Amino acid dipepetide frequency for Paucibacter sp. KCTC 42545

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.189AlaAla: 19.189 ± 0.187
1.338AlaCys: 1.338 ± 0.032
6.353AlaAsp: 6.353 ± 0.069
7.52AlaGlu: 7.52 ± 0.09
3.895AlaPhe: 3.895 ± 0.058
10.575AlaGly: 10.575 ± 0.143
2.508AlaHis: 2.508 ± 0.047
4.858AlaIle: 4.858 ± 0.074
4.827AlaLys: 4.827 ± 0.074
16.188AlaLeu: 16.188 ± 0.174
3.497AlaMet: 3.497 ± 0.052
3.304AlaAsn: 3.304 ± 0.059
6.072AlaPro: 6.072 ± 0.092
7.435AlaGln: 7.435 ± 0.11
7.979AlaArg: 7.979 ± 0.102
7.763AlaSer: 7.763 ± 0.094
5.609AlaThr: 5.609 ± 0.075
8.402AlaVal: 8.402 ± 0.089
2.092AlaTrp: 2.092 ± 0.047
2.436AlaTyr: 2.436 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.149CysAla: 1.149 ± 0.03
0.109CysCys: 0.109 ± 0.01
0.492CysAsp: 0.492 ± 0.016
0.517CysGlu: 0.517 ± 0.019
0.298CysPhe: 0.298 ± 0.013
0.926CysGly: 0.926 ± 0.028
0.231CysHis: 0.231 ± 0.015
0.35CysIle: 0.35 ± 0.016
0.246CysLys: 0.246 ± 0.011
0.963CysLeu: 0.963 ± 0.026
0.181CysMet: 0.181 ± 0.011
0.226CysAsn: 0.226 ± 0.012
0.45CysPro: 0.45 ± 0.018
0.309CysGln: 0.309 ± 0.016
0.558CysArg: 0.558 ± 0.021
0.53CysSer: 0.53 ± 0.019
0.426CysThr: 0.426 ± 0.019
0.645CysVal: 0.645 ± 0.022
0.129CysTrp: 0.129 ± 0.01
0.198CysTyr: 0.198 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.629AspAla: 6.629 ± 0.081
0.434AspCys: 0.434 ± 0.02
2.239AspAsp: 2.239 ± 0.042
3.08AspGlu: 3.08 ± 0.052
2.013AspPhe: 2.013 ± 0.032
4.308AspGly: 4.308 ± 0.065
0.934AspHis: 0.934 ± 0.027
2.195AspIle: 2.195 ± 0.041
1.828AspLys: 1.828 ± 0.042
5.669AspLeu: 5.669 ± 0.073
1.089AspMet: 1.089 ± 0.028
1.17AspAsn: 1.17 ± 0.034
2.562AspPro: 2.562 ± 0.044
1.932AspGln: 1.932 ± 0.077
2.763AspArg: 2.763 ± 0.049
2.545AspSer: 2.545 ± 0.042
2.103AspThr: 2.103 ± 0.043
3.524AspVal: 3.524 ± 0.053
1.035AspTrp: 1.035 ± 0.027
1.327AspTyr: 1.327 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.179GluAla: 7.179 ± 0.094
0.373GluCys: 0.373 ± 0.017
2.153GluAsp: 2.153 ± 0.04
2.381GluGlu: 2.381 ± 0.05
1.889GluPhe: 1.889 ± 0.036
3.752GluGly: 3.752 ± 0.054
1.263GluHis: 1.263 ± 0.033
2.491GluIle: 2.491 ± 0.053
1.68GluLys: 1.68 ± 0.044
6.9GluLeu: 6.9 ± 0.092
1.26GluMet: 1.26 ± 0.028
1.16GluAsn: 1.16 ± 0.028
2.483GluPro: 2.483 ± 0.049
3.128GluGln: 3.128 ± 0.051
4.42GluArg: 4.42 ± 0.065
2.56GluSer: 2.56 ± 0.049
2.165GluThr: 2.165 ± 0.05
3.986GluVal: 3.986 ± 0.061
0.703GluTrp: 0.703 ± 0.024
0.909GluTyr: 0.909 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.221PheAla: 4.221 ± 0.064
0.39PheCys: 0.39 ± 0.017
2.352PheAsp: 2.352 ± 0.041
2.254PheGlu: 2.254 ± 0.044
1.388PhePhe: 1.388 ± 0.044
3.247PheGly: 3.247 ± 0.056
0.649PheHis: 0.649 ± 0.021
1.455PheIle: 1.455 ± 0.034
1.46PheLys: 1.46 ± 0.032
2.806PheLeu: 2.806 ± 0.048
0.794PheMet: 0.794 ± 0.022
1.234PheAsn: 1.234 ± 0.03
1.258PhePro: 1.258 ± 0.033
1.103PheGln: 1.103 ± 0.028
1.604PheArg: 1.604 ± 0.033
2.348PheSer: 2.348 ± 0.046
1.791PheThr: 1.791 ± 0.039
2.656PheVal: 2.656 ± 0.052
0.53PheTrp: 0.53 ± 0.021
0.846PheTyr: 0.846 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.09GlyAla: 9.09 ± 0.11
0.814GlyCys: 0.814 ± 0.025
3.741GlyAsp: 3.741 ± 0.066
4.354GlyGlu: 4.354 ± 0.062
3.263GlyPhe: 3.263 ± 0.053
6.752GlyGly: 6.752 ± 0.138
1.828GlyHis: 1.828 ± 0.036
3.433GlyIle: 3.433 ± 0.054
3.234GlyLys: 3.234 ± 0.055
10.273GlyLeu: 10.273 ± 0.122
2.121GlyMet: 2.121 ± 0.043
2.294GlyAsn: 2.294 ± 0.058
2.918GlyPro: 2.918 ± 0.047
4.213GlyGln: 4.213 ± 0.075
5.271GlyArg: 5.271 ± 0.054
5.147GlySer: 5.147 ± 0.098
3.765GlyThr: 3.765 ± 0.073
5.943GlyVal: 5.943 ± 0.071
1.391GlyTrp: 1.391 ± 0.04
2.067GlyTyr: 2.067 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.666HisAla: 2.666 ± 0.04
0.299HisCys: 0.299 ± 0.014
0.946HisAsp: 0.946 ± 0.028
1.139HisGlu: 1.139 ± 0.031
0.844HisPhe: 0.844 ± 0.024
1.945HisGly: 1.945 ± 0.041
0.573HisHis: 0.573 ± 0.025
0.902HisIle: 0.902 ± 0.027
0.603HisLys: 0.603 ± 0.024
2.313HisLeu: 2.313 ± 0.044
0.428HisMet: 0.428 ± 0.019
0.465HisAsn: 0.465 ± 0.018
1.237HisPro: 1.237 ± 0.032
0.835HisGln: 0.835 ± 0.024
1.259HisArg: 1.259 ± 0.032
1.182HisSer: 1.182 ± 0.031
0.845HisThr: 0.845 ± 0.028
1.337HisVal: 1.337 ± 0.033
0.385HisTrp: 0.385 ± 0.018
0.572HisTyr: 0.572 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.481IleAla: 5.481 ± 0.07
0.424IleCys: 0.424 ± 0.018
2.725IleAsp: 2.725 ± 0.041
2.913IleGlu: 2.913 ± 0.048
1.271IlePhe: 1.271 ± 0.033
3.669IleGly: 3.669 ± 0.062
0.811IleHis: 0.811 ± 0.024
1.546IleIle: 1.546 ± 0.034
1.776IleLys: 1.776 ± 0.037
3.186IleLeu: 3.186 ± 0.052
0.705IleMet: 0.705 ± 0.027
1.582IleAsn: 1.582 ± 0.037
1.774IlePro: 1.774 ± 0.036
1.47IleGln: 1.47 ± 0.037
2.221IleArg: 2.221 ± 0.041
2.957IleSer: 2.957 ± 0.049
2.33IleThr: 2.33 ± 0.047
2.904IleVal: 2.904 ± 0.055
0.489IleTrp: 0.489 ± 0.02
0.937IleTyr: 0.937 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.5LysAla: 4.5 ± 0.074
0.17LysCys: 0.17 ± 0.011
1.632LysAsp: 1.632 ± 0.038
1.429LysGlu: 1.429 ± 0.041
1.05LysPhe: 1.05 ± 0.028
2.472LysGly: 2.472 ± 0.043
0.703LysHis: 0.703 ± 0.019
1.499LysIle: 1.499 ± 0.04
1.451LysLys: 1.451 ± 0.04
4.167LysLeu: 4.167 ± 0.063
0.791LysMet: 0.791 ± 0.024
1.065LysAsn: 1.065 ± 0.032
2.395LysPro: 2.395 ± 0.046
1.563LysGln: 1.563 ± 0.034
2.327LysArg: 2.327 ± 0.038
2.102LysSer: 2.102 ± 0.04
1.958LysThr: 1.958 ± 0.035
2.438LysVal: 2.438 ± 0.05
0.333LysTrp: 0.333 ± 0.015
0.631LysTyr: 0.631 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
16.239LeuAla: 16.239 ± 0.13
1.046LeuCys: 1.046 ± 0.025
6.203LeuAsp: 6.203 ± 0.072
5.166LeuGlu: 5.166 ± 0.075
3.359LeuPhe: 3.359 ± 0.056
9.5LeuGly: 9.5 ± 0.11
2.357LeuHis: 2.357 ± 0.04
4.653LeuIle: 4.653 ± 0.06
4.114LeuLys: 4.114 ± 0.055
13.116LeuLeu: 13.116 ± 0.163
2.803LeuMet: 2.803 ± 0.051
3.418LeuAsn: 3.418 ± 0.066
6.394LeuPro: 6.394 ± 0.081
5.594LeuGln: 5.594 ± 0.105
8.521LeuArg: 8.521 ± 0.114
8.172LeuSer: 8.172 ± 0.114
5.279LeuThr: 5.279 ± 0.092
7.325LeuVal: 7.325 ± 0.087
1.457LeuTrp: 1.457 ± 0.035
1.94LeuTyr: 1.94 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.076MetAla: 3.076 ± 0.051
0.164MetCys: 0.164 ± 0.011
1.098MetAsp: 1.098 ± 0.03
0.95MetGlu: 0.95 ± 0.032
0.711MetPhe: 0.711 ± 0.024
1.897MetGly: 1.897 ± 0.041
0.458MetHis: 0.458 ± 0.018
0.895MetIle: 0.895 ± 0.031
0.918MetLys: 0.918 ± 0.024
2.746MetLeu: 2.746 ± 0.049
0.575MetMet: 0.575 ± 0.022
0.829MetAsn: 0.829 ± 0.025
1.496MetPro: 1.496 ± 0.033
1.161MetGln: 1.161 ± 0.026
1.648MetArg: 1.648 ± 0.031
1.855MetSer: 1.855 ± 0.037
1.306MetThr: 1.306 ± 0.034
1.605MetVal: 1.605 ± 0.04
0.216MetTrp: 0.216 ± 0.013
0.315MetTyr: 0.315 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.513AsnAla: 3.513 ± 0.059
0.251AsnCys: 0.251 ± 0.013
1.263AsnAsp: 1.263 ± 0.029
1.36AsnGlu: 1.36 ± 0.035
1.058AsnPhe: 1.058 ± 0.033
2.369AsnGly: 2.369 ± 0.058
0.528AsnHis: 0.528 ± 0.018
1.204AsnIle: 1.204 ± 0.034
1.056AsnLys: 1.056 ± 0.033
2.978AsnLeu: 2.978 ± 0.052
0.577AsnMet: 0.577 ± 0.021
0.928AsnAsn: 0.928 ± 0.045
1.748AsnPro: 1.748 ± 0.04
1.126AsnGln: 1.126 ± 0.035
1.522AsnArg: 1.522 ± 0.033
1.652AsnSer: 1.652 ± 0.052
1.525AsnThr: 1.525 ± 0.047
1.802AsnVal: 1.802 ± 0.039
0.465AsnTrp: 0.465 ± 0.016
0.741AsnTyr: 0.741 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.121ProAla: 7.121 ± 0.1
0.335ProCys: 0.335 ± 0.015
2.681ProAsp: 2.681 ± 0.049
3.331ProGlu: 3.331 ± 0.053
1.62ProPhe: 1.62 ± 0.035
4.356ProGly: 4.356 ± 0.054
0.944ProHis: 0.944 ± 0.026
1.767ProIle: 1.767 ± 0.042
1.688ProLys: 1.688 ± 0.039
5.372ProLeu: 5.372 ± 0.063
1.233ProMet: 1.233 ± 0.029
1.308ProAsn: 1.308 ± 0.032
2.286ProPro: 2.286 ± 0.051
2.374ProGln: 2.374 ± 0.044
2.564ProArg: 2.564 ± 0.053
2.914ProSer: 2.914 ± 0.056
2.384ProThr: 2.384 ± 0.075
3.751ProVal: 3.751 ± 0.062
0.741ProTrp: 0.741 ± 0.025
0.987ProTyr: 0.987 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
7.996GlnAla: 7.996 ± 0.133
0.328GlnCys: 0.328 ± 0.016
2.035GlnAsp: 2.035 ± 0.041
1.865GlnGlu: 1.865 ± 0.043
1.468GlnPhe: 1.468 ± 0.033
3.786GlnGly: 3.786 ± 0.067
1.067GlnHis: 1.067 ± 0.029
2.183GlnIle: 2.183 ± 0.079
1.1GlnLys: 1.1 ± 0.029
5.606GlnLeu: 5.606 ± 0.101
1.134GlnMet: 1.134 ± 0.029
0.899GlnAsn: 0.899 ± 0.034
2.404GlnPro: 2.404 ± 0.05
2.686GlnGln: 2.686 ± 0.057
3.847GlnArg: 3.847 ± 0.06
2.549GlnSer: 2.549 ± 0.057
2.262GlnThr: 2.262 ± 0.054
3.416GlnVal: 3.416 ± 0.056
0.755GlnTrp: 0.755 ± 0.025
0.772GlnTyr: 0.772 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
7.394ArgAla: 7.394 ± 0.088
0.599ArgCys: 0.599 ± 0.023
3.154ArgAsp: 3.154 ± 0.054
3.981ArgGlu: 3.981 ± 0.069
2.595ArgPhe: 2.595 ± 0.046
4.347ArgGly: 4.347 ± 0.063
1.626ArgHis: 1.626 ± 0.04
3.053ArgIle: 3.053 ± 0.047
1.867ArgLys: 1.867 ± 0.039
8.006ArgLeu: 8.006 ± 0.093
1.756ArgMet: 1.756 ± 0.038
1.743ArgAsn: 1.743 ± 0.037
2.966ArgPro: 2.966 ± 0.048
3.234ArgGln: 3.234 ± 0.06
4.536ArgArg: 4.536 ± 0.07
3.763ArgSer: 3.763 ± 0.058
2.3ArgThr: 2.3 ± 0.039
4.612ArgVal: 4.612 ± 0.062
1.173ArgTrp: 1.173 ± 0.034
1.708ArgTyr: 1.708 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.734SerAla: 7.734 ± 0.097
0.506SerCys: 0.506 ± 0.019
2.844SerAsp: 2.844 ± 0.059
2.972SerGlu: 2.972 ± 0.058
2.319SerPhe: 2.319 ± 0.041
5.627SerGly: 5.627 ± 0.105
1.232SerHis: 1.232 ± 0.031
2.495SerIle: 2.495 ± 0.048
2.07SerLys: 2.07 ± 0.044
7.138SerLeu: 7.138 ± 0.097
1.377SerMet: 1.377 ± 0.03
1.807SerAsn: 1.807 ± 0.054
3.016SerPro: 3.016 ± 0.046
2.66SerGln: 2.66 ± 0.057
3.573SerArg: 3.573 ± 0.05
4.078SerSer: 4.078 ± 0.084
3.097SerThr: 3.097 ± 0.064
4.039SerVal: 4.039 ± 0.051
0.915SerTrp: 0.915 ± 0.029
1.522SerTyr: 1.522 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.712ThrAla: 5.712 ± 0.086
0.345ThrCys: 0.345 ± 0.018
2.101ThrAsp: 2.101 ± 0.055
2.335ThrGlu: 2.335 ± 0.043
1.414ThrPhe: 1.414 ± 0.037
4.209ThrGly: 4.209 ± 0.069
0.959ThrHis: 0.959 ± 0.028
1.823ThrIle: 1.823 ± 0.041
1.217ThrLys: 1.217 ± 0.036
6.07ThrLeu: 6.07 ± 0.078
0.949ThrMet: 0.949 ± 0.028
1.149ThrAsn: 1.149 ± 0.033
3.289ThrPro: 3.289 ± 0.089
2.239ThrGln: 2.239 ± 0.041
2.712ThrArg: 2.712 ± 0.045
2.577ThrSer: 2.577 ± 0.055
2.336ThrThr: 2.336 ± 0.068
3.812ThrVal: 3.812 ± 0.063
0.592ThrTrp: 0.592 ± 0.022
0.902ThrTyr: 0.902 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
8.694ValAla: 8.694 ± 0.091
0.631ValCys: 0.631 ± 0.022
3.734ValAsp: 3.734 ± 0.059
3.755ValGlu: 3.755 ± 0.053
2.485ValPhe: 2.485 ± 0.048
5.288ValGly: 5.288 ± 0.066
1.377ValHis: 1.377 ± 0.037
3.032ValIle: 3.032 ± 0.049
2.474ValLys: 2.474 ± 0.052
8.507ValLeu: 8.507 ± 0.084
1.838ValMet: 1.838 ± 0.04
2.139ValAsn: 2.139 ± 0.045
3.271ValPro: 3.271 ± 0.048
3.17ValGln: 3.17 ± 0.059
4.21ValArg: 4.21 ± 0.061
4.29ValSer: 4.29 ± 0.063
3.452ValThr: 3.452 ± 0.059
5.188ValVal: 5.188 ± 0.075
0.978ValTrp: 0.978 ± 0.028
1.338ValTyr: 1.338 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.659TrpAla: 1.659 ± 0.041
0.153TrpCys: 0.153 ± 0.01
0.631TrpAsp: 0.631 ± 0.021
0.53TrpGlu: 0.53 ± 0.021
0.534TrpPhe: 0.534 ± 0.022
0.981TrpGly: 0.981 ± 0.031
0.352TrpHis: 0.352 ± 0.015
0.577TrpIle: 0.577 ± 0.021
0.378TrpLys: 0.378 ± 0.015
2.25TrpLeu: 2.25 ± 0.049
0.426TrpMet: 0.426 ± 0.019
0.376TrpAsn: 0.376 ± 0.017
0.75TrpPro: 0.75 ± 0.028
0.957TrpGln: 0.957 ± 0.025
1.289TrpArg: 1.289 ± 0.035
0.823TrpSer: 0.823 ± 0.024
0.712TrpThr: 0.712 ± 0.023
1.075TrpVal: 1.075 ± 0.032
0.261TrpTrp: 0.261 ± 0.014
0.272TrpTyr: 0.272 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.601TyrAla: 2.601 ± 0.051
0.223TyrCys: 0.223 ± 0.013
1.002TyrAsp: 1.002 ± 0.028
1.004TyrGlu: 1.004 ± 0.028
0.912TyrPhe: 0.912 ± 0.028
1.906TyrGly: 1.906 ± 0.042
0.373TyrHis: 0.373 ± 0.014
0.758TyrIle: 0.758 ± 0.023
0.691TyrLys: 0.691 ± 0.023
2.404TyrLeu: 2.404 ± 0.043
0.383TyrMet: 0.383 ± 0.017
0.569TyrAsn: 0.569 ± 0.021
0.988TyrPro: 0.988 ± 0.026
0.97TyrGln: 0.97 ± 0.025
1.592TyrArg: 1.592 ± 0.034
1.213TyrSer: 1.213 ± 0.031
1.097TyrThr: 1.097 ± 0.031
1.39TyrVal: 1.39 ± 0.03
0.346TyrTrp: 0.346 ± 0.016
0.506TyrTyr: 0.506 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4190 proteins (1461542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski