Amino acid dipepetide frequency for Noviherbaspirillum autotrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.863AlaAla: 15.863 ± 0.176	1.351AlaCys: 1.351 ± 0.036	6.042AlaAsp: 6.042 ± 0.066	6.229AlaGlu: 6.229 ± 0.078	4.129AlaPhe: 4.129 ± 0.063	9.364AlaGly: 9.364 ± 0.096	2.685AlaHis: 2.685 ± 0.044	6.089AlaIle: 6.089 ± 0.077	4.685AlaLys: 4.685 ± 0.073	13.35AlaLeu: 13.35 ± 0.121	3.421AlaMet: 3.421 ± 0.06	3.196AlaAsn: 3.196 ± 0.058	5.261AlaPro: 5.261 ± 0.076	5.513AlaGln: 5.513 ± 0.07	7.601AlaArg: 7.601 ± 0.102	6.651AlaSer: 6.651 ± 0.081	5.48AlaThr: 5.48 ± 0.074	8.002AlaVal: 8.002 ± 0.083	1.526AlaTrp: 1.526 ± 0.046	2.745AlaTyr: 2.745 ± 0.046	0.002AlaXaa: 0.002 ± 0.001
Cys	1.218CysAla: 1.218 ± 0.031	0.151CysCys: 0.151 ± 0.013	0.631CysAsp: 0.631 ± 0.024	0.57CysGlu: 0.57 ± 0.022	0.354CysPhe: 0.354 ± 0.018	1.069CysGly: 1.069 ± 0.035	0.324CysHis: 0.324 ± 0.017	0.523CysIle: 0.523 ± 0.023	0.294CysLys: 0.294 ± 0.015	0.86CysLeu: 0.86 ± 0.025	0.218CysMet: 0.218 ± 0.013	0.312CysAsn: 0.312 ± 0.018	0.554CysPro: 0.554 ± 0.021	0.257CysGln: 0.257 ± 0.015	0.645CysArg: 0.645 ± 0.021	0.544CysSer: 0.544 ± 0.022	0.493CysThr: 0.493 ± 0.02	0.691CysVal: 0.691 ± 0.026	0.134CysTrp: 0.134 ± 0.009	0.252CysTyr: 0.252 ± 0.016	0.001CysXaa: 0.001 ± 0.001
Asp	6.833AspAla: 6.833 ± 0.081	0.542AspCys: 0.542 ± 0.021	2.875AspAsp: 2.875 ± 0.059	3.337AspGlu: 3.337 ± 0.065	2.151AspPhe: 2.151 ± 0.043	4.304AspGly: 4.304 ± 0.068	1.085AspHis: 1.085 ± 0.03	2.999AspIle: 2.999 ± 0.049	2.22AspLys: 2.22 ± 0.045	5.139AspLeu: 5.139 ± 0.062	1.458AspMet: 1.458 ± 0.038	1.465AspAsn: 1.465 ± 0.037	2.645AspPro: 2.645 ± 0.048	1.604AspGln: 1.604 ± 0.036	3.045AspArg: 3.045 ± 0.047	2.425AspSer: 2.425 ± 0.047	2.575AspThr: 2.575 ± 0.045	4.018AspVal: 4.018 ± 0.06	0.862AspTrp: 0.862 ± 0.029	1.486AspTyr: 1.486 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.316GluAla: 6.316 ± 0.076	0.472GluCys: 0.472 ± 0.02	2.273GluAsp: 2.273 ± 0.044	3.248GluGlu: 3.248 ± 0.069	2.041GluPhe: 2.041 ± 0.04	3.432GluGly: 3.432 ± 0.055	1.414GluHis: 1.414 ± 0.037	3.213GluIle: 3.213 ± 0.062	2.736GluLys: 2.736 ± 0.049	5.99GluLeu: 5.99 ± 0.076	1.51GluMet: 1.51 ± 0.034	1.706GluAsn: 1.706 ± 0.039	2.231GluPro: 2.231 ± 0.049	2.969GluGln: 2.969 ± 0.055	4.494GluArg: 4.494 ± 0.076	2.778GluSer: 2.778 ± 0.041	2.563GluThr: 2.563 ± 0.043	3.968GluVal: 3.968 ± 0.069	0.776GluTrp: 0.776 ± 0.028	1.294GluTyr: 1.294 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.257PheAla: 4.257 ± 0.063	0.481PheCys: 0.481 ± 0.021	2.488PheAsp: 2.488 ± 0.047	1.982PheGlu: 1.982 ± 0.036	1.6PhePhe: 1.6 ± 0.039	3.513PheGly: 3.513 ± 0.066	0.814PheHis: 0.814 ± 0.026	1.895PheIle: 1.895 ± 0.042	1.384PheLys: 1.384 ± 0.034	3.294PheLeu: 3.294 ± 0.053	0.906PheMet: 0.906 ± 0.03	1.311PheAsn: 1.311 ± 0.038	1.62PhePro: 1.62 ± 0.035	1.042PheGln: 1.042 ± 0.028	2.093PheArg: 2.093 ± 0.043	2.556PheSer: 2.556 ± 0.041	1.89PheThr: 1.89 ± 0.043	2.815PheVal: 2.815 ± 0.056	0.502PheTrp: 0.502 ± 0.022	1.036PheTyr: 1.036 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.184GlyAla: 8.184 ± 0.088	0.868GlyCys: 0.868 ± 0.03	3.762GlyAsp: 3.762 ± 0.062	4.119GlyGlu: 4.119 ± 0.059	3.307GlyPhe: 3.307 ± 0.053	6.077GlyGly: 6.077 ± 0.086	1.779GlyHis: 1.779 ± 0.039	4.495GlyIle: 4.495 ± 0.068	4.162GlyLys: 4.162 ± 0.061	7.647GlyLeu: 7.647 ± 0.077	2.535GlyMet: 2.535 ± 0.046	2.492GlyAsn: 2.492 ± 0.055	2.415GlyPro: 2.415 ± 0.05	2.817GlyGln: 2.817 ± 0.048	4.727GlyArg: 4.727 ± 0.068	4.3GlySer: 4.3 ± 0.069	4.162GlyThr: 4.162 ± 0.068	5.921GlyVal: 5.921 ± 0.077	1.166GlyTrp: 1.166 ± 0.038	2.383GlyTyr: 2.383 ± 0.044	0.001GlyXaa: 0.001 ± 0.001
His	2.961HisAla: 2.961 ± 0.061	0.309HisCys: 0.309 ± 0.015	1.3HisAsp: 1.3 ± 0.033	1.263HisGlu: 1.263 ± 0.031	1.001HisPhe: 1.001 ± 0.032	2.04HisGly: 2.04 ± 0.048	0.693HisHis: 0.693 ± 0.024	1.18HisIle: 1.18 ± 0.03	0.704HisLys: 0.704 ± 0.025	2.26HisLeu: 2.26 ± 0.038	0.597HisMet: 0.597 ± 0.021	0.631HisAsn: 0.631 ± 0.023	1.49HisPro: 1.49 ± 0.032	0.785HisGln: 0.785 ± 0.028	1.402HisArg: 1.402 ± 0.029	1.116HisSer: 1.116 ± 0.029	1.053HisThr: 1.053 ± 0.031	1.672HisVal: 1.672 ± 0.038	0.342HisTrp: 0.342 ± 0.018	0.704HisTyr: 0.704 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.979IleAla: 6.979 ± 0.079	0.479IleCys: 0.479 ± 0.018	3.522IleAsp: 3.522 ± 0.054	3.543IleGlu: 3.543 ± 0.059	1.628IlePhe: 1.628 ± 0.035	4.731IleGly: 4.731 ± 0.063	1.056IleHis: 1.056 ± 0.028	2.145IleIle: 2.145 ± 0.043	2.021IleLys: 2.021 ± 0.045	4.25IleLeu: 4.25 ± 0.06	1.098IleMet: 1.098 ± 0.03	1.77IleAsn: 1.77 ± 0.039	2.49IlePro: 2.49 ± 0.048	1.454IleGln: 1.454 ± 0.032	3.227IleArg: 3.227 ± 0.053	2.994IleSer: 2.994 ± 0.051	2.721IleThr: 2.721 ± 0.048	3.981IleVal: 3.981 ± 0.058	0.533IleTrp: 0.533 ± 0.021	1.192IleTyr: 1.192 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.472LysAla: 4.472 ± 0.075	0.24LysCys: 0.24 ± 0.014	1.955LysAsp: 1.955 ± 0.046	2.287LysGlu: 2.287 ± 0.045	1.253LysPhe: 1.253 ± 0.035	2.694LysGly: 2.694 ± 0.045	0.891LysHis: 0.891 ± 0.025	2.268LysIle: 2.268 ± 0.053	2.175LysLys: 2.175 ± 0.059	4.338LysLeu: 4.338 ± 0.064	1.26LysMet: 1.26 ± 0.035	1.441LysAsn: 1.441 ± 0.036	2.344LysPro: 2.344 ± 0.045	1.687LysGln: 1.687 ± 0.039	2.666LysArg: 2.666 ± 0.047	2.325LysSer: 2.325 ± 0.045	2.373LysThr: 2.373 ± 0.046	2.962LysVal: 2.962 ± 0.049	0.465LysTrp: 0.465 ± 0.02	0.956LysTyr: 0.956 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.256LeuAla: 13.256 ± 0.117	1.048LeuCys: 1.048 ± 0.029	5.662LeuAsp: 5.662 ± 0.071	5.345LeuGlu: 5.345 ± 0.075	3.842LeuPhe: 3.842 ± 0.062	7.663LeuGly: 7.663 ± 0.086	2.519LeuHis: 2.519 ± 0.047	4.832LeuIle: 4.832 ± 0.061	4.257LeuLys: 4.257 ± 0.066	10.901LeuLeu: 10.901 ± 0.12	2.506LeuMet: 2.506 ± 0.043	3.127LeuAsn: 3.127 ± 0.04	5.692LeuPro: 5.692 ± 0.064	4.065LeuGln: 4.065 ± 0.057	6.951LeuArg: 6.951 ± 0.092	6.356LeuSer: 6.356 ± 0.078	5.241LeuThr: 5.241 ± 0.07	7.061LeuVal: 7.061 ± 0.087	1.171LeuTrp: 1.171 ± 0.032	2.297LeuTyr: 2.297 ± 0.048	0.002LeuXaa: 0.002 ± 0.002
Met	2.958MetAla: 2.958 ± 0.052	0.208MetCys: 0.208 ± 0.014	1.21MetAsp: 1.21 ± 0.036	1.342MetGlu: 1.342 ± 0.033	0.823MetPhe: 0.823 ± 0.028	1.73MetGly: 1.73 ± 0.042	0.645MetHis: 0.645 ± 0.023	1.263MetIle: 1.263 ± 0.03	1.381MetLys: 1.381 ± 0.034	2.921MetLeu: 2.921 ± 0.047	0.744MetMet: 0.744 ± 0.028	0.965MetAsn: 0.965 ± 0.027	1.606MetPro: 1.606 ± 0.037	1.341MetGln: 1.341 ± 0.034	1.9MetArg: 1.9 ± 0.037	1.614MetSer: 1.614 ± 0.036	1.678MetThr: 1.678 ± 0.035	1.784MetVal: 1.784 ± 0.042	0.244MetTrp: 0.244 ± 0.015	0.484MetTyr: 0.484 ± 0.02	0.001MetXaa: 0.001 ± 0.001
Asn	3.74AsnAla: 3.74 ± 0.058	0.354AsnCys: 0.354 ± 0.019	1.529AsnAsp: 1.529 ± 0.033	1.526AsnGlu: 1.526 ± 0.034	1.096AsnPhe: 1.096 ± 0.035	2.634AsnGly: 2.634 ± 0.049	0.612AsnHis: 0.612 ± 0.022	1.624AsnIle: 1.624 ± 0.047	1.173AsnLys: 1.173 ± 0.033	2.957AsnLeu: 2.957 ± 0.054	0.763AsnMet: 0.763 ± 0.025	1.024AsnAsn: 1.024 ± 0.034	1.985AsnPro: 1.985 ± 0.044	1.097AsnGln: 1.097 ± 0.034	1.919AsnArg: 1.919 ± 0.042	1.494AsnSer: 1.494 ± 0.034	1.55AsnThr: 1.55 ± 0.036	2.276AsnVal: 2.276 ± 0.051	0.468AsnTrp: 0.468 ± 0.021	0.842AsnTyr: 0.842 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.835ProAla: 5.835 ± 0.086	0.378ProCys: 0.378 ± 0.019	3.193ProAsp: 3.193 ± 0.06	3.12ProGlu: 3.12 ± 0.051	1.794ProPhe: 1.794 ± 0.044	3.807ProGly: 3.807 ± 0.056	1.236ProHis: 1.236 ± 0.041	2.145ProIle: 2.145 ± 0.05	1.767ProLys: 1.767 ± 0.034	4.875ProLeu: 4.875 ± 0.051	1.152ProMet: 1.152 ± 0.032	1.475ProAsn: 1.475 ± 0.036	2.224ProPro: 2.224 ± 0.059	2.197ProGln: 2.197 ± 0.041	2.482ProArg: 2.482 ± 0.049	2.568ProSer: 2.568 ± 0.039	2.177ProThr: 2.177 ± 0.039	3.97ProVal: 3.97 ± 0.061	0.613ProTrp: 0.613 ± 0.02	1.225ProTyr: 1.225 ± 0.032	0.001ProXaa: 0.001 ± 0.001
Gln	5.086GlnAla: 5.086 ± 0.071	0.333GlnCys: 0.333 ± 0.015	1.689GlnAsp: 1.689 ± 0.037	2.183GlnGlu: 2.183 ± 0.049	1.385GlnPhe: 1.385 ± 0.034	2.64GlnGly: 2.64 ± 0.054	1.02GlnHis: 1.02 ± 0.027	2.114GlnIle: 2.114 ± 0.043	1.462GlnLys: 1.462 ± 0.035	4.188GlnLeu: 4.188 ± 0.066	1.088GlnMet: 1.088 ± 0.029	1.079GlnAsn: 1.079 ± 0.03	2.021GlnPro: 2.021 ± 0.041	2.103GlnGln: 2.103 ± 0.049	3.008GlnArg: 3.008 ± 0.051	2.135GlnSer: 2.135 ± 0.044	1.848GlnThr: 1.848 ± 0.043	2.937GlnVal: 2.937 ± 0.055	0.571GlnTrp: 0.571 ± 0.02	0.972GlnTyr: 0.972 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.769ArgAla: 6.769 ± 0.081	0.595ArgCys: 0.595 ± 0.021	3.565ArgAsp: 3.565 ± 0.06	4.006ArgGlu: 4.006 ± 0.062	2.694ArgPhe: 2.694 ± 0.043	3.996ArgGly: 3.996 ± 0.051	1.806ArgHis: 1.806 ± 0.044	3.795ArgIle: 3.795 ± 0.051	2.62ArgLys: 2.62 ± 0.044	7.158ArgLeu: 7.158 ± 0.093	1.936ArgMet: 1.936 ± 0.04	2.163ArgAsn: 2.163 ± 0.038	2.699ArgPro: 2.699 ± 0.049	2.9ArgGln: 2.9 ± 0.048	4.573ArgArg: 4.573 ± 0.071	3.213ArgSer: 3.213 ± 0.05	2.982ArgThr: 2.982 ± 0.047	4.388ArgVal: 4.388 ± 0.062	0.903ArgTrp: 0.903 ± 0.028	1.989ArgTyr: 1.989 ± 0.046	0.002ArgXaa: 0.002 ± 0.001
Ser	6.357SerAla: 6.357 ± 0.081	0.569SerCys: 0.569 ± 0.023	2.947SerAsp: 2.947 ± 0.053	2.874SerGlu: 2.874 ± 0.056	2.182SerPhe: 2.182 ± 0.045	5.277SerGly: 5.277 ± 0.067	1.275SerHis: 1.275 ± 0.032	2.809SerIle: 2.809 ± 0.051	2.051SerLys: 2.051 ± 0.045	5.717SerLeu: 5.717 ± 0.079	1.498SerMet: 1.498 ± 0.039	1.648SerAsn: 1.648 ± 0.041	2.574SerPro: 2.574 ± 0.041	1.94SerGln: 1.94 ± 0.042	3.332SerArg: 3.332 ± 0.052	3.26SerSer: 3.26 ± 0.049	2.836SerThr: 2.836 ± 0.059	3.947SerVal: 3.947 ± 0.064	0.712SerTrp: 0.712 ± 0.023	1.46SerTyr: 1.46 ± 0.035	0.002SerXaa: 0.002 ± 0.001
Thr	5.52ThrAla: 5.52 ± 0.08	0.472ThrCys: 0.472 ± 0.02	2.564ThrAsp: 2.564 ± 0.047	2.451ThrGlu: 2.451 ± 0.046	1.775ThrPhe: 1.775 ± 0.042	4.289ThrGly: 4.289 ± 0.061	1.187ThrHis: 1.187 ± 0.03	2.727ThrIle: 2.727 ± 0.054	1.62ThrLys: 1.62 ± 0.039	5.848ThrLeu: 5.848 ± 0.078	1.21ThrMet: 1.21 ± 0.037	1.419ThrAsn: 1.419 ± 0.036	2.954ThrPro: 2.954 ± 0.051	1.817ThrGln: 1.817 ± 0.035	3.012ThrArg: 3.012 ± 0.053	2.678ThrSer: 2.678 ± 0.052	2.701ThrThr: 2.701 ± 0.05	4.139ThrVal: 4.139 ± 0.063	0.544ThrTrp: 0.544 ± 0.022	1.28ThrTyr: 1.28 ± 0.029	0.001ThrXaa: 0.001 ± 0.001
Val	8.71ValAla: 8.71 ± 0.099	0.77ValCys: 0.77 ± 0.025	3.938ValAsp: 3.938 ± 0.06	4.114ValGlu: 4.114 ± 0.067	2.738ValPhe: 2.738 ± 0.054	5.098ValGly: 5.098 ± 0.076	1.53ValHis: 1.53 ± 0.038	3.899ValIle: 3.899 ± 0.068	2.949ValLys: 2.949 ± 0.053	7.592ValLeu: 7.592 ± 0.088	1.983ValMet: 1.983 ± 0.042	2.256ValAsn: 2.256 ± 0.048	3.593ValPro: 3.593 ± 0.052	2.549ValGln: 2.549 ± 0.051	4.71ValArg: 4.71 ± 0.062	4.16ValSer: 4.16 ± 0.052	4.071ValThr: 4.071 ± 0.059	5.922ValVal: 5.922 ± 0.082	0.845ValTrp: 0.845 ± 0.027	1.654ValTyr: 1.654 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	1.069TrpAla: 1.069 ± 0.035	0.168TrpCys: 0.168 ± 0.013	0.582TrpAsp: 0.582 ± 0.022	0.596TrpGlu: 0.596 ± 0.023	0.548TrpPhe: 0.548 ± 0.021	0.814TrpGly: 0.814 ± 0.027	0.371TrpHis: 0.371 ± 0.016	0.726TrpIle: 0.726 ± 0.026	0.51TrpLys: 0.51 ± 0.022	1.787TrpLeu: 1.787 ± 0.045	0.412TrpMet: 0.412 ± 0.02	0.459TrpAsn: 0.459 ± 0.018	0.567TrpPro: 0.567 ± 0.021	0.697TrpGln: 0.697 ± 0.025	1.024TrpArg: 1.024 ± 0.032	0.713TrpSer: 0.713 ± 0.023	0.601TrpThr: 0.601 ± 0.023	0.832TrpVal: 0.832 ± 0.029	0.204TrpTrp: 0.204 ± 0.014	0.306TrpTyr: 0.306 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.803TyrAla: 2.803 ± 0.046	0.309TyrCys: 0.309 ± 0.018	1.338TyrAsp: 1.338 ± 0.037	1.291TyrGlu: 1.291 ± 0.03	1.141TyrPhe: 1.141 ± 0.028	2.145TyrGly: 2.145 ± 0.047	0.562TyrHis: 0.562 ± 0.022	1.069TyrIle: 1.069 ± 0.031	0.882TyrLys: 0.882 ± 0.029	2.719TyrLeu: 2.719 ± 0.05	0.544TyrMet: 0.544 ± 0.022	0.722TyrAsn: 0.722 ± 0.026	1.265TyrPro: 1.265 ± 0.031	1.026TyrGln: 1.026 ± 0.031	1.94TyrArg: 1.94 ± 0.041	1.389TyrSer: 1.389 ± 0.033	1.211TyrThr: 1.211 ± 0.035	1.794TyrVal: 1.794 ± 0.038	0.407TyrTrp: 0.407 ± 0.021	0.744TyrTyr: 0.744 ± 0.028	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.044XaaXaa: 0.044 ± 0.015

Statistics based on 4102 proteins (1246646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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