Amino acid dipepetide frequency for Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.94AlaAla: 21.94 ± 0.217	1.014AlaCys: 1.014 ± 0.026	8.36AlaAsp: 8.36 ± 0.073	7.712AlaGlu: 7.712 ± 0.084	3.33AlaPhe: 3.33 ± 0.049	12.891AlaGly: 12.891 ± 0.115	2.736AlaHis: 2.736 ± 0.044	5.052AlaIle: 5.052 ± 0.069	3.015AlaLys: 3.015 ± 0.065	13.188AlaLeu: 13.188 ± 0.125	2.861AlaMet: 2.861 ± 0.047	2.626AlaAsn: 2.626 ± 0.048	6.992AlaPro: 6.992 ± 0.105	4.336AlaGln: 4.336 ± 0.055	9.623AlaArg: 9.623 ± 0.098	5.855AlaSer: 5.855 ± 0.072	6.979AlaThr: 6.979 ± 0.07	11.733AlaVal: 11.733 ± 0.102	1.627AlaTrp: 1.627 ± 0.039	2.263AlaTyr: 2.263 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.192CysAla: 1.192 ± 0.032	0.109CysCys: 0.109 ± 0.009	0.568CysAsp: 0.568 ± 0.022	0.423CysGlu: 0.423 ± 0.017	0.23CysPhe: 0.23 ± 0.011	1.001CysGly: 1.001 ± 0.031	0.21CysHis: 0.21 ± 0.013	0.267CysIle: 0.267 ± 0.013	0.135CysLys: 0.135 ± 0.009	0.689CysLeu: 0.689 ± 0.022	0.121CysMet: 0.121 ± 0.01	0.17CysAsn: 0.17 ± 0.012	0.549CysPro: 0.549 ± 0.022	0.21CysGln: 0.21 ± 0.011	0.669CysArg: 0.669 ± 0.023	0.492CysSer: 0.492 ± 0.018	0.486CysThr: 0.486 ± 0.019	0.693CysVal: 0.693 ± 0.022	0.159CysTrp: 0.159 ± 0.01	0.218CysTyr: 0.218 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.704AspAla: 7.704 ± 0.089	0.458AspCys: 0.458 ± 0.018	4.196AspAsp: 4.196 ± 0.06	3.925AspGlu: 3.925 ± 0.062	1.775AspPhe: 1.775 ± 0.036	5.794AspGly: 5.794 ± 0.069	1.448AspHis: 1.448 ± 0.032	2.53AspIle: 2.53 ± 0.043	1.29AspLys: 1.29 ± 0.032	5.704AspLeu: 5.704 ± 0.067	0.962AspMet: 0.962 ± 0.024	1.218AspAsn: 1.218 ± 0.033	4.555AspPro: 4.555 ± 0.064	1.768AspGln: 1.768 ± 0.036	4.677AspArg: 4.677 ± 0.06	2.621AspSer: 2.621 ± 0.041	3.079AspThr: 3.079 ± 0.056	5.121AspVal: 5.121 ± 0.058	0.958AspTrp: 0.958 ± 0.029	1.507AspTyr: 1.507 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.886GluAla: 5.886 ± 0.072	0.374GluCys: 0.374 ± 0.016	2.213GluAsp: 2.213 ± 0.051	2.389GluGlu: 2.389 ± 0.046	1.771GluPhe: 1.771 ± 0.036	3.032GluGly: 3.032 ± 0.05	1.597GluHis: 1.597 ± 0.033	2.46GluIle: 2.46 ± 0.041	1.226GluLys: 1.226 ± 0.034	6.62GluLeu: 6.62 ± 0.079	0.994GluMet: 0.994 ± 0.026	1.011GluAsn: 1.011 ± 0.031	3.003GluPro: 3.003 ± 0.049	2.213GluGln: 2.213 ± 0.041	4.381GluArg: 4.381 ± 0.057	2.504GluSer: 2.504 ± 0.045	2.493GluThr: 2.493 ± 0.04	4.07GluVal: 4.07 ± 0.059	0.724GluTrp: 0.724 ± 0.023	1.067GluTyr: 1.067 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.003PheAla: 4.003 ± 0.055	0.335PheCys: 0.335 ± 0.015	2.379PheAsp: 2.379 ± 0.049	1.49PheGlu: 1.49 ± 0.032	0.958PhePhe: 0.958 ± 0.027	3.363PheGly: 3.363 ± 0.056	0.652PheHis: 0.652 ± 0.026	0.998PheIle: 0.998 ± 0.031	0.534PheLys: 0.534 ± 0.02	2.423PheLeu: 2.423 ± 0.043	0.495PheMet: 0.495 ± 0.019	0.718PheAsn: 0.718 ± 0.022	1.467PhePro: 1.467 ± 0.035	0.704PheGln: 0.704 ± 0.022	1.7PheArg: 1.7 ± 0.036	1.692PheSer: 1.692 ± 0.035	1.962PheThr: 1.962 ± 0.036	2.478PheVal: 2.478 ± 0.041	0.423PheTrp: 0.423 ± 0.019	0.691PheTyr: 0.691 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.595GlyAla: 10.595 ± 0.091	0.907GlyCys: 0.907 ± 0.031	5.026GlyAsp: 5.026 ± 0.064	4.213GlyGlu: 4.213 ± 0.065	2.95GlyPhe: 2.95 ± 0.046	8.011GlyGly: 8.011 ± 0.113	2.116GlyHis: 2.116 ± 0.04	3.962GlyIle: 3.962 ± 0.048	2.344GlyLys: 2.344 ± 0.052	8.554GlyLeu: 8.554 ± 0.087	2.216GlyMet: 2.216 ± 0.042	1.869GlyAsn: 1.869 ± 0.039	5.137GlyPro: 5.137 ± 0.071	2.965GlyGln: 2.965 ± 0.048	6.931GlyArg: 6.931 ± 0.073	5.146GlySer: 5.146 ± 0.06	5.001GlyThr: 5.001 ± 0.063	7.564GlyVal: 7.564 ± 0.075	1.687GlyTrp: 1.687 ± 0.034	2.44GlyTyr: 2.44 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.616HisAla: 2.616 ± 0.042	0.245HisCys: 0.245 ± 0.012	1.477HisAsp: 1.477 ± 0.038	1.048HisGlu: 1.048 ± 0.03	0.651HisPhe: 0.651 ± 0.022	2.212HisGly: 2.212 ± 0.045	0.759HisHis: 0.759 ± 0.029	0.824HisIle: 0.824 ± 0.024	0.389HisLys: 0.389 ± 0.016	2.113HisLeu: 2.113 ± 0.042	0.332HisMet: 0.332 ± 0.016	0.539HisAsn: 0.539 ± 0.019	1.829HisPro: 1.829 ± 0.039	0.741HisGln: 0.741 ± 0.02	2.228HisArg: 2.228 ± 0.044	1.096HisSer: 1.096 ± 0.029	1.294HisThr: 1.294 ± 0.033	1.734HisVal: 1.734 ± 0.041	0.405HisTrp: 0.405 ± 0.017	0.579HisTyr: 0.579 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.081IleAla: 6.081 ± 0.057	0.424IleCys: 0.424 ± 0.018	3.279IleAsp: 3.279 ± 0.046	2.515IleGlu: 2.515 ± 0.042	1.018IlePhe: 1.018 ± 0.029	4.282IleGly: 4.282 ± 0.067	0.79IleHis: 0.79 ± 0.022	1.37IleIle: 1.37 ± 0.037	0.868IleLys: 0.868 ± 0.028	2.803IleLeu: 2.803 ± 0.05	0.576IleMet: 0.576 ± 0.021	1.136IleAsn: 1.136 ± 0.03	2.399IlePro: 2.399 ± 0.042	0.95IleGln: 0.95 ± 0.025	2.677IleArg: 2.677 ± 0.047	2.201IleSer: 2.201 ± 0.039	2.733IleThr: 2.733 ± 0.039	3.461IleVal: 3.461 ± 0.059	0.463IleTrp: 0.463 ± 0.016	0.794IleTyr: 0.794 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.649LysAla: 2.649 ± 0.058	0.124LysCys: 0.124 ± 0.009	1.081LysAsp: 1.081 ± 0.033	0.925LysGlu: 0.925 ± 0.031	0.593LysPhe: 0.593 ± 0.024	1.45LysGly: 1.45 ± 0.037	0.528LysHis: 0.528 ± 0.019	1.022LysIle: 1.022 ± 0.029	0.655LysLys: 0.655 ± 0.03	2.197LysLeu: 2.197 ± 0.046	0.471LysMet: 0.471 ± 0.02	0.517LysAsn: 0.517 ± 0.021	1.526LysPro: 1.526 ± 0.038	0.721LysGln: 0.721 ± 0.023	1.578LysArg: 1.578 ± 0.041	1.216LysSer: 1.216 ± 0.035	1.36LysThr: 1.36 ± 0.033	1.881LysVal: 1.881 ± 0.038	0.295LysTrp: 0.295 ± 0.015	0.46LysTyr: 0.46 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.533LeuAla: 14.533 ± 0.123	0.861LeuCys: 0.861 ± 0.025	6.503LeuAsp: 6.503 ± 0.072	4.069LeuGlu: 4.069 ± 0.059	2.623LeuPhe: 2.623 ± 0.048	8.84LeuGly: 8.84 ± 0.085	2.148LeuHis: 2.148 ± 0.037	3.994LeuIle: 3.994 ± 0.067	1.757LeuLys: 1.757 ± 0.041	9.799LeuLeu: 9.799 ± 0.12	1.705LeuMet: 1.705 ± 0.036	2.07LeuAsn: 2.07 ± 0.036	6.013LeuPro: 6.013 ± 0.077	2.667LeuGln: 2.667 ± 0.045	8.084LeuArg: 8.084 ± 0.084	5.658LeuSer: 5.658 ± 0.075	5.996LeuThr: 5.996 ± 0.078	8.154LeuVal: 8.154 ± 0.083	1.204LeuTrp: 1.204 ± 0.032	1.676LeuTyr: 1.676 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.645MetAla: 2.645 ± 0.043	0.185MetCys: 0.185 ± 0.013	0.875MetAsp: 0.875 ± 0.025	0.633MetGlu: 0.633 ± 0.023	0.625MetPhe: 0.625 ± 0.022	1.431MetGly: 1.431 ± 0.035	0.451MetHis: 0.451 ± 0.018	0.867MetIle: 0.867 ± 0.025	0.431MetLys: 0.431 ± 0.018	2.083MetLeu: 2.083 ± 0.036	0.44MetMet: 0.44 ± 0.019	0.467MetAsn: 0.467 ± 0.018	1.286MetPro: 1.286 ± 0.033	0.527MetGln: 0.527 ± 0.019	1.595MetArg: 1.595 ± 0.034	1.47MetSer: 1.47 ± 0.029	1.725MetThr: 1.725 ± 0.036	1.624MetVal: 1.624 ± 0.035	0.251MetTrp: 0.251 ± 0.013	0.346MetTyr: 0.346 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.682AsnAla: 2.682 ± 0.048	0.174AsnCys: 0.174 ± 0.011	1.178AsnAsp: 1.178 ± 0.03	0.958AsnGlu: 0.958 ± 0.029	0.706AsnPhe: 0.706 ± 0.022	2.008AsnGly: 2.008 ± 0.039	0.478AsnHis: 0.478 ± 0.016	0.938AsnIle: 0.938 ± 0.028	0.469AsnLys: 0.469 ± 0.021	2.081AsnLeu: 2.081 ± 0.039	0.432AsnMet: 0.432 ± 0.018	0.569AsnAsn: 0.569 ± 0.023	1.792AsnPro: 1.792 ± 0.04	0.695AsnGln: 0.695 ± 0.025	1.606AsnArg: 1.606 ± 0.033	1.157AsnSer: 1.157 ± 0.033	1.277AsnThr: 1.277 ± 0.033	1.732AsnVal: 1.732 ± 0.036	0.392AsnTrp: 0.392 ± 0.015	0.575AsnTyr: 0.575 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.354ProAla: 8.354 ± 0.108	0.34ProCys: 0.34 ± 0.016	4.488ProAsp: 4.488 ± 0.06	3.605ProGlu: 3.605 ± 0.064	1.656ProPhe: 1.656 ± 0.034	6.435ProGly: 6.435 ± 0.089	1.367ProHis: 1.367 ± 0.035	2.173ProIle: 2.173 ± 0.038	1.289ProLys: 1.289 ± 0.033	5.125ProLeu: 5.125 ± 0.061	1.188ProMet: 1.188 ± 0.032	1.338ProAsn: 1.338 ± 0.033	4.443ProPro: 4.443 ± 0.108	2.049ProGln: 2.049 ± 0.04	4.046ProArg: 4.046 ± 0.064	3.212ProSer: 3.212 ± 0.05	3.355ProThr: 3.355 ± 0.056	5.271ProVal: 5.271 ± 0.07	0.864ProTrp: 0.864 ± 0.023	1.242ProTyr: 1.242 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.796GlnAla: 3.796 ± 0.058	0.237GlnCys: 0.237 ± 0.013	1.228GlnAsp: 1.228 ± 0.026	1.067GlnGlu: 1.067 ± 0.029	0.947GlnPhe: 0.947 ± 0.025	2.058GlnGly: 2.058 ± 0.039	0.84GlnHis: 0.84 ± 0.026	1.442GlnIle: 1.442 ± 0.029	0.617GlnLys: 0.617 ± 0.022	3.818GlnLeu: 3.818 ± 0.055	0.686GlnMet: 0.686 ± 0.024	0.64GlnAsn: 0.64 ± 0.021	2.129GlnPro: 2.129 ± 0.049	1.436GlnGln: 1.436 ± 0.04	3.141GlnArg: 3.141 ± 0.051	1.51GlnSer: 1.51 ± 0.035	1.644GlnThr: 1.644 ± 0.032	2.559GlnVal: 2.559 ± 0.04	0.53GlnTrp: 0.53 ± 0.02	0.663GlnTyr: 0.663 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.226ArgAla: 9.226 ± 0.098	0.716ArgCys: 0.716 ± 0.026	4.417ArgAsp: 4.417 ± 0.06	3.819ArgGlu: 3.819 ± 0.054	2.504ArgPhe: 2.504 ± 0.046	5.743ArgGly: 5.743 ± 0.072	2.037ArgHis: 2.037 ± 0.042	3.481ArgIle: 3.481 ± 0.043	1.602ArgLys: 1.602 ± 0.04	8.064ArgLeu: 8.064 ± 0.088	1.829ArgMet: 1.829 ± 0.039	1.726ArgAsn: 1.726 ± 0.035	4.764ArgPro: 4.764 ± 0.075	2.446ArgGln: 2.446 ± 0.045	7.941ArgArg: 7.941 ± 0.118	4.045ArgSer: 4.045 ± 0.052	4.057ArgThr: 4.057 ± 0.054	5.892ArgVal: 5.892 ± 0.064	1.505ArgTrp: 1.505 ± 0.039	1.995ArgTyr: 1.995 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.023SerAla: 7.023 ± 0.077	0.427SerCys: 0.427 ± 0.019	3.005SerAsp: 3.005 ± 0.043	2.356SerGlu: 2.356 ± 0.043	1.582SerPhe: 1.582 ± 0.034	5.542SerGly: 5.542 ± 0.07	1.035SerHis: 1.035 ± 0.031	2.034SerIle: 2.034 ± 0.039	1.124SerLys: 1.124 ± 0.027	4.639SerLeu: 4.639 ± 0.055	1.25SerMet: 1.25 ± 0.028	1.118SerAsn: 1.118 ± 0.028	3.22SerPro: 3.22 ± 0.051	1.482SerGln: 1.482 ± 0.032	3.864SerArg: 3.864 ± 0.057	3.052SerSer: 3.052 ± 0.056	3.197SerThr: 3.197 ± 0.051	4.318SerVal: 4.318 ± 0.058	0.933SerTrp: 0.933 ± 0.023	1.256SerTyr: 1.256 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.783ThrAla: 7.783 ± 0.083	0.425ThrCys: 0.425 ± 0.02	3.389ThrAsp: 3.389 ± 0.048	2.977ThrGlu: 2.977 ± 0.045	1.687ThrPhe: 1.687 ± 0.034	5.64ThrGly: 5.64 ± 0.071	1.148ThrHis: 1.148 ± 0.029	2.261ThrIle: 2.261 ± 0.043	1.191ThrLys: 1.191 ± 0.034	5.441ThrLeu: 5.441 ± 0.057	1.189ThrMet: 1.189 ± 0.03	1.236ThrAsn: 1.236 ± 0.033	3.866ThrPro: 3.866 ± 0.058	1.52ThrGln: 1.52 ± 0.032	3.725ThrArg: 3.725 ± 0.051	2.916ThrSer: 2.916 ± 0.046	3.55ThrThr: 3.55 ± 0.063	5.532ThrVal: 5.532 ± 0.066	0.792ThrTrp: 0.792 ± 0.023	1.176ThrTyr: 1.176 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.366ValAla: 11.366 ± 0.1	0.821ValCys: 0.821 ± 0.027	5.496ValAsp: 5.496 ± 0.062	4.248ValGlu: 4.248 ± 0.062	2.592ValPhe: 2.592 ± 0.043	6.857ValGly: 6.857 ± 0.081	1.88ValHis: 1.88 ± 0.038	3.874ValIle: 3.874 ± 0.056	1.683ValLys: 1.683 ± 0.034	8.867ValLeu: 8.867 ± 0.085	1.582ValMet: 1.582 ± 0.039	2.074ValAsn: 2.074 ± 0.04	4.689ValPro: 4.689 ± 0.066	2.171ValGln: 2.171 ± 0.034	6.027ValArg: 6.027 ± 0.066	4.59ValSer: 4.59 ± 0.052	5.236ValThr: 5.236 ± 0.067	8.181ValVal: 8.181 ± 0.09	0.998ValTrp: 0.998 ± 0.026	1.505ValTyr: 1.505 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.589TrpAla: 1.589 ± 0.037	0.172TrpCys: 0.172 ± 0.012	0.798TrpAsp: 0.798 ± 0.023	0.644TrpGlu: 0.644 ± 0.019	0.492TrpPhe: 0.492 ± 0.017	0.99TrpGly: 0.99 ± 0.027	0.366TrpHis: 0.366 ± 0.016	0.605TrpIle: 0.605 ± 0.02	0.304TrpLys: 0.304 ± 0.014	1.764TrpLeu: 1.764 ± 0.039	0.349TrpMet: 0.349 ± 0.015	0.379TrpAsn: 0.379 ± 0.016	0.877TrpPro: 0.877 ± 0.025	0.636TrpGln: 0.636 ± 0.02	1.345TrpArg: 1.345 ± 0.035	0.943TrpSer: 0.943 ± 0.028	0.862TrpThr: 0.862 ± 0.024	1.141TrpVal: 1.141 ± 0.032	0.328TrpTrp: 0.328 ± 0.019	0.324TrpTyr: 0.324 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.473TyrAla: 2.473 ± 0.043	0.241TyrCys: 0.241 ± 0.013	1.333TyrAsp: 1.333 ± 0.031	1.013TyrGlu: 1.013 ± 0.031	0.776TyrPhe: 0.776 ± 0.026	2.052TyrGly: 2.052 ± 0.041	0.526TyrHis: 0.526 ± 0.024	0.664TyrIle: 0.664 ± 0.022	0.327TyrLys: 0.327 ± 0.018	2.381TyrLeu: 2.381 ± 0.045	0.28TyrMet: 0.28 ± 0.015	0.476TyrAsn: 0.476 ± 0.018	1.302TyrPro: 1.302 ± 0.036	0.755TyrGln: 0.755 ± 0.023	1.97TyrArg: 1.97 ± 0.042	1.081TyrSer: 1.081 ± 0.03	1.158TyrThr: 1.158 ± 0.026	1.597TyrVal: 1.597 ± 0.031	0.37TyrTrp: 0.37 ± 0.017	0.511TyrTyr: 0.511 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4316 proteins (1455413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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