Amino acid dipepetide frequency for Deinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.906AlaAla: 18.906 ± 0.198	0.865AlaCys: 0.865 ± 0.031	6.028AlaAsp: 6.028 ± 0.069	7.131AlaGlu: 7.131 ± 0.112	3.896AlaPhe: 3.896 ± 0.064	12.348AlaGly: 12.348 ± 0.129	2.626AlaHis: 2.626 ± 0.052	3.276AlaIle: 3.276 ± 0.062	2.261AlaLys: 2.261 ± 0.057	16.871AlaLeu: 16.871 ± 0.174	2.284AlaMet: 2.284 ± 0.046	2.077AlaAsn: 2.077 ± 0.055	7.138AlaPro: 7.138 ± 0.106	6.649AlaGln: 6.649 ± 0.099	10.73AlaArg: 10.73 ± 0.112	5.647AlaSer: 5.647 ± 0.075	6.082AlaThr: 6.082 ± 0.076	8.847AlaVal: 8.847 ± 0.089	1.88AlaTrp: 1.88 ± 0.043	2.936AlaTyr: 2.936 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.026	0.064CysCys: 0.064 ± 0.009	0.314CysAsp: 0.314 ± 0.018	0.263CysGlu: 0.263 ± 0.014	0.168CysPhe: 0.168 ± 0.012	0.724CysGly: 0.724 ± 0.028	0.134CysHis: 0.134 ± 0.01	0.185CysIle: 0.185 ± 0.013	0.096CysLys: 0.096 ± 0.008	0.535CysLeu: 0.535 ± 0.023	0.104CysMet: 0.104 ± 0.009	0.13CysAsn: 0.13 ± 0.01	0.432CysPro: 0.432 ± 0.021	0.177CysGln: 0.177 ± 0.011	0.462CysArg: 0.462 ± 0.021	0.291CysSer: 0.291 ± 0.017	0.398CysThr: 0.398 ± 0.019	0.474CysVal: 0.474 ± 0.02	0.082CysTrp: 0.082 ± 0.008	0.115CysTyr: 0.115 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.416AspAla: 6.416 ± 0.072	0.235AspCys: 0.235 ± 0.015	2.493AspAsp: 2.493 ± 0.047	2.965AspGlu: 2.965 ± 0.049	1.788AspPhe: 1.788 ± 0.036	4.377AspGly: 4.377 ± 0.062	1.142AspHis: 1.142 ± 0.032	1.774AspIle: 1.774 ± 0.041	1.093AspLys: 1.093 ± 0.031	7.178AspLeu: 7.178 ± 0.083	0.897AspMet: 0.897 ± 0.028	0.922AspAsn: 0.922 ± 0.03	3.639AspPro: 3.639 ± 0.062	1.623AspGln: 1.623 ± 0.039	3.414AspArg: 3.414 ± 0.055	1.911AspSer: 1.911 ± 0.041	2.962AspThr: 2.962 ± 0.057	4.184AspVal: 4.184 ± 0.069	0.854AspTrp: 0.854 ± 0.026	1.222AspTyr: 1.222 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.677GluAla: 7.677 ± 0.097	0.241GluCys: 0.241 ± 0.014	2.678GluAsp: 2.678 ± 0.05	2.924GluGlu: 2.924 ± 0.064	1.585GluPhe: 1.585 ± 0.04	4.678GluGly: 4.678 ± 0.06	1.304GluHis: 1.304 ± 0.036	2.056GluIle: 2.056 ± 0.047	1.476GluLys: 1.476 ± 0.045	6.326GluLeu: 6.326 ± 0.099	1.067GluMet: 1.067 ± 0.028	1.226GluAsn: 1.226 ± 0.033	2.195GluPro: 2.195 ± 0.049	2.49GluGln: 2.49 ± 0.053	5.114GluArg: 5.114 ± 0.08	2.084GluSer: 2.084 ± 0.042	2.925GluThr: 2.925 ± 0.049	4.905GluVal: 4.905 ± 0.069	0.772GluTrp: 0.772 ± 0.026	1.337GluTyr: 1.337 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.607PheAla: 3.607 ± 0.056	0.194PheCys: 0.194 ± 0.013	1.765PheAsp: 1.765 ± 0.037	1.586PheGlu: 1.586 ± 0.039	1.016PhePhe: 1.016 ± 0.032	3.153PheGly: 3.153 ± 0.061	0.539PheHis: 0.539 ± 0.021	1.024PheIle: 1.024 ± 0.032	0.768PheLys: 0.768 ± 0.026	3.065PheLeu: 3.065 ± 0.057	0.567PheMet: 0.567 ± 0.023	0.759PheAsn: 0.759 ± 0.026	1.626PhePro: 1.626 ± 0.039	1.002PheGln: 1.002 ± 0.027	1.999PheArg: 1.999 ± 0.038	1.876PheSer: 1.876 ± 0.041	1.999PheThr: 1.999 ± 0.037	2.344PheVal: 2.344 ± 0.039	0.481PheTrp: 0.481 ± 0.019	0.742PheTyr: 0.742 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.743GlyAla: 10.743 ± 0.13	0.57GlyCys: 0.57 ± 0.023	4.666GlyAsp: 4.666 ± 0.064	5.909GlyGlu: 5.909 ± 0.073	2.851GlyPhe: 2.851 ± 0.051	9.176GlyGly: 9.176 ± 0.128	2.112GlyHis: 2.112 ± 0.049	3.073GlyIle: 3.073 ± 0.06	2.642GlyLys: 2.642 ± 0.052	10.73GlyLeu: 10.73 ± 0.122	1.9GlyMet: 1.9 ± 0.051	2.178GlyAsn: 2.178 ± 0.055	4.044GlyPro: 4.044 ± 0.062	4.392GlyGln: 4.392 ± 0.062	7.324GlyArg: 7.324 ± 0.08	4.509GlySer: 4.509 ± 0.062	5.856GlyThr: 5.856 ± 0.087	7.758GlyVal: 7.758 ± 0.09	1.547GlyTrp: 1.547 ± 0.042	2.395GlyTyr: 2.395 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.72HisAla: 2.72 ± 0.052	0.151HisCys: 0.151 ± 0.012	1.108HisAsp: 1.108 ± 0.034	1.098HisGlu: 1.098 ± 0.03	0.677HisPhe: 0.677 ± 0.022	1.844HisGly: 1.844 ± 0.043	0.628HisHis: 0.628 ± 0.025	0.649HisIle: 0.649 ± 0.023	0.353HisLys: 0.353 ± 0.017	2.762HisLeu: 2.762 ± 0.059	0.356HisMet: 0.356 ± 0.015	0.39HisAsn: 0.39 ± 0.018	1.607HisPro: 1.607 ± 0.037	0.612HisGln: 0.612 ± 0.024	1.403HisArg: 1.403 ± 0.038	0.881HisSer: 0.881 ± 0.025	1.195HisThr: 1.195 ± 0.034	1.45HisVal: 1.45 ± 0.036	0.348HisTrp: 0.348 ± 0.015	0.528HisTyr: 0.528 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	3.742IleAla: 3.742 ± 0.058	0.201IleCys: 0.201 ± 0.011	1.726IleAsp: 1.726 ± 0.041	2.069IleGlu: 2.069 ± 0.042	0.987IlePhe: 0.987 ± 0.035	3.195IleGly: 3.195 ± 0.058	0.67IleHis: 0.67 ± 0.024	1.231IleIle: 1.231 ± 0.042	0.862IleLys: 0.862 ± 0.032	3.119IleLeu: 3.119 ± 0.058	0.525IleMet: 0.525 ± 0.024	0.916IleAsn: 0.916 ± 0.034	1.874IlePro: 1.874 ± 0.042	1.111IleGln: 1.111 ± 0.034	2.322IleArg: 2.322 ± 0.049	1.764IleSer: 1.764 ± 0.046	2.046IleThr: 2.046 ± 0.043	2.668IleVal: 2.668 ± 0.059	0.35IleTrp: 0.35 ± 0.018	0.773IleTyr: 0.773 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.905LysAla: 2.905 ± 0.062	0.105LysCys: 0.105 ± 0.01	1.227LysAsp: 1.227 ± 0.038	1.079LysGlu: 1.079 ± 0.037	0.705LysPhe: 0.705 ± 0.028	1.892LysGly: 1.892 ± 0.041	0.412LysHis: 0.412 ± 0.018	0.926LysIle: 0.926 ± 0.03	1.02LysLys: 1.02 ± 0.04	2.501LysLeu: 2.501 ± 0.054	0.595LysMet: 0.595 ± 0.023	0.762LysAsn: 0.762 ± 0.027	1.247LysPro: 1.247 ± 0.037	0.742LysGln: 0.742 ± 0.031	1.612LysArg: 1.612 ± 0.039	1.152LysSer: 1.152 ± 0.039	1.584LysThr: 1.584 ± 0.041	2.056LysVal: 2.056 ± 0.044	0.273LysTrp: 0.273 ± 0.016	0.68LysTyr: 0.68 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.841LeuAla: 14.841 ± 0.135	0.767LeuCys: 0.767 ± 0.028	6.582LeuAsp: 6.582 ± 0.082	6.164LeuGlu: 6.164 ± 0.083	2.889LeuPhe: 2.889 ± 0.062	11.231LeuGly: 11.231 ± 0.115	2.485LeuHis: 2.485 ± 0.051	3.95LeuIle: 3.95 ± 0.063	2.926LeuLys: 2.926 ± 0.055	13.23LeuLeu: 13.23 ± 0.165	1.933LeuMet: 1.933 ± 0.039	3.162LeuAsn: 3.162 ± 0.049	7.507LeuPro: 7.507 ± 0.113	3.328LeuGln: 3.328 ± 0.053	9.698LeuArg: 9.698 ± 0.1	7.348LeuSer: 7.348 ± 0.095	7.657LeuThr: 7.657 ± 0.083	7.396LeuVal: 7.396 ± 0.09	1.463LeuTrp: 1.463 ± 0.04	2.434LeuTyr: 2.434 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.91MetAla: 1.91 ± 0.042	0.087MetCys: 0.087 ± 0.008	0.878MetAsp: 0.878 ± 0.029	0.765MetGlu: 0.765 ± 0.028	0.512MetPhe: 0.512 ± 0.022	1.494MetGly: 1.494 ± 0.04	0.377MetHis: 0.377 ± 0.015	0.712MetIle: 0.712 ± 0.027	0.671MetLys: 0.671 ± 0.023	2.025MetLeu: 2.025 ± 0.04	0.339MetMet: 0.339 ± 0.017	0.665MetAsn: 0.665 ± 0.023	1.182MetPro: 1.182 ± 0.034	0.753MetGln: 0.753 ± 0.025	1.402MetArg: 1.402 ± 0.035	1.136MetSer: 1.136 ± 0.031	1.678MetThr: 1.678 ± 0.042	1.215MetVal: 1.215 ± 0.029	0.202MetTrp: 0.202 ± 0.013	0.377MetTyr: 0.377 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.88AsnAla: 2.88 ± 0.055	0.151AsnCys: 0.151 ± 0.012	1.05AsnAsp: 1.05 ± 0.031	0.901AsnGlu: 0.901 ± 0.026	0.859AsnPhe: 0.859 ± 0.027	1.935AsnGly: 1.935 ± 0.046	0.41AsnHis: 0.41 ± 0.018	0.99AsnIle: 0.99 ± 0.035	0.562AsnLys: 0.562 ± 0.027	2.83AsnLeu: 2.83 ± 0.058	0.509AsnMet: 0.509 ± 0.019	0.671AsnAsn: 0.671 ± 0.031	1.713AsnPro: 1.713 ± 0.044	0.64AsnGln: 0.64 ± 0.026	1.378AsnArg: 1.378 ± 0.032	1.107AsnSer: 1.107 ± 0.041	1.425AsnThr: 1.425 ± 0.039	2.033AsnVal: 2.033 ± 0.046	0.33AsnTrp: 0.33 ± 0.018	0.646AsnTyr: 0.646 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.259ProAla: 8.259 ± 0.121	0.268ProCys: 0.268 ± 0.016	3.955ProAsp: 3.955 ± 0.056	4.693ProGlu: 4.693 ± 0.068	1.654ProPhe: 1.654 ± 0.039	6.238ProGly: 6.238 ± 0.089	1.297ProHis: 1.297 ± 0.036	1.465ProIle: 1.465 ± 0.038	1.13ProLys: 1.13 ± 0.034	6.139ProLeu: 6.139 ± 0.075	1.075ProMet: 1.075 ± 0.032	1.205ProAsn: 1.205 ± 0.033	3.275ProPro: 3.275 ± 0.071	2.552ProGln: 2.552 ± 0.048	3.596ProArg: 3.596 ± 0.061	2.708ProSer: 2.708 ± 0.049	3.251ProThr: 3.251 ± 0.067	4.616ProVal: 4.616 ± 0.073	0.799ProTrp: 0.799 ± 0.028	1.322ProTyr: 1.322 ± 0.03	0.002ProXaa: 0.002 ± 0.002
Gln	5.964GlnAla: 5.964 ± 0.084	0.174GlnCys: 0.174 ± 0.012	2.041GlnAsp: 2.041 ± 0.036	2.132GlnGlu: 2.132 ± 0.044	1.041GlnPhe: 1.041 ± 0.028	3.954GlnGly: 3.954 ± 0.066	0.689GlnHis: 0.689 ± 0.025	1.348GlnIle: 1.348 ± 0.039	0.994GlnLys: 0.994 ± 0.026	3.772GlnLeu: 3.772 ± 0.063	0.726GlnMet: 0.726 ± 0.028	1.002GlnAsn: 1.002 ± 0.029	2.349GlnPro: 2.349 ± 0.047	1.492GlnGln: 1.492 ± 0.05	2.564GlnArg: 2.564 ± 0.052	1.816GlnSer: 1.816 ± 0.047	2.529GlnThr: 2.529 ± 0.055	3.405GlnVal: 3.405 ± 0.058	0.441GlnTrp: 0.441 ± 0.016	0.763GlnTyr: 0.763 ± 0.023	0.001GlnXaa: 0.001 ± 0.001
Arg	10.153ArgAla: 10.153 ± 0.113	0.438ArgCys: 0.438 ± 0.019	3.954ArgAsp: 3.954 ± 0.058	5.068ArgGlu: 5.068 ± 0.07	2.289ArgPhe: 2.289 ± 0.044	6.299ArgGly: 6.299 ± 0.08	1.638ArgHis: 1.638 ± 0.039	2.35ArgIle: 2.35 ± 0.043	1.634ArgLys: 1.634 ± 0.04	8.997ArgLeu: 8.997 ± 0.107	1.548ArgMet: 1.548 ± 0.035	1.467ArgAsn: 1.467 ± 0.037	4.61ArgPro: 4.61 ± 0.071	3.089ArgGln: 3.089 ± 0.063	6.431ArgArg: 6.431 ± 0.096	3.554ArgSer: 3.554 ± 0.057	4.163ArgThr: 4.163 ± 0.058	6.169ArgVal: 6.169 ± 0.071	1.122ArgTrp: 1.122 ± 0.035	1.858ArgTyr: 1.858 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	6.266SerAla: 6.266 ± 0.081	0.309SerCys: 0.309 ± 0.017	2.456SerAsp: 2.456 ± 0.047	2.221SerGlu: 2.221 ± 0.046	1.628SerPhe: 1.628 ± 0.034	6.184SerGly: 6.184 ± 0.093	0.822SerHis: 0.822 ± 0.027	1.544SerIle: 1.544 ± 0.042	1.094SerLys: 1.094 ± 0.036	5.491SerLeu: 5.491 ± 0.068	0.915SerMet: 0.915 ± 0.025	1.138SerAsn: 1.138 ± 0.04	3.193SerPro: 3.193 ± 0.057	1.498SerGln: 1.498 ± 0.042	3.482SerArg: 3.482 ± 0.058	2.676SerSer: 2.676 ± 0.057	2.664SerThr: 2.664 ± 0.056	3.996SerVal: 3.996 ± 0.064	0.641SerTrp: 0.641 ± 0.021	1.19SerTyr: 1.19 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.918ThrAla: 6.918 ± 0.085	0.36ThrCys: 0.36 ± 0.02	2.785ThrAsp: 2.785 ± 0.05	2.591ThrGlu: 2.591 ± 0.043	2.118ThrPhe: 2.118 ± 0.042	5.654ThrGly: 5.654 ± 0.076	1.282ThrHis: 1.282 ± 0.033	1.633ThrIle: 1.633 ± 0.041	1.028ThrLys: 1.028 ± 0.032	8.29ThrLeu: 8.29 ± 0.093	0.816ThrMet: 0.816 ± 0.026	1.19ThrAsn: 1.19 ± 0.037	4.948ThrPro: 4.948 ± 0.069	2.064ThrGln: 2.064 ± 0.046	4.317ThrArg: 4.317 ± 0.062	2.832ThrSer: 2.832 ± 0.053	3.328ThrThr: 3.328 ± 0.075	5.252ThrVal: 5.252 ± 0.085	0.82ThrTrp: 0.82 ± 0.028	1.646ThrTyr: 1.646 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.004ValAla: 9.004 ± 0.099	0.517ValCys: 0.517 ± 0.019	3.339ValAsp: 3.339 ± 0.058	3.73ValGlu: 3.73 ± 0.061	2.285ValPhe: 2.285 ± 0.043	6.415ValGly: 6.415 ± 0.082	1.375ValHis: 1.375 ± 0.032	2.962ValIle: 2.962 ± 0.05	1.998ValLys: 1.998 ± 0.046	8.884ValLeu: 8.884 ± 0.1	1.631ValMet: 1.631 ± 0.04	2.148ValAsn: 2.148 ± 0.047	4.732ValPro: 4.732 ± 0.068	3.439ValGln: 3.439 ± 0.061	6.334ValArg: 6.334 ± 0.07	4.252ValSer: 4.252 ± 0.064	5.6ValThr: 5.6 ± 0.08	6.132ValVal: 6.132 ± 0.084	1.08ValTrp: 1.08 ± 0.03	1.821ValTyr: 1.821 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.649TrpAla: 1.649 ± 0.042	0.087TrpCys: 0.087 ± 0.009	0.658TrpAsp: 0.658 ± 0.022	0.652TrpGlu: 0.652 ± 0.026	0.367TrpPhe: 0.367 ± 0.019	1.177TrpGly: 1.177 ± 0.032	0.342TrpHis: 0.342 ± 0.015	0.379TrpIle: 0.379 ± 0.017	0.362TrpLys: 0.362 ± 0.016	1.633TrpLeu: 1.633 ± 0.038	0.294TrpMet: 0.294 ± 0.014	0.452TrpAsn: 0.452 ± 0.02	0.87TrpPro: 0.87 ± 0.031	0.722TrpGln: 0.722 ± 0.023	1.211TrpArg: 1.211 ± 0.036	0.701TrpSer: 0.701 ± 0.026	1.006TrpThr: 1.006 ± 0.03	1.005TrpVal: 1.005 ± 0.031	0.272TrpTrp: 0.272 ± 0.016	0.249TrpTyr: 0.249 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.117TyrAla: 3.117 ± 0.05	0.164TyrCys: 0.164 ± 0.011	1.386TyrAsp: 1.386 ± 0.038	1.119TyrGlu: 1.119 ± 0.028	0.797TyrPhe: 0.797 ± 0.028	2.406TyrGly: 2.406 ± 0.045	0.479TyrHis: 0.479 ± 0.02	0.623TyrIle: 0.623 ± 0.024	0.508TyrLys: 0.508 ± 0.02	2.613TyrLeu: 2.613 ± 0.05	0.296TyrMet: 0.296 ± 0.015	0.56TyrAsn: 0.56 ± 0.026	1.316TyrPro: 1.316 ± 0.035	0.82TyrGln: 0.82 ± 0.028	2.041TyrArg: 2.041 ± 0.037	1.162TyrSer: 1.162 ± 0.03	1.523TyrThr: 1.523 ± 0.036	1.772TyrVal: 1.772 ± 0.037	0.33TyrTrp: 0.33 ± 0.016	0.567TyrTyr: 0.567 ± 0.024	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4329 proteins (1234809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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