Amino acid dipepetide frequency for Lactobacillus phage JNU_P7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.43AlaAla: 3.43 ± 0.659
0.264AlaCys: 0.264 ± 0.183
4.749AlaAsp: 4.749 ± 0.557
3.87AlaGlu: 3.87 ± 0.747
2.99AlaPhe: 2.99 ± 0.589
3.958AlaGly: 3.958 ± 0.965
1.407AlaHis: 1.407 ± 0.365
5.629AlaIle: 5.629 ± 0.624
6.948AlaLys: 6.948 ± 0.985
6.684AlaLeu: 6.684 ± 0.797
2.023AlaMet: 2.023 ± 0.472
4.485AlaAsn: 4.485 ± 0.614
2.111AlaPro: 2.111 ± 0.379
3.694AlaGln: 3.694 ± 0.701
3.342AlaArg: 3.342 ± 0.495
3.958AlaSer: 3.958 ± 0.593
4.661AlaThr: 4.661 ± 0.584
4.134AlaVal: 4.134 ± 0.72
0.704AlaTrp: 0.704 ± 0.231
1.847AlaTyr: 1.847 ± 0.414
0.0AlaXaa: 0.0 ± 0.0
Cys
0.176CysAla: 0.176 ± 0.13
0.0CysCys: 0.0 ± 0.0
0.176CysAsp: 0.176 ± 0.123
0.088CysGlu: 0.088 ± 0.093
0.352CysPhe: 0.352 ± 0.175
0.176CysGly: 0.176 ± 0.158
0.0CysHis: 0.0 ± 0.0
0.176CysIle: 0.176 ± 0.127
0.264CysLys: 0.264 ± 0.174
0.44CysLeu: 0.44 ± 0.19
0.176CysMet: 0.176 ± 0.114
0.176CysAsn: 0.176 ± 0.145
0.088CysPro: 0.088 ± 0.098
0.264CysGln: 0.264 ± 0.158
0.264CysArg: 0.264 ± 0.16
0.44CysSer: 0.44 ± 0.155
0.176CysThr: 0.176 ± 0.146
0.792CysVal: 0.792 ± 0.279
0.0CysTrp: 0.0 ± 0.0
0.176CysTyr: 0.176 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
4.573AspAla: 4.573 ± 0.517
0.352AspCys: 0.352 ± 0.163
4.925AspAsp: 4.925 ± 0.893
4.837AspGlu: 4.837 ± 0.716
2.814AspPhe: 2.814 ± 0.573
4.046AspGly: 4.046 ± 0.637
0.88AspHis: 0.88 ± 0.27
4.046AspIle: 4.046 ± 0.608
6.069AspLys: 6.069 ± 0.753
6.86AspLeu: 6.86 ± 0.806
2.111AspMet: 2.111 ± 0.451
4.485AspAsn: 4.485 ± 0.615
2.375AspPro: 2.375 ± 0.486
2.551AspGln: 2.551 ± 0.489
1.935AspArg: 1.935 ± 0.443
3.078AspSer: 3.078 ± 0.462
3.958AspThr: 3.958 ± 0.715
4.661AspVal: 4.661 ± 0.732
1.319AspTrp: 1.319 ± 0.267
2.551AspTyr: 2.551 ± 0.629
0.0AspXaa: 0.0 ± 0.0
Glu
3.43GluAla: 3.43 ± 0.806
0.0GluCys: 0.0 ± 0.0
3.782GluAsp: 3.782 ± 0.739
3.606GluGlu: 3.606 ± 0.71
2.814GluPhe: 2.814 ± 0.46
2.551GluGly: 2.551 ± 0.548
0.967GluHis: 0.967 ± 0.258
4.134GluIle: 4.134 ± 0.776
5.629GluLys: 5.629 ± 0.894
4.398GluLeu: 4.398 ± 0.588
1.495GluMet: 1.495 ± 0.332
3.694GluAsn: 3.694 ± 0.659
2.111GluPro: 2.111 ± 0.441
3.166GluGln: 3.166 ± 0.612
2.023GluArg: 2.023 ± 0.485
3.254GluSer: 3.254 ± 0.472
2.902GluThr: 2.902 ± 0.483
2.023GluVal: 2.023 ± 0.443
1.143GluTrp: 1.143 ± 0.306
3.43GluTyr: 3.43 ± 0.6
0.0GluXaa: 0.0 ± 0.0
Phe
2.023PheAla: 2.023 ± 0.374
0.088PheCys: 0.088 ± 0.1
3.166PheAsp: 3.166 ± 0.52
2.726PheGlu: 2.726 ± 0.533
1.231PhePhe: 1.231 ± 0.323
2.639PheGly: 2.639 ± 0.791
0.792PheHis: 0.792 ± 0.259
2.023PheIle: 2.023 ± 0.431
3.518PheLys: 3.518 ± 0.576
2.287PheLeu: 2.287 ± 0.56
0.88PheMet: 0.88 ± 0.217
2.99PheAsn: 2.99 ± 0.572
1.407PhePro: 1.407 ± 0.336
1.759PheGln: 1.759 ± 0.372
2.023PheArg: 2.023 ± 0.319
2.551PheSer: 2.551 ± 0.424
1.495PheThr: 1.495 ± 0.337
2.463PheVal: 2.463 ± 0.476
0.528PheTrp: 0.528 ± 0.224
2.023PheTyr: 2.023 ± 0.492
0.0PheXaa: 0.0 ± 0.0
Gly
4.485GlyAla: 4.485 ± 0.806
0.352GlyCys: 0.352 ± 0.186
3.166GlyAsp: 3.166 ± 0.476
2.639GlyGlu: 2.639 ± 0.579
2.551GlyPhe: 2.551 ± 0.474
3.87GlyGly: 3.87 ± 0.711
0.792GlyHis: 0.792 ± 0.225
4.837GlyIle: 4.837 ± 0.783
7.3GlyLys: 7.3 ± 1.069
5.365GlyLeu: 5.365 ± 0.704
2.463GlyMet: 2.463 ± 0.594
4.31GlyAsn: 4.31 ± 0.638
1.055GlyPro: 1.055 ± 0.303
1.935GlyGln: 1.935 ± 0.462
1.583GlyArg: 1.583 ± 0.333
4.222GlySer: 4.222 ± 0.702
3.958GlyThr: 3.958 ± 0.552
3.606GlyVal: 3.606 ± 0.45
1.407GlyTrp: 1.407 ± 0.499
2.375GlyTyr: 2.375 ± 0.526
0.0GlyXaa: 0.0 ± 0.0
His
1.055HisAla: 1.055 ± 0.27
0.0HisCys: 0.0 ± 0.0
0.88HisAsp: 0.88 ± 0.252
1.143HisGlu: 1.143 ± 0.317
0.616HisPhe: 0.616 ± 0.214
0.88HisGly: 0.88 ± 0.324
0.176HisHis: 0.176 ± 0.13
1.055HisIle: 1.055 ± 0.344
1.759HisLys: 1.759 ± 0.445
1.407HisLeu: 1.407 ± 0.367
0.264HisMet: 0.264 ± 0.191
0.967HisAsn: 0.967 ± 0.257
0.44HisPro: 0.44 ± 0.202
0.528HisGln: 0.528 ± 0.218
0.528HisArg: 0.528 ± 0.17
0.616HisSer: 0.616 ± 0.254
1.055HisThr: 1.055 ± 0.287
0.704HisVal: 0.704 ± 0.274
0.264HisTrp: 0.264 ± 0.129
1.231HisTyr: 1.231 ± 0.308
0.0HisXaa: 0.0 ± 0.0
Ile
4.925IleAla: 4.925 ± 0.558
0.176IleCys: 0.176 ± 0.121
4.661IleAsp: 4.661 ± 0.572
3.518IleGlu: 3.518 ± 0.653
1.935IlePhe: 1.935 ± 0.485
4.134IleGly: 4.134 ± 0.843
0.792IleHis: 0.792 ± 0.274
3.606IleIle: 3.606 ± 0.553
7.3IleLys: 7.3 ± 0.762
3.694IleLeu: 3.694 ± 0.674
1.143IleMet: 1.143 ± 0.243
5.365IleAsn: 5.365 ± 0.553
2.639IlePro: 2.639 ± 0.576
1.847IleGln: 1.847 ± 0.314
2.463IleArg: 2.463 ± 0.659
4.398IleSer: 4.398 ± 0.707
4.573IleThr: 4.573 ± 0.552
3.606IleVal: 3.606 ± 0.567
0.176IleTrp: 0.176 ± 0.125
3.078IleTyr: 3.078 ± 0.72
0.0IleXaa: 0.0 ± 0.0
Lys
8.179LysAla: 8.179 ± 1.377
0.264LysCys: 0.264 ± 0.13
5.893LysAsp: 5.893 ± 0.869
6.069LysGlu: 6.069 ± 0.861
3.342LysPhe: 3.342 ± 0.487
5.189LysGly: 5.189 ± 0.663
2.199LysHis: 2.199 ± 0.471
5.189LysIle: 5.189 ± 0.626
9.675LysLys: 9.675 ± 1.276
6.508LysLeu: 6.508 ± 0.768
2.463LysMet: 2.463 ± 0.43
4.661LysAsn: 4.661 ± 1.178
2.902LysPro: 2.902 ± 0.546
5.365LysGln: 5.365 ± 0.724
4.31LysArg: 4.31 ± 0.787
5.277LysSer: 5.277 ± 0.537
6.332LysThr: 6.332 ± 0.844
5.981LysVal: 5.981 ± 0.72
2.023LysTrp: 2.023 ± 0.504
3.782LysTyr: 3.782 ± 0.562
0.0LysXaa: 0.0 ± 0.0
Leu
6.157LeuAla: 6.157 ± 0.648
0.528LeuCys: 0.528 ± 0.245
4.485LeuAsp: 4.485 ± 0.659
4.485LeuGlu: 4.485 ± 0.803
2.639LeuPhe: 2.639 ± 0.557
5.013LeuGly: 5.013 ± 0.71
0.967LeuHis: 0.967 ± 0.289
4.573LeuIle: 4.573 ± 0.691
6.948LeuLys: 6.948 ± 1.035
4.837LeuLeu: 4.837 ± 0.688
1.319LeuMet: 1.319 ± 0.391
5.981LeuAsn: 5.981 ± 0.785
1.671LeuPro: 1.671 ± 0.315
3.43LeuGln: 3.43 ± 0.502
3.518LeuArg: 3.518 ± 0.702
5.981LeuSer: 5.981 ± 0.737
5.013LeuThr: 5.013 ± 0.836
3.694LeuVal: 3.694 ± 0.76
1.143LeuTrp: 1.143 ± 0.252
2.814LeuTyr: 2.814 ± 0.685
0.0LeuXaa: 0.0 ± 0.0
Met
2.287MetAla: 2.287 ± 0.416
0.088MetCys: 0.088 ± 0.096
1.143MetAsp: 1.143 ± 0.278
1.143MetGlu: 1.143 ± 0.292
0.704MetPhe: 0.704 ± 0.268
1.671MetGly: 1.671 ± 0.391
0.176MetHis: 0.176 ± 0.132
1.319MetIle: 1.319 ± 0.275
2.023MetLys: 2.023 ± 0.431
1.847MetLeu: 1.847 ± 0.419
1.319MetMet: 1.319 ± 0.343
1.847MetAsn: 1.847 ± 0.344
0.616MetPro: 0.616 ± 0.228
1.495MetGln: 1.495 ± 0.346
0.792MetArg: 0.792 ± 0.315
2.639MetSer: 2.639 ± 0.402
0.88MetThr: 0.88 ± 0.28
1.495MetVal: 1.495 ± 0.406
0.176MetTrp: 0.176 ± 0.121
0.88MetTyr: 0.88 ± 0.243
0.0MetXaa: 0.0 ± 0.0
Asn
3.782AsnAla: 3.782 ± 0.573
0.528AsnCys: 0.528 ± 0.212
3.87AsnAsp: 3.87 ± 0.549
3.254AsnGlu: 3.254 ± 0.683
3.078AsnPhe: 3.078 ± 0.765
5.453AsnGly: 5.453 ± 0.706
0.616AsnHis: 0.616 ± 0.212
4.134AsnIle: 4.134 ± 0.564
5.629AsnLys: 5.629 ± 0.797
4.925AsnLeu: 4.925 ± 0.762
0.792AsnMet: 0.792 ± 0.213
3.254AsnAsn: 3.254 ± 0.55
2.639AsnPro: 2.639 ± 0.582
2.902AsnGln: 2.902 ± 0.458
2.375AsnArg: 2.375 ± 0.437
5.277AsnSer: 5.277 ± 0.685
2.814AsnThr: 2.814 ± 0.686
3.342AsnVal: 3.342 ± 0.479
1.671AsnTrp: 1.671 ± 0.542
1.671AsnTyr: 1.671 ± 0.422
0.0AsnXaa: 0.0 ± 0.0
Pro
3.166ProAla: 3.166 ± 0.471
0.088ProCys: 0.088 ± 0.098
2.551ProAsp: 2.551 ± 0.538
2.023ProGlu: 2.023 ± 0.4
1.671ProPhe: 1.671 ± 0.391
1.935ProGly: 1.935 ± 0.371
0.44ProHis: 0.44 ± 0.209
1.935ProIle: 1.935 ± 0.389
3.254ProLys: 3.254 ± 0.574
3.078ProLeu: 3.078 ± 0.601
0.352ProMet: 0.352 ± 0.158
1.319ProAsn: 1.319 ± 0.379
0.704ProPro: 0.704 ± 0.234
1.671ProGln: 1.671 ± 0.288
1.143ProArg: 1.143 ± 0.303
1.847ProSer: 1.847 ± 0.322
2.463ProThr: 2.463 ± 0.56
1.847ProVal: 1.847 ± 0.437
0.264ProTrp: 0.264 ± 0.152
1.847ProTyr: 1.847 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
4.485GlnAla: 4.485 ± 0.686
0.352GlnCys: 0.352 ± 0.167
3.254GlnAsp: 3.254 ± 0.521
2.463GlnGlu: 2.463 ± 0.465
1.055GlnPhe: 1.055 ± 0.337
2.726GlnGly: 2.726 ± 0.472
0.352GlnHis: 0.352 ± 0.196
2.99GlnIle: 2.99 ± 0.493
4.134GlnLys: 4.134 ± 0.557
2.814GlnLeu: 2.814 ± 0.543
1.407GlnMet: 1.407 ± 0.4
2.814GlnAsn: 2.814 ± 0.644
1.583GlnPro: 1.583 ± 0.398
3.694GlnGln: 3.694 ± 0.742
2.199GlnArg: 2.199 ± 0.499
2.375GlnSer: 2.375 ± 0.516
2.902GlnThr: 2.902 ± 0.463
2.99GlnVal: 2.99 ± 0.504
0.528GlnTrp: 0.528 ± 0.168
1.847GlnTyr: 1.847 ± 0.32
0.0GlnXaa: 0.0 ± 0.0
Arg
2.726ArgAla: 2.726 ± 0.404
0.176ArgCys: 0.176 ± 0.109
2.639ArgAsp: 2.639 ± 0.516
2.375ArgGlu: 2.375 ± 0.483
1.055ArgPhe: 1.055 ± 0.335
2.463ArgGly: 2.463 ± 0.621
0.792ArgHis: 0.792 ± 0.228
3.078ArgIle: 3.078 ± 0.473
4.398ArgLys: 4.398 ± 0.848
3.078ArgLeu: 3.078 ± 0.642
1.231ArgMet: 1.231 ± 0.332
1.495ArgAsn: 1.495 ± 0.333
0.88ArgPro: 0.88 ± 0.249
1.495ArgGln: 1.495 ± 0.386
2.375ArgArg: 2.375 ± 0.587
2.639ArgSer: 2.639 ± 0.552
1.759ArgThr: 1.759 ± 0.423
2.726ArgVal: 2.726 ± 0.65
0.352ArgTrp: 0.352 ± 0.178
2.375ArgTyr: 2.375 ± 0.487
0.0ArgXaa: 0.0 ± 0.0
Ser
5.101SerAla: 5.101 ± 0.905
0.44SerCys: 0.44 ± 0.186
4.661SerAsp: 4.661 ± 0.629
3.166SerGlu: 3.166 ± 0.54
2.726SerPhe: 2.726 ± 0.709
5.101SerGly: 5.101 ± 0.971
1.143SerHis: 1.143 ± 0.358
4.046SerIle: 4.046 ± 0.537
5.277SerLys: 5.277 ± 0.854
4.925SerLeu: 4.925 ± 0.716
1.847SerMet: 1.847 ± 0.39
4.485SerAsn: 4.485 ± 0.598
2.111SerPro: 2.111 ± 0.363
2.375SerGln: 2.375 ± 0.482
1.407SerArg: 1.407 ± 0.382
4.398SerSer: 4.398 ± 0.621
4.661SerThr: 4.661 ± 0.676
4.046SerVal: 4.046 ± 0.837
0.616SerTrp: 0.616 ± 0.209
2.99SerTyr: 2.99 ± 0.612
0.0SerXaa: 0.0 ± 0.0
Thr
4.134ThrAla: 4.134 ± 0.583
0.176ThrCys: 0.176 ± 0.131
5.013ThrAsp: 5.013 ± 0.644
2.463ThrGlu: 2.463 ± 0.467
2.463ThrPhe: 2.463 ± 0.42
4.749ThrGly: 4.749 ± 0.717
1.055ThrHis: 1.055 ± 0.281
5.013ThrIle: 5.013 ± 0.598
3.782ThrLys: 3.782 ± 0.794
4.046ThrLeu: 4.046 ± 0.432
0.792ThrMet: 0.792 ± 0.227
3.782ThrAsn: 3.782 ± 0.504
2.814ThrPro: 2.814 ± 0.798
2.902ThrGln: 2.902 ± 0.524
2.375ThrArg: 2.375 ± 0.449
4.398ThrSer: 4.398 ± 0.666
3.518ThrThr: 3.518 ± 0.753
4.046ThrVal: 4.046 ± 0.479
0.528ThrTrp: 0.528 ± 0.229
2.199ThrTyr: 2.199 ± 0.612
0.0ThrXaa: 0.0 ± 0.0
Val
3.342ValAla: 3.342 ± 0.54
0.352ValCys: 0.352 ± 0.171
5.365ValAsp: 5.365 ± 0.685
3.87ValGlu: 3.87 ± 0.473
2.463ValPhe: 2.463 ± 0.51
2.199ValGly: 2.199 ± 0.464
1.055ValHis: 1.055 ± 0.315
3.342ValIle: 3.342 ± 0.546
6.772ValLys: 6.772 ± 0.791
3.694ValLeu: 3.694 ± 0.519
1.847ValMet: 1.847 ± 0.318
3.166ValAsn: 3.166 ± 0.504
3.078ValPro: 3.078 ± 0.464
2.726ValGln: 2.726 ± 0.398
2.375ValArg: 2.375 ± 0.508
3.606ValSer: 3.606 ± 0.49
3.518ValThr: 3.518 ± 0.477
3.166ValVal: 3.166 ± 0.547
0.352ValTrp: 0.352 ± 0.153
2.287ValTyr: 2.287 ± 0.537
0.0ValXaa: 0.0 ± 0.0
Trp
0.88TrpAla: 0.88 ± 0.293
0.088TrpCys: 0.088 ± 0.107
0.88TrpAsp: 0.88 ± 0.27
0.352TrpGlu: 0.352 ± 0.16
0.704TrpPhe: 0.704 ± 0.201
0.967TrpGly: 0.967 ± 0.348
0.176TrpHis: 0.176 ± 0.157
0.967TrpIle: 0.967 ± 0.274
1.231TrpLys: 1.231 ± 0.407
0.88TrpLeu: 0.88 ± 0.341
0.088TrpMet: 0.088 ± 0.07
0.792TrpAsn: 0.792 ± 0.296
0.44TrpPro: 0.44 ± 0.153
0.616TrpGln: 0.616 ± 0.291
0.704TrpArg: 0.704 ± 0.218
1.319TrpSer: 1.319 ± 0.381
0.967TrpThr: 0.967 ± 0.232
1.319TrpVal: 1.319 ± 0.375
0.176TrpTrp: 0.176 ± 0.128
0.792TrpTyr: 0.792 ± 0.263
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.551TyrAla: 2.551 ± 0.408
0.088TyrCys: 0.088 ± 0.079
3.166TyrAsp: 3.166 ± 0.8
2.463TyrGlu: 2.463 ± 0.502
1.407TyrPhe: 1.407 ± 0.353
2.639TyrGly: 2.639 ± 0.463
0.792TyrHis: 0.792 ± 0.276
1.935TyrIle: 1.935 ± 0.43
3.694TyrLys: 3.694 ± 0.75
3.43TyrLeu: 3.43 ± 0.557
0.44TyrMet: 0.44 ± 0.178
1.935TyrAsn: 1.935 ± 0.402
1.935TyrPro: 1.935 ± 0.424
2.551TyrGln: 2.551 ± 0.523
2.375TyrArg: 2.375 ± 0.611
3.254TyrSer: 3.254 ± 0.568
2.639TyrThr: 2.639 ± 0.687
1.935TyrVal: 1.935 ± 0.472
0.967TyrTrp: 0.967 ± 0.379
2.375TyrTyr: 2.375 ± 0.5
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski