Amino acid dipepetide frequency for Aureimonas sp. Leaf454

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.435AlaAla: 19.435 ± 0.19	1.003AlaCys: 1.003 ± 0.026	7.656AlaAsp: 7.656 ± 0.082	8.67AlaGlu: 8.67 ± 0.105	4.989AlaPhe: 4.989 ± 0.065	12.002AlaGly: 12.002 ± 0.111	2.114AlaHis: 2.114 ± 0.042	6.788AlaIle: 6.788 ± 0.079	4.01AlaLys: 4.01 ± 0.069	13.89AlaLeu: 13.89 ± 0.138	3.73AlaMet: 3.73 ± 0.061	2.573AlaAsn: 2.573 ± 0.049	6.001AlaPro: 6.001 ± 0.094	3.255AlaGln: 3.255 ± 0.06	9.398AlaArg: 9.398 ± 0.103	7.833AlaSer: 7.833 ± 0.088	6.516AlaThr: 6.516 ± 0.071	9.559AlaVal: 9.559 ± 0.101	1.337AlaTrp: 1.337 ± 0.037	2.561AlaTyr: 2.561 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.818CysAla: 0.818 ± 0.025	0.078CysCys: 0.078 ± 0.008	0.441CysAsp: 0.441 ± 0.019	0.434CysGlu: 0.434 ± 0.019	0.31CysPhe: 0.31 ± 0.015	0.839CysGly: 0.839 ± 0.026	0.202CysHis: 0.202 ± 0.013	0.316CysIle: 0.316 ± 0.018	0.14CysLys: 0.14 ± 0.01	0.774CysLeu: 0.774 ± 0.028	0.116CysMet: 0.116 ± 0.009	0.17CysAsn: 0.17 ± 0.011	0.36CysPro: 0.36 ± 0.017	0.176CysGln: 0.176 ± 0.012	0.636CysArg: 0.636 ± 0.024	0.357CysSer: 0.357 ± 0.015	0.335CysThr: 0.335 ± 0.017	0.56CysVal: 0.56 ± 0.022	0.087CysTrp: 0.087 ± 0.008	0.148CysTyr: 0.148 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.831AspAla: 7.831 ± 0.098	0.457AspCys: 0.457 ± 0.018	3.114AspAsp: 3.114 ± 0.058	3.884AspGlu: 3.884 ± 0.056	2.11AspPhe: 2.11 ± 0.041	5.71AspGly: 5.71 ± 0.073	1.243AspHis: 1.243 ± 0.033	3.038AspIle: 3.038 ± 0.048	1.405AspLys: 1.405 ± 0.036	6.662AspLeu: 6.662 ± 0.091	1.254AspMet: 1.254 ± 0.031	0.986AspAsn: 0.986 ± 0.028	3.667AspPro: 3.667 ± 0.054	1.352AspGln: 1.352 ± 0.038	5.024AspArg: 5.024 ± 0.056	1.828AspSer: 1.828 ± 0.042	2.465AspThr: 2.465 ± 0.048	4.527AspVal: 4.527 ± 0.058	0.937AspTrp: 0.937 ± 0.029	1.281AspTyr: 1.281 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	9.306GluAla: 9.306 ± 0.086	0.284GluCys: 0.284 ± 0.014	3.079GluAsp: 3.079 ± 0.059	3.362GluGlu: 3.362 ± 0.059	1.545GluPhe: 1.545 ± 0.037	4.753GluGly: 4.753 ± 0.064	1.075GluHis: 1.075 ± 0.032	3.866GluIle: 3.866 ± 0.055	1.936GluLys: 1.936 ± 0.041	4.79GluLeu: 4.79 ± 0.062	1.46GluMet: 1.46 ± 0.034	1.352GluAsn: 1.352 ± 0.036	3.047GluPro: 3.047 ± 0.064	1.598GluGln: 1.598 ± 0.035	5.717GluArg: 5.717 ± 0.085	2.282GluSer: 2.282 ± 0.036	4.229GluThr: 4.229 ± 0.058	3.918GluVal: 3.918 ± 0.056	0.596GluTrp: 0.596 ± 0.023	0.74GluTyr: 0.74 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.891PheAla: 4.891 ± 0.069	0.335PheCys: 0.335 ± 0.017	2.75PheAsp: 2.75 ± 0.048	2.331PheGlu: 2.331 ± 0.042	1.355PhePhe: 1.355 ± 0.037	3.725PheGly: 3.725 ± 0.057	0.76PheHis: 0.76 ± 0.025	1.411PheIle: 1.411 ± 0.036	0.89PheLys: 0.89 ± 0.027	3.566PheLeu: 3.566 ± 0.062	0.713PheMet: 0.713 ± 0.024	0.884PheAsn: 0.884 ± 0.029	1.532PhePro: 1.532 ± 0.037	1.031PheGln: 1.031 ± 0.028	2.334PheArg: 2.334 ± 0.037	2.147PheSer: 2.147 ± 0.039	1.822PheThr: 1.822 ± 0.04	3.104PheVal: 3.104 ± 0.05	0.499PheTrp: 0.499 ± 0.02	0.822PheTyr: 0.822 ± 0.025	0.001PheXaa: 0.001 ± 0.001
Gly	10.259GlyAla: 10.259 ± 0.094	0.747GlyCys: 0.747 ± 0.025	4.75GlyAsp: 4.75 ± 0.076	5.394GlyGlu: 5.394 ± 0.08	3.701GlyPhe: 3.701 ± 0.06	7.724GlyGly: 7.724 ± 0.114	1.81GlyHis: 1.81 ± 0.045	4.835GlyIle: 4.835 ± 0.058	2.63GlyLys: 2.63 ± 0.055	9.633GlyLeu: 9.633 ± 0.105	2.11GlyMet: 2.11 ± 0.043	1.797GlyAsn: 1.797 ± 0.041	3.822GlyPro: 3.822 ± 0.056	2.577GlyGln: 2.577 ± 0.047	7.352GlyArg: 7.352 ± 0.086	5.134GlySer: 5.134 ± 0.067	5.194GlyThr: 5.194 ± 0.081	6.177GlyVal: 6.177 ± 0.075	1.297GlyTrp: 1.297 ± 0.034	2.044GlyTyr: 2.044 ± 0.043	0.001GlyXaa: 0.001 ± 0.001
His	2.259HisAla: 2.259 ± 0.043	0.218HisCys: 0.218 ± 0.013	1.143HisAsp: 1.143 ± 0.032	1.001HisGlu: 1.001 ± 0.027	0.771HisPhe: 0.771 ± 0.025	1.811HisGly: 1.811 ± 0.05	0.575HisHis: 0.575 ± 0.023	0.75HisIle: 0.75 ± 0.025	0.372HisLys: 0.372 ± 0.017	2.072HisLeu: 2.072 ± 0.046	0.44HisMet: 0.44 ± 0.018	0.302HisAsn: 0.302 ± 0.015	1.344HisPro: 1.344 ± 0.029	0.519HisGln: 0.519 ± 0.021	1.596HisArg: 1.596 ± 0.037	0.821HisSer: 0.821 ± 0.028	0.68HisThr: 0.68 ± 0.025	1.516HisVal: 1.516 ± 0.036	0.262HisTrp: 0.262 ± 0.014	0.467HisTyr: 0.467 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	7.482IleAla: 7.482 ± 0.078	0.404IleCys: 0.404 ± 0.018	3.651IleAsp: 3.651 ± 0.051	3.64IleGlu: 3.64 ± 0.055	1.643IlePhe: 1.643 ± 0.039	5.087IleGly: 5.087 ± 0.061	0.863IleHis: 0.863 ± 0.024	1.704IleIle: 1.704 ± 0.045	1.124IleLys: 1.124 ± 0.032	4.922IleLeu: 4.922 ± 0.062	0.798IleMet: 0.798 ± 0.024	1.053IleAsn: 1.053 ± 0.037	2.064IlePro: 2.064 ± 0.034	1.144IleGln: 1.144 ± 0.027	3.47IleArg: 3.47 ± 0.05	2.568IleSer: 2.568 ± 0.049	2.184IleThr: 2.184 ± 0.041	4.677IleVal: 4.677 ± 0.061	0.532IleTrp: 0.532 ± 0.02	0.944IleTyr: 0.944 ± 0.025	0.001IleXaa: 0.001 ± 0.001
Lys	4.188LysAla: 4.188 ± 0.067	0.107LysCys: 0.107 ± 0.009	1.523LysAsp: 1.523 ± 0.037	1.281LysGlu: 1.281 ± 0.036	0.662LysPhe: 0.662 ± 0.022	2.609LysGly: 2.609 ± 0.053	0.457LysHis: 0.457 ± 0.018	1.466LysIle: 1.466 ± 0.033	0.943LysLys: 0.943 ± 0.028	2.703LysLeu: 2.703 ± 0.053	0.633LysMet: 0.633 ± 0.026	0.6LysAsn: 0.6 ± 0.023	1.91LysPro: 1.91 ± 0.04	0.663LysGln: 0.663 ± 0.025	2.278LysArg: 2.278 ± 0.041	1.623LysSer: 1.623 ± 0.037	1.896LysThr: 1.896 ± 0.038	2.154LysVal: 2.154 ± 0.046	0.251LysTrp: 0.251 ± 0.016	0.436LysTyr: 0.436 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.443LeuAla: 14.443 ± 0.133	0.898LeuCys: 0.898 ± 0.02	6.501LeuAsp: 6.501 ± 0.088	5.085LeuGlu: 5.085 ± 0.066	3.621LeuPhe: 3.621 ± 0.059	8.938LeuGly: 8.938 ± 0.091	1.703LeuHis: 1.703 ± 0.037	4.175LeuIle: 4.175 ± 0.07	3.416LeuLys: 3.416 ± 0.05	9.616LeuLeu: 9.616 ± 0.127	2.144LeuMet: 2.144 ± 0.037	2.166LeuAsn: 2.166 ± 0.042	5.524LeuPro: 5.524 ± 0.08	2.639LeuGln: 2.639 ± 0.042	7.078LeuArg: 7.078 ± 0.076	7.085LeuSer: 7.085 ± 0.083	5.282LeuThr: 5.282 ± 0.074	8.444LeuVal: 8.444 ± 0.099	1.047LeuTrp: 1.047 ± 0.033	1.939LeuTyr: 1.939 ± 0.045	0.001LeuXaa: 0.001 ± 0.001
Met	3.059MetAla: 3.059 ± 0.049	0.113MetCys: 0.113 ± 0.008	1.124MetAsp: 1.124 ± 0.033	1.135MetGlu: 1.135 ± 0.03	0.59MetPhe: 0.59 ± 0.021	1.721MetGly: 1.721 ± 0.041	0.364MetHis: 0.364 ± 0.02	1.314MetIle: 1.314 ± 0.034	0.885MetLys: 0.885 ± 0.025	2.213MetLeu: 2.213 ± 0.04	0.596MetMet: 0.596 ± 0.021	0.659MetAsn: 0.659 ± 0.021	1.452MetPro: 1.452 ± 0.031	0.687MetGln: 0.687 ± 0.026	1.854MetArg: 1.854 ± 0.039	1.685MetSer: 1.685 ± 0.036	1.879MetThr: 1.879 ± 0.043	1.486MetVal: 1.486 ± 0.035	0.147MetTrp: 0.147 ± 0.011	0.242MetTyr: 0.242 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.902AsnAla: 2.902 ± 0.051	0.169AsnCys: 0.169 ± 0.012	1.159AsnAsp: 1.159 ± 0.029	1.15AsnGlu: 1.15 ± 0.032	0.813AsnPhe: 0.813 ± 0.026	2.198AsnGly: 2.198 ± 0.052	0.415AsnHis: 0.415 ± 0.017	1.069AsnIle: 1.069 ± 0.033	0.51AsnLys: 0.51 ± 0.019	2.08AsnLeu: 2.08 ± 0.038	0.477AsnMet: 0.477 ± 0.021	0.529AsnAsn: 0.529 ± 0.025	1.442AsnPro: 1.442 ± 0.036	0.585AsnGln: 0.585 ± 0.023	1.635AsnArg: 1.635 ± 0.036	0.885AsnSer: 0.885 ± 0.03	1.063AsnThr: 1.063 ± 0.031	1.728AsnVal: 1.728 ± 0.038	0.311AsnTrp: 0.311 ± 0.015	0.509AsnTyr: 0.509 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.015ProAla: 7.015 ± 0.098	0.272ProCys: 0.272 ± 0.015	3.84ProAsp: 3.84 ± 0.058	3.515ProGlu: 3.515 ± 0.058	2.115ProPhe: 2.115 ± 0.039	4.651ProGly: 4.651 ± 0.071	0.963ProHis: 0.963 ± 0.031	2.422ProIle: 2.422 ± 0.04	1.54ProLys: 1.54 ± 0.037	4.715ProLeu: 4.715 ± 0.068	1.191ProMet: 1.191 ± 0.033	1.24ProAsn: 1.24 ± 0.035	2.378ProPro: 2.378 ± 0.059	1.284ProGln: 1.284 ± 0.028	3.091ProArg: 3.091 ± 0.049	3.079ProSer: 3.079 ± 0.051	2.524ProThr: 2.524 ± 0.047	4.349ProVal: 4.349 ± 0.059	0.537ProTrp: 0.537 ± 0.02	1.055ProTyr: 1.055 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.596GlnAla: 3.596 ± 0.051	0.142GlnCys: 0.142 ± 0.01	1.269GlnAsp: 1.269 ± 0.032	1.259GlnGlu: 1.259 ± 0.031	0.903GlnPhe: 0.903 ± 0.025	1.981GlnGly: 1.981 ± 0.038	0.488GlnHis: 0.488 ± 0.019	1.587GlnIle: 1.587 ± 0.036	0.88GlnLys: 0.88 ± 0.026	2.336GlnLeu: 2.336 ± 0.045	0.727GlnMet: 0.727 ± 0.025	0.7GlnAsn: 0.7 ± 0.025	1.459GlnPro: 1.459 ± 0.038	0.848GlnGln: 0.848 ± 0.034	2.263GlnArg: 2.263 ± 0.047	1.714GlnSer: 1.714 ± 0.041	1.753GlnThr: 1.753 ± 0.037	1.874GlnVal: 1.874 ± 0.043	0.292GlnTrp: 0.292 ± 0.017	0.451GlnTyr: 0.451 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.51ArgAla: 8.51 ± 0.082	0.476ArgCys: 0.476 ± 0.02	4.414ArgAsp: 4.414 ± 0.065	4.414ArgGlu: 4.414 ± 0.063	3.229ArgPhe: 3.229 ± 0.05	5.24ArgGly: 5.24 ± 0.069	1.847ArgHis: 1.847 ± 0.041	4.372ArgIle: 4.372 ± 0.059	1.883ArgLys: 1.883 ± 0.04	9.038ArgLeu: 9.038 ± 0.086	1.96ArgMet: 1.96 ± 0.043	1.614ArgAsn: 1.614 ± 0.039	4.041ArgPro: 4.041 ± 0.061	2.48ArgGln: 2.48 ± 0.044	7.053ArgArg: 7.053 ± 0.091	4.422ArgSer: 4.422 ± 0.064	3.846ArgThr: 3.846 ± 0.062	4.858ArgVal: 4.858 ± 0.07	1.0ArgTrp: 1.0 ± 0.028	1.613ArgTyr: 1.613 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.984SerAla: 6.984 ± 0.077	0.368SerCys: 0.368 ± 0.02	3.179SerAsp: 3.179 ± 0.052	2.929SerGlu: 2.929 ± 0.053	2.327SerPhe: 2.327 ± 0.042	5.933SerGly: 5.933 ± 0.085	1.022SerHis: 1.022 ± 0.031	2.88SerIle: 2.88 ± 0.052	1.459SerLys: 1.459 ± 0.035	5.714SerLeu: 5.714 ± 0.072	1.379SerMet: 1.379 ± 0.036	1.28SerAsn: 1.28 ± 0.034	2.977SerPro: 2.977 ± 0.052	1.531SerGln: 1.531 ± 0.04	4.009SerArg: 4.009 ± 0.058	3.151SerSer: 3.151 ± 0.053	2.86SerThr: 2.86 ± 0.051	4.197SerVal: 4.197 ± 0.061	0.674SerTrp: 0.674 ± 0.022	1.18SerTyr: 1.18 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	6.686ThrAla: 6.686 ± 0.096	0.361ThrCys: 0.361 ± 0.018	2.804ThrAsp: 2.804 ± 0.052	2.601ThrGlu: 2.601 ± 0.046	2.127ThrPhe: 2.127 ± 0.041	5.331ThrGly: 5.331 ± 0.077	0.931ThrHis: 0.931 ± 0.026	3.151ThrIle: 3.151 ± 0.055	1.397ThrLys: 1.397 ± 0.035	5.819ThrLeu: 5.819 ± 0.065	1.167ThrMet: 1.167 ± 0.033	1.157ThrAsn: 1.157 ± 0.028	3.202ThrPro: 3.202 ± 0.051	1.338ThrGln: 1.338 ± 0.034	3.543ThrArg: 3.543 ± 0.053	3.008ThrSer: 3.008 ± 0.051	2.944ThrThr: 2.944 ± 0.065	4.382ThrVal: 4.382 ± 0.068	0.551ThrTrp: 0.551 ± 0.019	1.175ThrTyr: 1.175 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.197ValAla: 10.197 ± 0.09	0.586ValCys: 0.586 ± 0.019	4.481ValAsp: 4.481 ± 0.065	5.226ValGlu: 5.226 ± 0.07	2.847ValPhe: 2.847 ± 0.051	6.033ValGly: 6.033 ± 0.066	1.398ValHis: 1.398 ± 0.037	3.438ValIle: 3.438 ± 0.056	2.064ValLys: 2.064 ± 0.043	7.741ValLeu: 7.741 ± 0.079	1.611ValMet: 1.611 ± 0.035	1.701ValAsn: 1.701 ± 0.042	3.948ValPro: 3.948 ± 0.06	1.812ValGln: 1.812 ± 0.04	5.188ValArg: 5.188 ± 0.054	4.654ValSer: 4.654 ± 0.055	4.492ValThr: 4.492 ± 0.061	6.575ValVal: 6.575 ± 0.074	0.825ValTrp: 0.825 ± 0.026	1.415ValTyr: 1.415 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	1.026TrpAla: 1.026 ± 0.029	0.102TrpCys: 0.102 ± 0.009	0.559TrpAsp: 0.559 ± 0.023	0.442TrpGlu: 0.442 ± 0.016	0.484TrpPhe: 0.484 ± 0.019	0.757TrpGly: 0.757 ± 0.028	0.28TrpHis: 0.28 ± 0.014	0.612TrpIle: 0.612 ± 0.023	0.385TrpLys: 0.385 ± 0.018	1.426TrpLeu: 1.426 ± 0.035	0.333TrpMet: 0.333 ± 0.016	0.39TrpAsn: 0.39 ± 0.016	0.621TrpPro: 0.621 ± 0.021	0.439TrpGln: 0.439 ± 0.019	1.131TrpArg: 1.131 ± 0.026	0.819TrpSer: 0.819 ± 0.024	0.819TrpThr: 0.819 ± 0.024	0.618TrpVal: 0.618 ± 0.019	0.191TrpTrp: 0.191 ± 0.013	0.231TrpTyr: 0.231 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.044	0.177TyrCys: 0.177 ± 0.011	1.338TyrAsp: 1.338 ± 0.031	1.182TyrGlu: 1.182 ± 0.032	0.762TyrPhe: 0.762 ± 0.027	1.947TyrGly: 1.947 ± 0.045	0.407TyrHis: 0.407 ± 0.014	0.759TyrIle: 0.759 ± 0.023	0.513TyrLys: 0.513 ± 0.019	2.035TyrLeu: 2.035 ± 0.042	0.365TyrMet: 0.365 ± 0.017	0.475TyrAsn: 0.475 ± 0.019	0.983TyrPro: 0.983 ± 0.03	0.565TyrGln: 0.565 ± 0.022	1.659TyrArg: 1.659 ± 0.037	0.938TyrSer: 0.938 ± 0.029	0.893TyrThr: 0.893 ± 0.027	1.53TyrVal: 1.53 ± 0.034	0.292TyrTrp: 0.292 ± 0.02	0.479TyrTyr: 0.479 ± 0.022	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4218 proteins (1340498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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