Amino acid dipepetide frequency for Nocardia puris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.188AlaAla: 22.188 ± 0.188	0.937AlaCys: 0.937 ± 0.025	9.133AlaAsp: 9.133 ± 0.09	9.387AlaGlu: 9.387 ± 0.099	3.464AlaPhe: 3.464 ± 0.042	12.374AlaGly: 12.374 ± 0.096	2.943AlaHis: 2.943 ± 0.04	4.835AlaIle: 4.835 ± 0.053	2.62AlaLys: 2.62 ± 0.05	14.3AlaLeu: 14.3 ± 0.111	2.578AlaMet: 2.578 ± 0.035	2.263AlaAsn: 2.263 ± 0.034	7.319AlaPro: 7.319 ± 0.092	3.716AlaGln: 3.716 ± 0.048	10.326AlaArg: 10.326 ± 0.084	5.54AlaSer: 5.54 ± 0.053	7.726AlaThr: 7.726 ± 0.064	12.136AlaVal: 12.136 ± 0.091	1.684AlaTrp: 1.684 ± 0.03	2.394AlaTyr: 2.394 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.095CysAla: 1.095 ± 0.023	0.082CysCys: 0.082 ± 0.007	0.444CysAsp: 0.444 ± 0.013	0.365CysGlu: 0.365 ± 0.012	0.207CysPhe: 0.207 ± 0.01	0.882CysGly: 0.882 ± 0.025	0.18CysHis: 0.18 ± 0.01	0.17CysIle: 0.17 ± 0.008	0.091CysLys: 0.091 ± 0.006	0.657CysLeu: 0.657 ± 0.018	0.095CysMet: 0.095 ± 0.007	0.112CysAsn: 0.112 ± 0.008	0.465CysPro: 0.465 ± 0.016	0.149CysGln: 0.149 ± 0.009	0.571CysArg: 0.571 ± 0.019	0.424CysSer: 0.424 ± 0.016	0.43CysThr: 0.43 ± 0.016	0.627CysVal: 0.627 ± 0.02	0.106CysTrp: 0.106 ± 0.007	0.156CysTyr: 0.156 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.088AspAla: 8.088 ± 0.088	0.412AspCys: 0.412 ± 0.014	3.745AspAsp: 3.745 ± 0.051	3.918AspGlu: 3.918 ± 0.044	1.679AspPhe: 1.679 ± 0.027	5.689AspGly: 5.689 ± 0.06	1.53AspHis: 1.53 ± 0.026	2.367AspIle: 2.367 ± 0.029	1.039AspLys: 1.039 ± 0.023	6.776AspLeu: 6.776 ± 0.069	0.888AspMet: 0.888 ± 0.023	1.075AspAsn: 1.075 ± 0.022	4.889AspPro: 4.889 ± 0.065	1.619AspGln: 1.619 ± 0.027	5.41AspArg: 5.41 ± 0.064	2.896AspSer: 2.896 ± 0.038	3.34AspThr: 3.34 ± 0.041	4.661AspVal: 4.661 ± 0.049	0.919AspTrp: 0.919 ± 0.018	1.326AspTyr: 1.326 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.276GluAla: 6.276 ± 0.071	0.373GluCys: 0.373 ± 0.014	2.475GluAsp: 2.475 ± 0.035	2.638GluGlu: 2.638 ± 0.037	2.059GluPhe: 2.059 ± 0.03	3.681GluGly: 3.681 ± 0.045	1.695GluHis: 1.695 ± 0.027	2.773GluIle: 2.773 ± 0.042	1.129GluLys: 1.129 ± 0.029	7.102GluLeu: 7.102 ± 0.068	0.989GluMet: 0.989 ± 0.024	1.168GluAsn: 1.168 ± 0.025	3.604GluPro: 3.604 ± 0.048	2.121GluGln: 2.121 ± 0.034	5.439GluArg: 5.439 ± 0.059	3.155GluSer: 3.155 ± 0.041	2.897GluThr: 2.897 ± 0.039	4.725GluVal: 4.725 ± 0.048	0.88GluTrp: 0.88 ± 0.021	1.265GluTyr: 1.265 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.311PheAla: 4.311 ± 0.047	0.243PheCys: 0.243 ± 0.011	2.427PheAsp: 2.427 ± 0.037	1.598PheGlu: 1.598 ± 0.032	0.855PhePhe: 0.855 ± 0.022	3.428PheGly: 3.428 ± 0.043	0.634PheHis: 0.634 ± 0.017	0.757PheIle: 0.757 ± 0.021	0.365PheLys: 0.365 ± 0.013	2.627PheLeu: 2.627 ± 0.044	0.366PheMet: 0.366 ± 0.014	0.5PheAsn: 0.5 ± 0.017	1.444PhePro: 1.444 ± 0.024	0.666PheGln: 0.666 ± 0.02	1.925PheArg: 1.925 ± 0.026	1.34PheSer: 1.34 ± 0.029	2.019PheThr: 2.019 ± 0.031	2.473PheVal: 2.473 ± 0.039	0.4PheTrp: 0.4 ± 0.013	0.6PheTyr: 0.6 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.355GlyAla: 11.355 ± 0.095	0.763GlyCys: 0.763 ± 0.021	5.096GlyAsp: 5.096 ± 0.062	4.955GlyGlu: 4.955 ± 0.053	2.92GlyPhe: 2.92 ± 0.044	7.994GlyGly: 7.994 ± 0.092	2.041GlyHis: 2.041 ± 0.031	3.873GlyIle: 3.873 ± 0.047	2.166GlyLys: 2.166 ± 0.039	8.76GlyLeu: 8.76 ± 0.075	1.979GlyMet: 1.979 ± 0.035	1.679GlyAsn: 1.679 ± 0.032	4.783GlyPro: 4.783 ± 0.06	2.4GlyGln: 2.4 ± 0.04	6.813GlyArg: 6.813 ± 0.067	4.858GlySer: 4.858 ± 0.059	5.492GlyThr: 5.492 ± 0.06	7.801GlyVal: 7.801 ± 0.058	1.588GlyTrp: 1.588 ± 0.029	2.316GlyTyr: 2.316 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.759HisAla: 2.759 ± 0.034	0.195HisCys: 0.195 ± 0.012	1.342HisAsp: 1.342 ± 0.026	1.132HisGlu: 1.132 ± 0.025	0.637HisPhe: 0.637 ± 0.018	2.198HisGly: 2.198 ± 0.035	0.724HisHis: 0.724 ± 0.019	0.753HisIle: 0.753 ± 0.016	0.305HisLys: 0.305 ± 0.01	2.366HisLeu: 2.366 ± 0.04	0.309HisMet: 0.309 ± 0.011	0.462HisAsn: 0.462 ± 0.013	1.803HisPro: 1.803 ± 0.03	0.568HisGln: 0.568 ± 0.018	2.194HisArg: 2.194 ± 0.03	1.046HisSer: 1.046 ± 0.022	1.369HisThr: 1.369 ± 0.026	1.568HisVal: 1.568 ± 0.023	0.346HisTrp: 0.346 ± 0.013	0.503HisTyr: 0.503 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.17IleAla: 6.17 ± 0.051	0.281IleCys: 0.281 ± 0.011	3.124IleAsp: 3.124 ± 0.039	2.499IleGlu: 2.499 ± 0.039	0.819IlePhe: 0.819 ± 0.021	4.159IleGly: 4.159 ± 0.047	0.675IleHis: 0.675 ± 0.017	1.148IleIle: 1.148 ± 0.028	0.63IleLys: 0.63 ± 0.02	2.958IleLeu: 2.958 ± 0.044	0.506IleMet: 0.506 ± 0.016	0.745IleAsn: 0.745 ± 0.021	2.354IlePro: 2.354 ± 0.036	0.787IleGln: 0.787 ± 0.02	2.529IleArg: 2.529 ± 0.031	1.917IleSer: 1.917 ± 0.032	2.664IleThr: 2.664 ± 0.035	3.409IleVal: 3.409 ± 0.045	0.395IleTrp: 0.395 ± 0.014	0.664IleTyr: 0.664 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.195LysAla: 2.195 ± 0.041	0.096LysCys: 0.096 ± 0.006	0.839LysAsp: 0.839 ± 0.022	0.83LysGlu: 0.83 ± 0.024	0.556LysPhe: 0.556 ± 0.016	1.287LysGly: 1.287 ± 0.026	0.428LysHis: 0.428 ± 0.015	0.836LysIle: 0.836 ± 0.022	0.517LysLys: 0.517 ± 0.02	1.913LysLeu: 1.913 ± 0.038	0.377LysMet: 0.377 ± 0.013	0.399LysAsn: 0.399 ± 0.014	1.197LysPro: 1.197 ± 0.024	0.592LysGln: 0.592 ± 0.018	1.371LysArg: 1.371 ± 0.031	1.078LysSer: 1.078 ± 0.023	1.12LysThr: 1.12 ± 0.026	1.631LysVal: 1.631 ± 0.029	0.264LysTrp: 0.264 ± 0.011	0.441LysTyr: 0.441 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.333LeuAla: 15.333 ± 0.103	0.792LeuCys: 0.792 ± 0.021	7.141LeuAsp: 7.141 ± 0.077	4.727LeuGlu: 4.727 ± 0.051	2.776LeuPhe: 2.776 ± 0.042	9.238LeuGly: 9.238 ± 0.073	2.14LeuHis: 2.14 ± 0.033	3.913LeuIle: 3.913 ± 0.051	1.295LeuLys: 1.295 ± 0.031	10.295LeuLeu: 10.295 ± 0.097	1.46LeuMet: 1.46 ± 0.023	1.748LeuAsn: 1.748 ± 0.03	6.245LeuPro: 6.245 ± 0.061	1.84LeuGln: 1.84 ± 0.034	8.958LeuArg: 8.958 ± 0.085	5.372LeuSer: 5.372 ± 0.053	6.837LeuThr: 6.837 ± 0.071	8.652LeuVal: 8.652 ± 0.083	1.242LeuTrp: 1.242 ± 0.027	1.683LeuTyr: 1.683 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.175MetAla: 2.175 ± 0.039	0.137MetCys: 0.137 ± 0.009	0.826MetAsp: 0.826 ± 0.022	0.607MetGlu: 0.607 ± 0.018	0.546MetPhe: 0.546 ± 0.017	1.264MetGly: 1.264 ± 0.029	0.359MetHis: 0.359 ± 0.012	0.798MetIle: 0.798 ± 0.017	0.359MetLys: 0.359 ± 0.014	1.855MetLeu: 1.855 ± 0.034	0.327MetMet: 0.327 ± 0.013	0.483MetAsn: 0.483 ± 0.017	1.05MetPro: 1.05 ± 0.021	0.422MetGln: 0.422 ± 0.014	1.517MetArg: 1.517 ± 0.032	1.386MetSer: 1.386 ± 0.027	1.605MetThr: 1.605 ± 0.026	1.453MetVal: 1.453 ± 0.028	0.231MetTrp: 0.231 ± 0.01	0.311MetTyr: 0.311 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.334AsnAla: 2.334 ± 0.036	0.136AsnCys: 0.136 ± 0.009	0.935AsnAsp: 0.935 ± 0.022	0.811AsnGlu: 0.811 ± 0.024	0.537AsnPhe: 0.537 ± 0.016	1.8AsnGly: 1.8 ± 0.028	0.411AsnHis: 0.411 ± 0.016	0.764AsnIle: 0.764 ± 0.02	0.375AsnLys: 0.375 ± 0.013	1.823AsnLeu: 1.823 ± 0.033	0.341AsnMet: 0.341 ± 0.013	0.425AsnAsn: 0.425 ± 0.018	1.638AsnPro: 1.638 ± 0.032	0.543AsnGln: 0.543 ± 0.019	1.422AsnArg: 1.422 ± 0.023	0.979AsnSer: 0.979 ± 0.027	1.198AsnThr: 1.198 ± 0.027	1.387AsnVal: 1.387 ± 0.029	0.298AsnTrp: 0.298 ± 0.013	0.429AsnTyr: 0.429 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.516ProAla: 8.516 ± 0.09	0.311ProCys: 0.311 ± 0.012	4.787ProAsp: 4.787 ± 0.052	4.446ProGlu: 4.446 ± 0.046	1.539ProPhe: 1.539 ± 0.028	6.446ProGly: 6.446 ± 0.076	1.306ProHis: 1.306 ± 0.03	2.069ProIle: 2.069 ± 0.03	1.117ProLys: 1.117 ± 0.023	5.102ProLeu: 5.102 ± 0.063	1.042ProMet: 1.042 ± 0.023	1.14ProAsn: 1.14 ± 0.029	3.76ProPro: 3.76 ± 0.066	1.543ProGln: 1.543 ± 0.036	3.977ProArg: 3.977 ± 0.052	3.06ProSer: 3.06 ± 0.052	3.551ProThr: 3.551 ± 0.049	5.552ProVal: 5.552 ± 0.069	0.863ProTrp: 0.863 ± 0.02	1.125ProTyr: 1.125 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.063GlnAla: 3.063 ± 0.041	0.15GlnCys: 0.15 ± 0.008	1.056GlnAsp: 1.056 ± 0.022	1.041GlnGlu: 1.041 ± 0.025	0.796GlnPhe: 0.796 ± 0.02	1.785GlnGly: 1.785 ± 0.03	0.615GlnHis: 0.615 ± 0.017	1.204GlnIle: 1.204 ± 0.022	0.45GlnLys: 0.45 ± 0.015	3.1GlnLeu: 3.1 ± 0.042	0.506GlnMet: 0.506 ± 0.017	0.502GlnAsn: 0.502 ± 0.018	1.739GlnPro: 1.739 ± 0.039	1.092GlnGln: 1.092 ± 0.032	2.598GlnArg: 2.598 ± 0.035	1.224GlnSer: 1.224 ± 0.028	1.232GlnThr: 1.232 ± 0.024	2.429GlnVal: 2.429 ± 0.037	0.457GlnTrp: 0.457 ± 0.014	0.567GlnTyr: 0.567 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.48ArgAla: 10.48 ± 0.108	0.607ArgCys: 0.607 ± 0.017	4.653ArgAsp: 4.653 ± 0.057	4.727ArgGlu: 4.727 ± 0.057	2.589ArgPhe: 2.589 ± 0.033	5.746ArgGly: 5.746 ± 0.056	2.009ArgHis: 2.009 ± 0.031	3.633ArgIle: 3.633 ± 0.041	1.67ArgLys: 1.67 ± 0.031	8.128ArgLeu: 8.128 ± 0.071	1.913ArgMet: 1.913 ± 0.028	1.508ArgAsn: 1.508 ± 0.03	4.635ArgPro: 4.635 ± 0.06	2.11ArgGln: 2.11 ± 0.033	7.365ArgArg: 7.365 ± 0.077	3.955ArgSer: 3.955 ± 0.042	5.198ArgThr: 5.198 ± 0.048	6.315ArgVal: 6.315 ± 0.06	1.503ArgTrp: 1.503 ± 0.029	1.946ArgTyr: 1.946 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.024SerAla: 7.024 ± 0.07	0.358SerCys: 0.358 ± 0.013	2.884SerAsp: 2.884 ± 0.042	2.611SerGlu: 2.611 ± 0.037	1.503SerPhe: 1.503 ± 0.026	5.747SerGly: 5.747 ± 0.06	0.939SerHis: 0.939 ± 0.022	1.824SerIle: 1.824 ± 0.032	0.876SerLys: 0.876 ± 0.019	4.445SerLeu: 4.445 ± 0.051	1.178SerMet: 1.178 ± 0.022	0.908SerAsn: 0.908 ± 0.024	3.031SerPro: 3.031 ± 0.037	1.134SerGln: 1.134 ± 0.028	3.632SerArg: 3.632 ± 0.036	2.636SerSer: 2.636 ± 0.045	3.17SerThr: 3.17 ± 0.04	4.287SerVal: 4.287 ± 0.049	0.847SerTrp: 0.847 ± 0.021	1.094SerTyr: 1.094 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	8.658ThrAla: 8.658 ± 0.064	0.388ThrCys: 0.388 ± 0.014	3.832ThrAsp: 3.832 ± 0.04	3.653ThrGlu: 3.653 ± 0.045	1.699ThrPhe: 1.699 ± 0.028	6.186ThrGly: 6.186 ± 0.071	1.232ThrHis: 1.232 ± 0.025	2.119ThrIle: 2.119 ± 0.033	1.114ThrLys: 1.114 ± 0.026	5.865ThrLeu: 5.865 ± 0.052	1.006ThrMet: 1.006 ± 0.023	1.05ThrAsn: 1.05 ± 0.024	4.26ThrPro: 4.26 ± 0.052	1.308ThrGln: 1.308 ± 0.026	4.056ThrArg: 4.056 ± 0.048	2.936ThrSer: 2.936 ± 0.039	4.068ThrThr: 4.068 ± 0.057	6.139ThrVal: 6.139 ± 0.065	0.845ThrTrp: 0.845 ± 0.019	1.247ThrTyr: 1.247 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	11.812ValAla: 11.812 ± 0.102	0.723ValCys: 0.723 ± 0.019	5.458ValAsp: 5.458 ± 0.048	4.684ValGlu: 4.684 ± 0.049	2.602ValPhe: 2.602 ± 0.042	6.766ValGly: 6.766 ± 0.065	1.932ValHis: 1.932 ± 0.033	3.393ValIle: 3.393 ± 0.049	1.259ValLys: 1.259 ± 0.027	9.563ValLeu: 9.563 ± 0.084	1.271ValMet: 1.271 ± 0.025	1.679ValAsn: 1.679 ± 0.022	5.094ValPro: 5.094 ± 0.061	1.839ValGln: 1.839 ± 0.03	7.205ValArg: 7.205 ± 0.058	4.359ValSer: 4.359 ± 0.049	5.637ValThr: 5.637 ± 0.049	8.257ValVal: 8.257 ± 0.071	1.062ValTrp: 1.062 ± 0.023	1.57ValTyr: 1.57 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.532TrpAla: 1.532 ± 0.028	0.14TrpCys: 0.14 ± 0.01	0.781TrpAsp: 0.781 ± 0.018	0.724TrpGlu: 0.724 ± 0.02	0.518TrpPhe: 0.518 ± 0.015	0.969TrpGly: 0.969 ± 0.021	0.368TrpHis: 0.368 ± 0.013	0.618TrpIle: 0.618 ± 0.019	0.285TrpLys: 0.285 ± 0.011	1.711TrpLeu: 1.711 ± 0.031	0.319TrpMet: 0.319 ± 0.012	0.348TrpAsn: 0.348 ± 0.014	0.758TrpPro: 0.758 ± 0.019	0.546TrpGln: 0.546 ± 0.016	1.388TrpArg: 1.388 ± 0.023	0.941TrpSer: 0.941 ± 0.019	0.938TrpThr: 0.938 ± 0.021	1.084TrpVal: 1.084 ± 0.026	0.352TrpTrp: 0.352 ± 0.013	0.319TrpTyr: 0.319 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.03	0.18TyrCys: 0.18 ± 0.01	1.288TyrAsp: 1.288 ± 0.026	1.091TyrGlu: 1.091 ± 0.022	0.68TyrPhe: 0.68 ± 0.019	1.995TyrGly: 1.995 ± 0.032	0.418TyrHis: 0.418 ± 0.014	0.586TyrIle: 0.586 ± 0.017	0.305TyrLys: 0.305 ± 0.012	2.343TyrLeu: 2.343 ± 0.034	0.26TyrMet: 0.26 ± 0.011	0.393TyrAsn: 0.393 ± 0.014	1.183TyrPro: 1.183 ± 0.028	0.611TyrGln: 0.611 ± 0.018	1.994TyrArg: 1.994 ± 0.029	1.024TyrSer: 1.024 ± 0.022	1.169TyrThr: 1.169 ± 0.024	1.578TyrVal: 1.578 ± 0.029	0.357TyrTrp: 0.357 ± 0.012	0.447TyrTyr: 0.447 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7050 proteins (2243064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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