Amino acid dipepetide frequency for Actinomadura darangshiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.776AlaAla: 21.776 ± 0.145	1.12AlaCys: 1.12 ± 0.023	8.125AlaAsp: 8.125 ± 0.066	8.607AlaGlu: 8.607 ± 0.069	3.803AlaPhe: 3.803 ± 0.039	14.32AlaGly: 14.32 ± 0.086	2.696AlaHis: 2.696 ± 0.033	4.155AlaIle: 4.155 ± 0.039	2.917AlaLys: 2.917 ± 0.037	14.181AlaLeu: 14.181 ± 0.079	2.732AlaMet: 2.732 ± 0.033	1.974AlaAsn: 1.974 ± 0.031	6.554AlaPro: 6.554 ± 0.058	3.44AlaGln: 3.44 ± 0.037	10.626AlaArg: 10.626 ± 0.069	5.867AlaSer: 5.867 ± 0.048	6.371AlaThr: 6.371 ± 0.054	11.752AlaVal: 11.752 ± 0.078	1.878AlaTrp: 1.878 ± 0.023	2.625AlaTyr: 2.625 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.03CysAla: 1.03 ± 0.022	0.1CysCys: 0.1 ± 0.006	0.519CysAsp: 0.519 ± 0.013	0.411CysGlu: 0.411 ± 0.012	0.227CysPhe: 0.227 ± 0.009	1.015CysGly: 1.015 ± 0.019	0.198CysHis: 0.198 ± 0.008	0.16CysIle: 0.16 ± 0.007	0.129CysLys: 0.129 ± 0.007	0.698CysLeu: 0.698 ± 0.015	0.138CysMet: 0.138 ± 0.007	0.136CysAsn: 0.136 ± 0.007	0.477CysPro: 0.477 ± 0.015	0.169CysGln: 0.169 ± 0.008	0.623CysArg: 0.623 ± 0.016	0.415CysSer: 0.415 ± 0.011	0.455CysThr: 0.455 ± 0.012	0.656CysVal: 0.656 ± 0.015	0.119CysTrp: 0.119 ± 0.007	0.169CysTyr: 0.169 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.783AspAla: 7.783 ± 0.055	0.401AspCys: 0.401 ± 0.012	4.041AspAsp: 4.041 ± 0.039	4.132AspGlu: 4.132 ± 0.041	1.56AspPhe: 1.56 ± 0.022	6.662AspGly: 6.662 ± 0.055	1.432AspHis: 1.432 ± 0.024	1.899AspIle: 1.899 ± 0.028	1.098AspLys: 1.098 ± 0.022	6.724AspLeu: 6.724 ± 0.056	0.951AspMet: 0.951 ± 0.019	0.859AspAsn: 0.859 ± 0.021	4.688AspPro: 4.688 ± 0.043	1.527AspGln: 1.527 ± 0.024	5.267AspArg: 5.267 ± 0.045	2.109AspSer: 2.109 ± 0.03	2.716AspThr: 2.716 ± 0.035	5.27AspVal: 5.27 ± 0.05	0.934AspTrp: 0.934 ± 0.017	1.191AspTyr: 1.191 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.99GluAla: 6.99 ± 0.065	0.365GluCys: 0.365 ± 0.013	2.828GluAsp: 2.828 ± 0.037	3.079GluGlu: 3.079 ± 0.045	1.507GluPhe: 1.507 ± 0.024	3.994GluGly: 3.994 ± 0.042	1.599GluHis: 1.599 ± 0.023	2.441GluIle: 2.441 ± 0.03	1.274GluLys: 1.274 ± 0.024	6.343GluLeu: 6.343 ± 0.057	1.017GluMet: 1.017 ± 0.02	1.022GluAsn: 1.022 ± 0.018	3.521GluPro: 3.521 ± 0.04	1.941GluGln: 1.941 ± 0.03	5.723GluArg: 5.723 ± 0.054	2.443GluSer: 2.443 ± 0.028	2.962GluThr: 2.962 ± 0.037	4.41GluVal: 4.41 ± 0.04	0.799GluTrp: 0.799 ± 0.018	1.094GluTyr: 1.094 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.943PheAla: 3.943 ± 0.038	0.289PheCys: 0.289 ± 0.008	1.992PheAsp: 1.992 ± 0.028	1.481PheGlu: 1.481 ± 0.024	0.883PhePhe: 0.883 ± 0.019	3.267PheGly: 3.267 ± 0.038	0.601PheHis: 0.601 ± 0.014	0.821PheIle: 0.821 ± 0.019	0.533PheLys: 0.533 ± 0.013	2.645PheLeu: 2.645 ± 0.037	0.46PheMet: 0.46 ± 0.014	0.592PheAsn: 0.592 ± 0.015	1.408PhePro: 1.408 ± 0.025	0.729PheGln: 0.729 ± 0.016	1.918PheArg: 1.918 ± 0.026	1.395PheSer: 1.395 ± 0.022	2.044PheThr: 2.044 ± 0.026	2.339PheVal: 2.339 ± 0.036	0.455PheTrp: 0.455 ± 0.014	0.618PheTyr: 0.618 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.12GlyAla: 11.12 ± 0.076	0.844GlyCys: 0.844 ± 0.017	5.822GlyAsp: 5.822 ± 0.048	5.284GlyGlu: 5.284 ± 0.049	3.021GlyPhe: 3.021 ± 0.035	9.398GlyGly: 9.398 ± 0.077	2.356GlyHis: 2.356 ± 0.029	3.563GlyIle: 3.563 ± 0.043	2.508GlyLys: 2.508 ± 0.033	9.973GlyLeu: 9.973 ± 0.058	2.197GlyMet: 2.197 ± 0.028	1.731GlyAsn: 1.731 ± 0.028	5.262GlyPro: 5.262 ± 0.047	2.552GlyGln: 2.552 ± 0.033	8.652GlyArg: 8.652 ± 0.053	4.845GlySer: 4.845 ± 0.045	6.159GlyThr: 6.159 ± 0.056	7.7GlyVal: 7.7 ± 0.059	1.8GlyTrp: 1.8 ± 0.027	2.349GlyTyr: 2.349 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.696HisAla: 2.696 ± 0.034	0.213HisCys: 0.213 ± 0.008	1.398HisAsp: 1.398 ± 0.024	1.161HisGlu: 1.161 ± 0.021	0.601HisPhe: 0.601 ± 0.014	2.404HisGly: 2.404 ± 0.03	0.618HisHis: 0.618 ± 0.014	0.718HisIle: 0.718 ± 0.016	0.344HisLys: 0.344 ± 0.011	2.362HisLeu: 2.362 ± 0.029	0.373HisMet: 0.373 ± 0.012	0.376HisAsn: 0.376 ± 0.012	1.684HisPro: 1.684 ± 0.027	0.558HisGln: 0.558 ± 0.013	2.12HisArg: 2.12 ± 0.029	0.91HisSer: 0.91 ± 0.018	1.087HisThr: 1.087 ± 0.024	1.767HisVal: 1.767 ± 0.025	0.37HisTrp: 0.37 ± 0.013	0.499HisTyr: 0.499 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.33IleAla: 5.33 ± 0.05	0.284IleCys: 0.284 ± 0.011	2.426IleAsp: 2.426 ± 0.032	2.199IleGlu: 2.199 ± 0.034	0.8IlePhe: 0.8 ± 0.019	3.968IleGly: 3.968 ± 0.043	0.585IleHis: 0.585 ± 0.015	1.079IleIle: 1.079 ± 0.022	0.757IleLys: 0.757 ± 0.016	2.647IleLeu: 2.647 ± 0.032	0.543IleMet: 0.543 ± 0.013	0.716IleAsn: 0.716 ± 0.017	1.878IlePro: 1.878 ± 0.026	0.734IleGln: 0.734 ± 0.017	2.385IleArg: 2.385 ± 0.031	1.722IleSer: 1.722 ± 0.025	2.298IleThr: 2.298 ± 0.029	3.295IleVal: 3.295 ± 0.033	0.425IleTrp: 0.425 ± 0.013	0.575IleTyr: 0.575 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.96LysAla: 2.96 ± 0.035	0.11LysCys: 0.11 ± 0.006	1.263LysAsp: 1.263 ± 0.024	1.09LysGlu: 1.09 ± 0.02	0.457LysPhe: 0.457 ± 0.014	1.859LysGly: 1.859 ± 0.027	0.426LysHis: 0.426 ± 0.011	0.979LysIle: 0.979 ± 0.019	0.756LysLys: 0.756 ± 0.021	1.898LysLeu: 1.898 ± 0.027	0.396LysMet: 0.396 ± 0.012	0.489LysAsn: 0.489 ± 0.013	1.39LysPro: 1.39 ± 0.026	0.646LysGln: 0.646 ± 0.016	1.554LysArg: 1.554 ± 0.027	1.115LysSer: 1.115 ± 0.02	1.318LysThr: 1.318 ± 0.021	1.982LysVal: 1.982 ± 0.031	0.27LysTrp: 0.27 ± 0.01	0.433LysTyr: 0.433 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.53LeuAla: 15.53 ± 0.085	0.792LeuCys: 0.792 ± 0.015	7.075LeuAsp: 7.075 ± 0.06	4.711LeuGlu: 4.711 ± 0.049	2.71LeuPhe: 2.71 ± 0.036	9.461LeuGly: 9.461 ± 0.059	2.217LeuHis: 2.217 ± 0.032	3.509LeuIle: 3.509 ± 0.039	2.016LeuLys: 2.016 ± 0.029	10.947LeuLeu: 10.947 ± 0.082	1.733LeuMet: 1.733 ± 0.028	1.822LeuAsn: 1.822 ± 0.026	6.304LeuPro: 6.304 ± 0.057	2.119LeuGln: 2.119 ± 0.028	8.919LeuArg: 8.919 ± 0.069	5.102LeuSer: 5.102 ± 0.043	6.504LeuThr: 6.504 ± 0.045	8.667LeuVal: 8.667 ± 0.057	1.268LeuTrp: 1.268 ± 0.024	1.795LeuTyr: 1.795 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.505MetAla: 2.505 ± 0.031	0.143MetCys: 0.143 ± 0.007	1.027MetAsp: 1.027 ± 0.02	0.81MetGlu: 0.81 ± 0.018	0.551MetPhe: 0.551 ± 0.015	1.414MetGly: 1.414 ± 0.024	0.381MetHis: 0.381 ± 0.011	0.803MetIle: 0.803 ± 0.018	0.424MetLys: 0.424 ± 0.012	2.0MetLeu: 2.0 ± 0.024	0.348MetMet: 0.348 ± 0.011	0.441MetAsn: 0.441 ± 0.012	1.25MetPro: 1.25 ± 0.021	0.441MetGln: 0.441 ± 0.012	1.721MetArg: 1.721 ± 0.024	1.308MetSer: 1.308 ± 0.022	1.577MetThr: 1.577 ± 0.025	1.434MetVal: 1.434 ± 0.022	0.236MetTrp: 0.236 ± 0.009	0.328MetTyr: 0.328 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.254AsnAla: 2.254 ± 0.03	0.17AsnCys: 0.17 ± 0.007	0.993AsnAsp: 0.993 ± 0.02	0.844AsnGlu: 0.844 ± 0.016	0.481AsnPhe: 0.481 ± 0.014	1.916AsnGly: 1.916 ± 0.033	0.386AsnHis: 0.386 ± 0.013	0.628AsnIle: 0.628 ± 0.016	0.389AsnLys: 0.389 ± 0.013	1.729AsnLeu: 1.729 ± 0.027	0.321AsnMet: 0.321 ± 0.011	0.348AsnAsn: 0.348 ± 0.012	1.327AsnPro: 1.327 ± 0.023	0.484AsnGln: 0.484 ± 0.014	1.314AsnArg: 1.314 ± 0.022	0.75AsnSer: 0.75 ± 0.018	1.0AsnThr: 1.0 ± 0.021	1.55AsnVal: 1.55 ± 0.025	0.283AsnTrp: 0.283 ± 0.01	0.417AsnTyr: 0.417 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.505ProAla: 8.505 ± 0.07	0.348ProCys: 0.348 ± 0.012	4.676ProAsp: 4.676 ± 0.044	4.059ProGlu: 4.059 ± 0.039	1.634ProPhe: 1.634 ± 0.026	7.051ProGly: 7.051 ± 0.06	1.309ProHis: 1.309 ± 0.022	1.632ProIle: 1.632 ± 0.023	1.26ProLys: 1.26 ± 0.025	5.163ProLeu: 5.163 ± 0.048	1.14ProMet: 1.14 ± 0.019	0.951ProAsn: 0.951 ± 0.02	4.017ProPro: 4.017 ± 0.05	1.536ProGln: 1.536 ± 0.027	4.095ProArg: 4.095 ± 0.043	3.358ProSer: 3.358 ± 0.041	2.652ProThr: 2.652 ± 0.033	5.257ProVal: 5.257 ± 0.05	0.918ProTrp: 0.918 ± 0.019	1.317ProTyr: 1.317 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.589GlnAla: 3.589 ± 0.037	0.17GlnCys: 0.17 ± 0.008	1.395GlnAsp: 1.395 ± 0.024	1.299GlnGlu: 1.299 ± 0.023	0.663GlnPhe: 0.663 ± 0.017	2.181GlnGly: 2.181 ± 0.032	0.56GlnHis: 0.56 ± 0.015	1.159GlnIle: 1.159 ± 0.021	0.6GlnLys: 0.6 ± 0.016	2.464GlnLeu: 2.464 ± 0.033	0.51GlnMet: 0.51 ± 0.014	0.535GlnAsn: 0.535 ± 0.016	1.454GlnPro: 1.454 ± 0.027	1.022GlnGln: 1.022 ± 0.03	2.324GlnArg: 2.324 ± 0.029	1.15GlnSer: 1.15 ± 0.022	1.306GlnThr: 1.306 ± 0.023	2.408GlnVal: 2.408 ± 0.028	0.418GlnTrp: 0.418 ± 0.012	0.515GlnTyr: 0.515 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.143ArgAla: 10.143 ± 0.08	0.594ArgCys: 0.594 ± 0.012	4.973ArgAsp: 4.973 ± 0.045	4.73ArgGlu: 4.73 ± 0.048	2.523ArgPhe: 2.523 ± 0.034	6.127ArgGly: 6.127 ± 0.051	2.166ArgHis: 2.166 ± 0.03	3.274ArgIle: 3.274 ± 0.036	1.697ArgLys: 1.697 ± 0.025	9.604ArgLeu: 9.604 ± 0.068	1.938ArgMet: 1.938 ± 0.027	1.403ArgAsn: 1.403 ± 0.021	5.511ArgPro: 5.511 ± 0.047	2.215ArgGln: 2.215 ± 0.029	8.624ArgArg: 8.624 ± 0.077	4.03ArgSer: 4.03 ± 0.036	5.029ArgThr: 5.029 ± 0.049	6.25ArgVal: 6.25 ± 0.047	1.453ArgTrp: 1.453 ± 0.025	1.922ArgTyr: 1.922 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.186SerAla: 6.186 ± 0.043	0.399SerCys: 0.399 ± 0.013	2.583SerAsp: 2.583 ± 0.028	2.253SerGlu: 2.253 ± 0.03	1.498SerPhe: 1.498 ± 0.023	5.949SerGly: 5.949 ± 0.05	0.924SerHis: 0.924 ± 0.02	1.607SerIle: 1.607 ± 0.024	1.023SerLys: 1.023 ± 0.02	4.604SerLeu: 4.604 ± 0.036	1.126SerMet: 1.126 ± 0.021	0.813SerAsn: 0.813 ± 0.02	3.158SerPro: 3.158 ± 0.034	1.152SerGln: 1.152 ± 0.024	3.72SerArg: 3.72 ± 0.033	2.558SerSer: 2.558 ± 0.036	2.67SerThr: 2.67 ± 0.036	3.908SerVal: 3.908 ± 0.038	0.849SerTrp: 0.849 ± 0.018	1.135SerTyr: 1.135 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.997ThrAla: 7.997 ± 0.065	0.452ThrCys: 0.452 ± 0.015	3.06ThrAsp: 3.06 ± 0.033	2.856ThrGlu: 2.856 ± 0.034	1.739ThrPhe: 1.739 ± 0.026	6.585ThrGly: 6.585 ± 0.052	1.045ThrHis: 1.045 ± 0.019	1.996ThrIle: 1.996 ± 0.029	1.112ThrLys: 1.112 ± 0.023	5.536ThrLeu: 5.536 ± 0.046	1.111ThrMet: 1.111 ± 0.019	0.857ThrAsn: 0.857 ± 0.018	3.668ThrPro: 3.668 ± 0.036	1.167ThrGln: 1.167 ± 0.02	4.045ThrArg: 4.045 ± 0.04	2.956ThrSer: 2.956 ± 0.035	3.272ThrThr: 3.272 ± 0.041	5.467ThrVal: 5.467 ± 0.045	0.913ThrTrp: 0.913 ± 0.019	1.203ThrTyr: 1.203 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.997ValAla: 10.997 ± 0.065	0.719ValCys: 0.719 ± 0.017	4.767ValAsp: 4.767 ± 0.043	4.431ValGlu: 4.431 ± 0.047	2.59ValPhe: 2.59 ± 0.031	6.26ValGly: 6.26 ± 0.054	1.965ValHis: 1.965 ± 0.027	3.109ValIle: 3.109 ± 0.038	1.777ValLys: 1.777 ± 0.029	9.741ValLeu: 9.741 ± 0.064	1.49ValMet: 1.49 ± 0.023	1.714ValAsn: 1.714 ± 0.03	5.41ValPro: 5.41 ± 0.048	2.19ValGln: 2.19 ± 0.03	7.22ValArg: 7.22 ± 0.051	4.249ValSer: 4.249 ± 0.042	5.373ValThr: 5.373 ± 0.05	7.786ValVal: 7.786 ± 0.068	1.123ValTrp: 1.123 ± 0.021	1.592ValTyr: 1.592 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.631TrpAla: 1.631 ± 0.027	0.143TrpCys: 0.143 ± 0.007	0.89TrpAsp: 0.89 ± 0.019	0.726TrpGlu: 0.726 ± 0.017	0.515TrpPhe: 0.515 ± 0.016	1.08TrpGly: 1.08 ± 0.021	0.386TrpHis: 0.386 ± 0.012	0.569TrpIle: 0.569 ± 0.014	0.351TrpLys: 0.351 ± 0.011	1.719TrpLeu: 1.719 ± 0.027	0.315TrpMet: 0.315 ± 0.011	0.408TrpAsn: 0.408 ± 0.012	0.86TrpPro: 0.86 ± 0.02	0.512TrpGln: 0.512 ± 0.014	1.507TrpArg: 1.507 ± 0.023	0.858TrpSer: 0.858 ± 0.019	1.112TrpThr: 1.112 ± 0.021	0.951TrpVal: 0.951 ± 0.018	0.347TrpTrp: 0.347 ± 0.011	0.341TrpTyr: 0.341 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.03	0.188TyrCys: 0.188 ± 0.008	1.391TyrAsp: 1.391 ± 0.023	1.189TyrGlu: 1.189 ± 0.022	0.649TyrPhe: 0.649 ± 0.016	2.226TyrGly: 2.226 ± 0.029	0.409TyrHis: 0.409 ± 0.013	0.547TyrIle: 0.547 ± 0.015	0.426TyrLys: 0.426 ± 0.014	2.221TyrLeu: 2.221 ± 0.031	0.306TyrMet: 0.306 ± 0.01	0.401TyrAsn: 0.401 ± 0.013	1.056TyrPro: 1.056 ± 0.019	0.587TyrGln: 0.587 ± 0.016	1.847TyrArg: 1.847 ± 0.026	0.974TyrSer: 0.974 ± 0.019	1.132TyrThr: 1.132 ± 0.022	1.654TyrVal: 1.654 ± 0.027	0.362TyrTrp: 0.362 ± 0.013	0.483TyrTyr: 0.483 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9026 proteins (2877669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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