Amino acid dipepetide frequency for Deinococcus hopiensis KR-140

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.952AlaAla: 15.952 ± 0.185	0.926AlaCys: 0.926 ± 0.021	5.272AlaAsp: 5.272 ± 0.055	6.916AlaGlu: 6.916 ± 0.081	4.05AlaPhe: 4.05 ± 0.055	10.678AlaGly: 10.678 ± 0.107	2.696AlaHis: 2.696 ± 0.045	3.253AlaIle: 3.253 ± 0.054	2.452AlaLys: 2.452 ± 0.046	16.403AlaLeu: 16.403 ± 0.155	2.136AlaMet: 2.136 ± 0.042	2.243AlaAsn: 2.243 ± 0.042	6.322AlaPro: 6.322 ± 0.092	5.777AlaGln: 5.777 ± 0.086	9.915AlaArg: 9.915 ± 0.097	6.073AlaSer: 6.073 ± 0.07	5.668AlaThr: 5.668 ± 0.067	8.866AlaVal: 8.866 ± 0.087	1.85AlaTrp: 1.85 ± 0.033	2.791AlaTyr: 2.791 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.792CysAla: 0.792 ± 0.021	0.107CysCys: 0.107 ± 0.008	0.282CysAsp: 0.282 ± 0.013	0.295CysGlu: 0.295 ± 0.013	0.179CysPhe: 0.179 ± 0.01	0.821CysGly: 0.821 ± 0.026	0.16CysHis: 0.16 ± 0.011	0.212CysIle: 0.212 ± 0.011	0.141CysLys: 0.141 ± 0.01	0.665CysLeu: 0.665 ± 0.022	0.122CysMet: 0.122 ± 0.008	0.143CysAsn: 0.143 ± 0.009	0.519CysPro: 0.519 ± 0.017	0.216CysGln: 0.216 ± 0.011	0.502CysArg: 0.502 ± 0.019	0.442CysSer: 0.442 ± 0.014	0.456CysThr: 0.456 ± 0.018	0.474CysVal: 0.474 ± 0.018	0.114CysTrp: 0.114 ± 0.009	0.122CysTyr: 0.122 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.174AspAla: 6.174 ± 0.066	0.252AspCys: 0.252 ± 0.011	2.1AspAsp: 2.1 ± 0.038	2.77AspGlu: 2.77 ± 0.046	1.732AspPhe: 1.732 ± 0.034	4.276AspGly: 4.276 ± 0.058	1.076AspHis: 1.076 ± 0.024	1.577AspIle: 1.577 ± 0.027	0.967AspLys: 0.967 ± 0.029	6.385AspLeu: 6.385 ± 0.057	0.802AspMet: 0.802 ± 0.022	0.934AspAsn: 0.934 ± 0.025	3.216AspPro: 3.216 ± 0.047	1.515AspGln: 1.515 ± 0.036	3.247AspArg: 3.247 ± 0.05	1.86AspSer: 1.86 ± 0.035	2.493AspThr: 2.493 ± 0.04	4.36AspVal: 4.36 ± 0.055	0.812AspTrp: 0.812 ± 0.024	1.003AspTyr: 1.003 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.876GluAla: 7.876 ± 0.097	0.26GluCys: 0.26 ± 0.011	2.787GluAsp: 2.787 ± 0.043	3.598GluGlu: 3.598 ± 0.06	1.628GluPhe: 1.628 ± 0.03	5.114GluGly: 5.114 ± 0.065	1.404GluHis: 1.404 ± 0.033	1.942GluIle: 1.942 ± 0.041	1.562GluLys: 1.562 ± 0.037	6.219GluLeu: 6.219 ± 0.078	1.063GluMet: 1.063 ± 0.025	1.346GluAsn: 1.346 ± 0.031	2.199GluPro: 2.199 ± 0.039	2.533GluGln: 2.533 ± 0.044	5.657GluArg: 5.657 ± 0.069	2.029GluSer: 2.029 ± 0.036	2.939GluThr: 2.939 ± 0.046	5.145GluVal: 5.145 ± 0.063	0.803GluTrp: 0.803 ± 0.02	1.24GluTyr: 1.24 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.533PheAla: 3.533 ± 0.053	0.241PheCys: 0.241 ± 0.013	1.753PheAsp: 1.753 ± 0.034	1.697PheGlu: 1.697 ± 0.032	1.047PhePhe: 1.047 ± 0.029	3.096PheGly: 3.096 ± 0.046	0.624PheHis: 0.624 ± 0.02	1.08PheIle: 1.08 ± 0.027	0.859PheLys: 0.859 ± 0.024	3.386PheLeu: 3.386 ± 0.05	0.556PheMet: 0.556 ± 0.016	0.841PheAsn: 0.841 ± 0.026	1.805PhePro: 1.805 ± 0.034	1.126PheGln: 1.126 ± 0.027	2.067PheArg: 2.067 ± 0.033	2.043PheSer: 2.043 ± 0.038	2.239PheThr: 2.239 ± 0.038	2.34PheVal: 2.34 ± 0.04	0.467PheTrp: 0.467 ± 0.017	0.773PheTyr: 0.773 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.484GlyAla: 9.484 ± 0.112	0.654GlyCys: 0.654 ± 0.024	4.134GlyAsp: 4.134 ± 0.058	5.731GlyGlu: 5.731 ± 0.06	2.973GlyPhe: 2.973 ± 0.044	8.37GlyGly: 8.37 ± 0.093	2.204GlyHis: 2.204 ± 0.039	3.023GlyIle: 3.023 ± 0.053	2.904GlyLys: 2.904 ± 0.047	9.996GlyLeu: 9.996 ± 0.1	1.983GlyMet: 1.983 ± 0.037	2.366GlyAsn: 2.366 ± 0.048	3.884GlyPro: 3.884 ± 0.055	4.222GlyGln: 4.222 ± 0.071	6.67GlyArg: 6.67 ± 0.078	4.593GlySer: 4.593 ± 0.069	5.921GlyThr: 5.921 ± 0.084	7.652GlyVal: 7.652 ± 0.072	1.54GlyTrp: 1.54 ± 0.033	2.237GlyTyr: 2.237 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.846HisAla: 2.846 ± 0.043	0.161HisCys: 0.161 ± 0.01	1.12HisAsp: 1.12 ± 0.028	1.15HisGlu: 1.15 ± 0.025	0.827HisPhe: 0.827 ± 0.022	2.014HisGly: 2.014 ± 0.034	0.726HisHis: 0.726 ± 0.019	0.753HisIle: 0.753 ± 0.023	0.395HisLys: 0.395 ± 0.014	3.13HisLeu: 3.13 ± 0.056	0.317HisMet: 0.317 ± 0.014	0.463HisAsn: 0.463 ± 0.018	1.758HisPro: 1.758 ± 0.034	0.698HisGln: 0.698 ± 0.023	1.652HisArg: 1.652 ± 0.035	1.034HisSer: 1.034 ± 0.026	1.327HisThr: 1.327 ± 0.03	1.718HisVal: 1.718 ± 0.034	0.346HisTrp: 0.346 ± 0.014	0.49HisTyr: 0.49 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.612IleAla: 3.612 ± 0.051	0.255IleCys: 0.255 ± 0.012	1.743IleAsp: 1.743 ± 0.034	1.892IleGlu: 1.892 ± 0.035	0.958IlePhe: 0.958 ± 0.027	3.092IleGly: 3.092 ± 0.046	0.812IleHis: 0.812 ± 0.023	1.183IleIle: 1.183 ± 0.033	0.915IleLys: 0.915 ± 0.029	3.223IleLeu: 3.223 ± 0.049	0.508IleMet: 0.508 ± 0.021	0.925IleAsn: 0.925 ± 0.027	1.873IlePro: 1.873 ± 0.035	1.152IleGln: 1.152 ± 0.031	2.455IleArg: 2.455 ± 0.034	1.938IleSer: 1.938 ± 0.04	2.227IleThr: 2.227 ± 0.042	2.542IleVal: 2.542 ± 0.046	0.393IleTrp: 0.393 ± 0.015	0.775IleTyr: 0.775 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.151LysAla: 3.151 ± 0.056	0.122LysCys: 0.122 ± 0.008	1.291LysAsp: 1.291 ± 0.033	1.154LysGlu: 1.154 ± 0.03	0.755LysPhe: 0.755 ± 0.022	2.118LysGly: 2.118 ± 0.037	0.492LysHis: 0.492 ± 0.016	0.956LysIle: 0.956 ± 0.025	1.101LysLys: 1.101 ± 0.037	2.627LysLeu: 2.627 ± 0.046	0.621LysMet: 0.621 ± 0.019	0.815LysAsn: 0.815 ± 0.027	1.553LysPro: 1.553 ± 0.041	0.908LysGln: 0.908 ± 0.023	1.988LysArg: 1.988 ± 0.036	1.271LysSer: 1.271 ± 0.035	1.65LysThr: 1.65 ± 0.036	2.144LysVal: 2.144 ± 0.045	0.315LysTrp: 0.315 ± 0.014	0.652LysTyr: 0.652 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.044LeuAla: 14.044 ± 0.128	0.792LeuCys: 0.792 ± 0.027	5.824LeuAsp: 5.824 ± 0.061	6.74LeuGlu: 6.74 ± 0.08	2.936LeuPhe: 2.936 ± 0.05	10.466LeuGly: 10.466 ± 0.103	2.834LeuHis: 2.834 ± 0.049	4.048LeuIle: 4.048 ± 0.052	3.291LeuLys: 3.291 ± 0.049	13.258LeuLeu: 13.258 ± 0.148	2.023LeuMet: 2.023 ± 0.035	3.223LeuAsn: 3.223 ± 0.043	7.562LeuPro: 7.562 ± 0.088	4.051LeuGln: 4.051 ± 0.054	9.004LeuArg: 9.004 ± 0.09	6.999LeuSer: 6.999 ± 0.074	8.345LeuThr: 8.345 ± 0.092	7.304LeuVal: 7.304 ± 0.082	1.422LeuTrp: 1.422 ± 0.027	2.389LeuTyr: 2.389 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.037	0.104MetCys: 0.104 ± 0.008	0.809MetAsp: 0.809 ± 0.023	0.849MetGlu: 0.849 ± 0.023	0.482MetPhe: 0.482 ± 0.017	1.486MetGly: 1.486 ± 0.033	0.418MetHis: 0.418 ± 0.016	0.682MetIle: 0.682 ± 0.02	0.711MetLys: 0.711 ± 0.02	1.927MetLeu: 1.927 ± 0.033	0.346MetMet: 0.346 ± 0.017	0.733MetAsn: 0.733 ± 0.022	1.199MetPro: 1.199 ± 0.03	0.716MetGln: 0.716 ± 0.022	1.453MetArg: 1.453 ± 0.031	1.096MetSer: 1.096 ± 0.024	1.854MetThr: 1.854 ± 0.033	1.194MetVal: 1.194 ± 0.028	0.2MetTrp: 0.2 ± 0.011	0.397MetTyr: 0.397 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.046	0.161AsnCys: 0.161 ± 0.01	1.095AsnAsp: 1.095 ± 0.026	1.032AsnGlu: 1.032 ± 0.026	0.871AsnPhe: 0.871 ± 0.024	2.316AsnGly: 2.316 ± 0.046	0.492AsnHis: 0.492 ± 0.018	0.959AsnIle: 0.959 ± 0.028	0.594AsnLys: 0.594 ± 0.021	2.935AsnLeu: 2.935 ± 0.048	0.449AsnMet: 0.449 ± 0.019	0.692AsnAsn: 0.692 ± 0.026	1.807AsnPro: 1.807 ± 0.041	0.704AsnGln: 0.704 ± 0.023	1.588AsnArg: 1.588 ± 0.034	1.153AsnSer: 1.153 ± 0.032	1.525AsnThr: 1.525 ± 0.043	2.28AsnVal: 2.28 ± 0.039	0.373AsnTrp: 0.373 ± 0.016	0.618AsnTyr: 0.618 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.965ProAla: 6.965 ± 0.082	0.35ProCys: 0.35 ± 0.017	3.583ProAsp: 3.583 ± 0.051	4.535ProGlu: 4.535 ± 0.065	1.896ProPhe: 1.896 ± 0.032	5.865ProGly: 5.865 ± 0.075	1.459ProHis: 1.459 ± 0.033	1.595ProIle: 1.595 ± 0.033	1.315ProLys: 1.315 ± 0.033	6.288ProLeu: 6.288 ± 0.067	1.084ProMet: 1.084 ± 0.027	1.387ProAsn: 1.387 ± 0.03	3.529ProPro: 3.529 ± 0.075	2.259ProGln: 2.259 ± 0.04	3.558ProArg: 3.558 ± 0.052	3.199ProSer: 3.199 ± 0.048	3.471ProThr: 3.471 ± 0.049	4.51ProVal: 4.51 ± 0.054	0.772ProTrp: 0.772 ± 0.02	1.277ProTyr: 1.277 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.544GlnAla: 5.544 ± 0.077	0.177GlnCys: 0.177 ± 0.01	1.863GlnAsp: 1.863 ± 0.034	2.25GlnGlu: 2.25 ± 0.044	1.037GlnPhe: 1.037 ± 0.028	3.719GlnGly: 3.719 ± 0.054	0.867GlnHis: 0.867 ± 0.024	1.338GlnIle: 1.338 ± 0.028	1.156GlnLys: 1.156 ± 0.033	3.908GlnLeu: 3.908 ± 0.054	0.748GlnMet: 0.748 ± 0.019	1.084GlnAsn: 1.084 ± 0.027	2.428GlnPro: 2.428 ± 0.039	1.725GlnGln: 1.725 ± 0.04	3.011GlnArg: 3.011 ± 0.051	1.788GlnSer: 1.788 ± 0.033	2.288GlnThr: 2.288 ± 0.037	3.392GlnVal: 3.392 ± 0.043	0.439GlnTrp: 0.439 ± 0.016	0.822GlnTyr: 0.822 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.299ArgAla: 9.299 ± 0.097	0.546ArgCys: 0.546 ± 0.019	3.624ArgAsp: 3.624 ± 0.054	5.569ArgGlu: 5.569 ± 0.081	2.554ArgPhe: 2.554 ± 0.043	5.907ArgGly: 5.907 ± 0.073	1.801ArgHis: 1.801 ± 0.034	2.494ArgIle: 2.494 ± 0.037	1.823ArgLys: 1.823 ± 0.04	8.891ArgLeu: 8.891 ± 0.082	1.573ArgMet: 1.573 ± 0.033	1.65ArgAsn: 1.65 ± 0.035	4.248ArgPro: 4.248 ± 0.054	3.053ArgGln: 3.053 ± 0.051	6.027ArgArg: 6.027 ± 0.075	3.919ArgSer: 3.919 ± 0.055	4.368ArgThr: 4.368 ± 0.057	6.347ArgVal: 6.347 ± 0.067	1.292ArgTrp: 1.292 ± 0.035	1.833ArgTyr: 1.833 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.208SerAla: 6.208 ± 0.068	0.402SerCys: 0.402 ± 0.017	2.233SerAsp: 2.233 ± 0.043	2.542SerGlu: 2.542 ± 0.041	1.684SerPhe: 1.684 ± 0.032	5.866SerGly: 5.866 ± 0.074	1.008SerHis: 1.008 ± 0.024	1.686SerIle: 1.686 ± 0.033	1.289SerLys: 1.289 ± 0.034	5.612SerLeu: 5.612 ± 0.065	0.964SerMet: 0.964 ± 0.024	1.222SerAsn: 1.222 ± 0.032	3.46SerPro: 3.46 ± 0.055	1.688SerGln: 1.688 ± 0.036	3.819SerArg: 3.819 ± 0.053	3.275SerSer: 3.275 ± 0.056	3.154SerThr: 3.154 ± 0.053	4.289SerVal: 4.289 ± 0.056	0.74SerTrp: 0.74 ± 0.021	1.109SerTyr: 1.109 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.16ThrAla: 7.16 ± 0.077	0.432ThrCys: 0.432 ± 0.018	2.717ThrAsp: 2.717 ± 0.038	2.705ThrGlu: 2.705 ± 0.043	2.357ThrPhe: 2.357 ± 0.04	5.583ThrGly: 5.583 ± 0.079	1.38ThrHis: 1.38 ± 0.035	1.685ThrIle: 1.685 ± 0.04	1.086ThrLys: 1.086 ± 0.029	8.485ThrLeu: 8.485 ± 0.081	0.832ThrMet: 0.832 ± 0.022	1.321ThrAsn: 1.321 ± 0.037	4.812ThrPro: 4.812 ± 0.068	2.191ThrGln: 2.191 ± 0.039	4.274ThrArg: 4.274 ± 0.048	3.192ThrSer: 3.192 ± 0.056	3.411ThrThr: 3.411 ± 0.065	5.464ThrVal: 5.464 ± 0.085	0.901ThrTrp: 0.901 ± 0.025	1.642ThrTyr: 1.642 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.239ValAla: 8.239 ± 0.088	0.547ValCys: 0.547 ± 0.021	3.561ValAsp: 3.561 ± 0.055	4.135ValGlu: 4.135 ± 0.058	2.434ValPhe: 2.434 ± 0.036	6.322ValGly: 6.322 ± 0.066	1.574ValHis: 1.574 ± 0.034	2.935ValIle: 2.935 ± 0.045	2.165ValLys: 2.165 ± 0.044	9.072ValLeu: 9.072 ± 0.084	1.642ValMet: 1.642 ± 0.032	2.281ValAsn: 2.281 ± 0.043	4.705ValPro: 4.705 ± 0.056	3.518ValGln: 3.518 ± 0.049	6.526ValArg: 6.526 ± 0.068	4.299ValSer: 4.299 ± 0.056	5.778ValThr: 5.778 ± 0.078	5.86ValVal: 5.86 ± 0.07	1.13ValTrp: 1.13 ± 0.028	1.873ValTyr: 1.873 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.562TrpAla: 1.562 ± 0.035	0.11TrpCys: 0.11 ± 0.008	0.636TrpAsp: 0.636 ± 0.022	0.686TrpGlu: 0.686 ± 0.02	0.406TrpPhe: 0.406 ± 0.016	1.144TrpGly: 1.144 ± 0.029	0.349TrpHis: 0.349 ± 0.015	0.434TrpIle: 0.434 ± 0.016	0.446TrpLys: 0.446 ± 0.018	1.636TrpLeu: 1.636 ± 0.032	0.338TrpMet: 0.338 ± 0.015	0.555TrpAsn: 0.555 ± 0.019	0.772TrpPro: 0.772 ± 0.021	0.721TrpGln: 0.721 ± 0.02	1.304TrpArg: 1.304 ± 0.03	0.81TrpSer: 0.81 ± 0.023	1.027TrpThr: 1.027 ± 0.025	1.041TrpVal: 1.041 ± 0.025	0.269TrpTrp: 0.269 ± 0.013	0.267TrpTyr: 0.267 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.893TyrAla: 2.893 ± 0.039	0.164TyrCys: 0.164 ± 0.01	1.126TyrAsp: 1.126 ± 0.028	1.098TyrGlu: 1.098 ± 0.028	0.766TyrPhe: 0.766 ± 0.025	2.289TyrGly: 2.289 ± 0.04	0.547TyrHis: 0.547 ± 0.017	0.639TyrIle: 0.639 ± 0.02	0.511TyrLys: 0.511 ± 0.019	2.507TyrLeu: 2.507 ± 0.036	0.309TyrMet: 0.309 ± 0.014	0.567TyrAsn: 0.567 ± 0.02	1.244TyrPro: 1.244 ± 0.029	0.81TyrGln: 0.81 ± 0.022	2.103TyrArg: 2.103 ± 0.037	1.236TyrSer: 1.236 ± 0.032	1.49TyrThr: 1.49 ± 0.037	1.674TyrVal: 1.674 ± 0.033	0.338TyrTrp: 0.338 ± 0.015	0.533TyrTyr: 0.533 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5843 proteins (1675551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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