Amino acid dipepetide frequency for Ruthia magnifica subsp. Calyptogena magnifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.79AlaAla: 3.79 ± 0.143
0.814AlaCys: 0.814 ± 0.05
3.601AlaAsp: 3.601 ± 0.116
2.806AlaGlu: 2.806 ± 0.097
2.992AlaPhe: 2.992 ± 0.116
4.192AlaGly: 4.192 ± 0.142
1.58AlaHis: 1.58 ± 0.07
6.227AlaIle: 6.227 ± 0.16
5.586AlaLys: 5.586 ± 0.142
7.571AlaLeu: 7.571 ± 0.187
1.992AlaMet: 1.992 ± 0.078
3.797AlaAsn: 3.797 ± 0.121
2.024AlaPro: 2.024 ± 0.095
3.47AlaGln: 3.47 ± 0.118
2.58AlaArg: 2.58 ± 0.1
4.444AlaSer: 4.444 ± 0.123
3.434AlaThr: 3.434 ± 0.122
3.774AlaVal: 3.774 ± 0.119
0.549AlaTrp: 0.549 ± 0.043
2.286AlaTyr: 2.286 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.056
0.105CysCys: 0.105 ± 0.021
0.602CysAsp: 0.602 ± 0.042
0.625CysGlu: 0.625 ± 0.043
0.383CysPhe: 0.383 ± 0.036
0.88CysGly: 0.88 ± 0.06
0.334CysHis: 0.334 ± 0.029
0.791CysIle: 0.791 ± 0.05
0.54CysLys: 0.54 ± 0.043
0.958CysLeu: 0.958 ± 0.057
0.268CysMet: 0.268 ± 0.029
0.451CysAsn: 0.451 ± 0.037
0.477CysPro: 0.477 ± 0.046
0.491CysGln: 0.491 ± 0.045
0.317CysArg: 0.317 ± 0.03
0.683CysSer: 0.683 ± 0.049
0.494CysThr: 0.494 ± 0.039
0.765CysVal: 0.765 ± 0.049
0.065CysTrp: 0.065 ± 0.017
0.294CysTyr: 0.294 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.797AspAla: 3.797 ± 0.118
0.585AspCys: 0.585 ± 0.047
2.875AspAsp: 2.875 ± 0.108
3.82AspGlu: 3.82 ± 0.134
2.773AspPhe: 2.773 ± 0.107
3.254AspGly: 3.254 ± 0.135
0.844AspHis: 0.844 ± 0.054
5.383AspIle: 5.383 ± 0.13
4.503AspLys: 4.503 ± 0.121
5.363AspLeu: 5.363 ± 0.126
1.442AspMet: 1.442 ± 0.079
3.028AspAsn: 3.028 ± 0.119
1.243AspPro: 1.243 ± 0.059
1.632AspGln: 1.632 ± 0.071
1.831AspArg: 1.831 ± 0.078
3.09AspSer: 3.09 ± 0.104
2.901AspThr: 2.901 ± 0.116
3.764AspVal: 3.764 ± 0.118
0.67AspTrp: 0.67 ± 0.05
2.155AspTyr: 2.155 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
3.535GluAla: 3.535 ± 0.105
0.461GluCys: 0.461 ± 0.038
2.413GluAsp: 2.413 ± 0.099
2.43GluGlu: 2.43 ± 0.095
2.531GluPhe: 2.531 ± 0.094
3.012GluGly: 3.012 ± 0.108
1.249GluHis: 1.249 ± 0.068
4.719GluIle: 4.719 ± 0.128
4.451GluLys: 4.451 ± 0.14
5.497GluLeu: 5.497 ± 0.149
1.508GluMet: 1.508 ± 0.064
3.005GluAsn: 3.005 ± 0.103
1.373GluPro: 1.373 ± 0.071
2.865GluGln: 2.865 ± 0.109
2.279GluArg: 2.279 ± 0.084
2.914GluSer: 2.914 ± 0.098
2.531GluThr: 2.531 ± 0.076
4.062GluVal: 4.062 ± 0.106
0.376GluTrp: 0.376 ± 0.033
1.697GluTyr: 1.697 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
2.616PheAla: 2.616 ± 0.101
0.51PheCys: 0.51 ± 0.044
3.345PheAsp: 3.345 ± 0.113
2.881PheGlu: 2.881 ± 0.093
2.031PhePhe: 2.031 ± 0.097
3.022PheGly: 3.022 ± 0.097
0.703PheHis: 0.703 ± 0.054
3.78PheIle: 3.78 ± 0.148
3.156PheLys: 3.156 ± 0.109
3.833PheLeu: 3.833 ± 0.139
1.073PheMet: 1.073 ± 0.067
2.806PheAsn: 2.806 ± 0.098
1.217PhePro: 1.217 ± 0.06
1.138PheGln: 1.138 ± 0.056
1.252PheArg: 1.252 ± 0.062
3.731PheSer: 3.731 ± 0.123
2.106PheThr: 2.106 ± 0.087
2.897PheVal: 2.897 ± 0.115
0.494PheTrp: 0.494 ± 0.046
1.468PheTyr: 1.468 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
4.703GlyAla: 4.703 ± 0.162
0.883GlyCys: 0.883 ± 0.063
3.303GlyAsp: 3.303 ± 0.117
3.303GlyGlu: 3.303 ± 0.104
3.47GlyPhe: 3.47 ± 0.116
4.546GlyGly: 4.546 ± 0.156
1.521GlyHis: 1.521 ± 0.081
5.527GlyIle: 5.527 ± 0.136
4.657GlyLys: 4.657 ± 0.138
6.383GlyLeu: 6.383 ± 0.155
1.988GlyMet: 1.988 ± 0.09
2.747GlyAsn: 2.747 ± 0.125
1.396GlyPro: 1.396 ± 0.085
2.243GlyGln: 2.243 ± 0.092
2.525GlyArg: 2.525 ± 0.097
3.852GlySer: 3.852 ± 0.119
3.224GlyThr: 3.224 ± 0.132
5.239GlyVal: 5.239 ± 0.14
0.683GlyTrp: 0.683 ± 0.05
2.149GlyTyr: 2.149 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.377HisAla: 1.377 ± 0.061
0.298HisCys: 0.298 ± 0.036
0.916HisAsp: 0.916 ± 0.052
0.88HisGlu: 0.88 ± 0.053
0.988HisPhe: 0.988 ± 0.055
1.406HisGly: 1.406 ± 0.057
0.687HisHis: 0.687 ± 0.057
1.844HisIle: 1.844 ± 0.071
1.351HisLys: 1.351 ± 0.073
2.253HisLeu: 2.253 ± 0.085
0.513HisMet: 0.513 ± 0.039
1.174HisAsn: 1.174 ± 0.059
1.079HisPro: 1.079 ± 0.072
1.171HisGln: 1.171 ± 0.069
0.837HisArg: 0.837 ± 0.056
1.341HisSer: 1.341 ± 0.069
1.269HisThr: 1.269 ± 0.063
1.122HisVal: 1.122 ± 0.062
0.239HisTrp: 0.239 ± 0.032
0.945HisTyr: 0.945 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
6.789IleAla: 6.789 ± 0.149
0.811IleCys: 0.811 ± 0.058
5.945IleAsp: 5.945 ± 0.126
5.775IleGlu: 5.775 ± 0.151
3.748IlePhe: 3.748 ± 0.106
5.85IleGly: 5.85 ± 0.16
1.727IleHis: 1.727 ± 0.078
7.505IleIle: 7.505 ± 0.173
7.603IleLys: 7.603 ± 0.167
8.11IleLeu: 8.11 ± 0.201
2.011IleMet: 2.011 ± 0.09
5.628IleAsn: 5.628 ± 0.166
2.76IlePro: 2.76 ± 0.087
3.094IleGln: 3.094 ± 0.102
2.914IleArg: 2.914 ± 0.095
6.187IleSer: 6.187 ± 0.153
5.151IleThr: 5.151 ± 0.139
5.406IleVal: 5.406 ± 0.138
0.651IleTrp: 0.651 ± 0.051
2.371IleTyr: 2.371 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
5.108LysAla: 5.108 ± 0.123
0.559LysCys: 0.559 ± 0.041
4.016LysAsp: 4.016 ± 0.131
3.617LysGlu: 3.617 ± 0.113
2.541LysPhe: 2.541 ± 0.104
4.143LysGly: 4.143 ± 0.128
1.714LysHis: 1.714 ± 0.081
7.191LysIle: 7.191 ± 0.161
5.903LysLys: 5.903 ± 0.168
7.015LysLeu: 7.015 ± 0.176
1.992LysMet: 1.992 ± 0.073
4.889LysAsn: 4.889 ± 0.144
2.404LysPro: 2.404 ± 0.091
3.95LysGln: 3.95 ± 0.129
3.12LysArg: 3.12 ± 0.114
4.431LysSer: 4.431 ± 0.135
4.382LysThr: 4.382 ± 0.102
5.026LysVal: 5.026 ± 0.132
0.52LysTrp: 0.52 ± 0.041
2.178LysTyr: 2.178 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
7.074LeuAla: 7.074 ± 0.175
0.909LeuCys: 0.909 ± 0.06
5.772LeuAsp: 5.772 ± 0.149
5.743LeuGlu: 5.743 ± 0.134
4.31LeuPhe: 4.31 ± 0.133
6.625LeuGly: 6.625 ± 0.156
1.651LeuHis: 1.651 ± 0.067
8.588LeuIle: 8.588 ± 0.206
7.577LeuLys: 7.577 ± 0.191
9.814LeuLeu: 9.814 ± 0.232
2.767LeuMet: 2.767 ± 0.097
6.02LeuAsn: 6.02 ± 0.171
3.548LeuPro: 3.548 ± 0.102
3.087LeuGln: 3.087 ± 0.113
3.421LeuArg: 3.421 ± 0.104
8.47LeuSer: 8.47 ± 0.188
5.494LeuThr: 5.494 ± 0.137
6.194LeuVal: 6.194 ± 0.169
0.788LeuTrp: 0.788 ± 0.054
2.505LeuTyr: 2.505 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
1.946MetAla: 1.946 ± 0.089
0.186MetCys: 0.186 ± 0.026
1.338MetAsp: 1.338 ± 0.064
1.046MetGlu: 1.046 ± 0.068
0.821MetPhe: 0.821 ± 0.052
1.946MetGly: 1.946 ± 0.094
0.595MetHis: 0.595 ± 0.046
2.155MetIle: 2.155 ± 0.079
1.727MetLys: 1.727 ± 0.066
2.59MetLeu: 2.59 ± 0.099
0.827MetMet: 0.827 ± 0.05
1.615MetAsn: 1.615 ± 0.073
1.181MetPro: 1.181 ± 0.061
1.285MetGln: 1.285 ± 0.062
1.069MetArg: 1.069 ± 0.063
2.194MetSer: 2.194 ± 0.078
1.406MetThr: 1.406 ± 0.067
1.884MetVal: 1.884 ± 0.076
0.167MetTrp: 0.167 ± 0.025
0.546MetTyr: 0.546 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.862AsnAla: 3.862 ± 0.112
0.576AsnCys: 0.576 ± 0.046
2.711AsnAsp: 2.711 ± 0.098
2.888AsnGlu: 2.888 ± 0.092
2.469AsnPhe: 2.469 ± 0.096
3.067AsnGly: 3.067 ± 0.115
1.419AsnHis: 1.419 ± 0.074
6.043AsnIle: 6.043 ± 0.156
4.451AsnLys: 4.451 ± 0.128
5.167AsnLeu: 5.167 ± 0.139
1.292AsnMet: 1.292 ± 0.072
3.597AsnAsn: 3.597 ± 0.14
2.155AsnPro: 2.155 ± 0.081
3.002AsnGln: 3.002 ± 0.104
1.884AsnArg: 1.884 ± 0.079
3.107AsnSer: 3.107 ± 0.108
3.604AsnThr: 3.604 ± 0.125
3.188AsnVal: 3.188 ± 0.117
0.579AsnTrp: 0.579 ± 0.049
1.759AsnTyr: 1.759 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.723ProAla: 1.723 ± 0.076
0.383ProCys: 0.383 ± 0.037
1.684ProAsp: 1.684 ± 0.073
1.969ProGlu: 1.969 ± 0.068
1.481ProPhe: 1.481 ± 0.074
1.835ProGly: 1.835 ± 0.087
0.69ProHis: 0.69 ± 0.048
3.218ProIle: 3.218 ± 0.12
2.384ProLys: 2.384 ± 0.085
2.927ProLeu: 2.927 ± 0.102
0.932ProMet: 0.932 ± 0.049
2.07ProAsn: 2.07 ± 0.075
0.831ProPro: 0.831 ± 0.051
1.014ProGln: 1.014 ± 0.054
0.876ProArg: 0.876 ± 0.054
1.988ProSer: 1.988 ± 0.079
1.818ProThr: 1.818 ± 0.085
2.155ProVal: 2.155 ± 0.075
0.383ProTrp: 0.383 ± 0.034
1.04ProTyr: 1.04 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
3.359GlnAla: 3.359 ± 0.109
0.379GlnCys: 0.379 ± 0.037
2.099GlnAsp: 2.099 ± 0.09
1.913GlnGlu: 1.913 ± 0.083
1.53GlnPhe: 1.53 ± 0.077
2.737GlnGly: 2.737 ± 0.101
0.929GlnHis: 0.929 ± 0.059
3.695GlnIle: 3.695 ± 0.135
2.966GlnLys: 2.966 ± 0.111
4.412GlnLeu: 4.412 ± 0.145
1.174GlnMet: 1.174 ± 0.071
2.086GlnAsn: 2.086 ± 0.085
0.978GlnPro: 0.978 ± 0.057
1.943GlnGln: 1.943 ± 0.106
1.39GlnArg: 1.39 ± 0.072
2.816GlnSer: 2.816 ± 0.109
2.423GlnThr: 2.423 ± 0.087
3.139GlnVal: 3.139 ± 0.101
0.373GlnTrp: 0.373 ± 0.034
1.403GlnTyr: 1.403 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
2.361ArgAla: 2.361 ± 0.094
0.347ArgCys: 0.347 ± 0.031
1.897ArgAsp: 1.897 ± 0.073
2.037ArgGlu: 2.037 ± 0.085
1.848ArgPhe: 1.848 ± 0.086
2.126ArgGly: 2.126 ± 0.087
0.873ArgHis: 0.873 ± 0.049
3.182ArgIle: 3.182 ± 0.109
2.371ArgLys: 2.371 ± 0.1
3.931ArgLeu: 3.931 ± 0.118
1.001ArgMet: 1.001 ± 0.048
1.678ArgAsn: 1.678 ± 0.079
1.122ArgPro: 1.122 ± 0.059
1.635ArgGln: 1.635 ± 0.075
1.622ArgArg: 1.622 ± 0.078
2.099ArgSer: 2.099 ± 0.08
1.871ArgThr: 1.871 ± 0.091
2.498ArgVal: 2.498 ± 0.095
0.379ArgTrp: 0.379 ± 0.039
1.465ArgTyr: 1.465 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
4.693SerAla: 4.693 ± 0.129
0.68SerCys: 0.68 ± 0.046
3.427SerAsp: 3.427 ± 0.117
3.381SerGlu: 3.381 ± 0.109
2.858SerPhe: 2.858 ± 0.103
4.814SerGly: 4.814 ± 0.127
1.308SerHis: 1.308 ± 0.065
6.465SerIle: 6.465 ± 0.139
4.791SerLys: 4.791 ± 0.143
6.534SerLeu: 6.534 ± 0.161
1.812SerMet: 1.812 ± 0.079
3.865SerAsn: 3.865 ± 0.103
1.723SerPro: 1.723 ± 0.083
2.299SerGln: 2.299 ± 0.077
2.505SerArg: 2.505 ± 0.082
4.431SerSer: 4.431 ± 0.161
3.519SerThr: 3.519 ± 0.121
4.5SerVal: 4.5 ± 0.134
0.657SerTrp: 0.657 ± 0.043
1.92SerTyr: 1.92 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
2.953ThrAla: 2.953 ± 0.111
0.553ThrCys: 0.553 ± 0.043
2.894ThrAsp: 2.894 ± 0.12
2.237ThrGlu: 2.237 ± 0.094
2.194ThrPhe: 2.194 ± 0.081
3.79ThrGly: 3.79 ± 0.153
1.459ThrHis: 1.459 ± 0.066
4.83ThrIle: 4.83 ± 0.14
3.702ThrLys: 3.702 ± 0.109
6.498ThrLeu: 6.498 ± 0.161
1.298ThrMet: 1.298 ± 0.072
3.143ThrAsn: 3.143 ± 0.117
2.387ThrPro: 2.387 ± 0.093
2.835ThrGln: 2.835 ± 0.098
1.907ThrArg: 1.907 ± 0.078
3.234ThrSer: 3.234 ± 0.105
3.218ThrThr: 3.218 ± 0.125
2.969ThrVal: 2.969 ± 0.13
0.458ThrTrp: 0.458 ± 0.038
1.674ThrTyr: 1.674 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
4.464ValAla: 4.464 ± 0.129
0.791ValCys: 0.791 ± 0.043
4.179ValAsp: 4.179 ± 0.129
3.81ValGlu: 3.81 ± 0.126
2.891ValPhe: 2.891 ± 0.098
4.372ValGly: 4.372 ± 0.139
1.2ValHis: 1.2 ± 0.068
6.007ValIle: 6.007 ± 0.159
4.562ValLys: 4.562 ± 0.132
6.707ValLeu: 6.707 ± 0.168
1.687ValMet: 1.687 ± 0.08
3.385ValAsn: 3.385 ± 0.105
2.083ValPro: 2.083 ± 0.077
2.077ValGln: 2.077 ± 0.07
2.4ValArg: 2.4 ± 0.093
4.614ValSer: 4.614 ± 0.137
3.394ValThr: 3.394 ± 0.132
4.889ValVal: 4.889 ± 0.132
0.487ValTrp: 0.487 ± 0.04
1.825ValTyr: 1.825 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.491TrpAla: 0.491 ± 0.039
0.128TrpCys: 0.128 ± 0.021
0.438TrpAsp: 0.438 ± 0.038
0.366TrpGlu: 0.366 ± 0.03
0.471TrpPhe: 0.471 ± 0.047
0.615TrpGly: 0.615 ± 0.057
0.347TrpHis: 0.347 ± 0.031
0.788TrpIle: 0.788 ± 0.053
0.464TrpLys: 0.464 ± 0.039
1.073TrpLeu: 1.073 ± 0.058
0.285TrpMet: 0.285 ± 0.032
0.366TrpAsn: 0.366 ± 0.04
0.173TrpPro: 0.173 ± 0.024
0.54TrpGln: 0.54 ± 0.039
0.409TrpArg: 0.409 ± 0.036
0.556TrpSer: 0.556 ± 0.04
0.402TrpThr: 0.402 ± 0.038
0.638TrpVal: 0.638 ± 0.05
0.121TrpTrp: 0.121 ± 0.019
0.298TrpTyr: 0.298 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.077TyrAla: 2.077 ± 0.086
0.356TyrCys: 0.356 ± 0.034
1.498TyrAsp: 1.498 ± 0.071
1.383TyrGlu: 1.383 ± 0.075
1.73TyrPhe: 1.73 ± 0.082
2.109TyrGly: 2.109 ± 0.092
0.86TyrHis: 0.86 ± 0.054
2.096TyrIle: 2.096 ± 0.08
1.956TyrLys: 1.956 ± 0.088
3.722TyrLeu: 3.722 ± 0.121
0.661TyrMet: 0.661 ± 0.047
1.468TyrAsn: 1.468 ± 0.075
1.246TyrPro: 1.246 ± 0.068
1.975TyrGln: 1.975 ± 0.087
1.203TyrArg: 1.203 ± 0.068
2.001TyrSer: 2.001 ± 0.087
1.593TyrThr: 1.593 ± 0.077
1.717TyrVal: 1.717 ± 0.091
0.327TyrTrp: 0.327 ± 0.036
1.115TyrTyr: 1.115 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 976 proteins (305790 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski