Amino acid dipepetide frequency for Vibrio proteolyticus NBRC 13287

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.423AlaAla: 8.423 ± 0.089	0.974AlaCys: 0.974 ± 0.029	4.919AlaAsp: 4.919 ± 0.064	5.752AlaGlu: 5.752 ± 0.084	3.516AlaPhe: 3.516 ± 0.048	6.281AlaGly: 6.281 ± 0.072	1.813AlaHis: 1.813 ± 0.036	5.679AlaIle: 5.679 ± 0.069	4.577AlaLys: 4.577 ± 0.061	10.879AlaLeu: 10.879 ± 0.109	2.958AlaMet: 2.958 ± 0.043	3.386AlaAsn: 3.386 ± 0.053	3.083AlaPro: 3.083 ± 0.057	4.544AlaGln: 4.544 ± 0.068	4.238AlaArg: 4.238 ± 0.069	5.576AlaSer: 5.576 ± 0.08	4.697AlaThr: 4.697 ± 0.064	6.19AlaVal: 6.19 ± 0.075	1.014AlaTrp: 1.014 ± 0.027	2.493AlaTyr: 2.493 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.851CysAla: 0.851 ± 0.024	0.161CysCys: 0.161 ± 0.012	0.673CysAsp: 0.673 ± 0.025	0.614CysGlu: 0.614 ± 0.018	0.469CysPhe: 0.469 ± 0.019	0.942CysGly: 0.942 ± 0.031	0.389CysHis: 0.389 ± 0.018	0.568CysIle: 0.568 ± 0.017	0.361CysLys: 0.361 ± 0.016	1.008CysLeu: 1.008 ± 0.029	0.227CysMet: 0.227 ± 0.013	0.321CysAsn: 0.321 ± 0.016	0.465CysPro: 0.465 ± 0.02	0.541CysGln: 0.541 ± 0.018	0.525CysArg: 0.525 ± 0.021	0.674CysSer: 0.674 ± 0.023	0.459CysThr: 0.459 ± 0.021	0.688CysVal: 0.688 ± 0.024	0.148CysTrp: 0.148 ± 0.01	0.335CysTyr: 0.335 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.981AspAla: 4.981 ± 0.069	0.531AspCys: 0.531 ± 0.02	3.171AspAsp: 3.171 ± 0.055	3.716AspGlu: 3.716 ± 0.062	2.32AspPhe: 2.32 ± 0.042	3.875AspGly: 3.875 ± 0.078	1.186AspHis: 1.186 ± 0.031	3.783AspIle: 3.783 ± 0.053	3.057AspLys: 3.057 ± 0.05	5.145AspLeu: 5.145 ± 0.069	1.496AspMet: 1.496 ± 0.029	2.381AspAsn: 2.381 ± 0.049	2.175AspPro: 2.175 ± 0.044	2.152AspGln: 2.152 ± 0.049	2.334AspArg: 2.334 ± 0.046	3.269AspSer: 3.269 ± 0.056	2.964AspThr: 2.964 ± 0.049	4.256AspVal: 4.256 ± 0.072	0.881AspTrp: 0.881 ± 0.03	2.085AspTyr: 2.085 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.275GluAla: 5.275 ± 0.081	0.534GluCys: 0.534 ± 0.02	2.68GluAsp: 2.68 ± 0.045	3.628GluGlu: 3.628 ± 0.059	2.432GluPhe: 2.432 ± 0.043	3.393GluGly: 3.393 ± 0.057	1.76GluHis: 1.76 ± 0.033	3.336GluIle: 3.336 ± 0.054	3.367GluLys: 3.367 ± 0.058	7.003GluLeu: 7.003 ± 0.084	1.745GluMet: 1.745 ± 0.034	2.225GluAsn: 2.225 ± 0.043	2.214GluPro: 2.214 ± 0.05	4.166GluGln: 4.166 ± 0.067	3.624GluArg: 3.624 ± 0.061	3.518GluSer: 3.518 ± 0.053	3.008GluThr: 3.008 ± 0.053	4.238GluVal: 4.238 ± 0.054	0.859GluTrp: 0.859 ± 0.026	1.776GluTyr: 1.776 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.644PheAla: 3.644 ± 0.058	0.502PheCys: 0.502 ± 0.021	2.744PheAsp: 2.744 ± 0.045	2.447PheGlu: 2.447 ± 0.04	1.599PhePhe: 1.599 ± 0.038	3.209PheGly: 3.209 ± 0.049	0.891PheHis: 0.891 ± 0.024	2.473PheIle: 2.473 ± 0.049	1.66PheLys: 1.66 ± 0.037	3.331PheLeu: 3.331 ± 0.061	0.985PheMet: 0.985 ± 0.026	1.856PheAsn: 1.856 ± 0.037	1.386PhePro: 1.386 ± 0.032	1.316PheGln: 1.316 ± 0.031	1.63PheArg: 1.63 ± 0.035	3.118PheSer: 3.118 ± 0.056	2.25PheThr: 2.25 ± 0.037	2.866PheVal: 2.866 ± 0.052	0.56PheTrp: 0.56 ± 0.022	1.286PheTyr: 1.286 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.51GlyAla: 5.51 ± 0.08	0.909GlyCys: 0.909 ± 0.025	3.709GlyAsp: 3.709 ± 0.057	4.459GlyGlu: 4.459 ± 0.063	3.189GlyPhe: 3.189 ± 0.057	4.795GlyGly: 4.795 ± 0.077	1.625GlyHis: 1.625 ± 0.031	4.493GlyIle: 4.493 ± 0.066	3.618GlyLys: 3.618 ± 0.045	7.061GlyLeu: 7.061 ± 0.093	2.1GlyMet: 2.1 ± 0.042	2.52GlyAsn: 2.52 ± 0.049	1.694GlyPro: 1.694 ± 0.037	3.182GlyGln: 3.182 ± 0.05	3.295GlyArg: 3.295 ± 0.054	4.045GlySer: 4.045 ± 0.06	3.411GlyThr: 3.411 ± 0.054	5.402GlyVal: 5.402 ± 0.068	1.001GlyTrp: 1.001 ± 0.028	2.667GlyTyr: 2.667 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.818HisAla: 1.818 ± 0.042	0.364HisCys: 0.364 ± 0.017	1.227HisAsp: 1.227 ± 0.031	1.198HisGlu: 1.198 ± 0.03	1.114HisPhe: 1.114 ± 0.03	1.656HisGly: 1.656 ± 0.034	0.821HisHis: 0.821 ± 0.026	1.431HisIle: 1.431 ± 0.031	1.025HisLys: 1.025 ± 0.027	2.409HisLeu: 2.409 ± 0.038	0.525HisMet: 0.525 ± 0.02	0.912HisAsn: 0.912 ± 0.025	1.261HisPro: 1.261 ± 0.031	1.424HisGln: 1.424 ± 0.035	1.139HisArg: 1.139 ± 0.034	1.498HisSer: 1.498 ± 0.034	1.206HisThr: 1.206 ± 0.033	1.401HisVal: 1.401 ± 0.031	0.408HisTrp: 0.408 ± 0.017	0.929HisTyr: 0.929 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.142IleAla: 6.142 ± 0.081	0.652IleCys: 0.652 ± 0.022	3.949IleAsp: 3.949 ± 0.058	4.394IleGlu: 4.394 ± 0.065	1.955IlePhe: 1.955 ± 0.041	4.447IleGly: 4.447 ± 0.067	1.278IleHis: 1.278 ± 0.033	3.06IleIle: 3.06 ± 0.058	2.668IleLys: 2.668 ± 0.046	4.98IleLeu: 4.98 ± 0.065	1.202IleMet: 1.202 ± 0.032	2.575IleAsn: 2.575 ± 0.044	2.541IlePro: 2.541 ± 0.045	2.297IleGln: 2.297 ± 0.044	3.051IleArg: 3.051 ± 0.047	4.081IleSer: 4.081 ± 0.053	3.338IleThr: 3.338 ± 0.058	4.02IleVal: 4.02 ± 0.057	0.641IleTrp: 0.641 ± 0.021	1.605IleTyr: 1.605 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.644LysAla: 4.644 ± 0.062	0.313LysCys: 0.313 ± 0.017	2.426LysAsp: 2.426 ± 0.046	2.822LysGlu: 2.822 ± 0.052	1.353LysPhe: 1.353 ± 0.036	3.064LysGly: 3.064 ± 0.051	1.186LysHis: 1.186 ± 0.031	2.432LysIle: 2.432 ± 0.041	2.442LysLys: 2.442 ± 0.051	4.982LysLeu: 4.982 ± 0.066	1.355LysMet: 1.355 ± 0.031	1.773LysAsn: 1.773 ± 0.035	2.306LysPro: 2.306 ± 0.047	2.774LysGln: 2.774 ± 0.06	2.675LysArg: 2.675 ± 0.047	2.749LysSer: 2.749 ± 0.048	2.518LysThr: 2.518 ± 0.038	3.583LysVal: 3.583 ± 0.048	0.546LysTrp: 0.546 ± 0.022	1.26LysTyr: 1.26 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.579LeuAla: 10.579 ± 0.105	1.165LeuCys: 1.165 ± 0.03	6.036LeuAsp: 6.036 ± 0.074	6.058LeuGlu: 6.058 ± 0.082	4.173LeuPhe: 4.173 ± 0.069	7.133LeuGly: 7.133 ± 0.076	2.152LeuHis: 2.152 ± 0.042	6.001LeuIle: 6.001 ± 0.08	5.059LeuLys: 5.059 ± 0.067	10.858LeuLeu: 10.858 ± 0.125	2.892LeuMet: 2.892 ± 0.05	4.587LeuAsn: 4.587 ± 0.062	4.929LeuPro: 4.929 ± 0.074	3.773LeuGln: 3.773 ± 0.061	4.756LeuArg: 4.756 ± 0.069	8.181LeuSer: 8.181 ± 0.086	6.4LeuThr: 6.4 ± 0.07	7.225LeuVal: 7.225 ± 0.082	1.132LeuTrp: 1.132 ± 0.031	2.703LeuTyr: 2.703 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.756MetAla: 2.756 ± 0.044	0.235MetCys: 0.235 ± 0.013	1.319MetAsp: 1.319 ± 0.032	1.302MetGlu: 1.302 ± 0.032	0.972MetPhe: 0.972 ± 0.024	1.776MetGly: 1.776 ± 0.041	0.497MetHis: 0.497 ± 0.016	1.537MetIle: 1.537 ± 0.035	1.487MetLys: 1.487 ± 0.03	2.958MetLeu: 2.958 ± 0.048	0.845MetMet: 0.845 ± 0.025	1.134MetAsn: 1.134 ± 0.027	1.287MetPro: 1.287 ± 0.032	1.227MetGln: 1.227 ± 0.031	1.274MetArg: 1.274 ± 0.029	2.05MetSer: 2.05 ± 0.044	1.735MetThr: 1.735 ± 0.036	1.943MetVal: 1.943 ± 0.037	0.24MetTrp: 0.24 ± 0.012	0.551MetTyr: 0.551 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.354AsnAla: 3.354 ± 0.052	0.384AsnCys: 0.384 ± 0.017	2.194AsnAsp: 2.194 ± 0.043	2.116AsnGlu: 2.116 ± 0.039	1.345AsnPhe: 1.345 ± 0.032	2.904AsnGly: 2.904 ± 0.049	0.952AsnHis: 0.952 ± 0.027	2.34AsnIle: 2.34 ± 0.042	1.856AsnLys: 1.856 ± 0.042	3.714AsnLeu: 3.714 ± 0.054	0.978AsnMet: 0.978 ± 0.026	1.546AsnAsn: 1.546 ± 0.038	2.072AsnPro: 2.072 ± 0.04	2.188AsnGln: 2.188 ± 0.039	1.957AsnArg: 1.957 ± 0.037	2.177AsnSer: 2.177 ± 0.05	2.069AsnThr: 2.069 ± 0.039	2.672AsnVal: 2.672 ± 0.048	0.599AsnTrp: 0.599 ± 0.021	1.212AsnTyr: 1.212 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	3.526ProAla: 3.526 ± 0.06	0.339ProCys: 0.339 ± 0.018	2.621ProAsp: 2.621 ± 0.044	3.151ProGlu: 3.151 ± 0.059	1.674ProPhe: 1.674 ± 0.035	2.579ProGly: 2.579 ± 0.053	0.99ProHis: 0.99 ± 0.028	2.255ProIle: 2.255 ± 0.041	1.791ProLys: 1.791 ± 0.033	4.351ProLeu: 4.351 ± 0.068	1.118ProMet: 1.118 ± 0.027	1.512ProAsn: 1.512 ± 0.034	1.265ProPro: 1.265 ± 0.038	2.064ProGln: 2.064 ± 0.034	1.456ProArg: 1.456 ± 0.036	2.426ProSer: 2.426 ± 0.042	2.109ProThr: 2.109 ± 0.041	3.45ProVal: 3.45 ± 0.054	0.525ProTrp: 0.525 ± 0.021	1.319ProTyr: 1.319 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.931GlnAla: 4.931 ± 0.075	0.435GlnCys: 0.435 ± 0.02	2.261GlnAsp: 2.261 ± 0.041	2.511GlnGlu: 2.511 ± 0.046	1.841GlnPhe: 1.841 ± 0.037	3.177GlnGly: 3.177 ± 0.053	1.472GlnHis: 1.472 ± 0.033	2.625GlnIle: 2.625 ± 0.039	1.933GlnLys: 1.933 ± 0.039	5.599GlnLeu: 5.599 ± 0.084	1.242GlnMet: 1.242 ± 0.03	1.525GlnAsn: 1.525 ± 0.036	2.093GlnPro: 2.093 ± 0.04	3.285GlnGln: 3.285 ± 0.064	2.819GlnArg: 2.819 ± 0.045	2.988GlnSer: 2.988 ± 0.059	2.504GlnThr: 2.504 ± 0.047	3.524GlnVal: 3.524 ± 0.055	0.737GlnTrp: 0.737 ± 0.022	1.499GlnTyr: 1.499 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.876ArgAla: 3.876 ± 0.055	0.53ArgCys: 0.53 ± 0.022	2.717ArgAsp: 2.717 ± 0.053	3.199ArgGlu: 3.199 ± 0.055	2.295ArgPhe: 2.295 ± 0.038	2.775ArgGly: 2.775 ± 0.046	1.353ArgHis: 1.353 ± 0.033	3.171ArgIle: 3.171 ± 0.046	2.356ArgLys: 2.356 ± 0.045	5.404ArgLeu: 5.404 ± 0.077	1.311ArgMet: 1.311 ± 0.031	1.856ArgAsn: 1.856 ± 0.036	1.705ArgPro: 1.705 ± 0.032	2.659ArgGln: 2.659 ± 0.044	2.684ArgArg: 2.684 ± 0.055	2.796ArgSer: 2.796 ± 0.049	2.275ArgThr: 2.275 ± 0.037	3.42ArgVal: 3.42 ± 0.048	0.703ArgTrp: 0.703 ± 0.024	1.928ArgTyr: 1.928 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.785SerAla: 5.785 ± 0.068	0.558SerCys: 0.558 ± 0.02	3.83SerAsp: 3.83 ± 0.067	3.987SerGlu: 3.987 ± 0.055	2.601SerPhe: 2.601 ± 0.045	5.164SerGly: 5.164 ± 0.072	1.567SerHis: 1.567 ± 0.038	3.565SerIle: 3.565 ± 0.056	2.811SerLys: 2.811 ± 0.052	6.847SerLeu: 6.847 ± 0.074	1.748SerMet: 1.748 ± 0.04	2.28SerAsn: 2.28 ± 0.041	2.51SerPro: 2.51 ± 0.042	3.121SerGln: 3.121 ± 0.055	3.057SerArg: 3.057 ± 0.049	4.112SerSer: 4.112 ± 0.073	3.192SerThr: 3.192 ± 0.055	4.877SerVal: 4.877 ± 0.067	0.854SerTrp: 0.854 ± 0.028	1.966SerTyr: 1.966 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.627ThrAla: 4.627 ± 0.053	0.485ThrCys: 0.485 ± 0.019	2.817ThrAsp: 2.817 ± 0.054	2.93ThrGlu: 2.93 ± 0.05	2.098ThrPhe: 2.098 ± 0.038	3.895ThrGly: 3.895 ± 0.062	1.28ThrHis: 1.28 ± 0.03	3.207ThrIle: 3.207 ± 0.053	2.051ThrLys: 2.051 ± 0.045	6.815ThrLeu: 6.815 ± 0.079	1.219ThrMet: 1.219 ± 0.033	1.826ThrAsn: 1.826 ± 0.038	2.803ThrPro: 2.803 ± 0.05	2.723ThrGln: 2.723 ± 0.042	2.519ThrArg: 2.519 ± 0.043	3.336ThrSer: 3.336 ± 0.058	2.896ThrThr: 2.896 ± 0.052	3.859ThrVal: 3.859 ± 0.061	0.607ThrTrp: 0.607 ± 0.021	1.532ThrTyr: 1.532 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.917ValAla: 6.917 ± 0.077	0.809ValCys: 0.809 ± 0.024	4.165ValAsp: 4.165 ± 0.061	4.507ValGlu: 4.507 ± 0.059	2.861ValPhe: 2.861 ± 0.042	4.739ValGly: 4.739 ± 0.068	1.345ValHis: 1.345 ± 0.03	4.702ValIle: 4.702 ± 0.065	3.399ValLys: 3.399 ± 0.052	7.089ValLeu: 7.089 ± 0.068	2.183ValMet: 2.183 ± 0.047	2.87ValAsn: 2.87 ± 0.053	2.821ValPro: 2.821 ± 0.051	2.366ValGln: 2.366 ± 0.044	3.357ValArg: 3.357 ± 0.049	5.146ValSer: 5.146 ± 0.071	4.394ValThr: 4.394 ± 0.072	5.708ValVal: 5.708 ± 0.066	0.842ValTrp: 0.842 ± 0.025	1.943ValTyr: 1.943 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.027	0.176TrpCys: 0.176 ± 0.01	0.626TrpAsp: 0.626 ± 0.025	0.556TrpGlu: 0.556 ± 0.022	0.624TrpPhe: 0.624 ± 0.025	0.818TrpGly: 0.818 ± 0.026	0.382TrpHis: 0.382 ± 0.018	0.712TrpIle: 0.712 ± 0.024	0.506TrpLys: 0.506 ± 0.019	1.863TrpLeu: 1.863 ± 0.044	0.368TrpMet: 0.368 ± 0.018	0.482TrpAsn: 0.482 ± 0.019	0.483TrpPro: 0.483 ± 0.02	1.0TrpGln: 1.0 ± 0.029	0.726TrpArg: 0.726 ± 0.026	0.769TrpSer: 0.769 ± 0.027	0.536TrpThr: 0.536 ± 0.022	0.89TrpVal: 0.89 ± 0.027	0.216TrpTrp: 0.216 ± 0.013	0.401TrpTyr: 0.401 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.468TyrAla: 2.468 ± 0.045	0.364TyrCys: 0.364 ± 0.016	1.674TyrAsp: 1.674 ± 0.036	1.432TyrGlu: 1.432 ± 0.03	1.319TyrPhe: 1.319 ± 0.03	2.062TyrGly: 2.062 ± 0.042	0.827TyrHis: 0.827 ± 0.022	1.505TyrIle: 1.505 ± 0.035	1.18TyrLys: 1.18 ± 0.031	3.496TyrLeu: 3.496 ± 0.054	0.63TyrMet: 0.63 ± 0.022	1.065TyrAsn: 1.065 ± 0.034	1.428TyrPro: 1.428 ± 0.036	2.201TyrGln: 2.201 ± 0.046	1.895TyrArg: 1.895 ± 0.04	1.922TyrSer: 1.922 ± 0.041	1.563TyrThr: 1.563 ± 0.034	1.954TyrVal: 1.954 ± 0.036	0.505TyrTrp: 0.505 ± 0.018	1.053TyrTyr: 1.053 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4347 proteins (1389250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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