Amino acid dipepetide frequency for Cuspidothrix issatschenkoi CHARLIE-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.557AlaAla: 6.557 ± 0.1	0.765AlaCys: 0.765 ± 0.022	3.787AlaAsp: 3.787 ± 0.063	4.82AlaGlu: 4.82 ± 0.066	2.612AlaPhe: 2.612 ± 0.045	4.946AlaGly: 4.946 ± 0.076	1.164AlaHis: 1.164 ± 0.034	6.537AlaIle: 6.537 ± 0.082	4.321AlaLys: 4.321 ± 0.06	7.481AlaLeu: 7.481 ± 0.09	1.525AlaMet: 1.525 ± 0.035	3.467AlaAsn: 3.467 ± 0.069	2.472AlaPro: 2.472 ± 0.053	3.36AlaGln: 3.36 ± 0.066	3.066AlaArg: 3.066 ± 0.061	3.937AlaSer: 3.937 ± 0.071	4.063AlaThr: 4.063 ± 0.071	5.083AlaVal: 5.083 ± 0.079	0.959AlaTrp: 0.959 ± 0.027	2.277AlaTyr: 2.277 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.578CysAla: 0.578 ± 0.021	0.145CysCys: 0.145 ± 0.012	0.565CysAsp: 0.565 ± 0.023	0.589CysGlu: 0.589 ± 0.021	0.404CysPhe: 0.404 ± 0.022	0.8CysGly: 0.8 ± 0.03	0.284CysHis: 0.284 ± 0.015	0.663CysIle: 0.663 ± 0.024	0.369CysLys: 0.369 ± 0.018	1.178CysLeu: 1.178 ± 0.029	0.184CysMet: 0.184 ± 0.012	0.386CysAsn: 0.386 ± 0.021	0.553CysPro: 0.553 ± 0.022	0.639CysGln: 0.639 ± 0.025	0.526CysArg: 0.526 ± 0.021	0.58CysSer: 0.58 ± 0.021	0.448CysThr: 0.448 ± 0.02	0.563CysVal: 0.563 ± 0.019	0.135CysTrp: 0.135 ± 0.011	0.372CysTyr: 0.372 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.241AspAla: 3.241 ± 0.055	0.504AspCys: 0.504 ± 0.021	2.33AspAsp: 2.33 ± 0.047	2.977AspGlu: 2.977 ± 0.053	2.441AspPhe: 2.441 ± 0.048	3.014AspGly: 3.014 ± 0.052	0.941AspHis: 0.941 ± 0.029	4.109AspIle: 4.109 ± 0.056	2.733AspLys: 2.733 ± 0.06	5.723AspLeu: 5.723 ± 0.074	0.827AspMet: 0.827 ± 0.031	2.341AspAsn: 2.341 ± 0.05	2.25AspPro: 2.25 ± 0.046	1.945AspGln: 1.945 ± 0.046	2.653AspArg: 2.653 ± 0.08	2.731AspSer: 2.731 ± 0.052	2.487AspThr: 2.487 ± 0.053	3.003AspVal: 3.003 ± 0.049	0.834AspTrp: 0.834 ± 0.027	1.916AspTyr: 1.916 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.632GluAla: 4.632 ± 0.064	0.504GluCys: 0.504 ± 0.02	2.792GluAsp: 2.792 ± 0.05	4.274GluGlu: 4.274 ± 0.078	2.524GluPhe: 2.524 ± 0.052	3.001GluGly: 3.001 ± 0.054	0.983GluHis: 0.983 ± 0.032	5.807GluIle: 5.807 ± 0.065	4.338GluLys: 4.338 ± 0.071	7.283GluLeu: 7.283 ± 0.084	1.413GluMet: 1.413 ± 0.036	3.579GluAsn: 3.579 ± 0.064	2.18GluPro: 2.18 ± 0.05	3.264GluGln: 3.264 ± 0.056	3.16GluArg: 3.16 ± 0.049	3.429GluSer: 3.429 ± 0.05	3.818GluThr: 3.818 ± 0.057	4.175GluVal: 4.175 ± 0.066	0.833GluTrp: 0.833 ± 0.028	2.193GluTyr: 2.193 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.901PheAla: 2.901 ± 0.054	0.561PheCys: 0.561 ± 0.023	2.259PheAsp: 2.259 ± 0.047	2.058PheGlu: 2.058 ± 0.044	1.738PhePhe: 1.738 ± 0.045	2.738PheGly: 2.738 ± 0.057	0.812PheHis: 0.812 ± 0.028	2.787PheIle: 2.787 ± 0.051	1.73PheLys: 1.73 ± 0.036	4.257PheLeu: 4.257 ± 0.072	0.724PheMet: 0.724 ± 0.022	1.967PheAsn: 1.967 ± 0.044	1.908PhePro: 1.908 ± 0.043	1.849PheGln: 1.849 ± 0.039	1.707PheArg: 1.707 ± 0.037	2.847PheSer: 2.847 ± 0.046	2.424PheThr: 2.424 ± 0.049	2.332PheVal: 2.332 ± 0.046	0.685PheTrp: 0.685 ± 0.025	1.452PheTyr: 1.452 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.271GlyAla: 4.271 ± 0.085	0.763GlyCys: 0.763 ± 0.026	3.146GlyAsp: 3.146 ± 0.057	4.089GlyGlu: 4.089 ± 0.055	2.933GlyPhe: 2.933 ± 0.05	4.471GlyGly: 4.471 ± 0.084	1.152GlyHis: 1.152 ± 0.036	5.292GlyIle: 5.292 ± 0.085	4.613GlyLys: 4.613 ± 0.072	6.688GlyLeu: 6.688 ± 0.083	1.553GlyMet: 1.553 ± 0.042	3.151GlyAsn: 3.151 ± 0.064	1.179GlyPro: 1.179 ± 0.031	2.622GlyGln: 2.622 ± 0.048	2.89GlyArg: 2.89 ± 0.053	3.709GlySer: 3.709 ± 0.063	3.648GlyThr: 3.648 ± 0.063	4.585GlyVal: 4.585 ± 0.072	1.05GlyTrp: 1.05 ± 0.034	2.396GlyTyr: 2.396 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.988HisAla: 0.988 ± 0.03	0.258HisCys: 0.258 ± 0.015	0.819HisAsp: 0.819 ± 0.029	0.949HisGlu: 0.949 ± 0.028	0.841HisPhe: 0.841 ± 0.028	1.14HisGly: 1.14 ± 0.035	0.676HisHis: 0.676 ± 0.027	1.371HisIle: 1.371 ± 0.036	0.86HisLys: 0.86 ± 0.025	2.294HisLeu: 2.294 ± 0.049	0.188HisMet: 0.188 ± 0.013	0.857HisAsn: 0.857 ± 0.028	1.39HisPro: 1.39 ± 0.04	1.272HisGln: 1.272 ± 0.035	1.097HisArg: 1.097 ± 0.029	1.198HisSer: 1.198 ± 0.029	0.961HisThr: 0.961 ± 0.029	0.823HisVal: 0.823 ± 0.027	0.317HisTrp: 0.317 ± 0.017	0.647HisTyr: 0.647 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.797IleAla: 6.797 ± 0.072	0.876IleCys: 0.876 ± 0.025	4.129IleAsp: 4.129 ± 0.062	4.728IleGlu: 4.728 ± 0.067	2.975IlePhe: 2.975 ± 0.065	4.676IleGly: 4.676 ± 0.068	1.431IleHis: 1.431 ± 0.035	5.433IleIle: 5.433 ± 0.089	4.118IleLys: 4.118 ± 0.067	7.63IleLeu: 7.63 ± 0.099	1.115IleMet: 1.115 ± 0.036	3.99IleAsn: 3.99 ± 0.065	3.984IlePro: 3.984 ± 0.066	3.418IleGln: 3.418 ± 0.062	3.231IleArg: 3.231 ± 0.051	5.246IleSer: 5.246 ± 0.064	4.559IleThr: 4.559 ± 0.078	4.416IleVal: 4.416 ± 0.066	0.972IleTrp: 0.972 ± 0.029	2.357IleTyr: 2.357 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.962LysAla: 3.962 ± 0.057	0.372LysCys: 0.372 ± 0.017	2.517LysAsp: 2.517 ± 0.045	3.327LysGlu: 3.327 ± 0.067	2.134LysPhe: 2.134 ± 0.047	2.871LysGly: 2.871 ± 0.056	0.88LysHis: 0.88 ± 0.027	4.646LysIle: 4.646 ± 0.07	3.066LysLys: 3.066 ± 0.064	6.099LysLeu: 6.099 ± 0.084	1.148LysMet: 1.148 ± 0.03	2.933LysAsn: 2.933 ± 0.055	2.7LysPro: 2.7 ± 0.054	3.063LysGln: 3.063 ± 0.056	2.503LysArg: 2.503 ± 0.048	3.669LysSer: 3.669 ± 0.057	3.424LysThr: 3.424 ± 0.06	3.333LysVal: 3.333 ± 0.051	0.601LysTrp: 0.601 ± 0.023	1.892LysTyr: 1.892 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	8.892LeuAla: 8.892 ± 0.106	1.004LeuCys: 1.004 ± 0.031	5.42LeuAsp: 5.42 ± 0.081	7.744LeuGlu: 7.744 ± 0.094	3.863LeuPhe: 3.863 ± 0.076	7.489LeuGly: 7.489 ± 0.102	1.926LeuHis: 1.926 ± 0.043	7.541LeuIle: 7.541 ± 0.097	5.868LeuLys: 5.868 ± 0.077	11.045LeuLeu: 11.045 ± 0.136	2.21LeuMet: 2.21 ± 0.048	4.872LeuAsn: 4.872 ± 0.076	5.478LeuPro: 5.478 ± 0.073	5.632LeuGln: 5.632 ± 0.084	5.001LeuArg: 5.001 ± 0.075	7.222LeuSer: 7.222 ± 0.081	6.468LeuThr: 6.468 ± 0.069	6.786LeuVal: 6.786 ± 0.075	1.351LeuTrp: 1.351 ± 0.042	2.73LeuTyr: 2.73 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.623MetAla: 1.623 ± 0.041	0.131MetCys: 0.131 ± 0.011	0.76MetAsp: 0.76 ± 0.03	1.082MetGlu: 1.082 ± 0.032	0.602MetPhe: 0.602 ± 0.023	1.449MetGly: 1.449 ± 0.042	0.263MetHis: 0.263 ± 0.014	1.348MetIle: 1.348 ± 0.035	1.089MetLys: 1.089 ± 0.032	1.93MetLeu: 1.93 ± 0.045	0.485MetMet: 0.485 ± 0.021	1.01MetAsn: 1.01 ± 0.029	0.844MetPro: 0.844 ± 0.026	0.93MetGln: 0.93 ± 0.024	0.941MetArg: 0.941 ± 0.027	1.373MetSer: 1.373 ± 0.032	1.414MetThr: 1.414 ± 0.04	1.275MetVal: 1.275 ± 0.038	0.17MetTrp: 0.17 ± 0.011	0.425MetTyr: 0.425 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.879AsnAla: 2.879 ± 0.048	0.571AsnCys: 0.571 ± 0.025	1.926AsnAsp: 1.926 ± 0.044	2.165AsnGlu: 2.165 ± 0.043	2.145AsnPhe: 2.145 ± 0.047	2.626AsnGly: 2.626 ± 0.049	1.116AsnHis: 1.116 ± 0.034	3.75AsnIle: 3.75 ± 0.067	2.425AsnLys: 2.425 ± 0.063	6.012AsnLeu: 6.012 ± 0.072	0.785AsnMet: 0.785 ± 0.024	2.757AsnAsn: 2.757 ± 0.071	2.918AsnPro: 2.918 ± 0.049	3.076AsnGln: 3.076 ± 0.063	2.443AsnArg: 2.443 ± 0.043	3.387AsnSer: 3.387 ± 0.061	2.618AsnThr: 2.618 ± 0.049	2.465AsnVal: 2.465 ± 0.053	0.868AsnTrp: 0.868 ± 0.03	1.929AsnTyr: 1.929 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.864ProAla: 2.864 ± 0.046	0.365ProCys: 0.365 ± 0.018	2.853ProAsp: 2.853 ± 0.045	3.981ProGlu: 3.981 ± 0.059	1.655ProPhe: 1.655 ± 0.038	2.975ProGly: 2.975 ± 0.062	0.997ProHis: 0.997 ± 0.036	3.23ProIle: 3.23 ± 0.055	2.309ProLys: 2.309 ± 0.046	4.396ProLeu: 4.396 ± 0.062	0.75ProMet: 0.75 ± 0.026	2.252ProAsn: 2.252 ± 0.04	2.086ProPro: 2.086 ± 0.049	2.585ProGln: 2.585 ± 0.048	1.637ProArg: 1.637 ± 0.042	2.779ProSer: 2.779 ± 0.056	2.828ProThr: 2.828 ± 0.055	3.193ProVal: 3.193 ± 0.056	0.595ProTrp: 0.595 ± 0.023	1.373ProTyr: 1.373 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.035GlnAla: 4.035 ± 0.068	0.34GlnCys: 0.34 ± 0.017	2.17GlnAsp: 2.17 ± 0.048	3.919GlnGlu: 3.919 ± 0.067	1.801GlnPhe: 1.801 ± 0.039	3.209GlnGly: 3.209 ± 0.055	0.867GlnHis: 0.867 ± 0.029	4.083GlnIle: 4.083 ± 0.065	3.298GlnLys: 3.298 ± 0.066	5.74GlnLeu: 5.74 ± 0.092	1.052GlnMet: 1.052 ± 0.031	2.449GlnAsn: 2.449 ± 0.05	2.468GlnPro: 2.468 ± 0.045	3.432GlnGln: 3.432 ± 0.078	2.579GlnArg: 2.579 ± 0.052	2.79GlnSer: 2.79 ± 0.051	2.856GlnThr: 2.856 ± 0.049	3.578GlnVal: 3.578 ± 0.056	0.647GlnTrp: 0.647 ± 0.024	1.335GlnTyr: 1.335 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.694ArgAla: 2.694 ± 0.047	0.473ArgCys: 0.473 ± 0.019	2.361ArgAsp: 2.361 ± 0.049	3.285ArgGlu: 3.285 ± 0.051	2.022ArgPhe: 2.022 ± 0.041	2.76ArgGly: 2.76 ± 0.056	0.951ArgHis: 0.951 ± 0.027	3.262ArgIle: 3.262 ± 0.055	2.47ArgLys: 2.47 ± 0.044	5.417ArgLeu: 5.417 ± 0.067	0.954ArgMet: 0.954 ± 0.029	2.12ArgAsn: 2.12 ± 0.046	1.912ArgPro: 1.912 ± 0.049	2.911ArgGln: 2.911 ± 0.056	2.606ArgArg: 2.606 ± 0.054	2.746ArgSer: 2.746 ± 0.062	2.326ArgThr: 2.326 ± 0.045	2.97ArgVal: 2.97 ± 0.053	0.681ArgTrp: 0.681 ± 0.024	1.775ArgTyr: 1.775 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.956SerAla: 3.956 ± 0.064	0.632SerCys: 0.632 ± 0.026	2.97SerAsp: 2.97 ± 0.048	3.706SerGlu: 3.706 ± 0.056	2.453SerPhe: 2.453 ± 0.041	4.355SerGly: 4.355 ± 0.07	1.331SerHis: 1.331 ± 0.037	4.164SerIle: 4.164 ± 0.052	2.952SerLys: 2.952 ± 0.057	7.293SerLeu: 7.293 ± 0.088	1.173SerMet: 1.173 ± 0.031	2.774SerAsn: 2.774 ± 0.05	3.392SerPro: 3.392 ± 0.059	3.788SerGln: 3.788 ± 0.066	2.923SerArg: 2.923 ± 0.045	4.194SerSer: 4.194 ± 0.071	3.274SerThr: 3.274 ± 0.052	3.743SerVal: 3.743 ± 0.062	0.922SerTrp: 0.922 ± 0.027	1.878SerTyr: 1.878 ± 0.047	0.001SerXaa: 0.001 ± 0.001
Thr	4.584ThrAla: 4.584 ± 0.078	0.485ThrCys: 0.485 ± 0.02	2.742ThrAsp: 2.742 ± 0.05	3.54ThrGlu: 3.54 ± 0.057	2.055ThrPhe: 2.055 ± 0.046	4.227ThrGly: 4.227 ± 0.066	1.019ThrHis: 1.019 ± 0.027	4.239ThrIle: 4.239 ± 0.07	2.757ThrLys: 2.757 ± 0.051	6.07ThrLeu: 6.07 ± 0.077	0.869ThrMet: 0.869 ± 0.033	2.755ThrAsn: 2.755 ± 0.051	3.381ThrPro: 3.381 ± 0.059	2.786ThrGln: 2.786 ± 0.047	2.235ThrArg: 2.235 ± 0.043	3.452ThrSer: 3.452 ± 0.06	3.498ThrThr: 3.498 ± 0.068	3.829ThrVal: 3.829 ± 0.057	0.72ThrTrp: 0.72 ± 0.024	1.712ThrTyr: 1.712 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.044ValAla: 5.044 ± 0.074	0.642ValCys: 0.642 ± 0.027	3.243ValAsp: 3.243 ± 0.06	4.158ValGlu: 4.158 ± 0.065	2.502ValPhe: 2.502 ± 0.048	4.395ValGly: 4.395 ± 0.069	1.009ValHis: 1.009 ± 0.035	4.826ValIle: 4.826 ± 0.083	3.687ValLys: 3.687 ± 0.059	6.272ValLeu: 6.272 ± 0.077	1.413ValMet: 1.413 ± 0.031	3.189ValAsn: 3.189 ± 0.051	2.63ValPro: 2.63 ± 0.052	2.56ValGln: 2.56 ± 0.043	2.885ValArg: 2.885 ± 0.053	3.906ValSer: 3.906 ± 0.057	3.618ValThr: 3.618 ± 0.058	4.385ValVal: 4.385 ± 0.069	0.779ValTrp: 0.779 ± 0.027	1.91ValTyr: 1.91 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.709TrpAla: 0.709 ± 0.027	0.149TrpCys: 0.149 ± 0.011	0.67TrpAsp: 0.67 ± 0.028	1.01TrpGlu: 1.01 ± 0.031	0.614TrpPhe: 0.614 ± 0.022	0.976TrpGly: 0.976 ± 0.031	0.337TrpHis: 0.337 ± 0.018	0.862TrpIle: 0.862 ± 0.026	0.644TrpLys: 0.644 ± 0.026	1.857TrpLeu: 1.857 ± 0.043	0.302TrpMet: 0.302 ± 0.016	0.6TrpAsn: 0.6 ± 0.023	0.294TrpPro: 0.294 ± 0.017	1.241TrpGln: 1.241 ± 0.031	0.787TrpArg: 0.787 ± 0.025	0.743TrpSer: 0.743 ± 0.025	0.566TrpThr: 0.566 ± 0.022	0.893TrpVal: 0.893 ± 0.03	0.228TrpTrp: 0.228 ± 0.014	0.413TrpTyr: 0.413 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.993TyrAla: 1.993 ± 0.048	0.421TyrCys: 0.421 ± 0.017	1.544TyrAsp: 1.544 ± 0.038	1.782TyrGlu: 1.782 ± 0.047	1.421TyrPhe: 1.421 ± 0.036	2.081TyrGly: 2.081 ± 0.047	0.809TyrHis: 0.809 ± 0.031	2.13TyrIle: 2.13 ± 0.044	1.495TyrLys: 1.495 ± 0.041	3.874TyrLeu: 3.874 ± 0.069	0.476TyrMet: 0.476 ± 0.019	1.413TyrAsn: 1.413 ± 0.031	1.683TyrPro: 1.683 ± 0.04	2.273TyrGln: 2.273 ± 0.05	1.826TyrArg: 1.826 ± 0.047	1.935TyrSer: 1.935 ± 0.047	1.655TyrThr: 1.655 ± 0.042	1.623TyrVal: 1.623 ± 0.038	0.548TyrTrp: 0.548 ± 0.023	1.202TyrTyr: 1.202 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3876 proteins (1187661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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