Amino acid dipepetide frequency for Algicoccus marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.474AlaAla: 10.474 ± 0.128	1.301AlaCys: 1.301 ± 0.035	5.344AlaAsp: 5.344 ± 0.072	4.715AlaGlu: 4.715 ± 0.071	3.723AlaPhe: 3.723 ± 0.06	8.592AlaGly: 8.592 ± 0.091	2.245AlaHis: 2.245 ± 0.045	5.838AlaIle: 5.838 ± 0.093	3.118AlaLys: 3.118 ± 0.061	11.584AlaLeu: 11.584 ± 0.13	3.354AlaMet: 3.354 ± 0.049	2.779AlaAsn: 2.779 ± 0.05	4.169AlaPro: 4.169 ± 0.066	5.228AlaGln: 5.228 ± 0.064	7.646AlaArg: 7.646 ± 0.101	6.819AlaSer: 6.819 ± 0.084	5.219AlaThr: 5.219 ± 0.083	7.426AlaVal: 7.426 ± 0.088	1.558AlaTrp: 1.558 ± 0.037	2.353AlaTyr: 2.353 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.033	0.161CysCys: 0.161 ± 0.013	0.625CysAsp: 0.625 ± 0.021	0.582CysGlu: 0.582 ± 0.022	0.389CysPhe: 0.389 ± 0.017	0.928CysGly: 0.928 ± 0.028	0.292CysHis: 0.292 ± 0.017	0.459CysIle: 0.459 ± 0.019	0.319CysLys: 0.319 ± 0.016	1.027CysLeu: 1.027 ± 0.03	0.242CysMet: 0.242 ± 0.012	0.26CysAsn: 0.26 ± 0.017	0.572CysPro: 0.572 ± 0.024	0.404CysGln: 0.404 ± 0.021	0.604CysArg: 0.604 ± 0.025	0.59CysSer: 0.59 ± 0.025	0.51CysThr: 0.51 ± 0.025	0.804CysVal: 0.804 ± 0.027	0.151CysTrp: 0.151 ± 0.014	0.24CysTyr: 0.24 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.496AspAla: 5.496 ± 0.081	0.524AspCys: 0.524 ± 0.019	2.79AspAsp: 2.79 ± 0.052	3.282AspGlu: 3.282 ± 0.062	1.917AspPhe: 1.917 ± 0.045	4.176AspGly: 4.176 ± 0.065	1.273AspHis: 1.273 ± 0.04	2.854AspIle: 2.854 ± 0.054	1.841AspLys: 1.841 ± 0.045	5.904AspLeu: 5.904 ± 0.076	1.438AspMet: 1.438 ± 0.039	1.329AspAsn: 1.329 ± 0.033	3.265AspPro: 3.265 ± 0.058	2.492AspGln: 2.492 ± 0.044	3.556AspArg: 3.556 ± 0.065	3.066AspSer: 3.066 ± 0.056	2.614AspThr: 2.614 ± 0.046	4.21AspVal: 4.21 ± 0.064	0.977AspTrp: 0.977 ± 0.028	1.425AspTyr: 1.425 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.101GluAla: 5.101 ± 0.071	0.393GluCys: 0.393 ± 0.02	2.455GluAsp: 2.455 ± 0.046	2.493GluGlu: 2.493 ± 0.051	1.997GluPhe: 1.997 ± 0.039	3.482GluGly: 3.482 ± 0.063	1.529GluHis: 1.529 ± 0.043	3.337GluIle: 3.337 ± 0.05	2.161GluLys: 2.161 ± 0.051	5.716GluLeu: 5.716 ± 0.078	1.541GluMet: 1.541 ± 0.036	1.627GluAsn: 1.627 ± 0.038	2.688GluPro: 2.688 ± 0.071	3.299GluGln: 3.299 ± 0.063	4.255GluArg: 4.255 ± 0.072	3.678GluSer: 3.678 ± 0.058	2.852GluThr: 2.852 ± 0.047	3.99GluVal: 3.99 ± 0.068	0.715GluTrp: 0.715 ± 0.026	1.169GluTyr: 1.169 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.668PheAla: 3.668 ± 0.062	0.461PheCys: 0.461 ± 0.023	2.541PheAsp: 2.541 ± 0.044	2.512PheGlu: 2.512 ± 0.04	1.403PhePhe: 1.403 ± 0.04	3.322PheGly: 3.322 ± 0.056	0.741PheHis: 0.741 ± 0.027	1.753PheIle: 1.753 ± 0.047	1.281PheLys: 1.281 ± 0.038	3.356PheLeu: 3.356 ± 0.058	0.92PheMet: 0.92 ± 0.028	1.208PheAsn: 1.208 ± 0.031	1.489PhePro: 1.489 ± 0.035	1.145PheGln: 1.145 ± 0.029	1.861PheArg: 1.861 ± 0.039	2.439PheSer: 2.439 ± 0.049	1.864PheThr: 1.864 ± 0.042	2.991PheVal: 2.991 ± 0.058	0.55PheTrp: 0.55 ± 0.023	0.939PheTyr: 0.939 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.073GlyAla: 7.073 ± 0.101	0.921GlyCys: 0.921 ± 0.032	3.602GlyAsp: 3.602 ± 0.065	3.842GlyGlu: 3.842 ± 0.065	3.248GlyPhe: 3.248 ± 0.049	5.582GlyGly: 5.582 ± 0.134	1.963GlyHis: 1.963 ± 0.041	4.447GlyIle: 4.447 ± 0.071	3.369GlyLys: 3.369 ± 0.058	8.735GlyLeu: 8.735 ± 0.117	2.537GlyMet: 2.537 ± 0.045	2.184GlyAsn: 2.184 ± 0.051	2.967GlyPro: 2.967 ± 0.056	3.757GlyGln: 3.757 ± 0.058	4.66GlyArg: 4.66 ± 0.074	4.974GlySer: 4.974 ± 0.075	4.054GlyThr: 4.054 ± 0.06	6.43GlyVal: 6.43 ± 0.081	1.411GlyTrp: 1.411 ± 0.033	2.37GlyTyr: 2.37 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.46HisAla: 2.46 ± 0.051	0.287HisCys: 0.287 ± 0.017	1.365HisAsp: 1.365 ± 0.042	1.215HisGlu: 1.215 ± 0.036	0.88HisPhe: 0.88 ± 0.03	1.902HisGly: 1.902 ± 0.047	0.682HisHis: 0.682 ± 0.025	1.15HisIle: 1.15 ± 0.032	0.659HisLys: 0.659 ± 0.027	2.233HisLeu: 2.233 ± 0.052	0.518HisMet: 0.518 ± 0.021	0.634HisAsn: 0.634 ± 0.026	1.591HisPro: 1.591 ± 0.044	0.965HisGln: 0.965 ± 0.034	1.466HisArg: 1.466 ± 0.042	1.208HisSer: 1.208 ± 0.034	1.103HisThr: 1.103 ± 0.035	1.606HisVal: 1.606 ± 0.035	0.438HisTrp: 0.438 ± 0.019	0.649HisTyr: 0.649 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.151IleAla: 6.151 ± 0.088	0.611IleCys: 0.611 ± 0.024	3.516IleAsp: 3.516 ± 0.059	3.856IleGlu: 3.856 ± 0.066	1.559IlePhe: 1.559 ± 0.041	4.688IleGly: 4.688 ± 0.073	1.11IleHis: 1.11 ± 0.034	2.366IleIle: 2.366 ± 0.054	1.889IleLys: 1.889 ± 0.044	4.876IleLeu: 4.876 ± 0.076	1.19IleMet: 1.19 ± 0.031	1.827IleAsn: 1.827 ± 0.041	2.522IlePro: 2.522 ± 0.049	1.807IleGln: 1.807 ± 0.046	3.473IleArg: 3.473 ± 0.048	3.328IleSer: 3.328 ± 0.06	2.72IleThr: 2.72 ± 0.056	4.058IleVal: 4.058 ± 0.067	0.709IleTrp: 0.709 ± 0.024	1.206IleTyr: 1.206 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.815LysAla: 3.815 ± 0.068	0.199LysCys: 0.199 ± 0.013	1.789LysAsp: 1.789 ± 0.048	1.832LysGlu: 1.832 ± 0.049	0.974LysPhe: 0.974 ± 0.03	2.593LysGly: 2.593 ± 0.044	0.731LysHis: 0.731 ± 0.025	1.684LysIle: 1.684 ± 0.041	1.305LysLys: 1.305 ± 0.045	3.391LysLeu: 3.391 ± 0.064	0.85LysMet: 0.85 ± 0.026	0.97LysAsn: 0.97 ± 0.032	2.098LysPro: 2.098 ± 0.054	1.446LysGln: 1.446 ± 0.037	2.432LysArg: 2.432 ± 0.05	2.237LysSer: 2.237 ± 0.044	1.9LysThr: 1.9 ± 0.041	2.746LysVal: 2.746 ± 0.052	0.432LysTrp: 0.432 ± 0.021	0.733LysTyr: 0.733 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.33LeuAla: 12.33 ± 0.114	1.007LeuCys: 1.007 ± 0.029	5.897LeuAsp: 5.897 ± 0.087	5.757LeuGlu: 5.757 ± 0.089	3.738LeuPhe: 3.738 ± 0.068	8.126LeuGly: 8.126 ± 0.098	2.19LeuHis: 2.19 ± 0.054	5.631LeuIle: 5.631 ± 0.077	3.794LeuLys: 3.794 ± 0.063	10.357LeuLeu: 10.357 ± 0.137	2.733LeuMet: 2.733 ± 0.056	3.138LeuAsn: 3.138 ± 0.055	5.385LeuPro: 5.385 ± 0.072	3.836LeuGln: 3.836 ± 0.059	6.607LeuArg: 6.607 ± 0.093	7.061LeuSer: 7.061 ± 0.094	5.823LeuThr: 5.823 ± 0.08	7.672LeuVal: 7.672 ± 0.093	1.201LeuTrp: 1.201 ± 0.038	2.242LeuTyr: 2.242 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.023MetAla: 3.023 ± 0.056	0.189MetCys: 0.189 ± 0.014	1.277MetAsp: 1.277 ± 0.036	1.057MetGlu: 1.057 ± 0.029	0.877MetPhe: 0.877 ± 0.026	2.013MetGly: 2.013 ± 0.04	0.585MetHis: 0.585 ± 0.025	1.465MetIle: 1.465 ± 0.035	1.082MetLys: 1.082 ± 0.033	2.967MetLeu: 2.967 ± 0.059	0.771MetMet: 0.771 ± 0.027	0.891MetAsn: 0.891 ± 0.032	1.511MetPro: 1.511 ± 0.038	1.338MetGln: 1.338 ± 0.032	1.854MetArg: 1.854 ± 0.04	2.025MetSer: 2.025 ± 0.04	1.873MetThr: 1.873 ± 0.042	2.01MetVal: 2.01 ± 0.047	0.254MetTrp: 0.254 ± 0.016	0.438MetTyr: 0.438 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.011AsnAla: 3.011 ± 0.057	0.284AsnCys: 0.284 ± 0.017	1.408AsnAsp: 1.408 ± 0.034	1.52AsnGlu: 1.52 ± 0.038	0.973AsnPhe: 0.973 ± 0.03	2.117AsnGly: 2.117 ± 0.053	0.663AsnHis: 0.663 ± 0.027	1.453AsnIle: 1.453 ± 0.036	0.97AsnLys: 0.97 ± 0.034	3.04AsnLeu: 3.04 ± 0.051	0.781AsnMet: 0.781 ± 0.03	0.878AsnAsn: 0.878 ± 0.03	2.098AsnPro: 2.098 ± 0.044	1.236AsnGln: 1.236 ± 0.035	1.984AsnArg: 1.984 ± 0.044	1.521AsnSer: 1.521 ± 0.039	1.464AsnThr: 1.464 ± 0.037	2.115AsnVal: 2.115 ± 0.047	0.527AsnTrp: 0.527 ± 0.021	0.764AsnTyr: 0.764 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.082ProAla: 5.082 ± 0.067	0.413ProCys: 0.413 ± 0.02	3.694ProAsp: 3.694 ± 0.066	3.533ProGlu: 3.533 ± 0.077	1.819ProPhe: 1.819 ± 0.035	4.529ProGly: 4.529 ± 0.073	1.014ProHis: 1.014 ± 0.026	2.198ProIle: 2.198 ± 0.048	1.479ProLys: 1.479 ± 0.043	4.518ProLeu: 4.518 ± 0.063	1.293ProMet: 1.293 ± 0.028	1.319ProAsn: 1.319 ± 0.037	1.932ProPro: 1.932 ± 0.052	1.92ProGln: 1.92 ± 0.043	2.481ProArg: 2.481 ± 0.049	3.008ProSer: 3.008 ± 0.053	2.361ProThr: 2.361 ± 0.044	4.545ProVal: 4.545 ± 0.075	0.776ProTrp: 0.776 ± 0.03	1.288ProTyr: 1.288 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.829GlnAla: 5.829 ± 0.079	0.383GlnCys: 0.383 ± 0.019	2.107GlnAsp: 2.107 ± 0.042	2.244GlnGlu: 2.244 ± 0.052	1.487GlnPhe: 1.487 ± 0.034	3.189GlnGly: 3.189 ± 0.055	1.019GlnHis: 1.019 ± 0.033	2.536GlnIle: 2.536 ± 0.053	1.468GlnLys: 1.468 ± 0.037	3.629GlnLeu: 3.629 ± 0.064	1.185GlnMet: 1.185 ± 0.032	1.175GlnAsn: 1.175 ± 0.037	2.085GlnPro: 2.085 ± 0.046	2.109GlnGln: 2.109 ± 0.058	2.917GlnArg: 2.917 ± 0.057	3.084GlnSer: 3.084 ± 0.054	2.759GlnThr: 2.759 ± 0.062	3.115GlnVal: 3.115 ± 0.057	0.837GlnTrp: 0.837 ± 0.031	0.997GlnTyr: 0.997 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.128ArgAla: 6.128 ± 0.069	0.619ArgCys: 0.619 ± 0.027	3.501ArgAsp: 3.501 ± 0.056	3.949ArgGlu: 3.949 ± 0.063	2.592ArgPhe: 2.592 ± 0.049	3.89ArgGly: 3.89 ± 0.057	1.82ArgHis: 1.82 ± 0.045	3.821ArgIle: 3.821 ± 0.061	2.518ArgLys: 2.518 ± 0.046	7.347ArgLeu: 7.347 ± 0.102	1.914ArgMet: 1.914 ± 0.046	1.984ArgAsn: 1.984 ± 0.042	2.985ArgPro: 2.985 ± 0.051	3.38ArgGln: 3.38 ± 0.066	4.272ArgArg: 4.272 ± 0.072	4.038ArgSer: 4.038 ± 0.066	3.327ArgThr: 3.327 ± 0.058	4.687ArgVal: 4.687 ± 0.073	1.112ArgTrp: 1.112 ± 0.036	1.933ArgTyr: 1.933 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.239SerAla: 6.239 ± 0.083	0.632SerCys: 0.632 ± 0.023	3.5SerAsp: 3.5 ± 0.059	3.418SerGlu: 3.418 ± 0.058	2.33SerPhe: 2.33 ± 0.048	5.816SerGly: 5.816 ± 0.071	1.435SerHis: 1.435 ± 0.037	3.449SerIle: 3.449 ± 0.06	1.913SerLys: 1.913 ± 0.044	7.005SerLeu: 7.005 ± 0.082	1.802SerMet: 1.802 ± 0.039	1.766SerAsn: 1.766 ± 0.044	3.145SerPro: 3.145 ± 0.056	2.699SerGln: 2.699 ± 0.057	4.367SerArg: 4.367 ± 0.068	4.112SerSer: 4.112 ± 0.073	3.27SerThr: 3.27 ± 0.058	4.862SerVal: 4.862 ± 0.069	0.878SerTrp: 0.878 ± 0.027	1.405SerTyr: 1.405 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.006ThrAla: 5.006 ± 0.064	0.488ThrCys: 0.488 ± 0.022	2.866ThrAsp: 2.866 ± 0.051	2.619ThrGlu: 2.619 ± 0.048	1.881ThrPhe: 1.881 ± 0.04	4.842ThrGly: 4.842 ± 0.071	1.266ThrHis: 1.266 ± 0.031	2.845ThrIle: 2.845 ± 0.061	1.235ThrLys: 1.235 ± 0.031	6.068ThrLeu: 6.068 ± 0.08	1.25ThrMet: 1.25 ± 0.038	1.3ThrAsn: 1.3 ± 0.039	3.121ThrPro: 3.121 ± 0.053	2.196ThrGln: 2.196 ± 0.047	3.548ThrArg: 3.548 ± 0.062	3.218ThrSer: 3.218 ± 0.055	2.769ThrThr: 2.769 ± 0.048	4.122ThrVal: 4.122 ± 0.063	0.716ThrTrp: 0.716 ± 0.027	1.226ThrTyr: 1.226 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.865ValAla: 7.865 ± 0.101	0.871ValCys: 0.871 ± 0.028	4.214ValAsp: 4.214 ± 0.066	4.02ValGlu: 4.02 ± 0.065	2.951ValPhe: 2.951 ± 0.058	5.365ValGly: 5.365 ± 0.079	1.567ValHis: 1.567 ± 0.039	4.306ValIle: 4.306 ± 0.057	2.495ValLys: 2.495 ± 0.055	8.121ValLeu: 8.121 ± 0.094	2.2ValMet: 2.2 ± 0.044	2.425ValAsn: 2.425 ± 0.048	3.585ValPro: 3.585 ± 0.06	2.99ValGln: 2.99 ± 0.052	4.946ValArg: 4.946 ± 0.06	5.326ValSer: 5.326 ± 0.065	4.27ValThr: 4.27 ± 0.073	6.103ValVal: 6.103 ± 0.089	1.085ValTrp: 1.085 ± 0.033	1.74ValTyr: 1.74 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.179TrpAla: 1.179 ± 0.032	0.188TrpCys: 0.188 ± 0.014	0.599TrpAsp: 0.599 ± 0.022	0.639TrpGlu: 0.639 ± 0.024	0.678TrpPhe: 0.678 ± 0.024	0.896TrpGly: 0.896 ± 0.03	0.427TrpHis: 0.427 ± 0.02	0.879TrpIle: 0.879 ± 0.026	0.509TrpLys: 0.509 ± 0.022	2.104TrpLeu: 2.104 ± 0.053	0.473TrpMet: 0.473 ± 0.021	0.475TrpAsn: 0.475 ± 0.019	0.727TrpPro: 0.727 ± 0.03	0.798TrpGln: 0.798 ± 0.028	1.124TrpArg: 1.124 ± 0.033	0.885TrpSer: 0.885 ± 0.027	0.651TrpThr: 0.651 ± 0.022	1.188TrpVal: 1.188 ± 0.035	0.259TrpTrp: 0.259 ± 0.015	0.345TrpTyr: 0.345 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.046	0.324TyrCys: 0.324 ± 0.018	1.337TyrAsp: 1.337 ± 0.036	1.394TyrGlu: 1.394 ± 0.036	1.031TyrPhe: 1.031 ± 0.03	2.076TyrGly: 2.076 ± 0.051	0.46TyrHis: 0.46 ± 0.023	0.991TyrIle: 0.991 ± 0.028	0.753TyrLys: 0.753 ± 0.025	2.551TyrLeu: 2.551 ± 0.046	0.508TyrMet: 0.508 ± 0.019	0.639TyrAsn: 0.639 ± 0.025	1.269TyrPro: 1.269 ± 0.03	1.11TyrGln: 1.11 ± 0.036	1.761TyrArg: 1.761 ± 0.041	1.424TyrSer: 1.424 ± 0.036	1.177TyrThr: 1.177 ± 0.032	1.767TyrVal: 1.767 ± 0.039	0.437TyrTrp: 0.437 ± 0.022	0.595TyrTyr: 0.595 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3564 proteins (1146415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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