Amino acid dipepetide frequency for Gammapapillomavirus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.198AlaAla: 4.198 ± 1.264
0.84AlaCys: 0.84 ± 0.991
3.359AlaAsp: 3.359 ± 0.753
4.618AlaGlu: 4.618 ± 0.842
4.198AlaPhe: 4.198 ± 1.68
1.679AlaGly: 1.679 ± 0.631
0.84AlaHis: 0.84 ± 0.466
2.519AlaIle: 2.519 ± 0.927
2.519AlaLys: 2.519 ± 1.446
3.359AlaLeu: 3.359 ± 1.131
0.0AlaMet: 0.0 ± 0.0
2.939AlaAsn: 2.939 ± 0.682
4.198AlaPro: 4.198 ± 0.812
0.0AlaGln: 0.0 ± 0.0
2.519AlaArg: 2.519 ± 0.489
5.038AlaSer: 5.038 ± 1.078
2.939AlaThr: 2.939 ± 0.574
3.359AlaVal: 3.359 ± 1.311
0.42AlaTrp: 0.42 ± 0.315
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.259CysCys: 1.259 ± 1.002
0.84CysAsp: 0.84 ± 0.793
0.84CysGlu: 0.84 ± 0.63
0.84CysPhe: 0.84 ± 0.65
1.259CysGly: 1.259 ± 0.753
0.0CysHis: 0.0 ± 0.0
1.259CysIle: 1.259 ± 1.002
1.679CysLys: 1.679 ± 0.484
2.519CysLeu: 2.519 ± 2.005
0.0CysMet: 0.0 ± 0.0
1.679CysAsn: 1.679 ± 0.98
1.679CysPro: 1.679 ± 0.917
1.259CysGln: 1.259 ± 0.558
1.259CysArg: 1.259 ± 0.972
0.42CysSer: 0.42 ± 0.679
1.679CysThr: 1.679 ± 0.678
1.679CysVal: 1.679 ± 1.107
0.84CysTrp: 0.84 ± 0.506
0.42CysTyr: 0.42 ± 0.315
0.0CysXaa: 0.0 ± 0.0
Asp
2.939AspAla: 2.939 ± 0.788
1.259AspCys: 1.259 ± 0.421
7.557AspAsp: 7.557 ± 2.108
6.717AspGlu: 6.717 ± 1.147
2.939AspPhe: 2.939 ± 1.28
2.939AspGly: 2.939 ± 1.089
0.42AspHis: 0.42 ± 0.455
5.458AspIle: 5.458 ± 1.887
1.679AspLys: 1.679 ± 0.763
8.396AspLeu: 8.396 ± 3.004
0.42AspMet: 0.42 ± 0.396
2.939AspAsn: 2.939 ± 1.055
4.618AspPro: 4.618 ± 1.142
1.679AspGln: 1.679 ± 0.847
2.939AspArg: 2.939 ± 1.371
6.297AspSer: 6.297 ± 0.904
2.939AspThr: 2.939 ± 0.682
5.458AspVal: 5.458 ± 1.447
1.679AspTrp: 1.679 ± 1.26
1.679AspTyr: 1.679 ± 0.631
0.0AspXaa: 0.0 ± 0.0
Glu
3.778GluAla: 3.778 ± 1.638
0.84GluCys: 0.84 ± 0.63
6.717GluAsp: 6.717 ± 1.538
5.877GluGlu: 5.877 ± 1.424
2.939GluPhe: 2.939 ± 0.897
1.679GluGly: 1.679 ± 0.8
0.84GluHis: 0.84 ± 0.664
1.679GluIle: 1.679 ± 0.958
0.0GluLys: 0.0 ± 0.0
5.458GluLeu: 5.458 ± 1.172
0.84GluMet: 0.84 ± 0.519
5.877GluAsn: 5.877 ± 1.255
2.939GluPro: 2.939 ± 0.881
2.099GluGln: 2.099 ± 1.012
3.778GluArg: 3.778 ± 1.412
4.198GluSer: 4.198 ± 1.347
2.099GluThr: 2.099 ± 0.614
3.778GluVal: 3.778 ± 0.918
0.0GluTrp: 0.0 ± 0.0
2.519GluTyr: 2.519 ± 1.294
0.0GluXaa: 0.0 ± 0.0
Phe
2.939PheAla: 2.939 ± 1.69
2.099PheCys: 2.099 ± 1.542
1.679PheAsp: 1.679 ± 0.959
3.778PheGlu: 3.778 ± 1.034
2.939PhePhe: 2.939 ± 1.704
3.359PheGly: 3.359 ± 1.088
0.84PheHis: 0.84 ± 0.722
2.519PheIle: 2.519 ± 1.064
3.778PheLys: 3.778 ± 1.365
4.198PheLeu: 4.198 ± 1.444
0.42PheMet: 0.42 ± 0.315
2.519PheAsn: 2.519 ± 1.125
0.84PhePro: 0.84 ± 0.471
2.519PheGln: 2.519 ± 0.946
1.679PheArg: 1.679 ± 0.56
2.939PheSer: 2.939 ± 1.291
2.099PheThr: 2.099 ± 0.803
2.519PheVal: 2.519 ± 1.117
0.84PheTrp: 0.84 ± 0.382
3.359PheTyr: 3.359 ± 1.132
0.0PheXaa: 0.0 ± 0.0
Gly
2.099GlyAla: 2.099 ± 0.732
0.42GlyCys: 0.42 ± 0.396
4.618GlyAsp: 4.618 ± 1.587
3.359GlyGlu: 3.359 ± 1.522
0.42GlyPhe: 0.42 ± 0.315
4.198GlyGly: 4.198 ± 1.204
2.519GlyHis: 2.519 ± 0.938
3.778GlyIle: 3.778 ± 1.147
3.359GlyLys: 3.359 ± 0.757
3.359GlyLeu: 3.359 ± 1.232
0.42GlyMet: 0.42 ± 0.315
0.84GlyAsn: 0.84 ± 0.63
2.519GlyPro: 2.519 ± 0.527
2.939GlyGln: 2.939 ± 0.574
4.198GlyArg: 4.198 ± 1.506
3.359GlySer: 3.359 ± 0.813
6.717GlyThr: 6.717 ± 1.662
3.359GlyVal: 3.359 ± 0.601
0.0GlyTrp: 0.0 ± 0.0
2.099GlyTyr: 2.099 ± 1.732
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.84HisCys: 0.84 ± 0.63
0.84HisAsp: 0.84 ± 0.722
0.0HisGlu: 0.0 ± 0.0
1.259HisPhe: 1.259 ± 0.725
0.42HisGly: 0.42 ± 0.679
0.84HisHis: 0.84 ± 0.87
0.84HisIle: 0.84 ± 0.426
0.84HisLys: 0.84 ± 0.478
2.519HisLeu: 2.519 ± 1.305
0.42HisMet: 0.42 ± 0.315
0.42HisAsn: 0.42 ± 0.455
1.679HisPro: 1.679 ± 0.813
0.84HisGln: 0.84 ± 0.478
0.42HisArg: 0.42 ± 0.437
0.84HisSer: 0.84 ± 0.471
1.259HisThr: 1.259 ± 0.656
1.679HisVal: 1.679 ± 0.301
1.259HisTrp: 1.259 ± 0.656
0.84HisTyr: 0.84 ± 0.426
0.0HisXaa: 0.0 ± 0.0
Ile
2.519IleAla: 2.519 ± 1.565
1.679IleCys: 1.679 ± 1.107
5.877IleAsp: 5.877 ± 2.083
5.038IleGlu: 5.038 ± 1.814
2.939IlePhe: 2.939 ± 1.967
3.778IleGly: 3.778 ± 1.443
0.42IleHis: 0.42 ± 0.437
5.038IleIle: 5.038 ± 2.783
0.84IleLys: 0.84 ± 0.65
3.778IleLeu: 3.778 ± 0.851
0.42IleMet: 0.42 ± 0.315
4.198IleAsn: 4.198 ± 1.464
4.618IlePro: 4.618 ± 1.68
3.778IleGln: 3.778 ± 1.015
1.259IleArg: 1.259 ± 0.451
5.877IleSer: 5.877 ± 1.468
4.618IleThr: 4.618 ± 0.899
3.359IleVal: 3.359 ± 2.022
0.84IleTrp: 0.84 ± 0.911
1.679IleTyr: 1.679 ± 0.647
0.0IleXaa: 0.0 ± 0.0
Lys
3.359LysAla: 3.359 ± 1.397
2.099LysCys: 2.099 ± 0.61
2.939LysAsp: 2.939 ± 0.656
0.84LysGlu: 0.84 ± 0.657
1.679LysPhe: 1.679 ± 0.766
2.099LysGly: 2.099 ± 0.414
1.259LysHis: 1.259 ± 0.752
3.359LysIle: 3.359 ± 0.915
3.778LysLys: 3.778 ± 1.451
3.778LysLeu: 3.778 ± 0.615
0.84LysMet: 0.84 ± 0.63
5.038LysAsn: 5.038 ± 0.721
1.259LysPro: 1.259 ± 0.559
1.679LysGln: 1.679 ± 0.647
4.618LysArg: 4.618 ± 1.049
3.359LysSer: 3.359 ± 1.246
2.939LysThr: 2.939 ± 0.963
3.359LysVal: 3.359 ± 1.282
1.679LysTrp: 1.679 ± 0.511
2.939LysTyr: 2.939 ± 1.282
0.0LysXaa: 0.0 ± 0.0
Leu
5.038LeuAla: 5.038 ± 1.344
1.259LeuCys: 1.259 ± 0.799
6.297LeuAsp: 6.297 ± 1.677
2.939LeuGlu: 2.939 ± 1.04
5.038LeuPhe: 5.038 ± 1.295
5.458LeuGly: 5.458 ± 1.922
1.679LeuHis: 1.679 ± 0.97
5.877LeuIle: 5.877 ± 0.876
5.877LeuLys: 5.877 ± 1.469
8.396LeuLeu: 8.396 ± 2.497
0.42LeuMet: 0.42 ± 0.475
2.939LeuAsn: 2.939 ± 0.979
5.877LeuPro: 5.877 ± 1.321
7.976LeuGln: 7.976 ± 0.989
3.778LeuArg: 3.778 ± 0.434
6.717LeuSer: 6.717 ± 1.365
4.198LeuThr: 4.198 ± 1.58
2.099LeuVal: 2.099 ± 0.977
0.0LeuTrp: 0.0 ± 0.0
4.618LeuTyr: 4.618 ± 0.63
0.0LeuXaa: 0.0 ± 0.0
Met
0.42MetAla: 0.42 ± 0.332
0.42MetCys: 0.42 ± 0.396
0.42MetAsp: 0.42 ± 0.315
0.42MetGlu: 0.42 ± 0.495
0.0MetPhe: 0.0 ± 0.0
0.42MetGly: 0.42 ± 0.315
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.84MetLys: 0.84 ± 0.426
1.259MetLeu: 1.259 ± 0.877
0.42MetMet: 0.42 ± 0.315
1.259MetAsn: 1.259 ± 0.408
0.84MetPro: 0.84 ± 0.426
0.84MetGln: 0.84 ± 0.478
1.259MetArg: 1.259 ± 0.679
2.519MetSer: 2.519 ± 0.884
0.42MetThr: 0.42 ± 0.396
1.259MetVal: 1.259 ± 0.672
0.0MetTrp: 0.0 ± 0.0
0.84MetTyr: 0.84 ± 0.478
0.0MetXaa: 0.0 ± 0.0
Asn
2.519AsnAla: 2.519 ± 0.39
0.84AsnCys: 0.84 ± 0.478
2.519AsnAsp: 2.519 ± 0.865
2.939AsnGlu: 2.939 ± 1.017
2.099AsnPhe: 2.099 ± 0.716
4.198AsnGly: 4.198 ± 1.57
0.42AsnHis: 0.42 ± 0.315
7.137AsnIle: 7.137 ± 1.959
4.618AsnLys: 4.618 ± 1.53
4.198AsnLeu: 4.198 ± 1.163
0.42AsnMet: 0.42 ± 0.396
2.519AsnAsn: 2.519 ± 0.716
2.099AsnPro: 2.099 ± 1.072
2.939AsnGln: 2.939 ± 1.023
3.359AsnArg: 3.359 ± 1.13
3.359AsnSer: 3.359 ± 2.185
3.778AsnThr: 3.778 ± 1.284
2.099AsnVal: 2.099 ± 0.881
0.84AsnTrp: 0.84 ± 0.506
0.84AsnTyr: 0.84 ± 0.911
0.0AsnXaa: 0.0 ± 0.0
Pro
3.359ProAla: 3.359 ± 1.213
0.84ProCys: 0.84 ± 0.601
4.198ProAsp: 4.198 ± 1.661
4.618ProGlu: 4.618 ± 1.872
0.84ProPhe: 0.84 ± 0.554
0.84ProGly: 0.84 ± 0.657
0.84ProHis: 0.84 ± 0.874
2.939ProIle: 2.939 ± 0.76
2.939ProLys: 2.939 ± 0.656
7.137ProLeu: 7.137 ± 2.157
0.0ProMet: 0.0 ± 0.0
3.359ProAsn: 3.359 ± 0.718
8.396ProPro: 8.396 ± 1.661
2.099ProGln: 2.099 ± 0.908
4.198ProArg: 4.198 ± 0.639
3.359ProSer: 3.359 ± 0.951
4.618ProThr: 4.618 ± 0.916
2.939ProVal: 2.939 ± 0.964
0.42ProTrp: 0.42 ± 0.455
2.939ProTyr: 2.939 ± 1.4
0.0ProXaa: 0.0 ± 0.0
Gln
1.679GlnAla: 1.679 ± 0.955
0.0GlnCys: 0.0 ± 0.0
4.198GlnAsp: 4.198 ± 0.974
1.679GlnGlu: 1.679 ± 0.981
1.259GlnPhe: 1.259 ± 0.706
1.679GlnGly: 1.679 ± 0.511
1.679GlnHis: 1.679 ± 0.571
5.458GlnIle: 5.458 ± 1.196
2.099GlnLys: 2.099 ± 1.072
4.198GlnLeu: 4.198 ± 1.498
1.679GlnMet: 1.679 ± 0.847
2.099GlnAsn: 2.099 ± 0.919
1.679GlnPro: 1.679 ± 0.98
2.099GlnGln: 2.099 ± 1.063
2.099GlnArg: 2.099 ± 0.823
2.099GlnSer: 2.099 ± 0.903
4.198GlnThr: 4.198 ± 1.643
3.359GlnVal: 3.359 ± 0.528
0.84GlnTrp: 0.84 ± 0.63
2.519GlnTyr: 2.519 ± 0.902
0.0GlnXaa: 0.0 ± 0.0
Arg
2.519ArgAla: 2.519 ± 0.863
2.519ArgCys: 2.519 ± 1.499
0.84ArgAsp: 0.84 ± 0.459
2.099ArgGlu: 2.099 ± 1.054
4.618ArgPhe: 4.618 ± 0.608
1.679ArgGly: 1.679 ± 0.919
2.519ArgHis: 2.519 ± 1.518
1.259ArgIle: 1.259 ± 0.725
3.778ArgLys: 3.778 ± 1.403
6.297ArgLeu: 6.297 ± 0.601
0.42ArgMet: 0.42 ± 0.455
1.259ArgAsn: 1.259 ± 0.637
5.038ArgPro: 5.038 ± 1.396
2.939ArgGln: 2.939 ± 0.987
6.717ArgArg: 6.717 ± 3.008
4.618ArgSer: 4.618 ± 1.425
2.099ArgThr: 2.099 ± 0.885
5.038ArgVal: 5.038 ± 1.826
0.42ArgTrp: 0.42 ± 0.437
0.84ArgTyr: 0.84 ± 0.478
0.0ArgXaa: 0.0 ± 0.0
Ser
3.778SerAla: 3.778 ± 0.985
1.259SerCys: 1.259 ± 0.746
5.458SerAsp: 5.458 ± 1.365
3.778SerGlu: 3.778 ± 1.04
5.038SerPhe: 5.038 ± 1.484
6.717SerGly: 6.717 ± 1.729
0.42SerHis: 0.42 ± 0.315
3.778SerIle: 3.778 ± 1.044
4.198SerLys: 4.198 ± 1.839
6.717SerLeu: 6.717 ± 1.757
2.099SerMet: 2.099 ± 0.894
3.359SerAsn: 3.359 ± 1.455
2.939SerPro: 2.939 ± 1.59
3.359SerGln: 3.359 ± 0.776
5.038SerArg: 5.038 ± 1.367
6.297SerSer: 6.297 ± 2.968
5.458SerThr: 5.458 ± 1.798
4.618SerVal: 4.618 ± 1.636
0.0SerTrp: 0.0 ± 0.0
2.099SerTyr: 2.099 ± 0.645
0.0SerXaa: 0.0 ± 0.0
Thr
4.618ThrAla: 4.618 ± 1.164
0.84ThrCys: 0.84 ± 0.722
3.778ThrAsp: 3.778 ± 0.845
2.939ThrGlu: 2.939 ± 0.707
2.519ThrPhe: 2.519 ± 0.537
5.038ThrGly: 5.038 ± 1.065
0.84ThrHis: 0.84 ± 0.459
2.099ThrIle: 2.099 ± 1.212
2.099ThrLys: 2.099 ± 0.919
4.198ThrLeu: 4.198 ± 0.941
1.259ThrMet: 1.259 ± 0.852
4.198ThrAsn: 4.198 ± 1.982
4.618ThrPro: 4.618 ± 1.33
2.099ThrGln: 2.099 ± 0.76
2.939ThrArg: 2.939 ± 0.537
9.656ThrSer: 9.656 ± 3.392
3.359ThrThr: 3.359 ± 0.686
5.877ThrVal: 5.877 ± 0.946
0.42ThrTrp: 0.42 ± 0.315
0.84ThrTyr: 0.84 ± 0.382
0.0ThrXaa: 0.0 ± 0.0
Val
1.679ValAla: 1.679 ± 0.58
1.679ValCys: 1.679 ± 1.121
5.458ValAsp: 5.458 ± 1.426
2.939ValGlu: 2.939 ± 1.361
2.939ValPhe: 2.939 ± 0.537
4.618ValGly: 4.618 ± 1.402
1.259ValHis: 1.259 ± 0.509
5.458ValIle: 5.458 ± 1.49
3.359ValLys: 3.359 ± 0.757
3.359ValLeu: 3.359 ± 0.696
1.259ValMet: 1.259 ± 0.712
4.198ValAsn: 4.198 ± 0.83
3.359ValPro: 3.359 ± 1.395
2.519ValGln: 2.519 ± 0.974
2.099ValArg: 2.099 ± 1.295
2.939ValSer: 2.939 ± 1.35
5.038ValThr: 5.038 ± 1.676
1.259ValVal: 1.259 ± 0.696
0.42ValTrp: 0.42 ± 0.396
2.099ValTyr: 2.099 ± 0.614
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.315
0.0TrpCys: 0.0 ± 0.0
1.679TrpAsp: 1.679 ± 0.849
0.84TrpGlu: 0.84 ± 0.657
0.42TrpPhe: 0.42 ± 0.315
0.0TrpGly: 0.0 ± 0.0
0.42TrpHis: 0.42 ± 0.455
1.259TrpIle: 1.259 ± 0.945
1.259TrpLys: 1.259 ± 0.577
1.679TrpLeu: 1.679 ± 0.763
0.0TrpMet: 0.0 ± 0.0
0.42TrpAsn: 0.42 ± 0.396
0.42TrpPro: 0.42 ± 0.396
0.42TrpGln: 0.42 ± 0.315
1.259TrpArg: 1.259 ± 0.656
0.42TrpSer: 0.42 ± 0.455
0.84TrpThr: 0.84 ± 0.911
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.679TyrAla: 1.679 ± 0.647
0.42TyrCys: 0.42 ± 0.455
1.679TyrAsp: 1.679 ± 0.301
1.679TyrGlu: 1.679 ± 0.948
2.939TyrPhe: 2.939 ± 0.734
2.519TyrGly: 2.519 ± 0.901
0.0TyrHis: 0.0 ± 0.0
0.84TyrIle: 0.84 ± 0.426
3.359TyrLys: 3.359 ± 1.581
2.099TyrLeu: 2.099 ± 0.732
1.679TyrMet: 1.679 ± 0.326
1.679TyrAsn: 1.679 ± 0.628
1.259TyrPro: 1.259 ± 0.735
2.519TyrGln: 2.519 ± 0.925
2.099TyrArg: 2.099 ± 0.709
2.099TyrSer: 2.099 ± 1.205
2.939TyrThr: 2.939 ± 1.045
0.84TyrVal: 0.84 ± 0.793
0.84TyrTrp: 0.84 ± 0.793
1.679TyrTyr: 1.679 ± 1.286
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski