Amino acid dipepetide frequency for Cronobacter phage ENT39118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.068AlaAla: 12.068 ± 1.869
0.823AlaCys: 0.823 ± 0.299
6.217AlaAsp: 6.217 ± 0.973
6.4AlaGlu: 6.4 ± 0.701
3.84AlaPhe: 3.84 ± 0.448
9.6AlaGly: 9.6 ± 1.017
2.103AlaHis: 2.103 ± 0.431
5.12AlaIle: 5.12 ± 0.633
4.023AlaLys: 4.023 ± 0.628
9.691AlaLeu: 9.691 ± 1.009
2.834AlaMet: 2.834 ± 0.692
4.937AlaAsn: 4.937 ± 0.792
3.291AlaPro: 3.291 ± 0.625
5.303AlaGln: 5.303 ± 1.179
6.034AlaArg: 6.034 ± 0.736
6.4AlaSer: 6.4 ± 1.7
5.943AlaThr: 5.943 ± 0.999
7.04AlaVal: 7.04 ± 1.0
1.646AlaTrp: 1.646 ± 0.424
1.646AlaTyr: 1.646 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.823CysAla: 0.823 ± 0.301
0.183CysCys: 0.183 ± 0.129
0.914CysAsp: 0.914 ± 0.305
0.914CysGlu: 0.914 ± 0.307
0.091CysPhe: 0.091 ± 0.102
1.371CysGly: 1.371 ± 0.412
0.274CysHis: 0.274 ± 0.131
0.183CysIle: 0.183 ± 0.108
0.549CysLys: 0.549 ± 0.206
0.823CysLeu: 0.823 ± 0.249
0.274CysMet: 0.274 ± 0.153
0.183CysAsn: 0.183 ± 0.123
0.366CysPro: 0.366 ± 0.175
0.091CysGln: 0.091 ± 0.08
1.189CysArg: 1.189 ± 0.408
0.914CysSer: 0.914 ± 0.38
0.64CysThr: 0.64 ± 0.28
0.549CysVal: 0.549 ± 0.215
0.091CysTrp: 0.091 ± 0.093
0.366CysTyr: 0.366 ± 0.206
0.0CysXaa: 0.0 ± 0.0
Asp
6.034AspAla: 6.034 ± 0.759
0.457AspCys: 0.457 ± 0.221
2.286AspAsp: 2.286 ± 0.551
3.291AspGlu: 3.291 ± 0.519
1.737AspPhe: 1.737 ± 0.474
5.394AspGly: 5.394 ± 0.888
0.731AspHis: 0.731 ± 0.297
2.926AspIle: 2.926 ± 0.398
2.56AspLys: 2.56 ± 0.62
5.851AspLeu: 5.851 ± 0.587
2.011AspMet: 2.011 ± 0.389
3.2AspAsn: 3.2 ± 0.49
1.646AspPro: 1.646 ± 0.405
2.194AspGln: 2.194 ± 0.38
2.743AspArg: 2.743 ± 0.458
3.2AspSer: 3.2 ± 0.585
2.651AspThr: 2.651 ± 0.589
5.12AspVal: 5.12 ± 0.987
1.463AspTrp: 1.463 ± 0.354
1.828AspTyr: 1.828 ± 0.431
0.0AspXaa: 0.0 ± 0.0
Glu
6.765GluAla: 6.765 ± 1.066
0.731GluCys: 0.731 ± 0.225
2.286GluAsp: 2.286 ± 0.457
4.206GluGlu: 4.206 ± 0.807
2.468GluPhe: 2.468 ± 0.368
2.926GluGly: 2.926 ± 0.706
1.463GluHis: 1.463 ± 0.459
3.657GluIle: 3.657 ± 0.572
3.383GluLys: 3.383 ± 0.417
5.028GluLeu: 5.028 ± 0.652
1.463GluMet: 1.463 ± 0.387
3.017GluAsn: 3.017 ± 0.398
2.194GluPro: 2.194 ± 0.45
3.291GluGln: 3.291 ± 0.521
4.206GluArg: 4.206 ± 0.533
2.56GluSer: 2.56 ± 0.544
2.926GluThr: 2.926 ± 0.43
3.474GluVal: 3.474 ± 0.504
0.64GluTrp: 0.64 ± 0.345
2.011GluTyr: 2.011 ± 0.376
0.0GluXaa: 0.0 ± 0.0
Phe
2.834PheAla: 2.834 ± 0.491
0.457PheCys: 0.457 ± 0.274
2.56PheAsp: 2.56 ± 0.482
2.194PheGlu: 2.194 ± 0.355
1.097PhePhe: 1.097 ± 0.254
2.468PheGly: 2.468 ± 0.517
0.274PheHis: 0.274 ± 0.148
2.103PheIle: 2.103 ± 0.489
1.737PheLys: 1.737 ± 0.459
1.554PheLeu: 1.554 ± 0.341
0.823PheMet: 0.823 ± 0.26
2.011PheAsn: 2.011 ± 0.37
2.011PhePro: 2.011 ± 0.462
1.189PheGln: 1.189 ± 0.275
2.377PheArg: 2.377 ± 0.484
2.743PheSer: 2.743 ± 0.574
2.651PheThr: 2.651 ± 0.523
1.646PheVal: 1.646 ± 0.345
0.549PheTrp: 0.549 ± 0.214
1.646PheTyr: 1.646 ± 0.377
0.0PheXaa: 0.0 ± 0.0
Gly
7.405GlyAla: 7.405 ± 1.241
0.914GlyCys: 0.914 ± 0.256
5.028GlyAsp: 5.028 ± 0.982
4.114GlyGlu: 4.114 ± 0.601
2.926GlyPhe: 2.926 ± 0.562
6.765GlyGly: 6.765 ± 0.92
1.189GlyHis: 1.189 ± 0.385
4.663GlyIle: 4.663 ± 0.682
4.845GlyLys: 4.845 ± 0.804
6.765GlyLeu: 6.765 ± 0.931
2.103GlyMet: 2.103 ± 0.353
3.931GlyAsn: 3.931 ± 0.418
1.828GlyPro: 1.828 ± 0.467
2.926GlyGln: 2.926 ± 0.475
5.028GlyArg: 5.028 ± 0.825
5.394GlySer: 5.394 ± 0.873
4.937GlyThr: 4.937 ± 0.579
5.943GlyVal: 5.943 ± 0.846
0.914GlyTrp: 0.914 ± 0.291
1.828GlyTyr: 1.828 ± 0.471
0.0GlyXaa: 0.0 ± 0.0
His
1.737HisAla: 1.737 ± 0.475
0.366HisCys: 0.366 ± 0.162
0.64HisAsp: 0.64 ± 0.434
1.189HisGlu: 1.189 ± 0.312
0.549HisPhe: 0.549 ± 0.209
1.189HisGly: 1.189 ± 0.337
0.457HisHis: 0.457 ± 0.205
1.189HisIle: 1.189 ± 0.339
1.006HisLys: 1.006 ± 0.294
1.92HisLeu: 1.92 ± 0.661
0.274HisMet: 0.274 ± 0.172
0.731HisAsn: 0.731 ± 0.285
1.189HisPro: 1.189 ± 0.383
0.731HisGln: 0.731 ± 0.239
1.737HisArg: 1.737 ± 0.43
1.189HisSer: 1.189 ± 0.379
0.549HisThr: 0.549 ± 0.176
0.731HisVal: 0.731 ± 0.302
0.274HisTrp: 0.274 ± 0.157
0.64HisTyr: 0.64 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
6.948IleAla: 6.948 ± 0.728
0.366IleCys: 0.366 ± 0.205
3.566IleAsp: 3.566 ± 0.533
3.291IleGlu: 3.291 ± 0.54
1.463IlePhe: 1.463 ± 0.344
3.748IleGly: 3.748 ± 0.77
1.463IleHis: 1.463 ± 0.362
2.377IleIle: 2.377 ± 0.431
3.017IleLys: 3.017 ± 0.825
2.743IleLeu: 2.743 ± 0.629
0.64IleMet: 0.64 ± 0.275
1.92IleAsn: 1.92 ± 0.497
2.011IlePro: 2.011 ± 0.515
2.011IleGln: 2.011 ± 0.499
2.468IleArg: 2.468 ± 0.594
4.297IleSer: 4.297 ± 0.617
4.206IleThr: 4.206 ± 0.433
3.748IleVal: 3.748 ± 0.702
0.731IleTrp: 0.731 ± 0.225
1.92IleTyr: 1.92 ± 0.406
0.0IleXaa: 0.0 ± 0.0
Lys
5.303LysAla: 5.303 ± 0.849
0.457LysCys: 0.457 ± 0.202
4.206LysAsp: 4.206 ± 0.714
2.011LysGlu: 2.011 ± 0.408
1.189LysPhe: 1.189 ± 0.33
3.2LysGly: 3.2 ± 0.523
1.463LysHis: 1.463 ± 0.497
2.194LysIle: 2.194 ± 0.42
3.017LysLys: 3.017 ± 0.7
3.931LysLeu: 3.931 ± 0.612
1.737LysMet: 1.737 ± 0.51
2.286LysAsn: 2.286 ± 0.441
2.377LysPro: 2.377 ± 0.599
2.194LysGln: 2.194 ± 0.43
2.194LysArg: 2.194 ± 0.461
3.108LysSer: 3.108 ± 0.64
3.383LysThr: 3.383 ± 0.458
2.56LysVal: 2.56 ± 0.551
0.731LysTrp: 0.731 ± 0.256
1.28LysTyr: 1.28 ± 0.403
0.0LysXaa: 0.0 ± 0.0
Leu
8.777LeuAla: 8.777 ± 0.805
1.28LeuCys: 1.28 ± 0.329
5.211LeuAsp: 5.211 ± 0.574
4.663LeuGlu: 4.663 ± 0.752
1.737LeuPhe: 1.737 ± 0.362
4.845LeuGly: 4.845 ± 0.697
1.006LeuHis: 1.006 ± 0.388
4.663LeuIle: 4.663 ± 0.756
4.388LeuLys: 4.388 ± 0.558
6.125LeuLeu: 6.125 ± 0.736
1.371LeuMet: 1.371 ± 0.389
3.84LeuAsn: 3.84 ± 0.505
3.657LeuPro: 3.657 ± 0.532
3.657LeuGln: 3.657 ± 0.561
7.314LeuArg: 7.314 ± 0.768
6.674LeuSer: 6.674 ± 0.895
5.577LeuThr: 5.577 ± 0.643
5.211LeuVal: 5.211 ± 0.92
0.457LeuTrp: 0.457 ± 0.165
2.743LeuTyr: 2.743 ± 0.482
0.0LeuXaa: 0.0 ± 0.0
Met
2.651MetAla: 2.651 ± 0.495
0.366MetCys: 0.366 ± 0.171
1.371MetAsp: 1.371 ± 0.398
1.554MetGlu: 1.554 ± 0.328
0.823MetPhe: 0.823 ± 0.295
1.28MetGly: 1.28 ± 0.445
0.366MetHis: 0.366 ± 0.161
0.64MetIle: 0.64 ± 0.232
1.646MetLys: 1.646 ± 0.468
2.286MetLeu: 2.286 ± 0.571
0.549MetMet: 0.549 ± 0.227
0.823MetAsn: 0.823 ± 0.261
1.006MetPro: 1.006 ± 0.284
1.28MetGln: 1.28 ± 0.305
1.371MetArg: 1.371 ± 0.371
1.554MetSer: 1.554 ± 0.392
1.828MetThr: 1.828 ± 0.374
1.006MetVal: 1.006 ± 0.289
0.183MetTrp: 0.183 ± 0.139
0.274MetTyr: 0.274 ± 0.154
0.0MetXaa: 0.0 ± 0.0
Asn
5.12AsnAla: 5.12 ± 0.81
0.366AsnCys: 0.366 ± 0.198
2.194AsnAsp: 2.194 ± 0.408
2.286AsnGlu: 2.286 ± 0.345
1.371AsnPhe: 1.371 ± 0.418
4.845AsnGly: 4.845 ± 0.825
1.189AsnHis: 1.189 ± 0.317
2.834AsnIle: 2.834 ± 0.45
1.554AsnLys: 1.554 ± 0.469
2.743AsnLeu: 2.743 ± 0.498
0.823AsnMet: 0.823 ± 0.285
2.011AsnAsn: 2.011 ± 0.457
2.103AsnPro: 2.103 ± 0.47
2.103AsnGln: 2.103 ± 0.413
1.371AsnArg: 1.371 ± 0.29
1.828AsnSer: 1.828 ± 0.406
2.56AsnThr: 2.56 ± 0.59
2.468AsnVal: 2.468 ± 0.41
1.28AsnTrp: 1.28 ± 0.35
1.463AsnTyr: 1.463 ± 0.342
0.0AsnXaa: 0.0 ± 0.0
Pro
4.48ProAla: 4.48 ± 0.621
0.64ProCys: 0.64 ± 0.282
2.194ProAsp: 2.194 ± 0.712
3.017ProGlu: 3.017 ± 0.571
1.371ProPhe: 1.371 ± 0.398
3.748ProGly: 3.748 ± 0.643
1.28ProHis: 1.28 ± 0.322
1.646ProIle: 1.646 ± 0.448
1.463ProLys: 1.463 ± 0.489
3.2ProLeu: 3.2 ± 0.565
1.006ProMet: 1.006 ± 0.379
0.731ProAsn: 0.731 ± 0.292
1.554ProPro: 1.554 ± 0.459
1.828ProGln: 1.828 ± 0.367
2.286ProArg: 2.286 ± 0.519
2.103ProSer: 2.103 ± 0.479
2.377ProThr: 2.377 ± 0.542
3.84ProVal: 3.84 ± 0.727
0.64ProTrp: 0.64 ± 0.233
1.371ProTyr: 1.371 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
4.663GlnAla: 4.663 ± 0.707
0.274GlnCys: 0.274 ± 0.153
1.737GlnAsp: 1.737 ± 0.299
1.92GlnGlu: 1.92 ± 0.362
1.828GlnPhe: 1.828 ± 0.457
2.56GlnGly: 2.56 ± 0.573
1.189GlnHis: 1.189 ± 0.346
3.2GlnIle: 3.2 ± 0.629
2.286GlnLys: 2.286 ± 0.691
4.48GlnLeu: 4.48 ± 0.776
0.64GlnMet: 0.64 ± 0.281
1.737GlnAsn: 1.737 ± 0.326
1.828GlnPro: 1.828 ± 0.439
2.834GlnGln: 2.834 ± 0.664
3.931GlnArg: 3.931 ± 0.718
2.834GlnSer: 2.834 ± 0.537
2.56GlnThr: 2.56 ± 0.375
3.108GlnVal: 3.108 ± 0.726
0.549GlnTrp: 0.549 ± 0.187
1.463GlnTyr: 1.463 ± 0.434
0.0GlnXaa: 0.0 ± 0.0
Arg
5.485ArgAla: 5.485 ± 0.665
0.549ArgCys: 0.549 ± 0.292
4.388ArgAsp: 4.388 ± 0.688
4.663ArgGlu: 4.663 ± 0.749
3.017ArgPhe: 3.017 ± 0.544
4.206ArgGly: 4.206 ± 0.562
0.823ArgHis: 0.823 ± 0.281
3.566ArgIle: 3.566 ± 0.631
3.108ArgLys: 3.108 ± 0.624
6.4ArgLeu: 6.4 ± 0.737
1.554ArgMet: 1.554 ± 0.374
2.56ArgAsn: 2.56 ± 0.485
1.463ArgPro: 1.463 ± 0.295
2.651ArgGln: 2.651 ± 0.295
3.566ArgArg: 3.566 ± 0.619
2.743ArgSer: 2.743 ± 0.506
3.474ArgThr: 3.474 ± 0.71
4.206ArgVal: 4.206 ± 0.884
1.28ArgTrp: 1.28 ± 0.302
2.651ArgTyr: 2.651 ± 0.432
0.0ArgXaa: 0.0 ± 0.0
Ser
7.497SerAla: 7.497 ± 1.163
0.366SerCys: 0.366 ± 0.171
3.383SerAsp: 3.383 ± 0.704
3.017SerGlu: 3.017 ± 0.436
2.103SerPhe: 2.103 ± 0.42
6.583SerGly: 6.583 ± 1.085
0.64SerHis: 0.64 ± 0.225
2.56SerIle: 2.56 ± 0.499
2.651SerLys: 2.651 ± 0.578
5.577SerLeu: 5.577 ± 0.821
1.189SerMet: 1.189 ± 0.319
2.286SerAsn: 2.286 ± 0.414
3.017SerPro: 3.017 ± 0.562
2.926SerGln: 2.926 ± 0.563
3.931SerArg: 3.931 ± 0.515
3.84SerSer: 3.84 ± 0.821
3.84SerThr: 3.84 ± 0.642
4.663SerVal: 4.663 ± 0.744
1.189SerTrp: 1.189 ± 0.342
1.92SerTyr: 1.92 ± 0.362
0.0SerXaa: 0.0 ± 0.0
Thr
5.668ThrAla: 5.668 ± 0.78
0.64ThrCys: 0.64 ± 0.299
3.566ThrAsp: 3.566 ± 0.468
3.108ThrGlu: 3.108 ± 0.571
2.468ThrPhe: 2.468 ± 0.527
6.217ThrGly: 6.217 ± 0.623
0.457ThrHis: 0.457 ± 0.184
4.114ThrIle: 4.114 ± 0.865
2.286ThrLys: 2.286 ± 0.617
5.028ThrLeu: 5.028 ± 0.614
0.823ThrMet: 0.823 ± 0.29
2.011ThrAsn: 2.011 ± 0.536
4.023ThrPro: 4.023 ± 0.551
3.657ThrGln: 3.657 ± 1.104
2.926ThrArg: 2.926 ± 0.47
4.023ThrSer: 4.023 ± 0.555
3.566ThrThr: 3.566 ± 0.637
3.474ThrVal: 3.474 ± 0.413
1.371ThrTrp: 1.371 ± 0.298
1.28ThrTyr: 1.28 ± 0.447
0.0ThrXaa: 0.0 ± 0.0
Val
6.217ValAla: 6.217 ± 0.807
0.823ValCys: 0.823 ± 0.288
2.926ValAsp: 2.926 ± 0.544
4.297ValGlu: 4.297 ± 0.499
2.651ValPhe: 2.651 ± 0.316
4.937ValGly: 4.937 ± 0.735
0.914ValHis: 0.914 ± 0.27
3.383ValIle: 3.383 ± 0.66
3.566ValLys: 3.566 ± 0.486
5.76ValLeu: 5.76 ± 0.837
1.828ValMet: 1.828 ± 0.403
2.743ValAsn: 2.743 ± 0.564
2.834ValPro: 2.834 ± 0.61
2.743ValGln: 2.743 ± 0.526
4.206ValArg: 4.206 ± 0.762
4.297ValSer: 4.297 ± 0.651
4.206ValThr: 4.206 ± 0.773
4.663ValVal: 4.663 ± 0.796
1.371ValTrp: 1.371 ± 0.344
2.103ValTyr: 2.103 ± 0.313
0.0ValXaa: 0.0 ± 0.0
Trp
1.28TrpAla: 1.28 ± 0.396
0.549TrpCys: 0.549 ± 0.215
1.097TrpAsp: 1.097 ± 0.256
1.097TrpGlu: 1.097 ± 0.296
0.823TrpPhe: 0.823 ± 0.326
0.914TrpGly: 0.914 ± 0.205
0.457TrpHis: 0.457 ± 0.22
0.366TrpIle: 0.366 ± 0.165
0.823TrpLys: 0.823 ± 0.288
1.463TrpLeu: 1.463 ± 0.352
0.274TrpMet: 0.274 ± 0.15
0.731TrpAsn: 0.731 ± 0.27
0.823TrpPro: 0.823 ± 0.204
0.731TrpGln: 0.731 ± 0.279
1.189TrpArg: 1.189 ± 0.246
0.823TrpSer: 0.823 ± 0.287
0.914TrpThr: 0.914 ± 0.255
1.097TrpVal: 1.097 ± 0.25
0.731TrpTrp: 0.731 ± 0.236
0.274TrpTyr: 0.274 ± 0.129
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.2TyrAla: 3.2 ± 0.446
0.183TyrCys: 0.183 ± 0.128
1.554TyrAsp: 1.554 ± 0.301
1.463TyrGlu: 1.463 ± 0.288
1.371TyrPhe: 1.371 ± 0.413
2.743TyrGly: 2.743 ± 0.479
0.549TyrHis: 0.549 ± 0.25
1.554TyrIle: 1.554 ± 0.255
0.914TyrLys: 0.914 ± 0.225
1.828TyrLeu: 1.828 ± 0.43
0.549TyrMet: 0.549 ± 0.217
0.823TyrAsn: 0.823 ± 0.238
1.554TyrPro: 1.554 ± 0.427
1.28TyrGln: 1.28 ± 0.344
2.286TyrArg: 2.286 ± 0.62
2.651TyrSer: 2.651 ± 0.513
1.92TyrThr: 1.92 ± 0.273
1.92TyrVal: 1.92 ± 0.46
0.366TyrTrp: 0.366 ± 0.151
1.006TyrTyr: 1.006 ± 0.284
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (10939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski