Amino acid dipepetide frequency for Roseovarius azorensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.398AlaAla: 16.398 ± 0.182	1.203AlaCys: 1.203 ± 0.034	6.749AlaAsp: 6.749 ± 0.075	8.189AlaGlu: 8.189 ± 0.093	4.037AlaPhe: 4.037 ± 0.061	10.96AlaGly: 10.96 ± 0.124	2.547AlaHis: 2.547 ± 0.052	5.908AlaIle: 5.908 ± 0.077	2.947AlaLys: 2.947 ± 0.06	13.964AlaLeu: 13.964 ± 0.14	3.938AlaMet: 3.938 ± 0.062	2.545AlaAsn: 2.545 ± 0.043	5.79AlaPro: 5.79 ± 0.083	4.592AlaGln: 4.592 ± 0.062	10.636AlaArg: 10.636 ± 0.118	5.182AlaSer: 5.182 ± 0.061	6.046AlaThr: 6.046 ± 0.074	8.677AlaVal: 8.677 ± 0.105	1.51AlaTrp: 1.51 ± 0.038	2.488AlaTyr: 2.488 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.148CysAla: 1.148 ± 0.027	0.127CysCys: 0.127 ± 0.012	0.653CysAsp: 0.653 ± 0.024	0.466CysGlu: 0.466 ± 0.021	0.346CysPhe: 0.346 ± 0.017	1.042CysGly: 1.042 ± 0.034	0.318CysHis: 0.318 ± 0.017	0.425CysIle: 0.425 ± 0.022	0.192CysLys: 0.192 ± 0.012	0.923CysLeu: 0.923 ± 0.032	0.173CysMet: 0.173 ± 0.012	0.261CysAsn: 0.261 ± 0.014	0.565CysPro: 0.565 ± 0.023	0.241CysGln: 0.241 ± 0.015	0.651CysArg: 0.651 ± 0.024	0.441CysSer: 0.441 ± 0.021	0.504CysThr: 0.504 ± 0.02	0.662CysVal: 0.662 ± 0.023	0.136CysTrp: 0.136 ± 0.011	0.239CysTyr: 0.239 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.057AspAla: 7.057 ± 0.084	0.616AspCys: 0.616 ± 0.026	3.028AspAsp: 3.028 ± 0.061	3.376AspGlu: 3.376 ± 0.064	2.16AspPhe: 2.16 ± 0.05	4.902AspGly: 4.902 ± 0.068	1.426AspHis: 1.426 ± 0.033	3.226AspIle: 3.226 ± 0.055	1.483AspLys: 1.483 ± 0.042	6.747AspLeu: 6.747 ± 0.073	1.768AspMet: 1.768 ± 0.034	1.239AspAsn: 1.239 ± 0.036	3.608AspPro: 3.608 ± 0.055	1.829AspGln: 1.829 ± 0.039	4.549AspArg: 4.549 ± 0.059	2.035AspSer: 2.035 ± 0.047	2.879AspThr: 2.879 ± 0.046	3.994AspVal: 3.994 ± 0.056	1.196AspTrp: 1.196 ± 0.033	1.527AspTyr: 1.527 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.034GluAla: 8.034 ± 0.102	0.373GluCys: 0.373 ± 0.017	3.191GluAsp: 3.191 ± 0.05	3.381GluGlu: 3.381 ± 0.068	1.942GluPhe: 1.942 ± 0.043	4.858GluGly: 4.858 ± 0.065	1.184GluHis: 1.184 ± 0.03	3.738GluIle: 3.738 ± 0.054	1.965GluLys: 1.965 ± 0.042	4.604GluLeu: 4.604 ± 0.07	1.97GluMet: 1.97 ± 0.043	1.694GluAsn: 1.694 ± 0.042	2.478GluPro: 2.478 ± 0.047	1.822GluGln: 1.822 ± 0.044	4.757GluArg: 4.757 ± 0.062	2.104GluSer: 2.104 ± 0.045	3.843GluThr: 3.843 ± 0.059	4.487GluVal: 4.487 ± 0.062	0.691GluTrp: 0.691 ± 0.027	1.051GluTyr: 1.051 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.35PheAla: 4.35 ± 0.064	0.424PheCys: 0.424 ± 0.019	2.819PheAsp: 2.819 ± 0.043	2.159PheGlu: 2.159 ± 0.047	1.379PhePhe: 1.379 ± 0.044	3.61PheGly: 3.61 ± 0.066	0.774PheHis: 0.774 ± 0.024	1.681PheIle: 1.681 ± 0.041	0.793PheLys: 0.793 ± 0.027	3.374PheLeu: 3.374 ± 0.062	0.868PheMet: 0.868 ± 0.027	1.007PheAsn: 1.007 ± 0.03	1.448PhePro: 1.448 ± 0.036	1.0PheGln: 1.0 ± 0.027	2.361PheArg: 2.361 ± 0.046	2.027PheSer: 2.027 ± 0.042	1.945PheThr: 1.945 ± 0.044	2.653PheVal: 2.653 ± 0.054	0.6PheTrp: 0.6 ± 0.025	0.926PheTyr: 0.926 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.229GlyAla: 10.229 ± 0.094	0.92GlyCys: 0.92 ± 0.031	4.55GlyAsp: 4.55 ± 0.064	4.609GlyGlu: 4.609 ± 0.067	3.62GlyPhe: 3.62 ± 0.058	7.551GlyGly: 7.551 ± 0.114	2.108GlyHis: 2.108 ± 0.051	4.593GlyIle: 4.593 ± 0.074	2.865GlyLys: 2.865 ± 0.059	9.444GlyLeu: 9.444 ± 0.097	2.787GlyMet: 2.787 ± 0.061	2.132GlyAsn: 2.132 ± 0.049	3.76GlyPro: 3.76 ± 0.066	3.222GlyGln: 3.222 ± 0.055	6.505GlyArg: 6.505 ± 0.08	3.997GlySer: 3.997 ± 0.059	4.55GlyThr: 4.55 ± 0.063	6.511GlyVal: 6.511 ± 0.082	1.538GlyTrp: 1.538 ± 0.037	2.415GlyTyr: 2.415 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.57HisAla: 2.57 ± 0.054	0.264HisCys: 0.264 ± 0.014	1.445HisAsp: 1.445 ± 0.032	1.124HisGlu: 1.124 ± 0.031	0.88HisPhe: 0.88 ± 0.031	2.027HisGly: 2.027 ± 0.044	0.604HisHis: 0.604 ± 0.029	0.957HisIle: 0.957 ± 0.025	0.529HisLys: 0.529 ± 0.022	2.273HisLeu: 2.273 ± 0.046	0.543HisMet: 0.543 ± 0.021	0.464HisAsn: 0.464 ± 0.022	1.453HisPro: 1.453 ± 0.044	0.594HisGln: 0.594 ± 0.023	1.445HisArg: 1.445 ± 0.035	0.946HisSer: 0.946 ± 0.03	0.838HisThr: 0.838 ± 0.027	1.685HisVal: 1.685 ± 0.038	0.398HisTrp: 0.398 ± 0.019	0.586HisTyr: 0.586 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.146IleAla: 7.146 ± 0.085	0.661IleCys: 0.661 ± 0.026	3.357IleAsp: 3.357 ± 0.057	3.644IleGlu: 3.644 ± 0.058	1.792IlePhe: 1.792 ± 0.048	4.886IleGly: 4.886 ± 0.064	0.954IleHis: 0.954 ± 0.032	2.327IleIle: 2.327 ± 0.045	1.265IleLys: 1.265 ± 0.034	4.982IleLeu: 4.982 ± 0.062	1.131IleMet: 1.131 ± 0.034	1.399IleAsn: 1.399 ± 0.037	2.382IlePro: 2.382 ± 0.046	1.031IleGln: 1.031 ± 0.03	3.748IleArg: 3.748 ± 0.059	2.894IleSer: 2.894 ± 0.052	2.982IleThr: 2.982 ± 0.057	3.845IleVal: 3.845 ± 0.055	0.73IleTrp: 0.73 ± 0.026	1.233IleTyr: 1.233 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.211LysAla: 3.211 ± 0.066	0.177LysCys: 0.177 ± 0.011	1.356LysAsp: 1.356 ± 0.036	1.343LysGlu: 1.343 ± 0.036	0.834LysPhe: 0.834 ± 0.025	2.368LysGly: 2.368 ± 0.054	0.558LysHis: 0.558 ± 0.022	1.389LysIle: 1.389 ± 0.039	0.973LysLys: 0.973 ± 0.037	2.591LysLeu: 2.591 ± 0.049	0.705LysMet: 0.705 ± 0.024	0.618LysAsn: 0.618 ± 0.023	1.701LysPro: 1.701 ± 0.047	0.774LysGln: 0.774 ± 0.027	2.035LysArg: 2.035 ± 0.042	1.71LysSer: 1.71 ± 0.039	1.735LysThr: 1.735 ± 0.039	1.966LysVal: 1.966 ± 0.05	0.378LysTrp: 0.378 ± 0.019	0.607LysTyr: 0.607 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.353LeuAla: 13.353 ± 0.131	1.035LeuCys: 1.035 ± 0.03	6.091LeuAsp: 6.091 ± 0.073	5.276LeuGlu: 5.276 ± 0.057	3.471LeuPhe: 3.471 ± 0.064	8.558LeuGly: 8.558 ± 0.085	2.047LeuHis: 2.047 ± 0.047	5.57LeuIle: 5.57 ± 0.071	2.85LeuLys: 2.85 ± 0.057	8.917LeuLeu: 8.917 ± 0.12	2.916LeuMet: 2.916 ± 0.055	2.62LeuAsn: 2.62 ± 0.054	5.664LeuPro: 5.664 ± 0.075	2.686LeuGln: 2.686 ± 0.051	8.051LeuArg: 8.051 ± 0.097	6.352LeuSer: 6.352 ± 0.074	5.933LeuThr: 5.933 ± 0.074	6.858LeuVal: 6.858 ± 0.09	1.433LeuTrp: 1.433 ± 0.041	2.028LeuTyr: 2.028 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.683MetAla: 3.683 ± 0.061	0.201MetCys: 0.201 ± 0.013	1.383MetAsp: 1.383 ± 0.036	1.284MetGlu: 1.284 ± 0.035	0.831MetPhe: 0.831 ± 0.028	2.462MetGly: 2.462 ± 0.049	0.486MetHis: 0.486 ± 0.022	1.677MetIle: 1.677 ± 0.041	0.95MetLys: 0.95 ± 0.03	2.819MetLeu: 2.819 ± 0.053	0.817MetMet: 0.817 ± 0.031	0.829MetAsn: 0.829 ± 0.026	1.633MetPro: 1.633 ± 0.041	1.111MetGln: 1.111 ± 0.029	2.153MetArg: 2.153 ± 0.049	1.639MetSer: 1.639 ± 0.039	2.175MetThr: 2.175 ± 0.041	1.954MetVal: 1.954 ± 0.043	0.256MetTrp: 0.256 ± 0.016	0.35MetTyr: 0.35 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.026AsnAla: 3.026 ± 0.049	0.271AsnCys: 0.271 ± 0.016	1.379AsnAsp: 1.379 ± 0.044	1.184AsnGlu: 1.184 ± 0.034	0.904AsnPhe: 0.904 ± 0.033	2.236AsnGly: 2.236 ± 0.055	0.5AsnHis: 0.5 ± 0.02	1.318AsnIle: 1.318 ± 0.035	0.601AsnLys: 0.601 ± 0.024	2.494AsnLeu: 2.494 ± 0.048	0.681AsnMet: 0.681 ± 0.022	0.639AsnAsn: 0.639 ± 0.026	1.89AsnPro: 1.89 ± 0.046	0.633AsnGln: 0.633 ± 0.024	1.866AsnArg: 1.866 ± 0.038	1.073AsnSer: 1.073 ± 0.035	1.317AsnThr: 1.317 ± 0.032	1.752AsnVal: 1.752 ± 0.038	0.407AsnTrp: 0.407 ± 0.019	0.612AsnTyr: 0.612 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.703ProAla: 5.703 ± 0.076	0.38ProCys: 0.38 ± 0.017	4.124ProAsp: 4.124 ± 0.061	4.249ProGlu: 4.249 ± 0.066	1.864ProPhe: 1.864 ± 0.044	4.919ProGly: 4.919 ± 0.072	1.128ProHis: 1.128 ± 0.035	2.155ProIle: 2.155 ± 0.044	1.312ProLys: 1.312 ± 0.04	4.786ProLeu: 4.786 ± 0.069	1.385ProMet: 1.385 ± 0.033	1.197ProAsn: 1.197 ± 0.03	2.469ProPro: 2.469 ± 0.052	1.644ProGln: 1.644 ± 0.038	3.255ProArg: 3.255 ± 0.055	2.281ProSer: 2.281 ± 0.046	2.228ProThr: 2.228 ± 0.049	4.404ProVal: 4.404 ± 0.064	0.734ProTrp: 0.734 ± 0.027	1.142ProTyr: 1.142 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.159GlnAla: 4.159 ± 0.063	0.229GlnCys: 0.229 ± 0.012	1.621GlnAsp: 1.621 ± 0.044	1.632GlnGlu: 1.632 ± 0.044	1.061GlnPhe: 1.061 ± 0.032	2.704GlnGly: 2.704 ± 0.05	0.582GlnHis: 0.582 ± 0.022	1.9GlnIle: 1.9 ± 0.035	0.956GlnLys: 0.956 ± 0.03	2.643GlnLeu: 2.643 ± 0.048	1.055GlnMet: 1.055 ± 0.03	0.888GlnAsn: 0.888 ± 0.025	1.516GlnPro: 1.516 ± 0.034	1.006GlnGln: 1.006 ± 0.033	2.158GlnArg: 2.158 ± 0.041	1.677GlnSer: 1.677 ± 0.036	1.824GlnThr: 1.824 ± 0.039	2.359GlnVal: 2.359 ± 0.044	0.421GlnTrp: 0.421 ± 0.018	0.575GlnTyr: 0.575 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.598ArgAla: 9.598 ± 0.099	0.589ArgCys: 0.589 ± 0.026	4.661ArgAsp: 4.661 ± 0.061	4.255ArgGlu: 4.255 ± 0.06	2.844ArgPhe: 2.844 ± 0.051	5.324ArgGly: 5.324 ± 0.072	1.849ArgHis: 1.849 ± 0.041	4.387ArgIle: 4.387 ± 0.06	2.191ArgLys: 2.191 ± 0.049	8.437ArgLeu: 8.437 ± 0.101	2.271ArgMet: 2.271 ± 0.04	1.977ArgAsn: 1.977 ± 0.038	3.749ArgPro: 3.749 ± 0.061	2.449ArgGln: 2.449 ± 0.047	6.089ArgArg: 6.089 ± 0.089	3.33ArgSer: 3.33 ± 0.06	3.29ArgThr: 3.29 ± 0.058	5.291ArgVal: 5.291 ± 0.074	0.996ArgTrp: 0.996 ± 0.035	1.693ArgTyr: 1.693 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.555SerAla: 5.555 ± 0.073	0.437SerCys: 0.437 ± 0.023	3.126SerAsp: 3.126 ± 0.055	2.767SerGlu: 2.767 ± 0.047	2.013SerPhe: 2.013 ± 0.051	5.314SerGly: 5.314 ± 0.077	1.08SerHis: 1.08 ± 0.036	2.29SerIle: 2.29 ± 0.05	1.209SerLys: 1.209 ± 0.031	4.852SerLeu: 4.852 ± 0.072	1.243SerMet: 1.243 ± 0.038	1.196SerAsn: 1.196 ± 0.03	2.4SerPro: 2.4 ± 0.045	1.42SerGln: 1.42 ± 0.035	3.329SerArg: 3.329 ± 0.056	2.261SerSer: 2.261 ± 0.043	2.26SerThr: 2.26 ± 0.036	3.697SerVal: 3.697 ± 0.065	0.646SerTrp: 0.646 ± 0.025	1.224SerTyr: 1.224 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.134ThrAla: 6.134 ± 0.081	0.513ThrCys: 0.513 ± 0.021	3.039ThrAsp: 3.039 ± 0.056	2.994ThrGlu: 2.994 ± 0.06	1.901ThrPhe: 1.901 ± 0.041	5.602ThrGly: 5.602 ± 0.07	1.144ThrHis: 1.144 ± 0.03	2.719ThrIle: 2.719 ± 0.048	1.172ThrLys: 1.172 ± 0.035	6.019ThrLeu: 6.019 ± 0.09	1.296ThrMet: 1.296 ± 0.033	1.15ThrAsn: 1.15 ± 0.029	3.447ThrPro: 3.447 ± 0.047	1.494ThrGln: 1.494 ± 0.034	3.964ThrArg: 3.964 ± 0.066	2.461ThrSer: 2.461 ± 0.052	2.826ThrThr: 2.826 ± 0.054	3.963ThrVal: 3.963 ± 0.062	0.699ThrTrp: 0.699 ± 0.026	1.222ThrTyr: 1.222 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.93ValAla: 8.93 ± 0.107	0.696ValCys: 0.696 ± 0.023	3.811ValAsp: 3.811 ± 0.062	4.263ValGlu: 4.263 ± 0.059	2.848ValPhe: 2.848 ± 0.049	5.371ValGly: 5.371 ± 0.071	1.408ValHis: 1.408 ± 0.037	4.487ValIle: 4.487 ± 0.064	1.832ValLys: 1.832 ± 0.046	7.74ValLeu: 7.74 ± 0.098	2.227ValMet: 2.227 ± 0.049	1.914ValAsn: 1.914 ± 0.043	3.566ValPro: 3.566 ± 0.055	2.09ValGln: 2.09 ± 0.041	4.751ValArg: 4.751 ± 0.078	4.056ValSer: 4.056 ± 0.061	4.759ValThr: 4.759 ± 0.078	5.588ValVal: 5.588 ± 0.089	1.003ValTrp: 1.003 ± 0.028	1.445ValTyr: 1.445 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.446TrpAla: 1.446 ± 0.039	0.154TrpCys: 0.154 ± 0.013	0.71TrpAsp: 0.71 ± 0.028	0.688TrpGlu: 0.688 ± 0.026	0.606TrpPhe: 0.606 ± 0.024	1.072TrpGly: 1.072 ± 0.034	0.372TrpHis: 0.372 ± 0.018	0.715TrpIle: 0.715 ± 0.02	0.407TrpLys: 0.407 ± 0.018	1.755TrpLeu: 1.755 ± 0.043	0.422TrpMet: 0.422 ± 0.018	0.424TrpAsn: 0.424 ± 0.02	0.753TrpPro: 0.753 ± 0.025	0.646TrpGln: 0.646 ± 0.024	1.238TrpArg: 1.238 ± 0.033	0.782TrpSer: 0.782 ± 0.027	0.76TrpThr: 0.76 ± 0.028	0.903TrpVal: 0.903 ± 0.031	0.233TrpTrp: 0.233 ± 0.016	0.276TrpTyr: 0.276 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.046	0.245TyrCys: 0.245 ± 0.014	1.549TyrAsp: 1.549 ± 0.036	1.283TyrGlu: 1.283 ± 0.038	0.867TyrPhe: 0.867 ± 0.025	2.138TyrGly: 2.138 ± 0.046	0.557TyrHis: 0.557 ± 0.025	0.927TyrIle: 0.927 ± 0.032	0.541TyrLys: 0.541 ± 0.025	2.344TyrLeu: 2.344 ± 0.045	0.496TyrMet: 0.496 ± 0.023	0.592TyrAsn: 0.592 ± 0.023	1.087TyrPro: 1.087 ± 0.033	0.683TyrGln: 0.683 ± 0.026	1.731TyrArg: 1.731 ± 0.041	1.07TyrSer: 1.07 ± 0.031	1.063TyrThr: 1.063 ± 0.032	1.537TyrVal: 1.537 ± 0.039	0.357TyrTrp: 0.357 ± 0.02	0.585TyrTyr: 0.585 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3792 proteins (1160880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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