Amino acid dipepetide frequency for Aquirufa antheringensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.996AlaAla: 6.996 ± 0.15
0.777AlaCys: 0.777 ± 0.042
4.376AlaAsp: 4.376 ± 0.076
5.059AlaGlu: 5.059 ± 0.093
3.924AlaPhe: 3.924 ± 0.07
6.329AlaGly: 6.329 ± 0.128
1.404AlaHis: 1.404 ± 0.042
5.635AlaIle: 5.635 ± 0.103
5.841AlaLys: 5.841 ± 0.115
7.863AlaLeu: 7.863 ± 0.12
2.004AlaMet: 2.004 ± 0.054
3.774AlaAsn: 3.774 ± 0.107
2.763AlaPro: 2.763 ± 0.082
3.184AlaGln: 3.184 ± 0.067
2.726AlaArg: 2.726 ± 0.064
5.526AlaSer: 5.526 ± 0.087
4.414AlaThr: 4.414 ± 0.128
4.707AlaVal: 4.707 ± 0.082
0.926AlaTrp: 0.926 ± 0.04
3.028AlaTyr: 3.028 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.577CysAla: 0.577 ± 0.032
0.113CysCys: 0.113 ± 0.013
0.444CysAsp: 0.444 ± 0.028
0.433CysGlu: 0.433 ± 0.027
0.38CysPhe: 0.38 ± 0.022
0.622CysGly: 0.622 ± 0.033
0.234CysHis: 0.234 ± 0.02
0.502CysIle: 0.502 ± 0.024
0.361CysLys: 0.361 ± 0.02
0.79CysLeu: 0.79 ± 0.035
0.169CysMet: 0.169 ± 0.013
0.312CysAsn: 0.312 ± 0.019
0.44CysPro: 0.44 ± 0.034
0.286CysGln: 0.286 ± 0.02
0.241CysArg: 0.241 ± 0.02
0.534CysSer: 0.534 ± 0.028
0.455CysThr: 0.455 ± 0.04
0.492CysVal: 0.492 ± 0.026
0.08CysTrp: 0.08 ± 0.011
0.276CysTyr: 0.276 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.043AspAla: 4.043 ± 0.098
0.368AspCys: 0.368 ± 0.024
2.044AspAsp: 2.044 ± 0.076
3.105AspGlu: 3.105 ± 0.072
3.252AspPhe: 3.252 ± 0.06
3.977AspGly: 3.977 ± 0.286
0.916AspHis: 0.916 ± 0.037
3.275AspIle: 3.275 ± 0.08
3.177AspLys: 3.177 ± 0.08
5.489AspLeu: 5.489 ± 0.095
1.04AspMet: 1.04 ± 0.036
1.947AspAsn: 1.947 ± 0.095
2.257AspPro: 2.257 ± 0.054
1.933AspGln: 1.933 ± 0.046
2.158AspArg: 2.158 ± 0.06
3.076AspSer: 3.076 ± 0.122
2.346AspThr: 2.346 ± 0.094
3.293AspVal: 3.293 ± 0.068
0.81AspTrp: 0.81 ± 0.032
2.399AspTyr: 2.399 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.987GluAla: 4.987 ± 0.08
0.351GluCys: 0.351 ± 0.02
2.759GluAsp: 2.759 ± 0.067
4.156GluGlu: 4.156 ± 0.093
2.73GluPhe: 2.73 ± 0.059
3.769GluGly: 3.769 ± 0.067
1.077GluHis: 1.077 ± 0.035
4.82GluIle: 4.82 ± 0.094
5.238GluLys: 5.238 ± 0.102
5.707GluLeu: 5.707 ± 0.105
1.753GluMet: 1.753 ± 0.049
3.327GluAsn: 3.327 ± 0.073
1.736GluPro: 1.736 ± 0.05
2.163GluGln: 2.163 ± 0.052
2.457GluArg: 2.457 ± 0.057
3.224GluSer: 3.224 ± 0.064
3.146GluThr: 3.146 ± 0.061
4.291GluVal: 4.291 ± 0.077
0.739GluTrp: 0.739 ± 0.035
1.896GluTyr: 1.896 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.831PheAla: 3.831 ± 0.076
0.482PheCys: 0.482 ± 0.026
2.926PheAsp: 2.926 ± 0.062
2.9PheGlu: 2.9 ± 0.06
2.588PhePhe: 2.588 ± 0.072
3.607PheGly: 3.607 ± 0.085
0.937PheHis: 0.937 ± 0.037
3.312PheIle: 3.312 ± 0.075
3.101PheLys: 3.101 ± 0.072
4.891PheLeu: 4.891 ± 0.11
1.09PheMet: 1.09 ± 0.041
2.291PheAsn: 2.291 ± 0.057
2.013PhePro: 2.013 ± 0.053
2.123PheGln: 2.123 ± 0.06
1.698PheArg: 1.698 ± 0.046
4.042PheSer: 4.042 ± 0.088
2.996PheThr: 2.996 ± 0.065
3.288PheVal: 3.288 ± 0.075
0.644PheTrp: 0.644 ± 0.028
1.916PheTyr: 1.916 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.391GlyAla: 5.391 ± 0.115
0.637GlyCys: 0.637 ± 0.036
3.631GlyAsp: 3.631 ± 0.112
3.758GlyGlu: 3.758 ± 0.077
3.938GlyPhe: 3.938 ± 0.078
5.385GlyGly: 5.385 ± 0.106
1.359GlyHis: 1.359 ± 0.047
5.911GlyIle: 5.911 ± 0.115
5.228GlyLys: 5.228 ± 0.099
7.197GlyLeu: 7.197 ± 0.119
1.995GlyMet: 1.995 ± 0.048
3.341GlyAsn: 3.341 ± 0.089
1.939GlyPro: 1.939 ± 0.053
2.395GlyGln: 2.395 ± 0.05
2.616GlyArg: 2.616 ± 0.074
4.597GlySer: 4.597 ± 0.097
4.396GlyThr: 4.396 ± 0.202
5.025GlyVal: 5.025 ± 0.089
0.928GlyTrp: 0.928 ± 0.037
2.807GlyTyr: 2.807 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.299HisAla: 1.299 ± 0.037
0.194HisCys: 0.194 ± 0.014
0.705HisAsp: 0.705 ± 0.029
1.015HisGlu: 1.015 ± 0.037
1.295HisPhe: 1.295 ± 0.046
1.264HisGly: 1.264 ± 0.042
0.498HisHis: 0.498 ± 0.029
1.251HisIle: 1.251 ± 0.04
0.948HisLys: 0.948 ± 0.036
2.092HisLeu: 2.092 ± 0.061
0.314HisMet: 0.314 ± 0.021
0.654HisAsn: 0.654 ± 0.031
1.186HisPro: 1.186 ± 0.043
0.765HisGln: 0.765 ± 0.033
0.829HisArg: 0.829 ± 0.032
1.185HisSer: 1.185 ± 0.046
0.956HisThr: 0.956 ± 0.038
1.138HisVal: 1.138 ± 0.039
0.267HisTrp: 0.267 ± 0.019
0.873HisTyr: 0.873 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.792IleAla: 5.792 ± 0.095
0.684IleCys: 0.684 ± 0.029
3.838IleAsp: 3.838 ± 0.063
4.568IleGlu: 4.568 ± 0.086
2.862IlePhe: 2.862 ± 0.067
4.968IleGly: 4.968 ± 0.089
1.38IleHis: 1.38 ± 0.041
4.287IleIle: 4.287 ± 0.099
4.223IleLys: 4.223 ± 0.082
6.514IleLeu: 6.514 ± 0.099
1.179IleMet: 1.179 ± 0.042
3.028IleAsn: 3.028 ± 0.076
3.645IlePro: 3.645 ± 0.077
3.089IleGln: 3.089 ± 0.066
2.865IleArg: 2.865 ± 0.067
5.318IleSer: 5.318 ± 0.086
3.992IleThr: 3.992 ± 0.085
4.172IleVal: 4.172 ± 0.078
0.705IleTrp: 0.705 ± 0.031
2.38IleTyr: 2.38 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.706LysAla: 5.706 ± 0.117
0.29LysCys: 0.29 ± 0.02
3.409LysAsp: 3.409 ± 0.073
4.869LysGlu: 4.869 ± 0.091
2.493LysPhe: 2.493 ± 0.058
4.997LysGly: 4.997 ± 0.093
1.138LysHis: 1.138 ± 0.038
4.789LysIle: 4.789 ± 0.085
5.272LysLys: 5.272 ± 0.113
5.304LysLeu: 5.304 ± 0.105
2.034LysMet: 2.034 ± 0.053
3.56LysAsn: 3.56 ± 0.083
2.762LysPro: 2.762 ± 0.064
2.452LysGln: 2.452 ± 0.062
2.59LysArg: 2.59 ± 0.069
4.116LysSer: 4.116 ± 0.087
3.943LysThr: 3.943 ± 0.074
4.291LysVal: 4.291 ± 0.085
0.74LysTrp: 0.74 ± 0.03
2.298LysTyr: 2.298 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
8.333LeuAla: 8.333 ± 0.12
0.777LeuCys: 0.777 ± 0.033
5.034LeuAsp: 5.034 ± 0.142
5.4LeuGlu: 5.4 ± 0.092
5.191LeuPhe: 5.191 ± 0.11
7.029LeuGly: 7.029 ± 0.123
1.895LeuHis: 1.895 ± 0.052
6.467LeuIle: 6.467 ± 0.114
6.457LeuLys: 6.457 ± 0.123
9.329LeuLeu: 9.329 ± 0.153
2.276LeuMet: 2.276 ± 0.056
4.75LeuAsn: 4.75 ± 0.095
4.18LeuPro: 4.18 ± 0.086
3.688LeuGln: 3.688 ± 0.076
3.76LeuArg: 3.76 ± 0.08
6.896LeuSer: 6.896 ± 0.112
5.261LeuThr: 5.261 ± 0.108
6.247LeuVal: 6.247 ± 0.092
0.956LeuTrp: 0.956 ± 0.037
2.988LeuTyr: 2.988 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.153MetAla: 2.153 ± 0.061
0.134MetCys: 0.134 ± 0.014
1.246MetAsp: 1.246 ± 0.042
1.532MetGlu: 1.532 ± 0.052
0.707MetPhe: 0.707 ± 0.031
1.895MetGly: 1.895 ± 0.056
0.43MetHis: 0.43 ± 0.023
1.452MetIle: 1.452 ± 0.042
2.094MetLys: 2.094 ± 0.051
1.933MetLeu: 1.933 ± 0.047
0.64MetMet: 0.64 ± 0.029
1.253MetAsn: 1.253 ± 0.042
1.086MetPro: 1.086 ± 0.034
0.864MetGln: 0.864 ± 0.039
1.13MetArg: 1.13 ± 0.041
1.582MetSer: 1.582 ± 0.047
1.253MetThr: 1.253 ± 0.039
1.389MetVal: 1.389 ± 0.043
0.238MetTrp: 0.238 ± 0.018
0.667MetTyr: 0.667 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.704AsnAla: 3.704 ± 0.084
0.337AsnCys: 0.337 ± 0.024
2.193AsnAsp: 2.193 ± 0.102
2.58AsnGlu: 2.58 ± 0.056
2.462AsnPhe: 2.462 ± 0.071
3.296AsnGly: 3.296 ± 0.1
0.892AsnHis: 0.892 ± 0.031
2.858AsnIle: 2.858 ± 0.061
2.756AsnLys: 2.756 ± 0.061
4.603AsnLeu: 4.603 ± 0.096
0.997AsnMet: 0.997 ± 0.032
2.198AsnAsn: 2.198 ± 0.076
2.881AsnPro: 2.881 ± 0.068
2.089AsnGln: 2.089 ± 0.055
2.047AsnArg: 2.047 ± 0.055
3.047AsnSer: 3.047 ± 0.087
2.782AsnThr: 2.782 ± 0.088
2.89AsnVal: 2.89 ± 0.076
0.746AsnTrp: 0.746 ± 0.03
2.181AsnTyr: 2.181 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
3.905ProAla: 3.905 ± 0.091
0.237ProCys: 0.237 ± 0.022
2.203ProAsp: 2.203 ± 0.064
2.8ProGlu: 2.8 ± 0.066
2.077ProPhe: 2.077 ± 0.058
2.746ProGly: 2.746 ± 0.058
0.746ProHis: 0.746 ± 0.032
2.781ProIle: 2.781 ± 0.065
2.399ProLys: 2.399 ± 0.054
3.685ProLeu: 3.685 ± 0.066
0.987ProMet: 0.987 ± 0.039
2.052ProAsn: 2.052 ± 0.076
0.891ProPro: 0.891 ± 0.044
1.118ProGln: 1.118 ± 0.038
1.253ProArg: 1.253 ± 0.046
2.898ProSer: 2.898 ± 0.069
2.527ProThr: 2.527 ± 0.083
2.972ProVal: 2.972 ± 0.074
0.409ProTrp: 0.409 ± 0.027
1.487ProTyr: 1.487 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.171GlnAla: 3.171 ± 0.073
0.184GlnCys: 0.184 ± 0.016
1.722GlnAsp: 1.722 ± 0.042
2.389GlnGlu: 2.389 ± 0.065
1.727GlnPhe: 1.727 ± 0.044
2.4GlnGly: 2.4 ± 0.05
0.651GlnHis: 0.651 ± 0.032
2.93GlnIle: 2.93 ± 0.058
2.83GlnLys: 2.83 ± 0.068
3.578GlnLeu: 3.578 ± 0.068
1.009GlnMet: 1.009 ± 0.029
1.797GlnAsn: 1.797 ± 0.048
1.307GlnPro: 1.307 ± 0.046
1.596GlnGln: 1.596 ± 0.059
1.398GlnArg: 1.398 ± 0.04
2.3GlnSer: 2.3 ± 0.056
2.143GlnThr: 2.143 ± 0.051
2.768GlnVal: 2.768 ± 0.063
0.455GlnTrp: 0.455 ± 0.028
1.217GlnTyr: 1.217 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.612ArgAla: 2.612 ± 0.061
0.226ArgCys: 0.226 ± 0.016
1.863ArgAsp: 1.863 ± 0.049
2.364ArgGlu: 2.364 ± 0.061
2.142ArgPhe: 2.142 ± 0.055
2.394ArgGly: 2.394 ± 0.065
0.689ArgHis: 0.689 ± 0.034
3.08ArgIle: 3.08 ± 0.059
2.708ArgLys: 2.708 ± 0.073
3.928ArgLeu: 3.928 ± 0.075
1.11ArgMet: 1.11 ± 0.035
1.912ArgAsn: 1.912 ± 0.055
1.447ArgPro: 1.447 ± 0.046
1.256ArgGln: 1.256 ± 0.049
1.531ArgArg: 1.531 ± 0.053
2.214ArgSer: 2.214 ± 0.06
2.072ArgThr: 2.072 ± 0.054
2.512ArgVal: 2.512 ± 0.062
0.532ArgTrp: 0.532 ± 0.028
1.465ArgTyr: 1.465 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.083SerAla: 5.083 ± 0.09
0.599SerCys: 0.599 ± 0.028
3.256SerAsp: 3.256 ± 0.112
3.53SerGlu: 3.53 ± 0.075
3.935SerPhe: 3.935 ± 0.073
4.995SerGly: 4.995 ± 0.11
1.233SerHis: 1.233 ± 0.039
4.903SerIle: 4.903 ± 0.081
4.045SerLys: 4.045 ± 0.074
7.171SerLeu: 7.171 ± 0.121
1.455SerMet: 1.455 ± 0.042
2.986SerAsn: 2.986 ± 0.074
2.656SerPro: 2.656 ± 0.075
2.16SerGln: 2.16 ± 0.05
2.305SerArg: 2.305 ± 0.058
4.72SerSer: 4.72 ± 0.099
4.072SerThr: 4.072 ± 0.13
4.37SerVal: 4.37 ± 0.074
0.752SerTrp: 0.752 ± 0.033
2.574SerTyr: 2.574 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.526ThrAla: 4.526 ± 0.135
0.403ThrCys: 0.403 ± 0.021
3.018ThrAsp: 3.018 ± 0.142
3.096ThrGlu: 3.096 ± 0.059
2.817ThrPhe: 2.817 ± 0.06
4.655ThrGly: 4.655 ± 0.132
1.07ThrHis: 1.07 ± 0.038
3.846ThrIle: 3.846 ± 0.091
3.19ThrLys: 3.19 ± 0.077
5.683ThrLeu: 5.683 ± 0.106
1.066ThrMet: 1.066 ± 0.036
2.701ThrAsn: 2.701 ± 0.092
2.606ThrPro: 2.606 ± 0.088
2.019ThrGln: 2.019 ± 0.053
1.872ThrArg: 1.872 ± 0.058
3.717ThrSer: 3.717 ± 0.099
3.21ThrThr: 3.21 ± 0.139
3.647ThrVal: 3.647 ± 0.109
0.758ThrTrp: 0.758 ± 0.03
2.441ThrTyr: 2.441 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
5.395ValAla: 5.395 ± 0.093
0.572ValCys: 0.572 ± 0.035
3.644ValAsp: 3.644 ± 0.079
4.043ValGlu: 4.043 ± 0.086
3.266ValPhe: 3.266 ± 0.068
4.59ValGly: 4.59 ± 0.081
1.156ValHis: 1.156 ± 0.042
4.474ValIle: 4.474 ± 0.084
4.308ValLys: 4.308 ± 0.083
6.192ValLeu: 6.192 ± 0.095
1.492ValMet: 1.492 ± 0.05
3.314ValAsn: 3.314 ± 0.087
2.511ValPro: 2.511 ± 0.064
2.193ValGln: 2.193 ± 0.056
2.438ValArg: 2.438 ± 0.059
4.628ValSer: 4.628 ± 0.092
3.504ValThr: 3.504 ± 0.101
4.31ValVal: 4.31 ± 0.087
0.745ValTrp: 0.745 ± 0.033
2.279ValTyr: 2.279 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.902TrpAla: 0.902 ± 0.037
0.086TrpCys: 0.086 ± 0.012
0.7TrpAsp: 0.7 ± 0.034
0.746TrpGlu: 0.746 ± 0.03
0.589TrpPhe: 0.589 ± 0.027
0.892TrpGly: 0.892 ± 0.04
0.234TrpHis: 0.234 ± 0.018
0.825TrpIle: 0.825 ± 0.035
0.859TrpLys: 0.859 ± 0.036
1.08TrpLeu: 1.08 ± 0.037
0.394TrpMet: 0.394 ± 0.024
0.703TrpAsn: 0.703 ± 0.034
0.289TrpPro: 0.289 ± 0.021
0.473TrpGln: 0.473 ± 0.024
0.45TrpArg: 0.45 ± 0.026
0.716TrpSer: 0.716 ± 0.038
0.656TrpThr: 0.656 ± 0.031
0.901TrpVal: 0.901 ± 0.04
0.169TrpTrp: 0.169 ± 0.015
0.419TrpTyr: 0.419 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.849TyrAla: 2.849 ± 0.064
0.289TyrCys: 0.289 ± 0.023
1.897TyrAsp: 1.897 ± 0.053
1.983TyrGlu: 1.983 ± 0.049
2.298TyrPhe: 2.298 ± 0.059
2.663TyrGly: 2.663 ± 0.054
0.788TyrHis: 0.788 ± 0.037
2.09TyrIle: 2.09 ± 0.055
2.018TyrLys: 2.018 ± 0.053
3.886TyrLeu: 3.886 ± 0.085
0.674TyrMet: 0.674 ± 0.03
1.64TyrAsn: 1.64 ± 0.056
1.58TyrPro: 1.58 ± 0.053
1.727TyrGln: 1.727 ± 0.057
1.691TyrArg: 1.691 ± 0.058
2.465TyrSer: 2.465 ± 0.057
2.215TyrThr: 2.215 ± 0.085
2.351TyrVal: 2.351 ± 0.055
0.487TyrTrp: 0.487 ± 0.025
1.555TyrTyr: 1.555 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2203 proteins (789050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski