpTrp: 0.219 ± 0.009	0.328TrpTyr: 0.328 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.804TyrAla: 2.804 ± 0.034	0.301TyrCys: 0.301 ± 0.01	1.364TyrAsp: 1.364 ± 0.025	1.27TyrGlu: 1.27 ± 0.02	1.026TyrPhe: 1.026 ± 0.02	2.173TyrGly: 2.173 ± 0.033	0.534TyrHis: 0.534 ± 0.015	0.876TyrIle: 0.876 ± 0.02	0.619TyrLys: 0.619 ± 0.014	2.426TyrLeu: 2.426 ± 0.029	0.478TyrMet: 0.478 ± 0.013	0.638TyrAsn: 0.638 ± 0.02	1.255TyrPro: 1.255 ± 0.02	0.856TyrGln: 0.856 ± 0.019	1.991TyrArg: 1.991 ± 0.026	1.337TyrSer: 1.337 ± 0.024	1.252TyrThr: 1.252 ± 0.022	1.917TyrVal: 1.917 ± 0.031	0.409TyrTrp: 0.409 ± 0.013	0.654TyrTyr: 0.654 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9923 proteins (2772491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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