Amino acid dipepetide frequency for Pseudonocardia sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.581AlaAla: 21.581 ± 0.164	0.967AlaCys: 0.967 ± 0.022	8.805AlaAsp: 8.805 ± 0.072	8.182AlaGlu: 8.182 ± 0.075	3.399AlaPhe: 3.399 ± 0.047	14.538AlaGly: 14.538 ± 0.106	2.731AlaHis: 2.731 ± 0.04	3.797AlaIle: 3.797 ± 0.045	2.009AlaLys: 2.009 ± 0.04	14.018AlaLeu: 14.018 ± 0.103	2.627AlaMet: 2.627 ± 0.04	1.849AlaAsn: 1.849 ± 0.038	7.66AlaPro: 7.66 ± 0.104	3.471AlaGln: 3.471 ± 0.047	10.537AlaArg: 10.537 ± 0.089	6.078AlaSer: 6.078 ± 0.051	7.722AlaThr: 7.722 ± 0.069	13.079AlaVal: 13.079 ± 0.1	1.798AlaTrp: 1.798 ± 0.031	2.115AlaTyr: 2.115 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.023	0.101CysCys: 0.101 ± 0.009	0.497CysAsp: 0.497 ± 0.015	0.379CysGlu: 0.379 ± 0.013	0.174CysPhe: 0.174 ± 0.011	0.942CysGly: 0.942 ± 0.026	0.182CysHis: 0.182 ± 0.01	0.177CysIle: 0.177 ± 0.01	0.077CysLys: 0.077 ± 0.006	0.613CysLeu: 0.613 ± 0.018	0.097CysMet: 0.097 ± 0.008	0.112CysAsn: 0.112 ± 0.007	0.493CysPro: 0.493 ± 0.016	0.131CysGln: 0.131 ± 0.008	0.621CysArg: 0.621 ± 0.019	0.426CysSer: 0.426 ± 0.016	0.451CysThr: 0.451 ± 0.017	0.613CysVal: 0.613 ± 0.019	0.124CysTrp: 0.124 ± 0.008	0.149CysTyr: 0.149 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.997AspAla: 8.997 ± 0.076	0.36AspCys: 0.36 ± 0.013	5.026AspAsp: 5.026 ± 0.065	4.325AspGlu: 4.325 ± 0.055	1.309AspPhe: 1.309 ± 0.028	7.247AspGly: 7.247 ± 0.072	1.444AspHis: 1.444 ± 0.029	1.625AspIle: 1.625 ± 0.028	0.869AspLys: 0.869 ± 0.022	6.679AspLeu: 6.679 ± 0.067	0.846AspMet: 0.846 ± 0.022	0.784AspAsn: 0.784 ± 0.02	5.468AspPro: 5.468 ± 0.07	1.383AspGln: 1.383 ± 0.025	5.752AspArg: 5.752 ± 0.066	2.471AspSer: 2.471 ± 0.037	3.404AspThr: 3.404 ± 0.05	6.1AspVal: 6.1 ± 0.059	0.865AspTrp: 0.865 ± 0.022	1.034AspTyr: 1.034 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.187GluAla: 6.187 ± 0.066	0.309GluCys: 0.309 ± 0.013	2.472GluAsp: 2.472 ± 0.041	2.494GluGlu: 2.494 ± 0.051	1.525GluPhe: 1.525 ± 0.029	3.544GluGly: 3.544 ± 0.046	1.666GluHis: 1.666 ± 0.031	2.532GluIle: 2.532 ± 0.033	1.243GluLys: 1.243 ± 0.033	6.627GluLeu: 6.627 ± 0.06	0.966GluMet: 0.966 ± 0.023	1.019GluAsn: 1.019 ± 0.026	3.61GluPro: 3.61 ± 0.049	2.304GluGln: 2.304 ± 0.04	5.366GluArg: 5.366 ± 0.063	2.534GluSer: 2.534 ± 0.037	2.9GluThr: 2.9 ± 0.037	4.631GluVal: 4.631 ± 0.049	0.745GluTrp: 0.745 ± 0.018	0.934GluTyr: 0.934 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.667PheAla: 3.667 ± 0.05	0.282PheCys: 0.282 ± 0.013	2.149PheAsp: 2.149 ± 0.033	1.186PheGlu: 1.186 ± 0.026	0.788PhePhe: 0.788 ± 0.022	3.114PheGly: 3.114 ± 0.046	0.567PheHis: 0.567 ± 0.015	0.539PheIle: 0.539 ± 0.017	0.308PheLys: 0.308 ± 0.012	2.463PheLeu: 2.463 ± 0.045	0.336PheMet: 0.336 ± 0.012	0.43PheAsn: 0.43 ± 0.015	1.325PhePro: 1.325 ± 0.028	0.489PheGln: 0.489 ± 0.015	1.742PheArg: 1.742 ± 0.032	1.456PheSer: 1.456 ± 0.028	1.832PheThr: 1.832 ± 0.029	2.434PheVal: 2.434 ± 0.035	0.411PheTrp: 0.411 ± 0.014	0.537PheTyr: 0.537 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.946GlyAla: 11.946 ± 0.089	0.786GlyCys: 0.786 ± 0.021	5.791GlyAsp: 5.791 ± 0.055	5.207GlyGlu: 5.207 ± 0.057	2.919GlyPhe: 2.919 ± 0.035	9.291GlyGly: 9.291 ± 0.103	2.249GlyHis: 2.249 ± 0.036	3.545GlyIle: 3.545 ± 0.051	1.845GlyLys: 1.845 ± 0.035	9.692GlyLeu: 9.692 ± 0.088	2.098GlyMet: 2.098 ± 0.036	1.573GlyAsn: 1.573 ± 0.035	6.241GlyPro: 6.241 ± 0.078	2.47GlyGln: 2.47 ± 0.044	8.318GlyArg: 8.318 ± 0.081	5.803GlySer: 5.803 ± 0.072	6.572GlyThr: 6.572 ± 0.072	8.482GlyVal: 8.482 ± 0.079	1.767GlyTrp: 1.767 ± 0.031	2.213GlyTyr: 2.213 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.57HisAla: 2.57 ± 0.036	0.194HisCys: 0.194 ± 0.01	1.546HisAsp: 1.546 ± 0.031	1.167HisGlu: 1.167 ± 0.026	0.506HisPhe: 0.506 ± 0.017	2.407HisGly: 2.407 ± 0.044	0.69HisHis: 0.69 ± 0.022	0.499HisIle: 0.499 ± 0.016	0.246HisLys: 0.246 ± 0.012	2.281HisLeu: 2.281 ± 0.037	0.296HisMet: 0.296 ± 0.012	0.336HisAsn: 0.336 ± 0.013	1.77HisPro: 1.77 ± 0.035	0.503HisGln: 0.503 ± 0.017	2.119HisArg: 2.119 ± 0.035	0.92HisSer: 0.92 ± 0.024	1.14HisThr: 1.14 ± 0.028	1.851HisVal: 1.851 ± 0.031	0.32HisTrp: 0.32 ± 0.013	0.439HisTyr: 0.439 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.978IleAla: 4.978 ± 0.051	0.259IleCys: 0.259 ± 0.013	2.421IleAsp: 2.421 ± 0.042	1.921IleGlu: 1.921 ± 0.033	0.652IlePhe: 0.652 ± 0.019	3.842IleGly: 3.842 ± 0.049	0.499IleHis: 0.499 ± 0.018	0.766IleIle: 0.766 ± 0.028	0.497IleLys: 0.497 ± 0.016	2.312IleLeu: 2.312 ± 0.038	0.41IleMet: 0.41 ± 0.015	0.611IleAsn: 0.611 ± 0.021	1.843IlePro: 1.843 ± 0.029	0.586IleGln: 0.586 ± 0.019	2.245IleArg: 2.245 ± 0.038	1.718IleSer: 1.718 ± 0.032	2.131IleThr: 2.131 ± 0.037	3.084IleVal: 3.084 ± 0.045	0.399IleTrp: 0.399 ± 0.015	0.564IleTyr: 0.564 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	1.99LysAla: 1.99 ± 0.044	0.07LysCys: 0.07 ± 0.006	0.877LysAsp: 0.877 ± 0.026	0.741LysGlu: 0.741 ± 0.022	0.365LysPhe: 0.365 ± 0.013	1.214LysGly: 1.214 ± 0.03	0.329LysHis: 0.329 ± 0.012	0.767LysIle: 0.767 ± 0.022	0.493LysLys: 0.493 ± 0.023	1.571LysLeu: 1.571 ± 0.034	0.292LysMet: 0.292 ± 0.013	0.343LysAsn: 0.343 ± 0.016	0.949LysPro: 0.949 ± 0.028	0.49LysGln: 0.49 ± 0.019	1.144LysArg: 1.144 ± 0.03	0.785LysSer: 0.785 ± 0.023	0.913LysThr: 0.913 ± 0.023	1.43LysVal: 1.43 ± 0.033	0.179LysTrp: 0.179 ± 0.011	0.302LysTyr: 0.302 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.987LeuAla: 14.987 ± 0.111	0.764LeuCys: 0.764 ± 0.021	7.411LeuAsp: 7.411 ± 0.07	4.322LeuGlu: 4.322 ± 0.053	2.574LeuPhe: 2.574 ± 0.043	9.76LeuGly: 9.76 ± 0.079	2.204LeuHis: 2.204 ± 0.037	2.93LeuIle: 2.93 ± 0.047	1.181LeuLys: 1.181 ± 0.029	10.739LeuLeu: 10.739 ± 0.118	1.416LeuMet: 1.416 ± 0.027	1.45LeuAsn: 1.45 ± 0.028	6.182LeuPro: 6.182 ± 0.062	2.125LeuGln: 2.125 ± 0.035	8.553LeuArg: 8.553 ± 0.078	5.204LeuSer: 5.204 ± 0.063	6.287LeuThr: 6.287 ± 0.057	9.842LeuVal: 9.842 ± 0.103	1.135LeuTrp: 1.135 ± 0.027	1.502LeuTyr: 1.502 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.17MetAla: 2.17 ± 0.033	0.138MetCys: 0.138 ± 0.009	0.849MetAsp: 0.849 ± 0.019	0.642MetGlu: 0.642 ± 0.022	0.51MetPhe: 0.51 ± 0.017	1.32MetGly: 1.32 ± 0.028	0.35MetHis: 0.35 ± 0.015	0.743MetIle: 0.743 ± 0.02	0.304MetLys: 0.304 ± 0.013	1.795MetLeu: 1.795 ± 0.033	0.275MetMet: 0.275 ± 0.012	0.372MetAsn: 0.372 ± 0.014	1.104MetPro: 1.104 ± 0.024	0.413MetGln: 0.413 ± 0.016	1.422MetArg: 1.422 ± 0.027	1.375MetSer: 1.375 ± 0.029	1.735MetThr: 1.735 ± 0.033	1.42MetVal: 1.42 ± 0.028	0.206MetTrp: 0.206 ± 0.01	0.238MetTyr: 0.238 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.013AsnAla: 2.013 ± 0.037	0.135AsnCys: 0.135 ± 0.008	0.924AsnAsp: 0.924 ± 0.025	0.713AsnGlu: 0.713 ± 0.024	0.408AsnPhe: 0.408 ± 0.017	1.802AsnGly: 1.802 ± 0.045	0.348AsnHis: 0.348 ± 0.014	0.538AsnIle: 0.538 ± 0.017	0.301AsnLys: 0.301 ± 0.014	1.56AsnLeu: 1.56 ± 0.026	0.257AsnMet: 0.257 ± 0.013	0.345AsnAsn: 0.345 ± 0.017	1.291AsnPro: 1.291 ± 0.028	0.419AsnGln: 0.419 ± 0.019	1.243AsnArg: 1.243 ± 0.027	0.78AsnSer: 0.78 ± 0.023	0.874AsnThr: 0.874 ± 0.024	1.311AsnVal: 1.311 ± 0.03	0.263AsnTrp: 0.263 ± 0.012	0.343AsnTyr: 0.343 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.162ProAla: 9.162 ± 0.112	0.317ProCys: 0.317 ± 0.013	5.536ProAsp: 5.536 ± 0.062	4.302ProGlu: 4.302 ± 0.053	1.476ProPhe: 1.476 ± 0.025	7.484ProGly: 7.484 ± 0.084	1.249ProHis: 1.249 ± 0.028	1.645ProIle: 1.645 ± 0.032	0.873ProLys: 0.873 ± 0.026	5.029ProLeu: 5.029 ± 0.054	1.079ProMet: 1.079 ± 0.023	0.893ProAsn: 0.893 ± 0.025	3.771ProPro: 3.771 ± 0.07	1.532ProGln: 1.532 ± 0.034	4.159ProArg: 4.159 ± 0.05	3.729ProSer: 3.729 ± 0.053	3.548ProThr: 3.548 ± 0.056	6.028ProVal: 6.028 ± 0.058	0.888ProTrp: 0.888 ± 0.02	1.032ProTyr: 1.032 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.212GlnAla: 3.212 ± 0.049	0.141GlnCys: 0.141 ± 0.009	1.272GlnAsp: 1.272 ± 0.024	1.125GlnGlu: 1.125 ± 0.029	0.627GlnPhe: 0.627 ± 0.016	1.956GlnGly: 1.956 ± 0.038	0.523GlnHis: 0.523 ± 0.017	1.045GlnIle: 1.045 ± 0.026	0.481GlnLys: 0.481 ± 0.021	2.651GlnLeu: 2.651 ± 0.041	0.49GlnMet: 0.49 ± 0.017	0.542GlnAsn: 0.542 ± 0.019	1.337GlnPro: 1.337 ± 0.029	0.942GlnGln: 0.942 ± 0.031	2.277GlnArg: 2.277 ± 0.037	1.085GlnSer: 1.085 ± 0.026	1.23GlnThr: 1.23 ± 0.026	2.467GlnVal: 2.467 ± 0.035	0.375GlnTrp: 0.375 ± 0.014	0.454GlnTyr: 0.454 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.342ArgAla: 10.342 ± 0.082	0.626ArgCys: 0.626 ± 0.019	4.982ArgAsp: 4.982 ± 0.058	4.613ArgGlu: 4.613 ± 0.055	2.42ArgPhe: 2.42 ± 0.034	6.112ArgGly: 6.112 ± 0.058	2.005ArgHis: 2.005 ± 0.033	3.314ArgIle: 3.314 ± 0.044	1.209ArgLys: 1.209 ± 0.025	8.106ArgLeu: 8.106 ± 0.075	1.888ArgMet: 1.888 ± 0.033	1.296ArgAsn: 1.296 ± 0.029	5.355ArgPro: 5.355 ± 0.069	1.831ArgGln: 1.831 ± 0.037	8.457ArgArg: 8.457 ± 0.089	4.643ArgSer: 4.643 ± 0.05	5.409ArgThr: 5.409 ± 0.053	6.464ArgVal: 6.464 ± 0.064	1.504ArgTrp: 1.504 ± 0.031	1.725ArgTyr: 1.725 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.694SerAla: 6.694 ± 0.07	0.394SerCys: 0.394 ± 0.017	3.206SerAsp: 3.206 ± 0.044	2.602SerGlu: 2.602 ± 0.039	1.433SerPhe: 1.433 ± 0.029	6.419SerGly: 6.419 ± 0.081	0.909SerHis: 0.909 ± 0.026	1.593SerIle: 1.593 ± 0.032	0.788SerLys: 0.788 ± 0.023	4.548SerLeu: 4.548 ± 0.053	1.204SerMet: 1.204 ± 0.028	0.838SerAsn: 0.838 ± 0.022	3.4SerPro: 3.4 ± 0.047	1.147SerGln: 1.147 ± 0.025	3.875SerArg: 3.875 ± 0.042	3.161SerSer: 3.161 ± 0.048	3.481SerThr: 3.481 ± 0.039	4.408SerVal: 4.408 ± 0.048	0.862SerTrp: 0.862 ± 0.023	0.97SerTyr: 0.97 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.66ThrAla: 8.66 ± 0.072	0.433ThrCys: 0.433 ± 0.014	4.156ThrAsp: 4.156 ± 0.052	3.232ThrGlu: 3.232 ± 0.04	1.554ThrPhe: 1.554 ± 0.028	7.163ThrGly: 7.163 ± 0.074	1.129ThrHis: 1.129 ± 0.025	1.933ThrIle: 1.933 ± 0.034	0.865ThrLys: 0.865 ± 0.026	5.479ThrLeu: 5.479 ± 0.053	1.006ThrMet: 1.006 ± 0.024	0.93ThrAsn: 0.93 ± 0.024	4.32ThrPro: 4.32 ± 0.058	1.129ThrGln: 1.129 ± 0.028	4.19ThrArg: 4.19 ± 0.047	3.335ThrSer: 3.335 ± 0.046	4.185ThrThr: 4.185 ± 0.062	6.294ThrVal: 6.294 ± 0.059	0.883ThrTrp: 0.883 ± 0.023	1.054ThrTyr: 1.054 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	13.021ValAla: 13.021 ± 0.102	0.723ValCys: 0.723 ± 0.018	6.018ValAsp: 6.018 ± 0.054	4.941ValGlu: 4.941 ± 0.05	2.362ValPhe: 2.362 ± 0.039	7.758ValGly: 7.758 ± 0.062	2.042ValHis: 2.042 ± 0.034	2.816ValIle: 2.816 ± 0.038	1.139ValLys: 1.139 ± 0.026	10.729ValLeu: 10.729 ± 0.104	1.305ValMet: 1.305 ± 0.028	1.496ValAsn: 1.496 ± 0.032	5.773ValPro: 5.773 ± 0.065	1.946ValGln: 1.946 ± 0.029	7.346ValArg: 7.346 ± 0.065	4.525ValSer: 4.525 ± 0.05	6.083ValThr: 6.083 ± 0.058	9.915ValVal: 9.915 ± 0.1	1.114ValTrp: 1.114 ± 0.026	1.356ValTyr: 1.356 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.661TrpAla: 1.661 ± 0.03	0.154TrpCys: 0.154 ± 0.009	0.813TrpAsp: 0.813 ± 0.023	0.658TrpGlu: 0.658 ± 0.019	0.536TrpPhe: 0.536 ± 0.016	1.028TrpGly: 1.028 ± 0.023	0.338TrpHis: 0.338 ± 0.014	0.534TrpIle: 0.534 ± 0.018	0.239TrpLys: 0.239 ± 0.011	1.648TrpLeu: 1.648 ± 0.031	0.284TrpMet: 0.284 ± 0.012	0.346TrpAsn: 0.346 ± 0.013	0.84TrpPro: 0.84 ± 0.024	0.458TrpGln: 0.458 ± 0.014	1.219TrpArg: 1.219 ± 0.024	1.006TrpSer: 1.006 ± 0.023	1.028TrpThr: 1.028 ± 0.021	1.08TrpVal: 1.08 ± 0.025	0.36TrpTrp: 0.36 ± 0.014	0.267TrpTyr: 0.267 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.158TyrAla: 2.158 ± 0.033	0.177TyrCys: 0.177 ± 0.01	1.234TyrAsp: 1.234 ± 0.031	0.857TyrGlu: 0.857 ± 0.021	0.518TyrPhe: 0.518 ± 0.017	1.868TyrGly: 1.868 ± 0.036	0.346TyrHis: 0.346 ± 0.013	0.398TyrIle: 0.398 ± 0.016	0.274TyrLys: 0.274 ± 0.012	2.028TyrLeu: 2.028 ± 0.034	0.21TyrMet: 0.21 ± 0.012	0.304TyrAsn: 0.304 ± 0.013	1.001TyrPro: 1.001 ± 0.025	0.466TyrGln: 0.466 ± 0.017	1.719TyrArg: 1.719 ± 0.027	0.898TyrSer: 0.898 ± 0.023	1.001TyrThr: 1.001 ± 0.027	1.474TyrVal: 1.474 ± 0.024	0.296TyrTrp: 0.296 ± 0.012	0.398TyrTyr: 0.398 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6113 proteins (1958073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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