Amino acid dipepetide frequency for Candidatus Gallionella acididurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.56AlaAla: 12.56 ± 0.149	1.089AlaCys: 1.089 ± 0.034	5.413AlaAsp: 5.413 ± 0.067	6.327AlaGlu: 6.327 ± 0.102	3.428AlaPhe: 3.428 ± 0.063	8.665AlaGly: 8.665 ± 0.1	2.392AlaHis: 2.392 ± 0.048	5.872AlaIle: 5.872 ± 0.088	4.587AlaLys: 4.587 ± 0.083	11.559AlaLeu: 11.559 ± 0.137	3.255AlaMet: 3.255 ± 0.063	3.423AlaAsn: 3.423 ± 0.07	3.896AlaPro: 3.896 ± 0.066	4.715AlaGln: 4.715 ± 0.086	6.436AlaArg: 6.436 ± 0.097	5.603AlaSer: 5.603 ± 0.076	5.286AlaThr: 5.286 ± 0.075	7.316AlaVal: 7.316 ± 0.089	1.261AlaTrp: 1.261 ± 0.037	2.469AlaTyr: 2.469 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.051CysAla: 1.051 ± 0.034	0.16CysCys: 0.16 ± 0.014	0.529CysAsp: 0.529 ± 0.022	0.525CysGlu: 0.525 ± 0.021	0.356CysPhe: 0.356 ± 0.021	1.023CysGly: 1.023 ± 0.039	0.327CysHis: 0.327 ± 0.021	0.499CysIle: 0.499 ± 0.023	0.386CysLys: 0.386 ± 0.018	0.801CysLeu: 0.801 ± 0.03	0.211CysMet: 0.211 ± 0.016	0.384CysAsn: 0.384 ± 0.016	0.484CysPro: 0.484 ± 0.027	0.283CysGln: 0.283 ± 0.016	0.582CysArg: 0.582 ± 0.024	0.629CysSer: 0.629 ± 0.026	0.467CysThr: 0.467 ± 0.026	0.696CysVal: 0.696 ± 0.025	0.129CysTrp: 0.129 ± 0.013	0.291CysTyr: 0.291 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.635AspAla: 5.635 ± 0.076	0.503AspCys: 0.503 ± 0.023	2.623AspAsp: 2.623 ± 0.059	3.395AspGlu: 3.395 ± 0.063	2.263AspPhe: 2.263 ± 0.054	3.885AspGly: 3.885 ± 0.061	1.092AspHis: 1.092 ± 0.038	3.353AspIle: 3.353 ± 0.061	2.475AspLys: 2.475 ± 0.055	4.952AspLeu: 4.952 ± 0.084	1.48AspMet: 1.48 ± 0.038	1.708AspAsn: 1.708 ± 0.035	2.34AspPro: 2.34 ± 0.049	1.764AspGln: 1.764 ± 0.047	2.818AspArg: 2.818 ± 0.061	2.772AspSer: 2.772 ± 0.054	2.668AspThr: 2.668 ± 0.055	3.553AspVal: 3.553 ± 0.061	0.86AspTrp: 0.86 ± 0.037	1.689AspTyr: 1.689 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.663GluAla: 5.663 ± 0.096	0.441GluCys: 0.441 ± 0.023	2.32GluAsp: 2.32 ± 0.047	2.966GluGlu: 2.966 ± 0.068	2.204GluPhe: 2.204 ± 0.043	3.163GluGly: 3.163 ± 0.066	1.511GluHis: 1.511 ± 0.043	3.823GluIle: 3.823 ± 0.068	3.08GluLys: 3.08 ± 0.063	6.129GluLeu: 6.129 ± 0.096	1.682GluMet: 1.682 ± 0.039	2.094GluAsn: 2.094 ± 0.046	1.987GluPro: 1.987 ± 0.043	3.171GluGln: 3.171 ± 0.069	3.712GluArg: 3.712 ± 0.066	2.975GluSer: 2.975 ± 0.06	2.883GluThr: 2.883 ± 0.054	3.954GluVal: 3.954 ± 0.069	0.74GluTrp: 0.74 ± 0.025	1.459GluTyr: 1.459 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.95PheAla: 3.95 ± 0.063	0.443PheCys: 0.443 ± 0.022	2.39PheAsp: 2.39 ± 0.048	2.011PheGlu: 2.011 ± 0.045	1.655PhePhe: 1.655 ± 0.049	3.291PheGly: 3.291 ± 0.057	0.849PheHis: 0.849 ± 0.03	2.149PheIle: 2.149 ± 0.045	1.5PheLys: 1.5 ± 0.035	3.327PheLeu: 3.327 ± 0.064	0.971PheMet: 0.971 ± 0.033	1.481PheAsn: 1.481 ± 0.042	1.662PhePro: 1.662 ± 0.039	1.127PheGln: 1.127 ± 0.034	2.015PheArg: 2.015 ± 0.047	2.797PheSer: 2.797 ± 0.061	1.97PheThr: 1.97 ± 0.043	2.833PheVal: 2.833 ± 0.054	0.521PheTrp: 0.521 ± 0.026	1.107PheTyr: 1.107 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.872GlyAla: 6.872 ± 0.084	0.894GlyCys: 0.894 ± 0.032	3.722GlyAsp: 3.722 ± 0.063	4.255GlyGlu: 4.255 ± 0.07	3.171GlyPhe: 3.171 ± 0.065	5.746GlyGly: 5.746 ± 0.097	1.77GlyHis: 1.77 ± 0.041	5.11GlyIle: 5.11 ± 0.078	4.453GlyLys: 4.453 ± 0.079	7.724GlyLeu: 7.724 ± 0.087	2.63GlyMet: 2.63 ± 0.058	2.915GlyAsn: 2.915 ± 0.064	1.775GlyPro: 1.775 ± 0.045	2.826GlyGln: 2.826 ± 0.06	4.306GlyArg: 4.306 ± 0.066	4.542GlySer: 4.542 ± 0.075	3.975GlyThr: 3.975 ± 0.079	5.763GlyVal: 5.763 ± 0.076	1.211GlyTrp: 1.211 ± 0.035	2.662GlyTyr: 2.662 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.504HisAla: 2.504 ± 0.048	0.29HisCys: 0.29 ± 0.019	1.324HisAsp: 1.324 ± 0.041	1.321HisGlu: 1.321 ± 0.036	1.04HisPhe: 1.04 ± 0.032	2.022HisGly: 2.022 ± 0.053	0.713HisHis: 0.713 ± 0.031	1.387HisIle: 1.387 ± 0.033	0.892HisLys: 0.892 ± 0.029	2.502HisLeu: 2.502 ± 0.05	0.523HisMet: 0.523 ± 0.025	0.794HisAsn: 0.794 ± 0.026	1.579HisPro: 1.579 ± 0.041	0.935HisGln: 0.935 ± 0.032	1.351HisArg: 1.351 ± 0.037	1.343HisSer: 1.343 ± 0.044	1.162HisThr: 1.162 ± 0.035	1.406HisVal: 1.406 ± 0.041	0.372HisTrp: 0.372 ± 0.019	0.804HisTyr: 0.804 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.061IleAla: 7.061 ± 0.095	0.533IleCys: 0.533 ± 0.023	3.183IleAsp: 3.183 ± 0.052	3.683IleGlu: 3.683 ± 0.071	2.072IlePhe: 2.072 ± 0.044	4.514IleGly: 4.514 ± 0.079	1.316IleHis: 1.316 ± 0.038	2.959IleIle: 2.959 ± 0.064	2.563IleLys: 2.563 ± 0.054	5.207IleLeu: 5.207 ± 0.075	1.261IleMet: 1.261 ± 0.04	2.188IleAsn: 2.188 ± 0.053	2.719IlePro: 2.719 ± 0.049	1.751IleGln: 1.751 ± 0.045	3.214IleArg: 3.214 ± 0.067	3.877IleSer: 3.877 ± 0.061	3.34IleThr: 3.34 ± 0.054	3.988IleVal: 3.988 ± 0.066	0.585IleTrp: 0.585 ± 0.023	1.428IleTyr: 1.428 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.099LysAla: 4.099 ± 0.072	0.301LysCys: 0.301 ± 0.018	2.139LysAsp: 2.139 ± 0.057	2.246LysGlu: 2.246 ± 0.058	1.427LysPhe: 1.427 ± 0.034	2.692LysGly: 2.692 ± 0.058	1.161LysHis: 1.161 ± 0.036	2.747LysIle: 2.747 ± 0.055	2.379LysLys: 2.379 ± 0.067	5.064LysLeu: 5.064 ± 0.081	1.401LysMet: 1.401 ± 0.039	1.879LysAsn: 1.879 ± 0.039	2.553LysPro: 2.553 ± 0.058	2.268LysGln: 2.268 ± 0.045	2.66LysArg: 2.66 ± 0.054	2.707LysSer: 2.707 ± 0.051	2.592LysThr: 2.592 ± 0.053	3.042LysVal: 3.042 ± 0.063	0.518LysTrp: 0.518 ± 0.026	1.116LysTyr: 1.116 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	12.036LeuAla: 12.036 ± 0.152	1.058LeuCys: 1.058 ± 0.03	5.718LeuAsp: 5.718 ± 0.086	5.667LeuGlu: 5.667 ± 0.083	3.989LeuPhe: 3.989 ± 0.065	7.857LeuGly: 7.857 ± 0.108	2.653LeuHis: 2.653 ± 0.058	5.478LeuIle: 5.478 ± 0.08	4.809LeuLys: 4.809 ± 0.073	11.721LeuLeu: 11.721 ± 0.167	2.601LeuMet: 2.601 ± 0.052	3.737LeuAsn: 3.737 ± 0.064	5.523LeuPro: 5.523 ± 0.079	4.14LeuGln: 4.14 ± 0.065	6.58LeuArg: 6.58 ± 0.111	6.674LeuSer: 6.674 ± 0.092	5.317LeuThr: 5.317 ± 0.074	7.195LeuVal: 7.195 ± 0.104	1.204LeuTrp: 1.204 ± 0.039	2.423LeuTyr: 2.423 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.601MetAla: 2.601 ± 0.051	0.199MetCys: 0.199 ± 0.013	1.358MetAsp: 1.358 ± 0.036	1.386MetGlu: 1.386 ± 0.034	0.862MetPhe: 0.862 ± 0.032	1.931MetGly: 1.931 ± 0.051	0.698MetHis: 0.698 ± 0.026	1.398MetIle: 1.398 ± 0.046	1.425MetLys: 1.425 ± 0.039	3.262MetLeu: 3.262 ± 0.064	0.773MetMet: 0.773 ± 0.03	1.194MetAsn: 1.194 ± 0.031	1.563MetPro: 1.563 ± 0.043	1.358MetGln: 1.358 ± 0.043	1.75MetArg: 1.75 ± 0.04	1.735MetSer: 1.735 ± 0.038	1.564MetThr: 1.564 ± 0.041	1.868MetVal: 1.868 ± 0.047	0.237MetTrp: 0.237 ± 0.018	0.496MetTyr: 0.496 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.49AsnAla: 3.49 ± 0.066	0.347AsnCys: 0.347 ± 0.021	1.771AsnAsp: 1.771 ± 0.043	1.763AsnGlu: 1.763 ± 0.043	1.46AsnPhe: 1.46 ± 0.038	2.84AsnGly: 2.84 ± 0.059	0.771AsnHis: 0.771 ± 0.028	2.237AsnIle: 2.237 ± 0.054	1.601AsnLys: 1.601 ± 0.047	3.796AsnLeu: 3.796 ± 0.068	0.94AsnMet: 0.94 ± 0.032	1.322AsnAsn: 1.322 ± 0.046	2.199AsnPro: 2.199 ± 0.053	1.376AsnGln: 1.376 ± 0.044	2.151AsnArg: 2.151 ± 0.042	1.952AsnSer: 1.952 ± 0.053	1.899AsnThr: 1.899 ± 0.053	2.343AsnVal: 2.343 ± 0.053	0.479AsnTrp: 0.479 ± 0.024	1.056AsnTyr: 1.056 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.988ProAla: 4.988 ± 0.075	0.403ProCys: 0.403 ± 0.025	3.08ProAsp: 3.08 ± 0.056	3.181ProGlu: 3.181 ± 0.067	1.679ProPhe: 1.679 ± 0.04	3.751ProGly: 3.751 ± 0.073	1.074ProHis: 1.074 ± 0.034	2.139ProIle: 2.139 ± 0.054	1.76ProLys: 1.76 ± 0.038	4.623ProLeu: 4.623 ± 0.071	1.078ProMet: 1.078 ± 0.032	1.5ProAsn: 1.5 ± 0.045	2.074ProPro: 2.074 ± 0.055	1.839ProGln: 1.839 ± 0.04	2.134ProArg: 2.134 ± 0.053	2.513ProSer: 2.513 ± 0.057	2.005ProThr: 2.005 ± 0.046	3.801ProVal: 3.801 ± 0.058	0.54ProTrp: 0.54 ± 0.021	1.267ProTyr: 1.267 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.64GlnAla: 4.64 ± 0.079	0.329GlnCys: 0.329 ± 0.018	1.8GlnAsp: 1.8 ± 0.044	1.899GlnGlu: 1.899 ± 0.048	1.397GlnPhe: 1.397 ± 0.036	2.866GlnGly: 2.866 ± 0.061	1.208GlnHis: 1.208 ± 0.036	2.371GlnIle: 2.371 ± 0.048	1.695GlnLys: 1.695 ± 0.043	4.299GlnLeu: 4.299 ± 0.067	1.14GlnMet: 1.14 ± 0.035	1.396GlnAsn: 1.396 ± 0.037	2.105GlnPro: 2.105 ± 0.042	2.322GlnGln: 2.322 ± 0.061	2.765GlnArg: 2.765 ± 0.062	2.342GlnSer: 2.342 ± 0.049	2.057GlnThr: 2.057 ± 0.05	2.846GlnVal: 2.846 ± 0.058	0.52GlnTrp: 0.52 ± 0.023	1.051GlnTyr: 1.051 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.497ArgAla: 5.497 ± 0.093	0.516ArgCys: 0.516 ± 0.023	3.42ArgAsp: 3.42 ± 0.065	3.875ArgGlu: 3.875 ± 0.069	2.481ArgPhe: 2.481 ± 0.048	3.891ArgGly: 3.891 ± 0.072	1.656ArgHis: 1.656 ± 0.038	3.828ArgIle: 3.828 ± 0.074	2.828ArgLys: 2.828 ± 0.063	6.455ArgLeu: 6.455 ± 0.089	1.75ArgMet: 1.75 ± 0.05	2.292ArgAsn: 2.292 ± 0.046	2.258ArgPro: 2.258 ± 0.047	2.513ArgGln: 2.513 ± 0.048	3.61ArgArg: 3.61 ± 0.07	3.104ArgSer: 3.104 ± 0.049	2.552ArgThr: 2.552 ± 0.048	4.024ArgVal: 4.024 ± 0.063	0.778ArgTrp: 0.778 ± 0.031	1.9ArgTyr: 1.9 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.149SerAla: 6.149 ± 0.09	0.605SerCys: 0.605 ± 0.027	3.06SerAsp: 3.06 ± 0.057	3.059SerGlu: 3.059 ± 0.058	2.334SerPhe: 2.334 ± 0.05	5.726SerGly: 5.726 ± 0.089	1.316SerHis: 1.316 ± 0.042	3.188SerIle: 3.188 ± 0.058	2.349SerLys: 2.349 ± 0.053	6.144SerLeu: 6.144 ± 0.09	1.601SerMet: 1.601 ± 0.045	2.1SerAsn: 2.1 ± 0.054	2.695SerPro: 2.695 ± 0.054	2.055SerGln: 2.055 ± 0.05	3.335SerArg: 3.335 ± 0.05	3.62SerSer: 3.62 ± 0.08	3.001SerThr: 3.001 ± 0.058	4.108SerVal: 4.108 ± 0.066	0.75SerTrp: 0.75 ± 0.026	1.583SerTyr: 1.583 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.235ThrAla: 5.235 ± 0.081	0.494ThrCys: 0.494 ± 0.024	2.528ThrAsp: 2.528 ± 0.056	2.575ThrGlu: 2.575 ± 0.058	1.771ThrPhe: 1.771 ± 0.043	4.851ThrGly: 4.851 ± 0.087	1.217ThrHis: 1.217 ± 0.033	2.75ThrIle: 2.75 ± 0.055	1.728ThrLys: 1.728 ± 0.04	6.172ThrLeu: 6.172 ± 0.083	1.296ThrMet: 1.296 ± 0.041	1.606ThrAsn: 1.606 ± 0.048	2.985ThrPro: 2.985 ± 0.066	1.988ThrGln: 1.988 ± 0.043	2.951ThrArg: 2.951 ± 0.054	2.819ThrSer: 2.819 ± 0.072	2.815ThrThr: 2.815 ± 0.082	3.764ThrVal: 3.764 ± 0.063	0.563ThrTrp: 0.563 ± 0.027	1.171ThrTyr: 1.171 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.737ValAla: 7.737 ± 0.088	0.729ValCys: 0.729 ± 0.026	3.555ValAsp: 3.555 ± 0.067	4.038ValGlu: 4.038 ± 0.073	2.666ValPhe: 2.666 ± 0.057	4.719ValGly: 4.719 ± 0.081	1.47ValHis: 1.47 ± 0.042	4.173ValIle: 4.173 ± 0.069	2.991ValLys: 2.991 ± 0.057	7.804ValLeu: 7.804 ± 0.096	2.132ValMet: 2.132 ± 0.05	2.481ValAsn: 2.481 ± 0.057	3.231ValPro: 3.231 ± 0.06	2.535ValGln: 2.535 ± 0.046	4.045ValArg: 4.045 ± 0.069	4.392ValSer: 4.392 ± 0.064	3.806ValThr: 3.806 ± 0.063	5.498ValVal: 5.498 ± 0.091	0.886ValTrp: 0.886 ± 0.031	1.709ValTyr: 1.709 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.98TrpAla: 0.98 ± 0.034	0.159TrpCys: 0.159 ± 0.013	0.581TrpAsp: 0.581 ± 0.028	0.544TrpGlu: 0.544 ± 0.023	0.551TrpPhe: 0.551 ± 0.027	0.798TrpGly: 0.798 ± 0.026	0.397TrpHis: 0.397 ± 0.022	0.702TrpIle: 0.702 ± 0.029	0.576TrpLys: 0.576 ± 0.026	1.856TrpLeu: 1.856 ± 0.057	0.388TrpMet: 0.388 ± 0.02	0.455TrpAsn: 0.455 ± 0.022	0.454TrpPro: 0.454 ± 0.023	0.792TrpGln: 0.792 ± 0.036	0.881TrpArg: 0.881 ± 0.036	0.667TrpSer: 0.667 ± 0.026	0.544TrpThr: 0.544 ± 0.023	0.915TrpVal: 0.915 ± 0.03	0.23TrpTrp: 0.23 ± 0.016	0.319TrpTyr: 0.319 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.802TyrAla: 2.802 ± 0.056	0.318TyrCys: 0.318 ± 0.019	1.311TyrAsp: 1.311 ± 0.034	1.242TyrGlu: 1.242 ± 0.037	1.245TyrPhe: 1.245 ± 0.033	2.094TyrGly: 2.094 ± 0.043	0.674TyrHis: 0.674 ± 0.029	1.28TyrIle: 1.28 ± 0.039	0.914TyrLys: 0.914 ± 0.032	2.981TyrLeu: 2.981 ± 0.057	0.545TyrMet: 0.545 ± 0.024	0.846TyrAsn: 0.846 ± 0.032	1.348TyrPro: 1.348 ± 0.043	1.288TyrGln: 1.288 ± 0.032	1.929TyrArg: 1.929 ± 0.045	1.714TyrSer: 1.714 ± 0.046	1.378TyrThr: 1.378 ± 0.041	1.685TyrVal: 1.685 ± 0.042	0.404TyrTrp: 0.404 ± 0.023	0.803TyrTyr: 0.803 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3512 proteins (1004978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---