Amino acid dipepetide frequency for Acidovorax sp. 16-35-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.364AlaAla: 20.364 ± 0.223
1.353AlaCys: 1.353 ± 0.036
6.475AlaAsp: 6.475 ± 0.08
6.781AlaGlu: 6.781 ± 0.091
3.892AlaPhe: 3.892 ± 0.059
11.61AlaGly: 11.61 ± 0.158
2.929AlaHis: 2.929 ± 0.051
5.186AlaIle: 5.186 ± 0.07
3.745AlaLys: 3.745 ± 0.076
16.653AlaLeu: 16.653 ± 0.151
3.524AlaMet: 3.524 ± 0.052
2.93AlaAsn: 2.93 ± 0.065
7.228AlaPro: 7.228 ± 0.105
7.827AlaGln: 7.827 ± 0.094
9.632AlaArg: 9.632 ± 0.118
7.009AlaSer: 7.009 ± 0.104
6.317AlaThr: 6.317 ± 0.093
9.159AlaVal: 9.159 ± 0.118
2.029AlaTrp: 2.029 ± 0.044
2.503AlaTyr: 2.503 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.318CysAla: 1.318 ± 0.034
0.134CysCys: 0.134 ± 0.009
0.484CysAsp: 0.484 ± 0.018
0.488CysGlu: 0.488 ± 0.017
0.297CysPhe: 0.297 ± 0.015
0.915CysGly: 0.915 ± 0.03
0.242CysHis: 0.242 ± 0.012
0.434CysIle: 0.434 ± 0.018
0.209CysLys: 0.209 ± 0.012
0.889CysLeu: 0.889 ± 0.026
0.237CysMet: 0.237 ± 0.014
0.234CysAsn: 0.234 ± 0.013
0.472CysPro: 0.472 ± 0.019
0.275CysGln: 0.275 ± 0.017
0.529CysArg: 0.529 ± 0.019
0.505CysSer: 0.505 ± 0.018
0.512CysThr: 0.512 ± 0.02
0.683CysVal: 0.683 ± 0.024
0.126CysTrp: 0.126 ± 0.01
0.182CysTyr: 0.182 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.229AspAla: 7.229 ± 0.096
0.447AspCys: 0.447 ± 0.017
2.311AspAsp: 2.311 ± 0.047
2.687AspGlu: 2.687 ± 0.043
1.956AspPhe: 1.956 ± 0.04
4.484AspGly: 4.484 ± 0.101
1.018AspHis: 1.018 ± 0.029
2.412AspIle: 2.412 ± 0.043
1.525AspLys: 1.525 ± 0.046
5.186AspLeu: 5.186 ± 0.066
1.23AspMet: 1.23 ± 0.027
1.21AspAsn: 1.21 ± 0.038
2.695AspPro: 2.695 ± 0.048
1.737AspGln: 1.737 ± 0.033
2.856AspArg: 2.856 ± 0.048
2.372AspSer: 2.372 ± 0.047
2.496AspThr: 2.496 ± 0.064
3.691AspVal: 3.691 ± 0.053
0.958AspTrp: 0.958 ± 0.027
1.293AspTyr: 1.293 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.507GluAla: 6.507 ± 0.077
0.383GluCys: 0.383 ± 0.016
2.216GluAsp: 2.216 ± 0.05
2.378GluGlu: 2.378 ± 0.047
1.631GluPhe: 1.631 ± 0.035
3.623GluGly: 3.623 ± 0.051
1.257GluHis: 1.257 ± 0.031
2.625GluIle: 2.625 ± 0.05
1.788GluLys: 1.788 ± 0.042
5.715GluLeu: 5.715 ± 0.082
1.284GluMet: 1.284 ± 0.028
1.364GluAsn: 1.364 ± 0.031
2.279GluPro: 2.279 ± 0.051
2.813GluGln: 2.813 ± 0.045
4.396GluArg: 4.396 ± 0.068
2.344GluSer: 2.344 ± 0.039
2.432GluThr: 2.432 ± 0.047
3.925GluVal: 3.925 ± 0.057
0.689GluTrp: 0.689 ± 0.023
1.013GluTyr: 1.013 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.37PheAla: 4.37 ± 0.06
0.368PheCys: 0.368 ± 0.017
2.237PheAsp: 2.237 ± 0.038
1.866PheGlu: 1.866 ± 0.041
1.264PhePhe: 1.264 ± 0.039
3.074PheGly: 3.074 ± 0.057
0.697PheHis: 0.697 ± 0.022
1.428PheIle: 1.428 ± 0.035
1.095PheLys: 1.095 ± 0.03
2.826PheLeu: 2.826 ± 0.048
0.781PheMet: 0.781 ± 0.024
1.093PheAsn: 1.093 ± 0.034
1.368PhePro: 1.368 ± 0.032
1.085PheGln: 1.085 ± 0.027
1.595PheArg: 1.595 ± 0.035
2.083PheSer: 2.083 ± 0.042
1.824PheThr: 1.824 ± 0.04
2.586PheVal: 2.586 ± 0.055
0.493PheTrp: 0.493 ± 0.019
0.785PheTyr: 0.785 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.076GlyAla: 10.076 ± 0.142
0.853GlyCys: 0.853 ± 0.024
3.648GlyAsp: 3.648 ± 0.054
4.138GlyGlu: 4.138 ± 0.058
3.148GlyPhe: 3.148 ± 0.049
6.87GlyGly: 6.87 ± 0.114
1.841GlyHis: 1.841 ± 0.043
3.9GlyIle: 3.9 ± 0.058
3.098GlyLys: 3.098 ± 0.063
9.053GlyLeu: 9.053 ± 0.097
2.512GlyMet: 2.512 ± 0.043
2.406GlyAsn: 2.406 ± 0.072
3.049GlyPro: 3.049 ± 0.046
3.818GlyGln: 3.818 ± 0.084
5.365GlyArg: 5.365 ± 0.074
4.965GlySer: 4.965 ± 0.1
4.694GlyThr: 4.694 ± 0.145
6.427GlyVal: 6.427 ± 0.077
1.466GlyTrp: 1.466 ± 0.041
2.308GlyTyr: 2.308 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
3.151HisAla: 3.151 ± 0.063
0.303HisCys: 0.303 ± 0.014
1.153HisAsp: 1.153 ± 0.031
1.092HisGlu: 1.092 ± 0.028
0.843HisPhe: 0.843 ± 0.028
2.045HisGly: 2.045 ± 0.04
0.583HisHis: 0.583 ± 0.024
0.92HisIle: 0.92 ± 0.028
0.5HisLys: 0.5 ± 0.02
2.281HisLeu: 2.281 ± 0.046
0.54HisMet: 0.54 ± 0.023
0.495HisAsn: 0.495 ± 0.019
1.46HisPro: 1.46 ± 0.036
0.809HisGln: 0.809 ± 0.024
1.353HisArg: 1.353 ± 0.031
1.15HisSer: 1.15 ± 0.026
1.079HisThr: 1.079 ± 0.029
1.489HisVal: 1.489 ± 0.034
0.459HisTrp: 0.459 ± 0.017
0.611HisTyr: 0.611 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.175IleAla: 6.175 ± 0.079
0.401IleCys: 0.401 ± 0.017
3.033IleAsp: 3.033 ± 0.05
2.873IleGlu: 2.873 ± 0.051
1.185IlePhe: 1.185 ± 0.035
4.042IleGly: 4.042 ± 0.052
0.835IleHis: 0.835 ± 0.024
1.49IleIle: 1.49 ± 0.039
1.38IleLys: 1.38 ± 0.036
3.1IleLeu: 3.1 ± 0.059
0.731IleMet: 0.731 ± 0.023
1.351IleAsn: 1.351 ± 0.037
1.966IlePro: 1.966 ± 0.045
1.384IleGln: 1.384 ± 0.042
2.349IleArg: 2.349 ± 0.04
2.337IleSer: 2.337 ± 0.046
2.471IleThr: 2.471 ± 0.075
3.342IleVal: 3.342 ± 0.055
0.468IleTrp: 0.468 ± 0.022
0.925IleTyr: 0.925 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.828LysAla: 3.828 ± 0.067
0.147LysCys: 0.147 ± 0.011
1.579LysAsp: 1.579 ± 0.036
1.351LysGlu: 1.351 ± 0.034
0.822LysPhe: 0.822 ± 0.024
2.191LysGly: 2.191 ± 0.049
0.604LysHis: 0.604 ± 0.021
1.349LysIle: 1.349 ± 0.036
1.199LysLys: 1.199 ± 0.036
3.185LysLeu: 3.185 ± 0.054
0.71LysMet: 0.71 ± 0.023
0.882LysAsn: 0.882 ± 0.028
1.911LysPro: 1.911 ± 0.045
1.23LysGln: 1.23 ± 0.034
1.887LysArg: 1.887 ± 0.041
1.722LysSer: 1.722 ± 0.039
1.777LysThr: 1.777 ± 0.044
2.219LysVal: 2.219 ± 0.047
0.307LysTrp: 0.307 ± 0.014
0.627LysTyr: 0.627 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.146LeuAla: 16.146 ± 0.152
1.097LeuCys: 1.097 ± 0.027
5.72LeuAsp: 5.72 ± 0.083
5.43LeuGlu: 5.43 ± 0.081
3.225LeuPhe: 3.225 ± 0.056
9.045LeuGly: 9.045 ± 0.098
2.47LeuHis: 2.47 ± 0.049
4.043LeuIle: 4.043 ± 0.055
3.12LeuLys: 3.12 ± 0.055
12.182LeuLeu: 12.182 ± 0.17
2.423LeuMet: 2.423 ± 0.045
2.709LeuAsn: 2.709 ± 0.045
6.42LeuPro: 6.42 ± 0.079
5.469LeuGln: 5.469 ± 0.072
8.044LeuArg: 8.044 ± 0.098
6.291LeuSer: 6.291 ± 0.065
5.08LeuThr: 5.08 ± 0.082
7.876LeuVal: 7.876 ± 0.078
1.406LeuTrp: 1.406 ± 0.036
1.97LeuTyr: 1.97 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.262MetAla: 3.262 ± 0.05
0.165MetCys: 0.165 ± 0.01
1.064MetAsp: 1.064 ± 0.03
1.074MetGlu: 1.074 ± 0.027
0.699MetPhe: 0.699 ± 0.021
1.961MetGly: 1.961 ± 0.036
0.61MetHis: 0.61 ± 0.019
0.809MetIle: 0.809 ± 0.027
0.874MetLys: 0.874 ± 0.027
2.765MetLeu: 2.765 ± 0.048
0.506MetMet: 0.506 ± 0.021
0.797MetAsn: 0.797 ± 0.023
1.546MetPro: 1.546 ± 0.034
1.28MetGln: 1.28 ± 0.03
1.626MetArg: 1.626 ± 0.036
1.453MetSer: 1.453 ± 0.033
1.439MetThr: 1.439 ± 0.032
1.73MetVal: 1.73 ± 0.037
0.209MetTrp: 0.209 ± 0.011
0.366MetTyr: 0.366 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.618AsnAla: 3.618 ± 0.07
0.237AsnCys: 0.237 ± 0.013
1.376AsnAsp: 1.376 ± 0.059
1.13AsnGlu: 1.13 ± 0.028
0.914AsnPhe: 0.914 ± 0.027
2.224AsnGly: 2.224 ± 0.069
0.52AsnHis: 0.52 ± 0.019
1.167AsnIle: 1.167 ± 0.031
0.767AsnLys: 0.767 ± 0.024
2.549AsnLeu: 2.549 ± 0.043
0.576AsnMet: 0.576 ± 0.021
0.801AsnAsn: 0.801 ± 0.035
1.832AsnPro: 1.832 ± 0.047
1.035AsnGln: 1.035 ± 0.026
1.576AsnArg: 1.576 ± 0.033
1.3AsnSer: 1.3 ± 0.046
1.461AsnThr: 1.461 ± 0.04
1.924AsnVal: 1.924 ± 0.048
0.366AsnTrp: 0.366 ± 0.016
0.715AsnTyr: 0.715 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
8.217ProAla: 8.217 ± 0.118
0.369ProCys: 0.369 ± 0.017
2.889ProAsp: 2.889 ± 0.044
3.291ProGlu: 3.291 ± 0.056
1.647ProPhe: 1.647 ± 0.036
4.854ProGly: 4.854 ± 0.076
1.148ProHis: 1.148 ± 0.026
1.737ProIle: 1.737 ± 0.033
1.255ProLys: 1.255 ± 0.031
5.473ProLeu: 5.473 ± 0.069
1.289ProMet: 1.289 ± 0.031
1.141ProAsn: 1.141 ± 0.03
2.542ProPro: 2.542 ± 0.065
2.572ProGln: 2.572 ± 0.049
3.037ProArg: 3.037 ± 0.051
2.62ProSer: 2.62 ± 0.048
2.456ProThr: 2.456 ± 0.054
4.399ProVal: 4.399 ± 0.081
0.801ProTrp: 0.801 ± 0.024
1.126ProTyr: 1.126 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
7.108GlnAla: 7.108 ± 0.088
0.354GlnCys: 0.354 ± 0.018
1.822GlnAsp: 1.822 ± 0.043
1.913GlnGlu: 1.913 ± 0.039
1.303GlnPhe: 1.303 ± 0.032
3.679GlnGly: 3.679 ± 0.057
1.053GlnHis: 1.053 ± 0.031
1.898GlnIle: 1.898 ± 0.035
1.164GlnLys: 1.164 ± 0.027
5.457GlnLeu: 5.457 ± 0.069
1.076GlnMet: 1.076 ± 0.026
0.928GlnAsn: 0.928 ± 0.031
2.603GlnPro: 2.603 ± 0.046
2.778GlnGln: 2.778 ± 0.069
4.081GlnArg: 4.081 ± 0.063
2.32GlnSer: 2.32 ± 0.047
2.039GlnThr: 2.039 ± 0.043
3.407GlnVal: 3.407 ± 0.052
0.853GlnTrp: 0.853 ± 0.027
0.85GlnTyr: 0.85 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.249ArgAla: 8.249 ± 0.114
0.622ArgCys: 0.622 ± 0.026
3.243ArgAsp: 3.243 ± 0.051
3.944ArgGlu: 3.944 ± 0.056
2.568ArgPhe: 2.568 ± 0.043
4.504ArgGly: 4.504 ± 0.057
1.821ArgHis: 1.821 ± 0.036
3.402ArgIle: 3.402 ± 0.05
1.958ArgLys: 1.958 ± 0.04
7.801ArgLeu: 7.801 ± 0.1
1.95ArgMet: 1.95 ± 0.044
1.896ArgAsn: 1.896 ± 0.034
3.066ArgPro: 3.066 ± 0.052
3.128ArgGln: 3.128 ± 0.051
4.832ArgArg: 4.832 ± 0.068
3.716ArgSer: 3.716 ± 0.054
3.012ArgThr: 3.012 ± 0.05
4.672ArgVal: 4.672 ± 0.06
1.261ArgTrp: 1.261 ± 0.029
1.668ArgTyr: 1.668 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.071SerAla: 7.071 ± 0.092
0.428SerCys: 0.428 ± 0.019
2.552SerAsp: 2.552 ± 0.049
2.547SerGlu: 2.547 ± 0.045
2.049SerPhe: 2.049 ± 0.04
5.293SerGly: 5.293 ± 0.102
1.178SerHis: 1.178 ± 0.028
2.447SerIle: 2.447 ± 0.058
1.472SerLys: 1.472 ± 0.037
5.736SerLeu: 5.736 ± 0.064
1.402SerMet: 1.402 ± 0.032
1.478SerAsn: 1.478 ± 0.048
2.765SerPro: 2.765 ± 0.048
2.066SerGln: 2.066 ± 0.044
3.262SerArg: 3.262 ± 0.044
3.22SerSer: 3.22 ± 0.055
2.902SerThr: 2.902 ± 0.056
4.094SerVal: 4.094 ± 0.077
0.8SerTrp: 0.8 ± 0.022
1.423SerTyr: 1.423 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.467ThrAla: 6.467 ± 0.13
0.365ThrCys: 0.365 ± 0.016
2.407ThrAsp: 2.407 ± 0.063
2.207ThrGlu: 2.207 ± 0.054
1.497ThrPhe: 1.497 ± 0.036
4.769ThrGly: 4.769 ± 0.113
1.108ThrHis: 1.108 ± 0.029
2.041ThrIle: 2.041 ± 0.082
1.089ThrLys: 1.089 ± 0.032
6.513ThrLeu: 6.513 ± 0.097
0.988ThrMet: 0.988 ± 0.025
1.186ThrAsn: 1.186 ± 0.047
3.698ThrPro: 3.698 ± 0.057
2.129ThrGln: 2.129 ± 0.046
3.192ThrArg: 3.192 ± 0.052
2.725ThrSer: 2.725 ± 0.054
2.745ThrThr: 2.745 ± 0.08
3.949ThrVal: 3.949 ± 0.095
0.606ThrTrp: 0.606 ± 0.024
1.048ThrTyr: 1.048 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
9.692ValAla: 9.692 ± 0.109
0.704ValCys: 0.704 ± 0.025
3.767ValAsp: 3.767 ± 0.056
3.863ValGlu: 3.863 ± 0.055
2.61ValPhe: 2.61 ± 0.049
5.448ValGly: 5.448 ± 0.077
1.589ValHis: 1.589 ± 0.034
3.188ValIle: 3.188 ± 0.054
2.214ValLys: 2.214 ± 0.051
8.264ValLeu: 8.264 ± 0.105
1.726ValMet: 1.726 ± 0.036
2.169ValAsn: 2.169 ± 0.076
4.089ValPro: 4.089 ± 0.067
3.398ValGln: 3.398 ± 0.054
4.953ValArg: 4.953 ± 0.07
3.91ValSer: 3.91 ± 0.081
4.055ValThr: 4.055 ± 0.108
6.16ValVal: 6.16 ± 0.095
0.91ValTrp: 0.91 ± 0.025
1.483ValTyr: 1.483 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.45TrpAla: 1.45 ± 0.036
0.172TrpCys: 0.172 ± 0.012
0.603TrpAsp: 0.603 ± 0.021
0.551TrpGlu: 0.551 ± 0.018
0.516TrpPhe: 0.516 ± 0.021
1.034TrpGly: 1.034 ± 0.03
0.378TrpHis: 0.378 ± 0.014
0.652TrpIle: 0.652 ± 0.022
0.431TrpLys: 0.431 ± 0.017
2.184TrpLeu: 2.184 ± 0.05
0.37TrpMet: 0.37 ± 0.018
0.453TrpAsn: 0.453 ± 0.02
0.744TrpPro: 0.744 ± 0.026
0.943TrpGln: 0.943 ± 0.032
1.203TrpArg: 1.203 ± 0.034
0.914TrpSer: 0.914 ± 0.028
0.728TrpThr: 0.728 ± 0.029
0.97TrpVal: 0.97 ± 0.03
0.28TrpTrp: 0.28 ± 0.014
0.259TrpTyr: 0.259 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.051
0.262TyrCys: 0.262 ± 0.015
1.21TyrAsp: 1.21 ± 0.037
1.058TyrGlu: 1.058 ± 0.03
0.851TyrPhe: 0.851 ± 0.024
1.967TyrGly: 1.967 ± 0.048
0.434TyrHis: 0.434 ± 0.017
0.712TyrIle: 0.712 ± 0.026
0.647TyrLys: 0.647 ± 0.021
2.356TyrLeu: 2.356 ± 0.038
0.379TyrMet: 0.379 ± 0.019
0.566TyrAsn: 0.566 ± 0.022
1.132TyrPro: 1.132 ± 0.031
0.91TyrGln: 0.91 ± 0.023
1.545TyrArg: 1.545 ± 0.033
1.228TyrSer: 1.228 ± 0.032
1.212TyrThr: 1.212 ± 0.038
1.491TyrVal: 1.491 ± 0.035
0.348TyrTrp: 0.348 ± 0.014
0.543TyrTyr: 0.543 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4441 proteins (1479896 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski