Amino acid dipepetide frequency for Desulfallas geothermicus DSM 3669

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.723AlaAla: 9.723 ± 0.135	1.098AlaCys: 1.098 ± 0.037	4.255AlaAsp: 4.255 ± 0.073	5.879AlaGlu: 5.879 ± 0.094	2.857AlaPhe: 2.857 ± 0.054	9.47AlaGly: 9.47 ± 0.125	1.438AlaHis: 1.438 ± 0.036	5.083AlaIle: 5.083 ± 0.08	3.913AlaLys: 3.913 ± 0.063	9.263AlaLeu: 9.263 ± 0.119	2.459AlaMet: 2.459 ± 0.055	2.648AlaAsn: 2.648 ± 0.053	3.053AlaPro: 3.053 ± 0.06	2.572AlaGln: 2.572 ± 0.05	6.229AlaArg: 6.229 ± 0.098	3.639AlaSer: 3.639 ± 0.066	3.687AlaThr: 3.687 ± 0.061	8.079AlaVal: 8.079 ± 0.094	0.779AlaTrp: 0.779 ± 0.027	2.242AlaTyr: 2.242 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.961CysAla: 0.961 ± 0.034	0.265CysCys: 0.265 ± 0.018	0.544CysAsp: 0.544 ± 0.026	0.538CysGlu: 0.538 ± 0.024	0.423CysPhe: 0.423 ± 0.021	1.296CysGly: 1.296 ± 0.04	0.295CysHis: 0.295 ± 0.018	0.689CysIle: 0.689 ± 0.024	0.572CysLys: 0.572 ± 0.027	1.12CysLeu: 1.12 ± 0.035	0.301CysMet: 0.301 ± 0.015	0.454CysAsn: 0.454 ± 0.019	0.832CysPro: 0.832 ± 0.035	0.354CysGln: 0.354 ± 0.019	0.982CysArg: 0.982 ± 0.029	0.769CysSer: 0.769 ± 0.035	0.604CysThr: 0.604 ± 0.025	0.687CysVal: 0.687 ± 0.027	0.121CysTrp: 0.121 ± 0.011	0.391CysTyr: 0.391 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.773AspAla: 3.773 ± 0.064	0.646AspCys: 0.646 ± 0.028	2.304AspAsp: 2.304 ± 0.058	3.439AspGlu: 3.439 ± 0.066	2.194AspPhe: 2.194 ± 0.048	3.69AspGly: 3.69 ± 0.067	0.841AspHis: 0.841 ± 0.029	4.115AspIle: 4.115 ± 0.058	2.812AspLys: 2.812 ± 0.059	5.24AspLeu: 5.24 ± 0.072	1.49AspMet: 1.49 ± 0.035	2.05AspAsn: 2.05 ± 0.048	2.552AspPro: 2.552 ± 0.046	1.276AspGln: 1.276 ± 0.039	3.184AspArg: 3.184 ± 0.06	2.083AspSer: 2.083 ± 0.044	2.286AspThr: 2.286 ± 0.044	3.668AspVal: 3.668 ± 0.069	0.551AspTrp: 0.551 ± 0.025	1.948AspTyr: 1.948 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.684GluAla: 5.684 ± 0.086	0.607GluCys: 0.607 ± 0.027	3.066GluAsp: 3.066 ± 0.059	5.428GluGlu: 5.428 ± 0.086	2.107GluPhe: 2.107 ± 0.044	4.0GluGly: 4.0 ± 0.061	1.195GluHis: 1.195 ± 0.039	5.306GluIle: 5.306 ± 0.07	5.548GluLys: 5.548 ± 0.078	7.131GluLeu: 7.131 ± 0.089	2.145GluMet: 2.145 ± 0.043	2.937GluAsn: 2.937 ± 0.05	2.306GluPro: 2.306 ± 0.056	2.915GluGln: 2.915 ± 0.058	3.791GluArg: 3.791 ± 0.068	2.705GluSer: 2.705 ± 0.053	3.183GluThr: 3.183 ± 0.056	5.081GluVal: 5.081 ± 0.074	0.581GluTrp: 0.581 ± 0.027	2.117GluTyr: 2.117 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.066PheAla: 3.066 ± 0.058	0.523PheCys: 0.523 ± 0.025	1.966PheAsp: 1.966 ± 0.05	1.86PheGlu: 1.86 ± 0.046	1.762PhePhe: 1.762 ± 0.048	2.973PheGly: 2.973 ± 0.055	0.687PheHis: 0.687 ± 0.03	2.778PheIle: 2.778 ± 0.056	1.971PheLys: 1.971 ± 0.047	3.621PheLeu: 3.621 ± 0.064	1.077PheMet: 1.077 ± 0.035	1.788PheAsn: 1.788 ± 0.043	1.556PhePro: 1.556 ± 0.039	1.016PheGln: 1.016 ± 0.031	1.775PheArg: 1.775 ± 0.045	2.197PheSer: 2.197 ± 0.052	2.18PheThr: 2.18 ± 0.05	2.479PheVal: 2.479 ± 0.05	0.437PheTrp: 0.437 ± 0.024	1.358PheTyr: 1.358 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.74GlyAla: 6.74 ± 0.097	1.247GlyCys: 1.247 ± 0.042	3.866GlyAsp: 3.866 ± 0.071	5.078GlyGlu: 5.078 ± 0.08	3.183GlyPhe: 3.183 ± 0.061	6.345GlyGly: 6.345 ± 0.092	1.522GlyHis: 1.522 ± 0.035	5.723GlyIle: 5.723 ± 0.086	5.0GlyLys: 5.0 ± 0.064	8.086GlyLeu: 8.086 ± 0.099	2.378GlyMet: 2.378 ± 0.049	2.822GlyAsn: 2.822 ± 0.054	2.623GlyPro: 2.623 ± 0.045	2.687GlyGln: 2.687 ± 0.054	4.796GlyArg: 4.796 ± 0.083	3.902GlySer: 3.902 ± 0.058	4.2GlyThr: 4.2 ± 0.07	6.356GlyVal: 6.356 ± 0.08	0.894GlyTrp: 0.894 ± 0.033	2.927GlyTyr: 2.927 ± 0.059	0.001GlyXaa: 0.001 ± 0.001
His	1.357HisAla: 1.357 ± 0.037	0.31HisCys: 0.31 ± 0.02	0.938HisAsp: 0.938 ± 0.029	0.979HisGlu: 0.979 ± 0.027	0.81HisPhe: 0.81 ± 0.032	1.56HisGly: 1.56 ± 0.041	0.488HisHis: 0.488 ± 0.024	1.278HisIle: 1.278 ± 0.032	0.865HisLys: 0.865 ± 0.031	1.944HisLeu: 1.944 ± 0.041	0.498HisMet: 0.498 ± 0.026	0.779HisAsn: 0.779 ± 0.026	1.134HisPro: 1.134 ± 0.034	0.563HisGln: 0.563 ± 0.022	1.269HisArg: 1.269 ± 0.038	0.902HisSer: 0.902 ± 0.027	0.958HisThr: 0.958 ± 0.03	1.219HisVal: 1.219 ± 0.034	0.208HisTrp: 0.208 ± 0.014	0.678HisTyr: 0.678 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.66IleAla: 5.66 ± 0.087	0.822IleCys: 0.822 ± 0.029	3.481IleAsp: 3.481 ± 0.063	3.998IleGlu: 3.998 ± 0.062	2.639IlePhe: 2.639 ± 0.056	4.591IleGly: 4.591 ± 0.081	1.206IleHis: 1.206 ± 0.035	5.275IleIle: 5.275 ± 0.073	4.499IleLys: 4.499 ± 0.061	6.09IleLeu: 6.09 ± 0.086	1.847IleMet: 1.847 ± 0.046	3.365IleAsn: 3.365 ± 0.061	3.275IlePro: 3.275 ± 0.06	1.823IleGln: 1.823 ± 0.042	3.29IleArg: 3.29 ± 0.058	3.964IleSer: 3.964 ± 0.058	4.136IleThr: 4.136 ± 0.065	4.419IleVal: 4.419 ± 0.075	0.566IleTrp: 0.566 ± 0.025	2.134IleTyr: 2.134 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.316LysAla: 4.316 ± 0.071	0.581LysCys: 0.581 ± 0.028	2.819LysAsp: 2.819 ± 0.063	4.554LysGlu: 4.554 ± 0.075	1.774LysPhe: 1.774 ± 0.041	3.608LysGly: 3.608 ± 0.053	1.058LysHis: 1.058 ± 0.036	4.289LysIle: 4.289 ± 0.072	4.27LysLys: 4.27 ± 0.079	5.238LysLeu: 5.238 ± 0.066	1.723LysMet: 1.723 ± 0.046	2.656LysAsn: 2.656 ± 0.055	2.473LysPro: 2.473 ± 0.048	2.216LysGln: 2.216 ± 0.051	2.731LysArg: 2.731 ± 0.05	2.583LysSer: 2.583 ± 0.051	3.02LysThr: 3.02 ± 0.046	4.22LysVal: 4.22 ± 0.067	0.514LysTrp: 0.514 ± 0.028	2.133LysTyr: 2.133 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	10.685LeuAla: 10.685 ± 0.118	1.067LeuCys: 1.067 ± 0.037	5.091LeuAsp: 5.091 ± 0.078	6.891LeuGlu: 6.891 ± 0.09	3.569LeuPhe: 3.569 ± 0.067	7.739LeuGly: 7.739 ± 0.105	1.934LeuHis: 1.934 ± 0.045	5.703LeuIle: 5.703 ± 0.082	5.563LeuLys: 5.563 ± 0.074	10.22LeuLeu: 10.22 ± 0.14	2.362LeuMet: 2.362 ± 0.052	3.77LeuAsn: 3.77 ± 0.054	4.953LeuPro: 4.953 ± 0.075	3.737LeuGln: 3.737 ± 0.068	5.491LeuArg: 5.491 ± 0.075	5.309LeuSer: 5.309 ± 0.074	5.147LeuThr: 5.147 ± 0.072	7.852LeuVal: 7.852 ± 0.095	0.889LeuTrp: 0.889 ± 0.034	2.683LeuTyr: 2.683 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.814MetAla: 2.814 ± 0.051	0.254MetCys: 0.254 ± 0.015	1.436MetAsp: 1.436 ± 0.039	1.923MetGlu: 1.923 ± 0.045	0.888MetPhe: 0.888 ± 0.031	2.171MetGly: 2.171 ± 0.047	0.577MetHis: 0.577 ± 0.023	1.549MetIle: 1.549 ± 0.044	1.46MetLys: 1.46 ± 0.039	2.689MetLeu: 2.689 ± 0.052	0.632MetMet: 0.632 ± 0.028	0.985MetAsn: 0.985 ± 0.034	1.358MetPro: 1.358 ± 0.037	1.19MetGln: 1.19 ± 0.034	1.526MetArg: 1.526 ± 0.038	1.447MetSer: 1.447 ± 0.039	1.333MetThr: 1.333 ± 0.036	2.176MetVal: 2.176 ± 0.041	0.178MetTrp: 0.178 ± 0.014	0.617MetTyr: 0.617 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.821AsnAla: 2.821 ± 0.055	0.531AsnCys: 0.531 ± 0.026	1.77AsnAsp: 1.77 ± 0.047	2.258AsnGlu: 2.258 ± 0.047	1.472AsnPhe: 1.472 ± 0.04	2.789AsnGly: 2.789 ± 0.06	0.687AsnHis: 0.687 ± 0.027	3.22AsnIle: 3.22 ± 0.058	2.443AsnLys: 2.443 ± 0.05	4.181AsnLeu: 4.181 ± 0.062	1.129AsnMet: 1.129 ± 0.033	1.88AsnAsn: 1.88 ± 0.051	2.128AsnPro: 2.128 ± 0.046	1.246AsnGln: 1.246 ± 0.036	2.333AsnArg: 2.333 ± 0.042	1.872AsnSer: 1.872 ± 0.051	1.928AsnThr: 1.928 ± 0.04	2.644AsnVal: 2.644 ± 0.052	0.472AsnTrp: 0.472 ± 0.022	1.482AsnTyr: 1.482 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	4.205ProAla: 4.205 ± 0.066	0.461ProCys: 0.461 ± 0.025	2.77ProAsp: 2.77 ± 0.058	3.81ProGlu: 3.81 ± 0.064	1.584ProPhe: 1.584 ± 0.037	4.757ProGly: 4.757 ± 0.091	0.828ProHis: 0.828 ± 0.025	1.875ProIle: 1.875 ± 0.046	1.732ProLys: 1.732 ± 0.04	4.08ProLeu: 4.08 ± 0.074	0.921ProMet: 0.921 ± 0.031	1.332ProAsn: 1.332 ± 0.037	1.933ProPro: 1.933 ± 0.05	1.395ProGln: 1.395 ± 0.036	2.371ProArg: 2.371 ± 0.051	1.78ProSer: 1.78 ± 0.047	1.766ProThr: 1.766 ± 0.04	4.704ProVal: 4.704 ± 0.068	0.459ProTrp: 0.459 ± 0.023	1.37ProTyr: 1.37 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.206GlnAla: 3.206 ± 0.055	0.349GlnCys: 0.349 ± 0.018	1.49GlnAsp: 1.49 ± 0.038	2.484GlnGlu: 2.484 ± 0.054	1.074GlnPhe: 1.074 ± 0.033	2.232GlnGly: 2.232 ± 0.051	0.609GlnHis: 0.609 ± 0.023	2.23GlnIle: 2.23 ± 0.046	2.329GlnLys: 2.329 ± 0.052	3.23GlnLeu: 3.23 ± 0.054	0.961GlnMet: 0.961 ± 0.032	1.408GlnAsn: 1.408 ± 0.037	1.265GlnPro: 1.265 ± 0.035	1.464GlnGln: 1.464 ± 0.044	1.896GlnArg: 1.896 ± 0.045	1.47GlnSer: 1.47 ± 0.038	1.512GlnThr: 1.512 ± 0.036	2.916GlnVal: 2.916 ± 0.051	0.328GlnTrp: 0.328 ± 0.017	0.987GlnTyr: 0.987 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.822ArgAla: 4.822 ± 0.086	0.704ArgCys: 0.704 ± 0.022	3.065ArgAsp: 3.065 ± 0.061	5.333ArgGlu: 5.333 ± 0.095	2.071ArgPhe: 2.071 ± 0.045	4.134ArgGly: 4.134 ± 0.074	1.2ArgHis: 1.2 ± 0.037	3.486ArgIle: 3.486 ± 0.058	3.197ArgLys: 3.197 ± 0.058	5.956ArgLeu: 5.956 ± 0.088	1.567ArgMet: 1.567 ± 0.04	2.068ArgAsn: 2.068 ± 0.043	2.353ArgPro: 2.353 ± 0.056	2.368ArgGln: 2.368 ± 0.049	3.946ArgArg: 3.946 ± 0.075	2.569ArgSer: 2.569 ± 0.051	2.392ArgThr: 2.392 ± 0.049	4.803ArgVal: 4.803 ± 0.083	0.704ArgTrp: 0.704 ± 0.026	1.943ArgTyr: 1.943 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.879SerAla: 3.879 ± 0.063	0.667SerCys: 0.667 ± 0.027	2.229SerAsp: 2.229 ± 0.048	2.793SerGlu: 2.793 ± 0.057	2.051SerPhe: 2.051 ± 0.045	4.72SerGly: 4.72 ± 0.066	0.919SerHis: 0.919 ± 0.031	3.145SerIle: 3.145 ± 0.061	2.252SerLys: 2.252 ± 0.046	5.046SerLeu: 5.046 ± 0.076	1.336SerMet: 1.336 ± 0.036	1.719SerAsn: 1.719 ± 0.043	2.341SerPro: 2.341 ± 0.042	1.406SerGln: 1.406 ± 0.038	3.128SerArg: 3.128 ± 0.057	2.569SerSer: 2.569 ± 0.051	2.455SerThr: 2.455 ± 0.052	3.579SerVal: 3.579 ± 0.059	0.474SerTrp: 0.474 ± 0.02	1.598SerTyr: 1.598 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.622ThrAla: 4.622 ± 0.077	0.577ThrCys: 0.577 ± 0.025	2.436ThrAsp: 2.436 ± 0.053	2.81ThrGlu: 2.81 ± 0.046	1.874ThrPhe: 1.874 ± 0.049	5.654ThrGly: 5.654 ± 0.076	0.924ThrHis: 0.924 ± 0.033	3.137ThrIle: 3.137 ± 0.056	2.0ThrLys: 2.0 ± 0.055	4.835ThrLeu: 4.835 ± 0.062	1.235ThrMet: 1.235 ± 0.038	1.637ThrAsn: 1.637 ± 0.036	2.513ThrPro: 2.513 ± 0.054	1.15ThrGln: 1.15 ± 0.032	2.759ThrArg: 2.759 ± 0.054	2.329ThrSer: 2.329 ± 0.049	2.477ThrThr: 2.477 ± 0.05	4.626ThrVal: 4.626 ± 0.066	0.475ThrTrp: 0.475 ± 0.022	1.39ThrTyr: 1.39 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.894ValAla: 6.894 ± 0.088	0.922ValCys: 0.922 ± 0.037	4.39ValAsp: 4.39 ± 0.069	5.326ValGlu: 5.326 ± 0.084	2.975ValPhe: 2.975 ± 0.054	5.379ValGly: 5.379 ± 0.075	1.387ValHis: 1.387 ± 0.042	5.545ValIle: 5.545 ± 0.081	4.309ValLys: 4.309 ± 0.067	8.094ValLeu: 8.094 ± 0.093	2.134ValMet: 2.134 ± 0.047	3.178ValAsn: 3.178 ± 0.053	3.567ValPro: 3.567 ± 0.053	2.51ValGln: 2.51 ± 0.054	4.247ValArg: 4.247 ± 0.069	4.095ValSer: 4.095 ± 0.064	4.232ValThr: 4.232 ± 0.065	6.45ValVal: 6.45 ± 0.097	0.584ValTrp: 0.584 ± 0.023	2.365ValTyr: 2.365 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.031	0.123TrpCys: 0.123 ± 0.01	0.548TrpAsp: 0.548 ± 0.023	0.695TrpGlu: 0.695 ± 0.027	0.389TrpPhe: 0.389 ± 0.019	0.776TrpGly: 0.776 ± 0.034	0.241TrpHis: 0.241 ± 0.013	0.479TrpIle: 0.479 ± 0.024	0.46TrpLys: 0.46 ± 0.021	1.151TrpLeu: 1.151 ± 0.039	0.253TrpMet: 0.253 ± 0.015	0.37TrpAsn: 0.37 ± 0.02	0.421TrpPro: 0.421 ± 0.02	0.48TrpGln: 0.48 ± 0.022	0.614TrpArg: 0.614 ± 0.025	0.496TrpSer: 0.496 ± 0.023	0.372TrpThr: 0.372 ± 0.019	0.67TrpVal: 0.67 ± 0.027	0.143TrpTrp: 0.143 ± 0.013	0.304TrpTyr: 0.304 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.056	0.444TyrCys: 0.444 ± 0.02	1.679TyrAsp: 1.679 ± 0.039	1.758TyrGlu: 1.758 ± 0.043	1.373TyrPhe: 1.373 ± 0.041	2.492TyrGly: 2.492 ± 0.048	0.703TyrHis: 0.703 ± 0.028	2.173TyrIle: 2.173 ± 0.049	1.579TyrLys: 1.579 ± 0.039	3.44TyrLeu: 3.44 ± 0.061	0.754TyrMet: 0.754 ± 0.028	1.438TyrAsn: 1.438 ± 0.039	1.495TyrPro: 1.495 ± 0.039	1.07TyrGln: 1.07 ± 0.036	2.328TyrArg: 2.328 ± 0.05	1.628TyrSer: 1.628 ± 0.048	1.59TyrThr: 1.59 ± 0.041	1.958TyrVal: 1.958 ± 0.04	0.377TyrTrp: 0.377 ± 0.018	1.274TyrTyr: 1.274 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3693 proteins (1034905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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