Amino acid dipepetide frequency for Mycobacterium xenopi RIVM700367

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.244AlaAla: 21.244 ± 0.196	1.082AlaCys: 1.082 ± 0.031	8.225AlaAsp: 8.225 ± 0.08	7.892AlaGlu: 7.892 ± 0.101	3.282AlaPhe: 3.282 ± 0.053	11.616AlaGly: 11.616 ± 0.109	2.751AlaHis: 2.751 ± 0.042	5.204AlaIle: 5.204 ± 0.062	3.201AlaLys: 3.201 ± 0.059	13.038AlaLeu: 13.038 ± 0.103	2.891AlaMet: 2.891 ± 0.053	2.649AlaAsn: 2.649 ± 0.039	6.356AlaPro: 6.356 ± 0.09	4.263AlaGln: 4.263 ± 0.055	9.462AlaArg: 9.462 ± 0.098	6.045AlaSer: 6.045 ± 0.076	6.993AlaThr: 6.993 ± 0.072	11.903AlaVal: 11.903 ± 0.109	1.736AlaTrp: 1.736 ± 0.036	2.385AlaTyr: 2.385 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.145CysAla: 1.145 ± 0.035	0.098CysCys: 0.098 ± 0.009	0.621CysAsp: 0.621 ± 0.023	0.445CysGlu: 0.445 ± 0.016	0.253CysPhe: 0.253 ± 0.015	1.028CysGly: 1.028 ± 0.033	0.205CysHis: 0.205 ± 0.012	0.272CysIle: 0.272 ± 0.014	0.128CysLys: 0.128 ± 0.009	0.715CysLeu: 0.715 ± 0.024	0.159CysMet: 0.159 ± 0.012	0.177CysAsn: 0.177 ± 0.012	0.638CysPro: 0.638 ± 0.025	0.246CysGln: 0.246 ± 0.013	0.723CysArg: 0.723 ± 0.025	0.476CysSer: 0.476 ± 0.022	0.496CysThr: 0.496 ± 0.018	0.679CysVal: 0.679 ± 0.025	0.179CysTrp: 0.179 ± 0.011	0.214CysTyr: 0.214 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.533AspAla: 7.533 ± 0.083	0.481AspCys: 0.481 ± 0.019	4.151AspAsp: 4.151 ± 0.078	4.112AspGlu: 4.112 ± 0.058	1.696AspPhe: 1.696 ± 0.034	5.536AspGly: 5.536 ± 0.068	1.445AspHis: 1.445 ± 0.034	2.641AspIle: 2.641 ± 0.053	1.334AspLys: 1.334 ± 0.03	5.669AspLeu: 5.669 ± 0.074	0.92AspMet: 0.92 ± 0.026	1.183AspAsn: 1.183 ± 0.03	4.351AspPro: 4.351 ± 0.049	1.819AspGln: 1.819 ± 0.041	4.562AspArg: 4.562 ± 0.063	2.545AspSer: 2.545 ± 0.047	3.189AspThr: 3.189 ± 0.05	5.439AspVal: 5.439 ± 0.068	0.932AspTrp: 0.932 ± 0.025	1.481AspTyr: 1.481 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.975GluAla: 5.975 ± 0.092	0.383GluCys: 0.383 ± 0.018	2.24GluAsp: 2.24 ± 0.034	2.395GluGlu: 2.395 ± 0.048	1.799GluPhe: 1.799 ± 0.038	3.088GluGly: 3.088 ± 0.049	1.596GluHis: 1.596 ± 0.037	2.645GluIle: 2.645 ± 0.052	1.298GluLys: 1.298 ± 0.034	6.809GluLeu: 6.809 ± 0.08	1.071GluMet: 1.071 ± 0.028	1.05GluAsn: 1.05 ± 0.026	3.039GluPro: 3.039 ± 0.048	2.349GluGln: 2.349 ± 0.043	4.53GluArg: 4.53 ± 0.068	2.513GluSer: 2.513 ± 0.043	2.545GluThr: 2.545 ± 0.048	4.316GluVal: 4.316 ± 0.059	0.725GluTrp: 0.725 ± 0.024	1.133GluTyr: 1.133 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.978PheAla: 3.978 ± 0.059	0.352PheCys: 0.352 ± 0.018	2.463PheAsp: 2.463 ± 0.043	1.511PheGlu: 1.511 ± 0.035	0.971PhePhe: 0.971 ± 0.034	3.326PheGly: 3.326 ± 0.056	0.68PheHis: 0.68 ± 0.022	0.987PheIle: 0.987 ± 0.03	0.531PheLys: 0.531 ± 0.022	2.356PheLeu: 2.356 ± 0.047	0.487PheMet: 0.487 ± 0.02	0.688PheAsn: 0.688 ± 0.021	1.516PhePro: 1.516 ± 0.03	0.675PheGln: 0.675 ± 0.022	1.713PheArg: 1.713 ± 0.033	1.617PheSer: 1.617 ± 0.04	1.966PheThr: 1.966 ± 0.039	2.584PheVal: 2.584 ± 0.046	0.437PheTrp: 0.437 ± 0.018	0.727PheTyr: 0.727 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.699GlyAla: 9.699 ± 0.108	0.904GlyCys: 0.904 ± 0.029	4.614GlyAsp: 4.614 ± 0.054	4.204GlyGlu: 4.204 ± 0.063	2.929GlyPhe: 2.929 ± 0.047	7.434GlyGly: 7.434 ± 0.1	2.091GlyHis: 2.091 ± 0.041	4.032GlyIle: 4.032 ± 0.058	2.388GlyLys: 2.388 ± 0.045	8.464GlyLeu: 8.464 ± 0.093	2.034GlyMet: 2.034 ± 0.044	1.812GlyAsn: 1.812 ± 0.04	4.612GlyPro: 4.612 ± 0.07	2.893GlyGln: 2.893 ± 0.046	6.475GlyArg: 6.475 ± 0.082	4.898GlySer: 4.898 ± 0.062	4.835GlyThr: 4.835 ± 0.071	7.498GlyVal: 7.498 ± 0.085	1.697GlyTrp: 1.697 ± 0.036	2.466GlyTyr: 2.466 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.686HisAla: 2.686 ± 0.045	0.257HisCys: 0.257 ± 0.014	1.427HisAsp: 1.427 ± 0.038	1.073HisGlu: 1.073 ± 0.028	0.665HisPhe: 0.665 ± 0.022	2.21HisGly: 2.21 ± 0.043	0.777HisHis: 0.777 ± 0.025	0.888HisIle: 0.888 ± 0.027	0.415HisLys: 0.415 ± 0.017	2.195HisLeu: 2.195 ± 0.04	0.338HisMet: 0.338 ± 0.016	0.552HisAsn: 0.552 ± 0.015	1.791HisPro: 1.791 ± 0.033	0.726HisGln: 0.726 ± 0.023	2.078HisArg: 2.078 ± 0.04	1.085HisSer: 1.085 ± 0.03	1.323HisThr: 1.323 ± 0.035	1.747HisVal: 1.747 ± 0.04	0.395HisTrp: 0.395 ± 0.017	0.589HisTyr: 0.589 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.282IleAla: 6.282 ± 0.075	0.445IleCys: 0.445 ± 0.016	3.449IleAsp: 3.449 ± 0.057	2.6IleGlu: 2.6 ± 0.044	0.999IlePhe: 0.999 ± 0.029	4.21IleGly: 4.21 ± 0.06	0.821IleHis: 0.821 ± 0.025	1.386IleIle: 1.386 ± 0.031	0.914IleLys: 0.914 ± 0.029	2.895IleLeu: 2.895 ± 0.049	0.581IleMet: 0.581 ± 0.021	1.136IleAsn: 1.136 ± 0.028	2.42IlePro: 2.42 ± 0.046	0.986IleGln: 0.986 ± 0.028	2.75IleArg: 2.75 ± 0.049	2.238IleSer: 2.238 ± 0.036	2.847IleThr: 2.847 ± 0.041	3.572IleVal: 3.572 ± 0.058	0.493IleTrp: 0.493 ± 0.019	0.858IleTyr: 0.858 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.721LysAla: 2.721 ± 0.054	0.137LysCys: 0.137 ± 0.01	1.089LysAsp: 1.089 ± 0.029	0.975LysGlu: 0.975 ± 0.031	0.663LysPhe: 0.663 ± 0.023	1.439LysGly: 1.439 ± 0.039	0.551LysHis: 0.551 ± 0.022	1.08LysIle: 1.08 ± 0.035	0.651LysLys: 0.651 ± 0.027	2.372LysLeu: 2.372 ± 0.045	0.455LysMet: 0.455 ± 0.019	0.511LysAsn: 0.511 ± 0.019	1.569LysPro: 1.569 ± 0.035	0.808LysGln: 0.808 ± 0.03	1.728LysArg: 1.728 ± 0.036	1.235LysSer: 1.235 ± 0.031	1.483LysThr: 1.483 ± 0.038	1.962LysVal: 1.962 ± 0.045	0.302LysTrp: 0.302 ± 0.015	0.481LysTyr: 0.481 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.595LeuAla: 14.595 ± 0.102	0.901LeuCys: 0.901 ± 0.029	6.449LeuAsp: 6.449 ± 0.077	4.38LeuGlu: 4.38 ± 0.062	2.672LeuPhe: 2.672 ± 0.045	8.539LeuGly: 8.539 ± 0.101	2.138LeuHis: 2.138 ± 0.042	3.904LeuIle: 3.904 ± 0.055	1.853LeuLys: 1.853 ± 0.038	9.706LeuLeu: 9.706 ± 0.109	1.679LeuMet: 1.679 ± 0.035	2.041LeuAsn: 2.041 ± 0.044	5.996LeuPro: 5.996 ± 0.068	2.743LeuGln: 2.743 ± 0.052	8.142LeuArg: 8.142 ± 0.08	5.559LeuSer: 5.559 ± 0.059	6.183LeuThr: 6.183 ± 0.067	8.564LeuVal: 8.564 ± 0.088	1.273LeuTrp: 1.273 ± 0.032	1.698LeuTyr: 1.698 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.565MetAla: 2.565 ± 0.046	0.206MetCys: 0.206 ± 0.013	0.785MetAsp: 0.785 ± 0.025	0.683MetGlu: 0.683 ± 0.024	0.635MetPhe: 0.635 ± 0.022	1.383MetGly: 1.383 ± 0.037	0.439MetHis: 0.439 ± 0.021	0.855MetIle: 0.855 ± 0.029	0.412MetLys: 0.412 ± 0.018	2.154MetLeu: 2.154 ± 0.039	0.385MetMet: 0.385 ± 0.019	0.481MetAsn: 0.481 ± 0.02	1.29MetPro: 1.29 ± 0.034	0.563MetGln: 0.563 ± 0.021	1.59MetArg: 1.59 ± 0.036	1.396MetSer: 1.396 ± 0.032	1.668MetThr: 1.668 ± 0.033	1.676MetVal: 1.676 ± 0.04	0.295MetTrp: 0.295 ± 0.016	0.361MetTyr: 0.361 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.601AsnAla: 2.601 ± 0.044	0.21AsnCys: 0.21 ± 0.012	1.148AsnAsp: 1.148 ± 0.032	0.946AsnGlu: 0.946 ± 0.024	0.686AsnPhe: 0.686 ± 0.02	2.002AsnGly: 2.002 ± 0.043	0.488AsnHis: 0.488 ± 0.022	0.912AsnIle: 0.912 ± 0.025	0.412AsnLys: 0.412 ± 0.019	2.015AsnLeu: 2.015 ± 0.041	0.421AsnMet: 0.421 ± 0.017	0.57AsnAsn: 0.57 ± 0.022	1.767AsnPro: 1.767 ± 0.043	0.677AsnGln: 0.677 ± 0.021	1.646AsnArg: 1.646 ± 0.037	1.063AsnSer: 1.063 ± 0.032	1.338AsnThr: 1.338 ± 0.033	1.742AsnVal: 1.742 ± 0.036	0.403AsnTrp: 0.403 ± 0.018	0.597AsnTyr: 0.597 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.535ProAla: 7.535 ± 0.117	0.338ProCys: 0.338 ± 0.015	4.346ProAsp: 4.346 ± 0.067	3.596ProGlu: 3.596 ± 0.053	1.635ProPhe: 1.635 ± 0.035	5.956ProGly: 5.956 ± 0.08	1.299ProHis: 1.299 ± 0.026	2.282ProIle: 2.282 ± 0.045	1.388ProLys: 1.388 ± 0.031	5.091ProLeu: 5.091 ± 0.071	1.198ProMet: 1.198 ± 0.031	1.317ProAsn: 1.317 ± 0.037	4.254ProPro: 4.254 ± 0.094	1.962ProGln: 1.962 ± 0.044	3.841ProArg: 3.841 ± 0.062	3.084ProSer: 3.084 ± 0.051	3.536ProThr: 3.536 ± 0.056	5.275ProVal: 5.275 ± 0.069	0.898ProTrp: 0.898 ± 0.029	1.21ProTyr: 1.21 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.052GlnAla: 4.052 ± 0.063	0.253GlnCys: 0.253 ± 0.016	1.16GlnAsp: 1.16 ± 0.03	1.061GlnGlu: 1.061 ± 0.032	1.001GlnPhe: 1.001 ± 0.031	1.885GlnGly: 1.885 ± 0.04	0.852GlnHis: 0.852 ± 0.024	1.529GlnIle: 1.529 ± 0.034	0.636GlnLys: 0.636 ± 0.025	4.013GlnLeu: 4.013 ± 0.063	0.656GlnMet: 0.656 ± 0.023	0.597GlnAsn: 0.597 ± 0.019	2.2GlnPro: 2.2 ± 0.043	1.4GlnGln: 1.4 ± 0.038	3.154GlnArg: 3.154 ± 0.05	1.403GlnSer: 1.403 ± 0.037	1.606GlnThr: 1.606 ± 0.043	2.746GlnVal: 2.746 ± 0.05	0.583GlnTrp: 0.583 ± 0.023	0.638GlnTyr: 0.638 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.922ArgAla: 8.922 ± 0.095	0.729ArgCys: 0.729 ± 0.026	4.37ArgAsp: 4.37 ± 0.071	3.901ArgGlu: 3.901 ± 0.056	2.533ArgPhe: 2.533 ± 0.046	5.463ArgGly: 5.463 ± 0.078	2.018ArgHis: 2.018 ± 0.039	3.615ArgIle: 3.615 ± 0.049	1.71ArgLys: 1.71 ± 0.038	8.271ArgLeu: 8.271 ± 0.105	1.848ArgMet: 1.848 ± 0.037	1.63ArgAsn: 1.63 ± 0.032	4.306ArgPro: 4.306 ± 0.058	2.549ArgGln: 2.549 ± 0.05	7.512ArgArg: 7.512 ± 0.101	4.082ArgSer: 4.082 ± 0.057	3.916ArgThr: 3.916 ± 0.056	5.946ArgVal: 5.946 ± 0.068	1.526ArgTrp: 1.526 ± 0.032	2.118ArgTyr: 2.118 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.985SerAla: 6.985 ± 0.077	0.436SerCys: 0.436 ± 0.022	2.934SerAsp: 2.934 ± 0.047	2.308SerGlu: 2.308 ± 0.044	1.571SerPhe: 1.571 ± 0.036	5.277SerGly: 5.277 ± 0.07	1.067SerHis: 1.067 ± 0.029	2.055SerIle: 2.055 ± 0.039	1.13SerLys: 1.13 ± 0.033	4.657SerLeu: 4.657 ± 0.06	1.226SerMet: 1.226 ± 0.03	1.058SerAsn: 1.058 ± 0.029	3.154SerPro: 3.154 ± 0.051	1.555SerGln: 1.555 ± 0.038	3.829SerArg: 3.829 ± 0.055	2.871SerSer: 2.871 ± 0.053	3.137SerThr: 3.137 ± 0.049	4.284SerVal: 4.284 ± 0.057	0.923SerTrp: 0.923 ± 0.028	1.257SerTyr: 1.257 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.78ThrAla: 7.78 ± 0.071	0.437ThrCys: 0.437 ± 0.018	3.445ThrAsp: 3.445 ± 0.048	2.966ThrGlu: 2.966 ± 0.055	1.677ThrPhe: 1.677 ± 0.041	5.666ThrGly: 5.666 ± 0.064	1.173ThrHis: 1.173 ± 0.032	2.344ThrIle: 2.344 ± 0.05	1.318ThrLys: 1.318 ± 0.038	5.395ThrLeu: 5.395 ± 0.071	1.239ThrMet: 1.239 ± 0.029	1.22ThrAsn: 1.22 ± 0.032	3.758ThrPro: 3.758 ± 0.06	1.518ThrGln: 1.518 ± 0.036	3.651ThrArg: 3.651 ± 0.056	2.966ThrSer: 2.966 ± 0.042	3.781ThrThr: 3.781 ± 0.067	5.654ThrVal: 5.654 ± 0.06	0.816ThrTrp: 0.816 ± 0.026	1.278ThrTyr: 1.278 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.675ValAla: 11.675 ± 0.118	0.827ValCys: 0.827 ± 0.027	5.903ValAsp: 5.903 ± 0.079	4.683ValGlu: 4.683 ± 0.066	2.588ValPhe: 2.588 ± 0.041	6.889ValGly: 6.889 ± 0.075	1.918ValHis: 1.918 ± 0.037	3.981ValIle: 3.981 ± 0.049	1.796ValLys: 1.796 ± 0.041	8.907ValLeu: 8.907 ± 0.092	1.591ValMet: 1.591 ± 0.038	2.091ValAsn: 2.091 ± 0.039	4.761ValPro: 4.761 ± 0.07	2.219ValGln: 2.219 ± 0.041	6.089ValArg: 6.089 ± 0.071	4.597ValSer: 4.597 ± 0.055	5.213ValThr: 5.213 ± 0.074	8.824ValVal: 8.824 ± 0.09	1.127ValTrp: 1.127 ± 0.028	1.638ValTyr: 1.638 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.649TrpAla: 1.649 ± 0.042	0.192TrpCys: 0.192 ± 0.011	0.814TrpAsp: 0.814 ± 0.028	0.684TrpGlu: 0.684 ± 0.021	0.507TrpPhe: 0.507 ± 0.021	0.97TrpGly: 0.97 ± 0.031	0.379TrpHis: 0.379 ± 0.015	0.62TrpIle: 0.62 ± 0.021	0.297TrpLys: 0.297 ± 0.016	1.918TrpLeu: 1.918 ± 0.04	0.332TrpMet: 0.332 ± 0.017	0.4TrpAsn: 0.4 ± 0.021	0.891TrpPro: 0.891 ± 0.025	0.692TrpGln: 0.692 ± 0.025	1.466TrpArg: 1.466 ± 0.032	0.962TrpSer: 0.962 ± 0.026	0.853TrpThr: 0.853 ± 0.028	1.159TrpVal: 1.159 ± 0.033	0.365TrpTrp: 0.365 ± 0.02	0.355TrpTyr: 0.355 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.592TyrAla: 2.592 ± 0.045	0.23TyrCys: 0.23 ± 0.012	1.389TyrAsp: 1.389 ± 0.032	1.083TyrGlu: 1.083 ± 0.031	0.801TyrPhe: 0.801 ± 0.025	2.061TyrGly: 2.061 ± 0.043	0.526TyrHis: 0.526 ± 0.02	0.649TyrIle: 0.649 ± 0.023	0.4TyrLys: 0.4 ± 0.019	2.374TyrLeu: 2.374 ± 0.047	0.31TyrMet: 0.31 ± 0.015	0.479TyrAsn: 0.479 ± 0.018	1.374TyrPro: 1.374 ± 0.036	0.781TyrGln: 0.781 ± 0.024	2.027TyrArg: 2.027 ± 0.042	1.08TyrSer: 1.08 ± 0.031	1.177TyrThr: 1.177 ± 0.031	1.749TyrVal: 1.749 ± 0.043	0.4TyrTrp: 0.4 ± 0.018	0.505TyrTyr: 0.505 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4272 proteins (1335962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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