Amino acid dipepetide frequency for Pseudomonas phage vB_Pae-SS2019XI

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.877AlaAla: 14.877 ± 1.895
1.221AlaCys: 1.221 ± 0.274
6.106AlaAsp: 6.106 ± 0.591
7.938AlaGlu: 7.938 ± 0.919
3.941AlaPhe: 3.941 ± 0.489
6.995AlaGly: 6.995 ± 0.827
1.721AlaHis: 1.721 ± 0.411
4.385AlaIle: 4.385 ± 0.409
4.441AlaLys: 4.441 ± 0.675
10.325AlaLeu: 10.325 ± 0.678
3.83AlaMet: 3.83 ± 0.433
3.442AlaAsn: 3.442 ± 0.571
5.496AlaPro: 5.496 ± 0.622
4.608AlaGln: 4.608 ± 0.638
7.328AlaArg: 7.328 ± 0.663
6.051AlaSer: 6.051 ± 0.665
4.497AlaThr: 4.497 ± 0.629
9.16AlaVal: 9.16 ± 0.925
1.554AlaTrp: 1.554 ± 0.309
2.998AlaTyr: 2.998 ± 0.444
0.0AlaXaa: 0.0 ± 0.0
Cys
0.888CysAla: 0.888 ± 0.233
0.167CysCys: 0.167 ± 0.097
0.777CysAsp: 0.777 ± 0.252
0.333CysGlu: 0.333 ± 0.142
0.333CysPhe: 0.333 ± 0.143
1.332CysGly: 1.332 ± 0.312
0.333CysHis: 0.333 ± 0.158
0.5CysIle: 0.5 ± 0.162
0.5CysLys: 0.5 ± 0.167
1.277CysLeu: 1.277 ± 0.285
0.111CysMet: 0.111 ± 0.089
0.444CysAsn: 0.444 ± 0.146
0.944CysPro: 0.944 ± 0.231
0.222CysGln: 0.222 ± 0.117
0.944CysArg: 0.944 ± 0.278
0.777CysSer: 0.777 ± 0.219
0.555CysThr: 0.555 ± 0.241
0.611CysVal: 0.611 ± 0.181
0.222CysTrp: 0.222 ± 0.096
0.333CysTyr: 0.333 ± 0.216
0.0CysXaa: 0.0 ± 0.0
Asp
5.551AspAla: 5.551 ± 0.669
0.888AspCys: 0.888 ± 0.21
5.107AspAsp: 5.107 ± 0.682
4.274AspGlu: 4.274 ± 0.572
2.942AspPhe: 2.942 ± 0.406
4.497AspGly: 4.497 ± 0.576
1.499AspHis: 1.499 ± 0.326
2.443AspIle: 2.443 ± 0.352
2.498AspLys: 2.498 ± 0.342
6.884AspLeu: 6.884 ± 0.696
1.332AspMet: 1.332 ± 0.263
1.832AspAsn: 1.832 ± 0.344
2.998AspPro: 2.998 ± 0.403
2.165AspGln: 2.165 ± 0.346
4.441AspArg: 4.441 ± 0.535
2.109AspSer: 2.109 ± 0.373
3.275AspThr: 3.275 ± 0.422
3.608AspVal: 3.608 ± 0.453
1.61AspTrp: 1.61 ± 0.373
1.776AspTyr: 1.776 ± 0.27
0.0AspXaa: 0.0 ± 0.0
Glu
6.162GluAla: 6.162 ± 0.734
0.777GluCys: 0.777 ± 0.211
3.109GluAsp: 3.109 ± 0.528
4.83GluGlu: 4.83 ± 0.496
2.609GluPhe: 2.609 ± 0.396
4.608GluGly: 4.608 ± 0.497
1.332GluHis: 1.332 ± 0.276
3.775GluIle: 3.775 ± 0.575
3.553GluLys: 3.553 ± 0.525
6.773GluLeu: 6.773 ± 0.592
1.721GluMet: 1.721 ± 0.329
2.387GluAsn: 2.387 ± 0.458
2.165GluPro: 2.165 ± 0.401
3.164GluGln: 3.164 ± 0.382
4.219GluArg: 4.219 ± 0.439
3.553GluSer: 3.553 ± 0.483
3.275GluThr: 3.275 ± 0.371
4.774GluVal: 4.774 ± 0.504
1.055GluTrp: 1.055 ± 0.248
1.721GluTyr: 1.721 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
3.608PheAla: 3.608 ± 0.357
0.222PheCys: 0.222 ± 0.132
2.609PheAsp: 2.609 ± 0.349
3.109PheGlu: 3.109 ± 0.483
1.11PhePhe: 1.11 ± 0.228
2.998PheGly: 2.998 ± 0.393
0.555PheHis: 0.555 ± 0.165
1.443PheIle: 1.443 ± 0.257
1.721PheLys: 1.721 ± 0.415
2.054PheLeu: 2.054 ± 0.355
0.666PheMet: 0.666 ± 0.18
1.443PheAsn: 1.443 ± 0.253
1.499PhePro: 1.499 ± 0.259
1.166PheGln: 1.166 ± 0.261
2.443PheArg: 2.443 ± 0.313
2.387PheSer: 2.387 ± 0.367
2.276PheThr: 2.276 ± 0.379
2.054PheVal: 2.054 ± 0.322
0.5PheTrp: 0.5 ± 0.15
1.11PheTyr: 1.11 ± 0.265
0.0PheXaa: 0.0 ± 0.0
Gly
7.494GlyAla: 7.494 ± 0.898
1.055GlyCys: 1.055 ± 0.308
4.385GlyAsp: 4.385 ± 0.516
4.385GlyGlu: 4.385 ± 0.573
2.554GlyPhe: 2.554 ± 0.305
5.94GlyGly: 5.94 ± 0.724
1.277GlyHis: 1.277 ± 0.252
2.554GlyIle: 2.554 ± 0.366
3.83GlyLys: 3.83 ± 0.429
6.106GlyLeu: 6.106 ± 0.639
1.166GlyMet: 1.166 ± 0.244
2.942GlyAsn: 2.942 ± 0.432
2.443GlyPro: 2.443 ± 0.524
2.72GlyGln: 2.72 ± 0.387
6.273GlyArg: 6.273 ± 0.44
4.608GlySer: 4.608 ± 0.528
3.386GlyThr: 3.386 ± 0.448
6.162GlyVal: 6.162 ± 0.558
1.554GlyTrp: 1.554 ± 0.275
2.831GlyTyr: 2.831 ± 0.396
0.0GlyXaa: 0.0 ± 0.0
His
1.443HisAla: 1.443 ± 0.315
0.278HisCys: 0.278 ± 0.147
0.944HisAsp: 0.944 ± 0.221
1.055HisGlu: 1.055 ± 0.212
0.611HisPhe: 0.611 ± 0.216
2.165HisGly: 2.165 ± 0.44
0.389HisHis: 0.389 ± 0.159
0.999HisIle: 0.999 ± 0.237
0.611HisLys: 0.611 ± 0.155
2.054HisLeu: 2.054 ± 0.328
0.833HisMet: 0.833 ± 0.236
0.5HisAsn: 0.5 ± 0.153
1.166HisPro: 1.166 ± 0.262
0.5HisGln: 0.5 ± 0.175
1.388HisArg: 1.388 ± 0.323
0.944HisSer: 0.944 ± 0.235
0.666HisThr: 0.666 ± 0.179
1.055HisVal: 1.055 ± 0.326
0.5HisTrp: 0.5 ± 0.189
0.555HisTyr: 0.555 ± 0.175
0.0HisXaa: 0.0 ± 0.0
Ile
5.107IleAla: 5.107 ± 0.571
0.222IleCys: 0.222 ± 0.125
3.109IleAsp: 3.109 ± 0.381
3.331IleGlu: 3.331 ± 0.463
0.944IlePhe: 0.944 ± 0.219
3.497IleGly: 3.497 ± 0.405
0.944IleHis: 0.944 ± 0.24
1.499IleIle: 1.499 ± 0.246
1.887IleLys: 1.887 ± 0.327
2.498IleLeu: 2.498 ± 0.401
0.278IleMet: 0.278 ± 0.123
2.443IleAsn: 2.443 ± 0.333
2.332IlePro: 2.332 ± 0.323
1.499IleGln: 1.499 ± 0.274
3.664IleArg: 3.664 ± 0.306
2.554IleSer: 2.554 ± 0.476
2.276IleThr: 2.276 ± 0.319
2.387IleVal: 2.387 ± 0.355
0.555IleTrp: 0.555 ± 0.168
1.332IleTyr: 1.332 ± 0.282
0.0IleXaa: 0.0 ± 0.0
Lys
6.162LysAla: 6.162 ± 0.679
0.278LysCys: 0.278 ± 0.129
2.887LysAsp: 2.887 ± 0.411
2.831LysGlu: 2.831 ± 0.404
1.388LysPhe: 1.388 ± 0.297
2.887LysGly: 2.887 ± 0.352
0.888LysHis: 0.888 ± 0.2
2.109LysIle: 2.109 ± 0.335
3.275LysLys: 3.275 ± 0.553
4.274LysLeu: 4.274 ± 0.598
0.888LysMet: 0.888 ± 0.238
1.721LysAsn: 1.721 ± 0.315
2.554LysPro: 2.554 ± 0.339
1.499LysGln: 1.499 ± 0.296
3.386LysArg: 3.386 ± 0.571
1.998LysSer: 1.998 ± 0.331
2.498LysThr: 2.498 ± 0.302
3.22LysVal: 3.22 ± 0.381
0.5LysTrp: 0.5 ± 0.183
1.11LysTyr: 1.11 ± 0.264
0.0LysXaa: 0.0 ± 0.0
Leu
11.991LeuAla: 11.991 ± 0.914
0.666LeuCys: 0.666 ± 0.201
5.329LeuAsp: 5.329 ± 0.49
6.051LeuGlu: 6.051 ± 0.723
2.498LeuPhe: 2.498 ± 0.387
5.274LeuGly: 5.274 ± 0.506
1.332LeuHis: 1.332 ± 0.308
3.719LeuIle: 3.719 ± 0.408
4.941LeuLys: 4.941 ± 0.674
8.105LeuLeu: 8.105 ± 0.804
2.276LeuMet: 2.276 ± 0.311
3.386LeuAsn: 3.386 ± 0.393
4.108LeuPro: 4.108 ± 0.54
3.608LeuGln: 3.608 ± 0.472
6.106LeuArg: 6.106 ± 0.639
5.218LeuSer: 5.218 ± 0.632
5.274LeuThr: 5.274 ± 0.533
5.995LeuVal: 5.995 ± 0.62
0.999LeuTrp: 0.999 ± 0.239
2.22LeuTyr: 2.22 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
3.053MetAla: 3.053 ± 0.472
0.222MetCys: 0.222 ± 0.121
1.277MetAsp: 1.277 ± 0.283
1.61MetGlu: 1.61 ± 0.287
0.555MetPhe: 0.555 ± 0.195
1.499MetGly: 1.499 ± 0.288
0.444MetHis: 0.444 ± 0.168
0.555MetIle: 0.555 ± 0.17
0.833MetLys: 0.833 ± 0.199
1.998MetLeu: 1.998 ± 0.328
0.222MetMet: 0.222 ± 0.118
1.277MetAsn: 1.277 ± 0.232
1.443MetPro: 1.443 ± 0.262
0.666MetGln: 0.666 ± 0.185
1.832MetArg: 1.832 ± 0.318
1.554MetSer: 1.554 ± 0.368
1.554MetThr: 1.554 ± 0.272
1.499MetVal: 1.499 ± 0.353
0.333MetTrp: 0.333 ± 0.112
0.278MetTyr: 0.278 ± 0.114
0.0MetXaa: 0.0 ± 0.0
Asn
3.83AsnAla: 3.83 ± 0.41
0.555AsnCys: 0.555 ± 0.193
2.332AsnAsp: 2.332 ± 0.337
1.998AsnGlu: 1.998 ± 0.314
0.722AsnPhe: 0.722 ± 0.226
4.219AsnGly: 4.219 ± 0.56
0.555AsnHis: 0.555 ± 0.19
1.443AsnIle: 1.443 ± 0.323
1.277AsnLys: 1.277 ± 0.263
2.776AsnLeu: 2.776 ± 0.406
0.611AsnMet: 0.611 ± 0.186
0.944AsnAsn: 0.944 ± 0.242
2.443AsnPro: 2.443 ± 0.346
1.665AsnGln: 1.665 ± 0.289
2.498AsnArg: 2.498 ± 0.349
1.443AsnSer: 1.443 ± 0.285
1.832AsnThr: 1.832 ± 0.342
2.498AsnVal: 2.498 ± 0.292
0.888AsnTrp: 0.888 ± 0.22
0.944AsnTyr: 0.944 ± 0.273
0.0AsnXaa: 0.0 ± 0.0
Pro
5.218ProAla: 5.218 ± 0.501
0.444ProCys: 0.444 ± 0.159
3.442ProAsp: 3.442 ± 0.522
3.164ProGlu: 3.164 ± 0.51
1.998ProPhe: 1.998 ± 0.354
3.83ProGly: 3.83 ± 0.538
1.055ProHis: 1.055 ± 0.24
1.887ProIle: 1.887 ± 0.276
2.22ProLys: 2.22 ± 0.384
3.608ProLeu: 3.608 ± 0.58
0.777ProMet: 0.777 ± 0.213
1.665ProAsn: 1.665 ± 0.355
1.887ProPro: 1.887 ± 0.475
1.832ProGln: 1.832 ± 0.322
3.109ProArg: 3.109 ± 0.403
3.331ProSer: 3.331 ± 0.427
2.22ProThr: 2.22 ± 0.344
2.942ProVal: 2.942 ± 0.43
1.166ProTrp: 1.166 ± 0.285
2.498ProTyr: 2.498 ± 0.42
0.0ProXaa: 0.0 ± 0.0
Gln
4.774GlnAla: 4.774 ± 0.772
0.444GlnCys: 0.444 ± 0.151
1.887GlnAsp: 1.887 ± 0.376
2.332GlnGlu: 2.332 ± 0.409
1.443GlnPhe: 1.443 ± 0.314
2.554GlnGly: 2.554 ± 0.381
0.666GlnHis: 0.666 ± 0.187
1.721GlnIle: 1.721 ± 0.328
1.61GlnLys: 1.61 ± 0.308
3.664GlnLeu: 3.664 ± 0.551
0.888GlnMet: 0.888 ± 0.237
1.443GlnAsn: 1.443 ± 0.248
2.109GlnPro: 2.109 ± 0.363
2.443GlnGln: 2.443 ± 0.523
2.887GlnArg: 2.887 ± 0.394
1.665GlnSer: 1.665 ± 0.415
2.276GlnThr: 2.276 ± 0.436
3.22GlnVal: 3.22 ± 0.471
0.833GlnTrp: 0.833 ± 0.232
0.833GlnTyr: 0.833 ± 0.212
0.0GlnXaa: 0.0 ± 0.0
Arg
6.717ArgAla: 6.717 ± 0.587
0.722ArgCys: 0.722 ± 0.201
3.941ArgAsp: 3.941 ± 0.42
3.886ArgGlu: 3.886 ± 0.429
3.053ArgPhe: 3.053 ± 0.42
4.552ArgGly: 4.552 ± 0.562
1.443ArgHis: 1.443 ± 0.363
3.442ArgIle: 3.442 ± 0.424
3.331ArgLys: 3.331 ± 0.428
7.439ArgLeu: 7.439 ± 0.601
2.054ArgMet: 2.054 ± 0.315
2.109ArgAsn: 2.109 ± 0.297
3.331ArgPro: 3.331 ± 0.537
3.608ArgGln: 3.608 ± 0.592
6.439ArgArg: 6.439 ± 0.755
3.275ArgSer: 3.275 ± 0.458
4.163ArgThr: 4.163 ± 0.522
4.663ArgVal: 4.663 ± 0.533
1.776ArgTrp: 1.776 ± 0.327
2.332ArgTyr: 2.332 ± 0.346
0.0ArgXaa: 0.0 ± 0.0
Ser
6.939SerAla: 6.939 ± 0.789
0.666SerCys: 0.666 ± 0.2
3.386SerAsp: 3.386 ± 0.424
3.442SerGlu: 3.442 ± 0.451
2.276SerPhe: 2.276 ± 0.328
5.218SerGly: 5.218 ± 0.752
0.5SerHis: 0.5 ± 0.201
2.165SerIle: 2.165 ± 0.327
2.998SerLys: 2.998 ± 0.424
4.441SerLeu: 4.441 ± 0.452
1.166SerMet: 1.166 ± 0.245
1.277SerAsn: 1.277 ± 0.206
2.22SerPro: 2.22 ± 0.402
1.832SerGln: 1.832 ± 0.383
3.331SerArg: 3.331 ± 0.468
3.719SerSer: 3.719 ± 0.499
3.386SerThr: 3.386 ± 0.438
3.22SerVal: 3.22 ± 0.548
1.388SerTrp: 1.388 ± 0.273
1.998SerTyr: 1.998 ± 0.357
0.0SerXaa: 0.0 ± 0.0
Thr
5.718ThrAla: 5.718 ± 0.578
0.888ThrCys: 0.888 ± 0.27
2.887ThrAsp: 2.887 ± 0.539
2.776ThrGlu: 2.776 ± 0.366
1.665ThrPhe: 1.665 ± 0.292
4.274ThrGly: 4.274 ± 0.568
0.833ThrHis: 0.833 ± 0.235
2.054ThrIle: 2.054 ± 0.426
2.443ThrLys: 2.443 ± 0.36
5.274ThrLeu: 5.274 ± 0.561
1.221ThrMet: 1.221 ± 0.218
1.887ThrAsn: 1.887 ± 0.36
3.497ThrPro: 3.497 ± 0.398
1.61ThrGln: 1.61 ± 0.3
2.831ThrArg: 2.831 ± 0.39
3.664ThrSer: 3.664 ± 0.579
3.053ThrThr: 3.053 ± 0.488
3.553ThrVal: 3.553 ± 0.507
0.999ThrTrp: 0.999 ± 0.222
2.165ThrTyr: 2.165 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
7.05ValAla: 7.05 ± 0.71
0.999ValCys: 0.999 ± 0.304
4.663ValAsp: 4.663 ± 0.531
5.607ValGlu: 5.607 ± 0.597
2.831ValPhe: 2.831 ± 0.364
4.219ValGly: 4.219 ± 0.488
1.776ValHis: 1.776 ± 0.361
3.775ValIle: 3.775 ± 0.481
2.998ValLys: 2.998 ± 0.357
4.941ValLeu: 4.941 ± 0.474
1.388ValMet: 1.388 ± 0.22
2.276ValAsn: 2.276 ± 0.344
3.386ValPro: 3.386 ± 0.566
2.942ValGln: 2.942 ± 0.418
4.996ValArg: 4.996 ± 0.546
3.442ValSer: 3.442 ± 0.347
4.108ValThr: 4.108 ± 0.567
5.829ValVal: 5.829 ± 0.658
0.666ValTrp: 0.666 ± 0.229
1.887ValTyr: 1.887 ± 0.342
0.0ValXaa: 0.0 ± 0.0
Trp
1.443TrpAla: 1.443 ± 0.322
0.444TrpCys: 0.444 ± 0.193
1.11TrpAsp: 1.11 ± 0.278
0.999TrpGlu: 0.999 ± 0.239
0.666TrpPhe: 0.666 ± 0.193
0.944TrpGly: 0.944 ± 0.23
0.5TrpHis: 0.5 ± 0.199
0.555TrpIle: 0.555 ± 0.175
0.5TrpLys: 0.5 ± 0.153
1.887TrpLeu: 1.887 ± 0.328
0.5TrpMet: 0.5 ± 0.185
0.944TrpAsn: 0.944 ± 0.243
1.055TrpPro: 1.055 ± 0.286
0.611TrpGln: 0.611 ± 0.178
1.61TrpArg: 1.61 ± 0.326
1.221TrpSer: 1.221 ± 0.302
1.166TrpThr: 1.166 ± 0.341
1.221TrpVal: 1.221 ± 0.279
0.222TrpTrp: 0.222 ± 0.109
0.5TrpTyr: 0.5 ± 0.163
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.942TyrAla: 2.942 ± 0.379
0.444TyrCys: 0.444 ± 0.154
2.443TyrAsp: 2.443 ± 0.479
1.61TyrGlu: 1.61 ± 0.352
0.833TyrPhe: 0.833 ± 0.23
2.165TyrGly: 2.165 ± 0.433
0.611TyrHis: 0.611 ± 0.141
1.332TyrIle: 1.332 ± 0.253
0.888TyrLys: 0.888 ± 0.195
2.72TyrLeu: 2.72 ± 0.296
0.722TyrMet: 0.722 ± 0.205
1.11TyrAsn: 1.11 ± 0.315
1.221TyrPro: 1.221 ± 0.263
1.332TyrGln: 1.332 ± 0.309
2.554TyrArg: 2.554 ± 0.399
2.054TyrSer: 2.054 ± 0.335
1.554TyrThr: 1.554 ± 0.321
2.109TyrVal: 2.109 ± 0.324
0.777TyrTrp: 0.777 ± 0.18
0.5TyrTyr: 0.5 ± 0.154
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (18015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski