Amino acid dipepetide frequency for Pyrobaculum filamentous virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.08AlaAla: 3.08 ± 0.749
1.087AlaCys: 1.087 ± 0.436
2.718AlaAsp: 2.718 ± 0.828
3.805AlaGlu: 3.805 ± 1.024
3.261AlaPhe: 3.261 ± 0.887
3.261AlaGly: 3.261 ± 0.927
1.087AlaHis: 1.087 ± 0.413
2.718AlaIle: 2.718 ± 0.565
3.624AlaLys: 3.624 ± 0.669
6.342AlaLeu: 6.342 ± 1.193
3.08AlaMet: 3.08 ± 0.664
1.45AlaAsn: 1.45 ± 0.459
2.174AlaPro: 2.174 ± 0.743
1.45AlaGln: 1.45 ± 0.487
3.08AlaArg: 3.08 ± 0.909
4.53AlaSer: 4.53 ± 1.012
3.624AlaThr: 3.624 ± 0.883
9.966AlaVal: 9.966 ± 1.582
1.268AlaTrp: 1.268 ± 0.457
3.08AlaTyr: 3.08 ± 0.695
0.0AlaXaa: 0.0 ± 0.0
Cys
0.725CysAla: 0.725 ± 0.394
0.544CysCys: 0.544 ± 0.303
1.268CysAsp: 1.268 ± 0.537
2.174CysGlu: 2.174 ± 0.78
0.544CysPhe: 0.544 ± 0.3
1.631CysGly: 1.631 ± 0.606
0.362CysHis: 0.362 ± 0.228
1.268CysIle: 1.268 ± 0.381
0.362CysLys: 0.362 ± 0.349
0.906CysLeu: 0.906 ± 0.527
0.906CysMet: 0.906 ± 0.462
0.906CysAsn: 0.906 ± 0.36
0.362CysPro: 0.362 ± 0.22
0.0CysGln: 0.0 ± 0.0
2.355CysArg: 2.355 ± 0.673
1.087CysSer: 1.087 ± 0.551
0.906CysThr: 0.906 ± 0.349
2.355CysVal: 2.355 ± 0.488
0.362CysTrp: 0.362 ± 0.268
0.362CysTyr: 0.362 ± 0.31
0.0CysXaa: 0.0 ± 0.0
Asp
4.167AspAla: 4.167 ± 1.087
0.906AspCys: 0.906 ± 0.351
3.08AspAsp: 3.08 ± 0.712
3.986AspGlu: 3.986 ± 0.972
2.174AspPhe: 2.174 ± 0.702
4.892AspGly: 4.892 ± 0.996
0.362AspHis: 0.362 ± 0.258
4.711AspIle: 4.711 ± 1.085
3.805AspLys: 3.805 ± 0.792
2.899AspLeu: 2.899 ± 0.762
2.174AspMet: 2.174 ± 0.535
1.631AspAsn: 1.631 ± 0.559
2.355AspPro: 2.355 ± 0.645
0.362AspGln: 0.362 ± 0.238
4.892AspArg: 4.892 ± 1.099
3.624AspSer: 3.624 ± 0.602
1.812AspThr: 1.812 ± 0.592
7.429AspVal: 7.429 ± 1.223
2.174AspTrp: 2.174 ± 0.589
2.174AspTyr: 2.174 ± 0.601
0.0AspXaa: 0.0 ± 0.0
Glu
4.711GluAla: 4.711 ± 1.074
2.174GluCys: 2.174 ± 0.772
4.167GluAsp: 4.167 ± 1.303
4.892GluGlu: 4.892 ± 1.036
3.08GluPhe: 3.08 ± 0.612
3.443GluGly: 3.443 ± 0.67
0.544GluHis: 0.544 ± 0.311
4.167GluIle: 4.167 ± 1.223
5.798GluLys: 5.798 ± 1.288
5.073GluLeu: 5.073 ± 0.924
1.631GluMet: 1.631 ± 0.635
1.993GluAsn: 1.993 ± 0.544
2.174GluPro: 2.174 ± 0.679
1.087GluGln: 1.087 ± 0.401
2.174GluArg: 2.174 ± 0.512
1.812GluSer: 1.812 ± 0.48
2.174GluThr: 2.174 ± 0.444
6.161GluVal: 6.161 ± 1.255
1.087GluTrp: 1.087 ± 0.399
3.261GluTyr: 3.261 ± 0.775
0.0GluXaa: 0.0 ± 0.0
Phe
3.986PheAla: 3.986 ± 0.796
0.725PheCys: 0.725 ± 0.293
3.443PheAsp: 3.443 ± 0.85
1.631PheGlu: 1.631 ± 0.556
1.631PhePhe: 1.631 ± 0.541
3.443PheGly: 3.443 ± 0.738
0.544PheHis: 0.544 ± 0.321
2.899PheIle: 2.899 ± 0.7
1.45PheLys: 1.45 ± 0.551
3.986PheLeu: 3.986 ± 1.021
0.362PheMet: 0.362 ± 0.247
1.268PheAsn: 1.268 ± 0.457
0.906PhePro: 0.906 ± 0.39
0.362PheGln: 0.362 ± 0.241
3.261PheArg: 3.261 ± 0.611
3.624PheSer: 3.624 ± 0.707
2.537PheThr: 2.537 ± 0.832
5.436PheVal: 5.436 ± 0.894
1.268PheTrp: 1.268 ± 0.349
1.45PheTyr: 1.45 ± 0.377
0.0PheXaa: 0.0 ± 0.0
Gly
4.53GlyAla: 4.53 ± 0.899
1.812GlyCys: 1.812 ± 0.684
3.986GlyAsp: 3.986 ± 0.966
5.073GlyGlu: 5.073 ± 1.055
4.167GlyPhe: 4.167 ± 0.957
9.241GlyGly: 9.241 ± 2.823
1.268GlyHis: 1.268 ± 0.55
5.798GlyIle: 5.798 ± 1.105
2.355GlyLys: 2.355 ± 0.703
5.073GlyLeu: 5.073 ± 0.766
2.355GlyMet: 2.355 ± 0.59
2.899GlyAsn: 2.899 ± 0.805
1.45GlyPro: 1.45 ± 0.672
1.812GlyGln: 1.812 ± 0.509
4.167GlyArg: 4.167 ± 1.028
2.899GlySer: 2.899 ± 0.748
3.443GlyThr: 3.443 ± 1.197
6.704GlyVal: 6.704 ± 1.205
1.45GlyTrp: 1.45 ± 0.624
5.436GlyTyr: 5.436 ± 0.947
0.0GlyXaa: 0.0 ± 0.0
His
0.544HisAla: 0.544 ± 0.288
0.362HisCys: 0.362 ± 0.256
0.725HisAsp: 0.725 ± 0.44
0.906HisGlu: 0.906 ± 0.518
0.544HisPhe: 0.544 ± 0.367
0.725HisGly: 0.725 ± 0.364
0.181HisHis: 0.181 ± 0.15
0.725HisIle: 0.725 ± 0.287
1.087HisLys: 1.087 ± 0.378
0.544HisLeu: 0.544 ± 0.285
0.0HisMet: 0.0 ± 0.0
0.906HisAsn: 0.906 ± 0.366
0.906HisPro: 0.906 ± 0.38
0.0HisGln: 0.0 ± 0.0
1.45HisArg: 1.45 ± 0.492
0.725HisSer: 0.725 ± 0.319
0.362HisThr: 0.362 ± 0.262
1.993HisVal: 1.993 ± 0.698
0.181HisTrp: 0.181 ± 0.164
0.725HisTyr: 0.725 ± 0.292
0.0HisXaa: 0.0 ± 0.0
Ile
5.255IleAla: 5.255 ± 0.972
0.544IleCys: 0.544 ± 0.304
4.892IleAsp: 4.892 ± 0.896
6.523IleGlu: 6.523 ± 0.959
3.08IlePhe: 3.08 ± 0.77
3.805IleGly: 3.805 ± 0.734
0.544IleHis: 0.544 ± 0.308
4.711IleIle: 4.711 ± 1.077
2.355IleLys: 2.355 ± 0.626
4.349IleLeu: 4.349 ± 0.812
1.993IleMet: 1.993 ± 0.528
2.718IleAsn: 2.718 ± 0.713
2.355IlePro: 2.355 ± 0.694
0.544IleGln: 0.544 ± 0.23
3.624IleArg: 3.624 ± 0.739
4.53IleSer: 4.53 ± 0.943
3.986IleThr: 3.986 ± 0.973
6.704IleVal: 6.704 ± 1.171
0.544IleTrp: 0.544 ± 0.333
3.624IleTyr: 3.624 ± 0.721
0.0IleXaa: 0.0 ± 0.0
Lys
3.443LysAla: 3.443 ± 0.699
0.362LysCys: 0.362 ± 0.258
2.537LysAsp: 2.537 ± 0.579
2.899LysGlu: 2.899 ± 0.923
2.174LysPhe: 2.174 ± 0.657
2.899LysGly: 2.899 ± 0.804
0.544LysHis: 0.544 ± 0.305
4.167LysIle: 4.167 ± 0.91
1.812LysLys: 1.812 ± 0.564
5.073LysLeu: 5.073 ± 0.959
2.355LysMet: 2.355 ± 0.587
1.268LysAsn: 1.268 ± 0.481
2.718LysPro: 2.718 ± 0.664
0.906LysGln: 0.906 ± 0.432
3.08LysArg: 3.08 ± 0.774
1.45LysSer: 1.45 ± 0.509
3.261LysThr: 3.261 ± 0.726
6.161LysVal: 6.161 ± 1.27
1.45LysTrp: 1.45 ± 0.741
4.349LysTyr: 4.349 ± 0.931
0.0LysXaa: 0.0 ± 0.0
Leu
4.53LeuAla: 4.53 ± 0.784
1.812LeuCys: 1.812 ± 0.625
4.167LeuAsp: 4.167 ± 0.759
3.624LeuGlu: 3.624 ± 0.917
3.08LeuPhe: 3.08 ± 0.649
6.342LeuGly: 6.342 ± 1.102
0.906LeuHis: 0.906 ± 0.479
6.161LeuIle: 6.161 ± 1.339
3.261LeuLys: 3.261 ± 0.68
5.798LeuLeu: 5.798 ± 1.194
2.355LeuMet: 2.355 ± 0.736
2.174LeuAsn: 2.174 ± 0.639
2.537LeuPro: 2.537 ± 0.701
0.906LeuGln: 0.906 ± 0.458
5.073LeuArg: 5.073 ± 1.005
4.892LeuSer: 4.892 ± 1.164
2.174LeuThr: 2.174 ± 0.604
6.161LeuVal: 6.161 ± 1.054
1.45LeuTrp: 1.45 ± 0.477
3.986LeuTyr: 3.986 ± 0.778
0.0LeuXaa: 0.0 ± 0.0
Met
2.718MetAla: 2.718 ± 0.748
1.268MetCys: 1.268 ± 0.447
1.268MetAsp: 1.268 ± 0.498
2.174MetGlu: 2.174 ± 0.827
0.906MetPhe: 0.906 ± 0.416
1.087MetGly: 1.087 ± 0.447
0.725MetHis: 0.725 ± 0.311
1.993MetIle: 1.993 ± 0.62
2.174MetLys: 2.174 ± 0.649
1.45MetLeu: 1.45 ± 0.485
1.268MetMet: 1.268 ± 0.394
0.544MetAsn: 0.544 ± 0.295
1.812MetPro: 1.812 ± 0.617
0.544MetGln: 0.544 ± 0.309
2.355MetArg: 2.355 ± 0.597
2.537MetSer: 2.537 ± 0.585
1.268MetThr: 1.268 ± 0.461
1.993MetVal: 1.993 ± 0.51
1.087MetTrp: 1.087 ± 0.445
2.355MetTyr: 2.355 ± 0.708
0.0MetXaa: 0.0 ± 0.0
Asn
1.268AsnAla: 1.268 ± 0.429
0.181AsnCys: 0.181 ± 0.179
1.812AsnAsp: 1.812 ± 0.485
1.631AsnGlu: 1.631 ± 0.484
1.45AsnPhe: 1.45 ± 0.507
3.624AsnGly: 3.624 ± 0.799
0.544AsnHis: 0.544 ± 0.305
1.631AsnIle: 1.631 ± 0.43
2.718AsnLys: 2.718 ± 0.658
2.355AsnLeu: 2.355 ± 0.879
0.906AsnMet: 0.906 ± 0.388
0.906AsnAsn: 0.906 ± 0.35
1.993AsnPro: 1.993 ± 0.628
0.544AsnGln: 0.544 ± 0.269
1.631AsnArg: 1.631 ± 0.517
1.631AsnSer: 1.631 ± 0.55
2.718AsnThr: 2.718 ± 0.59
5.255AsnVal: 5.255 ± 0.934
0.544AsnTrp: 0.544 ± 0.273
1.812AsnTyr: 1.812 ± 0.73
0.0AsnXaa: 0.0 ± 0.0
Pro
2.355ProAla: 2.355 ± 0.748
0.906ProCys: 0.906 ± 0.302
1.45ProAsp: 1.45 ± 0.552
1.993ProGlu: 1.993 ± 0.577
1.087ProPhe: 1.087 ± 0.436
2.537ProGly: 2.537 ± 0.636
0.362ProHis: 0.362 ± 0.231
2.355ProIle: 2.355 ± 0.588
1.993ProLys: 1.993 ± 0.569
2.174ProLeu: 2.174 ± 0.728
1.087ProMet: 1.087 ± 0.382
1.087ProAsn: 1.087 ± 0.377
1.45ProPro: 1.45 ± 0.693
0.362ProGln: 0.362 ± 0.236
1.268ProArg: 1.268 ± 0.551
1.087ProSer: 1.087 ± 0.469
3.986ProThr: 3.986 ± 2.058
3.443ProVal: 3.443 ± 0.756
0.362ProTrp: 0.362 ± 0.269
2.174ProTyr: 2.174 ± 0.665
0.0ProXaa: 0.0 ± 0.0
Gln
0.544GlnAla: 0.544 ± 0.316
0.544GlnCys: 0.544 ± 0.284
0.362GlnAsp: 0.362 ± 0.221
1.268GlnGlu: 1.268 ± 0.489
1.268GlnPhe: 1.268 ± 0.465
0.362GlnGly: 0.362 ± 0.268
0.362GlnHis: 0.362 ± 0.238
1.268GlnIle: 1.268 ± 0.591
1.087GlnLys: 1.087 ± 0.43
1.268GlnLeu: 1.268 ± 0.518
0.544GlnMet: 0.544 ± 0.277
0.362GlnAsn: 0.362 ± 0.219
0.181GlnPro: 0.181 ± 0.202
0.181GlnGln: 0.181 ± 0.202
0.362GlnArg: 0.362 ± 0.278
1.087GlnSer: 1.087 ± 0.433
1.812GlnThr: 1.812 ± 0.711
1.268GlnVal: 1.268 ± 0.469
0.181GlnTrp: 0.181 ± 0.207
0.906GlnTyr: 0.906 ± 0.356
0.0GlnXaa: 0.0 ± 0.0
Arg
3.805ArgAla: 3.805 ± 1.005
2.174ArgCys: 2.174 ± 0.51
2.718ArgAsp: 2.718 ± 0.657
5.073ArgGlu: 5.073 ± 1.079
2.355ArgPhe: 2.355 ± 0.564
5.073ArgGly: 5.073 ± 1.117
0.362ArgHis: 0.362 ± 0.2
3.805ArgIle: 3.805 ± 0.922
3.624ArgLys: 3.624 ± 0.701
4.167ArgLeu: 4.167 ± 0.865
1.993ArgMet: 1.993 ± 0.622
1.631ArgAsn: 1.631 ± 0.526
1.812ArgPro: 1.812 ± 0.568
0.725ArgGln: 0.725 ± 0.365
6.161ArgArg: 6.161 ± 1.075
2.899ArgSer: 2.899 ± 0.654
1.993ArgThr: 1.993 ± 0.511
5.073ArgVal: 5.073 ± 1.108
1.631ArgTrp: 1.631 ± 0.469
4.167ArgTyr: 4.167 ± 0.925
0.0ArgXaa: 0.0 ± 0.0
Ser
2.355SerAla: 2.355 ± 0.775
0.544SerCys: 0.544 ± 0.371
4.53SerAsp: 4.53 ± 0.986
2.355SerGlu: 2.355 ± 0.551
1.631SerPhe: 1.631 ± 0.58
5.073SerGly: 5.073 ± 0.888
1.45SerHis: 1.45 ± 0.607
2.899SerIle: 2.899 ± 0.655
3.261SerLys: 3.261 ± 0.663
3.624SerLeu: 3.624 ± 0.79
0.725SerMet: 0.725 ± 0.352
2.899SerAsn: 2.899 ± 0.649
1.268SerPro: 1.268 ± 0.309
0.725SerGln: 0.725 ± 0.358
2.355SerArg: 2.355 ± 0.57
2.174SerSer: 2.174 ± 0.607
2.174SerThr: 2.174 ± 0.651
8.516SerVal: 8.516 ± 1.016
1.268SerTrp: 1.268 ± 0.385
2.355SerTyr: 2.355 ± 0.755
0.0SerXaa: 0.0 ± 0.0
Thr
2.718ThrAla: 2.718 ± 0.798
1.087ThrCys: 1.087 ± 0.466
2.537ThrAsp: 2.537 ± 0.634
2.537ThrGlu: 2.537 ± 0.624
2.174ThrPhe: 2.174 ± 0.579
4.349ThrGly: 4.349 ± 1.463
0.544ThrHis: 0.544 ± 0.331
2.899ThrIle: 2.899 ± 0.653
1.993ThrLys: 1.993 ± 0.843
3.805ThrLeu: 3.805 ± 0.882
0.725ThrMet: 0.725 ± 0.345
1.812ThrAsn: 1.812 ± 0.744
3.443ThrPro: 3.443 ± 2.173
1.993ThrGln: 1.993 ± 0.991
2.174ThrArg: 2.174 ± 0.805
2.537ThrSer: 2.537 ± 0.583
2.537ThrThr: 2.537 ± 0.818
5.617ThrVal: 5.617 ± 0.843
1.268ThrTrp: 1.268 ± 0.569
2.537ThrTyr: 2.537 ± 0.691
0.0ThrXaa: 0.0 ± 0.0
Val
9.422ValAla: 9.422 ± 1.654
1.268ValCys: 1.268 ± 0.509
8.335ValAsp: 8.335 ± 1.206
5.073ValGlu: 5.073 ± 1.108
6.161ValPhe: 6.161 ± 1.113
8.335ValGly: 8.335 ± 1.202
1.631ValHis: 1.631 ± 0.532
5.798ValIle: 5.798 ± 1.039
6.161ValLys: 6.161 ± 1.025
8.516ValLeu: 8.516 ± 1.507
3.986ValMet: 3.986 ± 0.835
4.711ValAsn: 4.711 ± 0.91
2.537ValPro: 2.537 ± 0.662
1.45ValGln: 1.45 ± 0.58
6.704ValArg: 6.704 ± 0.849
5.979ValSer: 5.979 ± 1.193
4.892ValThr: 4.892 ± 0.878
14.314ValVal: 14.314 ± 1.651
1.268ValTrp: 1.268 ± 0.486
7.066ValTyr: 7.066 ± 0.93
0.0ValXaa: 0.0 ± 0.0
Trp
1.087TrpAla: 1.087 ± 0.396
0.544TrpCys: 0.544 ± 0.305
2.174TrpAsp: 2.174 ± 0.616
1.268TrpGlu: 1.268 ± 0.602
1.993TrpPhe: 1.993 ± 0.49
1.45TrpGly: 1.45 ± 0.544
0.181TrpHis: 0.181 ± 0.214
1.812TrpIle: 1.812 ± 0.572
0.725TrpLys: 0.725 ± 0.283
1.087TrpLeu: 1.087 ± 0.47
0.362TrpMet: 0.362 ± 0.259
0.906TrpAsn: 0.906 ± 0.335
0.0TrpPro: 0.0 ± 0.0
0.362TrpGln: 0.362 ± 0.219
1.087TrpArg: 1.087 ± 0.573
0.544TrpSer: 0.544 ± 0.383
0.725TrpThr: 0.725 ± 0.355
2.355TrpVal: 2.355 ± 0.842
0.906TrpTrp: 0.906 ± 0.39
1.812TrpTyr: 1.812 ± 0.563
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.443TyrAla: 3.443 ± 0.757
0.544TyrCys: 0.544 ± 0.297
3.443TyrAsp: 3.443 ± 0.754
2.718TyrGlu: 2.718 ± 0.793
1.45TyrPhe: 1.45 ± 0.471
4.349TyrGly: 4.349 ± 0.758
1.087TyrHis: 1.087 ± 0.358
4.892TyrIle: 4.892 ± 1.009
3.261TyrLys: 3.261 ± 0.656
2.899TyrLeu: 2.899 ± 0.594
2.537TyrMet: 2.537 ± 0.606
3.08TyrAsn: 3.08 ± 0.57
1.087TyrPro: 1.087 ± 0.424
0.906TyrGln: 0.906 ± 0.372
4.167TyrArg: 4.167 ± 1.036
2.537TyrSer: 2.537 ± 0.613
2.899TyrThr: 2.899 ± 0.702
6.704TyrVal: 6.704 ± 1.202
1.631TyrTrp: 1.631 ± 0.668
3.261TyrTyr: 3.261 ± 0.678
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 39 proteins (5520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski